Prof. Dr. Jean Pieters

Biozentrum
University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Raum 505 Tel.: +41 61 267 14 94
E-Mail: jean.pieters-at-unibas.ch
Lebenslauf

Administrative Assistent/in

Maja Heckel
Biozentrum, Raum 508
Tel.: +41 61 267 21 51
Fax: +41 61 267 21 48
E-Mail: maja.heckel-at-unibas.ch

Forschungsgruppe Jean Pieters

Artikel

2012
Janssen, S; Jayachandran, R; Khathi, L; Zinsstag, J; Grobusch, MP; Pieters, J;  (2012). Exploring prospects of novel drugs for tuberculosis. Drug design, development and therapy, 6, 217-224.
Jayachandran, R.; Bosedasgupta, S.; Pieters, J. (2012). Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis. Current topics in microbiology and immunology, , 23154833.
Jayachandran, R.; Scherr, N.; Pieters, J. (2012). Elimination of intracellularly residing Mycobacterium tuberculosis through targeting of host and bacterial signaling mechanisms. Expert review of anti-infective therapy, 10(9), 1007-22.
Westritschnig, K.; Bosedasgupta, S.; Tchang, V.; Siegmund, K.; Pieters, J. (2012). Antigen processing and presentation by dendritic cells is independent of coronin 1. Molecular immunology, 53(4), 379-386.
2011
Mueller, P.; Liu, X.; Pieters, J. (2011). Migration and homeostasis of naive T cells depends on coronin 1-mediated prosurvival signals and not on coronin 1-dependent filamentous actin modulation. The Journal of Immunology, 186(7), 4039-50.
Siegmund, K.; Zeis, T.; Kunk, G.; Rolink, T.; Schaeren-Wiemers, N.; Pieters, J. (2011). Coronin 1-mediated naive T cell survival is essential for the development of autoimmune encephalomyelitis. The Journal of Immunology, 186(6), 3452-61.
2010
Cheng, Y.; Pieters, J. (2010). Novel proteasome inhibitors as potential drugs to combat tuberculosis. Journal of Molecular Cell Biology, 2, 173-5.
2009
Scherr, N.; Jayachandran, R.; Mueller, P.; Pieters, J. (2009). Interference of Mycobacterium tuberculosis with macrophage responses. Indian Journal of Experimental Biology, 47(6), 401-406.
Scherr, N.; Muller, P.; Perisa, D.; Combaluzier, B.; Jenö, P.; Pieters, J. (2009). Survival of pathogenic mycobacteria in macrophages is mediated through autophosphorylation of protein kinase G. Journal of Bacteriology, 191(14), 4546-4554.
Bottova, I.; Hehl, A.B.; Stefanic, S.; Fabrias, G.; Casas, J.; Schraner, E.; Pieters, J.; Sonda, S. (2009). Host cell P-glycoprotein is essential for cholesterol uptake and replication of Toxoplasma gondii. The Journal of Biological Chemistry, 284(26), 17438-17448.
Nguyen, L.; Pieters, J. (2009). Mycobacterial subversion of chemotherapeutic reagents and host defense tactics: challenges in tuberculosis drug development. Annual Review of Pharmacology and Toxicology, 49, 427-453.
Combaluzier, B.; Pieters, J. (2009). Chemotaxis and phagocytosis in neutrophils is independent of coronin 1. Journal of Immunology (Baltimore, Md. : 1950), 182(5), 2745-2752.
Houben, E.N.G.; Walburger, A.; Ferrari, G.; Nguyen, L.; Thompson, C.J.; Miess, C.; Vogel, G.; Mueller, B.; Pieters, J. (2009). Differential expression of a virulence factor in pathogenic and non-pathogenic mycobacteria. Molecular Microbiology, 72(1), 41-52.
Combaluzier, B.; Mueller, P.; Massner, J.; Finke, D.; Pieters, J. (2009). Coronin 1 is essential for IgM-mediated Ca2+ mobilization in B cells but dispensable for the generation of immune responses in vivo. Journal of Immunology (Baltimore, Md. : 1950), 182(4), 1954-1961.
Jayachandran, R.; Scherr, N.; Pieters, J. (2009). Analyzing the interaction of pathogens with the host immune system. Immunology Letters, 122(2), 112-114.
Mueller, P.; Scherr, N.; Jayachandran, R.; Pieters, J.: Subversion of host immune responses by Macobacterium tuberculosis, in: (2009). Host-Pathogen Interactions: Genetics, Immunology and Physiology, Nova Science Publishers Inc .
Scherr, N.; Pieters, J.: The Eukaryotic-like Serine/Threonine Kinase Family in Mycobacteria, in: Tanya Parish and Amanda Brown (Ed.). (2009). Mycobacterium: Genomics and Molecular Biology, Caister Academic Press .
2008
Mueller, P.; Massner, J.; Jayachandran, R.; Combaluzier, B.; Albrecht, I.; Gatfield, J.; Blum, C.; Ceredig, R.; Rodewald, H.-R.; Rolink, A.G.; Pieters, J. (2008). Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering. Nature Immunology, 9(4), 424-431.
Jayachandran, R.; Gatfield, J.; Massner, J.; Albrecht, I.; Zanolari, B.; Pieters, J. (2008). RNA interference in J774 macrophages reveals a role for coronin 1 in mycobacterial trafficking but not in actin-dependent processes. Molecular Biology of the Cell, 19(3), 1241-1251.
Pieters, J. (2008). The role of signal transduction pathways in the survival of Mycobacterium tuberculosis inside macrophages. Cell Host and Microbes, (3), 399-407.
Pieters, J. (2008). Coronin 1 in innate immunity. Sub-Cellular Biochemistry, 48, 116-123.
Pieters, J. (2008). Mycobacterium Tuberculosis and the macrophage: maintaining a balance. Cell Host & Microbe, 3(6), 399-407.
Pieters, J.: Manipulation of the Macrophage Response by Pathogenic Mycobacteria, in: Kaufmann, Stefan H. E. /. Rubin (Ed.). (2008). Handbook of Tuberculosis: Molecular Biology and Biochemistry, Wiley-VCH , S. 423.
2007
Nguyen, L.; Scherr, N.; Gatfield, J.; Walburger, A.; Pieters, J.; Thompson, C.J. (2007). Antigen 84, an effector of pleiomorphism in Mycobacterium smegmatis. Journal of Bacteriology, 189(21), 7896-7910.
Sundaramurthy, V.; Pieters, J. (2007). Interactions of pathogenic mycobacteria with host macrophages. Microbes and Infection / Institut Pasteur, 9(14-15), 1671-1679.
Scherr, N.; Honnappa, S.; Kunz, G.; Mueller, P.; Jayachandran, R.; Winkler, F.; Pieters, J.; Steinmetz, M.O. (2007). Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America, 104(29), 12151-12156.
Mueller, P.; Quintana, A.; Griesemer, D.; Hoth, M.; Pieters, J. (2007). Disruption of the cortical actin cytoskeleton does not affect store operated Ca2+ channels in human T-cells. FEBS Letters, 581(18), 3557-3562.
Jayachandran, R.; Sundaramurthy, V.; Combaluzier, B.; Mueller, P.; Korf, H.; Huygen, K.; Miyazaki, T.; Albrecht, I.; Massner, J.; Pieters, J. (2007). Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin. Cell, 130(1), 37-50.
Majlessi, L.; Combaluzier, B.; Albrecht, I.; Garcia, J.E.; Nouze, C.; Pieters, J.; Leclerc, C. (2007). Inhibition of phagosome maturation by mycobacteria does not interfere with presentation of mycobacterial antigens by MHC molecules. Journal of Immunology (Baltimore, Md. : 1950), 179(3), 1825-1833.
2006
Floto, R.A.; MacAry, P.A.; Boname, J.M.; Mien, T.S.; Kampmann, B.; Hair, J.R.; Huey, O.S.; Houben, E.N.G.; Pieters, J.; Day, C.; Oehlmann, W.; Singh, M.; Smith, K.G.C.; Lehner, P.J. (2006). Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5. Science (New York, N.Y.), 314(5798), 454-458.
Nguyen, L.; Pieters, J. (2006). Battle for survival: interplay between pathogenic mycobacteria and the host immune system. Discovery Medicine, 6(32), 82-86.
Mueller, P.; Pieters, J. (2006). Modulation of macrophage antimicrobial mechanisms by pathogenic mycobacteria. Immunobiology, 211(6-8), 549-556.
Albrecht, I.; Gatfield, J.; Mini, T.; Jeno, P.; Pieters, J. (2006). Essential role for cholesterol in the delivery of exogenous antigens to the MHC class I-presentation pathway. International Immunology, 18(5), 755-765.
Houben, E.N.G.; Nguyen, L.; Pieters, J. (2006). Interaction of pathogenic mycobacteria with the host immune system. Current Opinion in Microbiology, 9(1), 76-85.
2005
Kammerer, R.A.; Kostrewa, D.; Progias, P.; Honnappa, S.; Avila, D.; Lustig, A.; Winkler, F.K.; Pieters, J.; Steinmetz, M.O. (2005). A conserved trimerization motif controls the topology of short coiled coils. Proceedings of the National Academy of Sciences of the United States of America, 102(39), 13891-13896.
Morris, R.P.; Nguyen, L.; Gatfield, J.; Visconti, K.; Nguyen, K.; Schnappinger, D.; Ehrt, S.; Liu, Y.; Heifets, L.; Pieters, J.; Schoolnik, G.; Thompson, C.J. (2005). Ancestral antibiotic resistance in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America, 102(34), 12200-12205.
Nguyen, L.; Walburger, A.; Houben, E.; Koul, A.; Muller, S.; Morbitzer, M.; Klebl, B.; Ferrari, G.; Pieters, J. (2005). Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG. Journal of Bacteriology, 187(16), 5852-5856.
Gatfield, J.; Albrecht, I.; Zanolari, B.; Steinmetz, M.O.; Pieters, J. (2005). Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules. Molecular Biology of the Cell, 16(6), 2786-2798.
Nguyen, L.; Pieters, J. (2005). The Trojan horse: survival tactics of pathogenic mycobacteria in macrophages. Trends in Cell Biology, 15(5), 269-276.
Sonda, S.; Sala, G.; Ghidoni, R.; Hemphill, A.; Pieters, J. (2005). Inhibitory effect of aureobasidin A on Toxoplasma gondii. Antimicrobial Agents and Chemotherapy, 49(5), 1794-1801.
2004
Walburger, A.; Koul, A.; Ferrari, G.; Nguyen, L.; Prescianotto-Baschong, C.; Huygen, K.; Klebl, B.; Thompson, C.; Bacher, G.; Pieters, J. (2004). Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science (New York, N.Y.), 304(5678), 1800-1804.
2003
Pieters, J.: Molecular Mechanisms Regulating Membrane Traffic in Macrophages: Lessons from the Intracellular Pathogen Mycobacterium spp,, in: Jean-Pierre Gorvel (Ed.). (2003). Intracellular Pathogens in Membrane Interactions and Vacuole Biogenesis, Springer Netherlands , S. 316 pp.
Dory, D.; Echchannaoui, H.; Letiembre, M.; Ferracin, F.; Pieters, J.; Adachi, Y.; Akashi, S.; Zimmerli, W.; Landmann, R. (2003). Generation and functional characterization of a clonal murine periportal Kupffer cell line from H-2Kb -tsA58 mice. Journal of Leukocyte Biology, 74(1), 49-59.
Pieters, J.: Regulation of Membrane Fusion Processes in Eukaryotic Cells: What Can We Learn From Pathogenic Mycobacteria?, in: C.D. O'Connor (Ed.). (2003). Microbial Subversion of host cells, Cambridge University Press .
Engering, A.; Kuhn, L.; Fluitsma, D.; Hoefsmit, E.; Pieters, J. (2003). Differential post-translational modification of CD63 molecules during maturation of human dendritic cells. European Journal of Biochemistry / FEBS, 270(11), 2412-2420.
Gatfield, J.; Pieters, J. (2003). Molecular mechanisms of host-pathogen interaction: entry and survival of mycobacteria in macrophages. Advances in Immunology, 81, 45-96.
Pieters, J.; Ploegh, H. (2003). Chemical warfare and mycobacterial defense. Science (New York, N.Y.), 302(5652), 1900-1902.
2002
Pieters, J.; Gatfield, J. (2002). Hijacking the host: survival of pathogenic mycobacteria inside macrophages. Trends in Microbiology, 10(3), 142-146.
2001
Engering, A.; Pieters, J. (2001). Association of distinct tetraspanins with MHC class ll molecules at different subcellular locations in human immature dendritic cells. Int Immunol, (13), 127-34.
Pieters, J. (2001). Evasion of host cell defense mechanisms by pathogenic bacteria. Curr Opin Immunol, 13, 37-44.
Pieters, J. (2001). Entry and survival of pathogenic mycobacteria in macrophages. Microbes Infect, 3, 249-55.
2000
Gatfield, J.; Ferrari, G.; Pieters, J. (2000). Immunity against Extracellular Pathogens. Protoplasma, 210, 99-107.
Gatfield, J.; Pieters, J. (2000). Essential role for cholesterol in entry of mycobacteria into macrophages. Science, 288, 1647-50.
Pieters, J. (2000). MHC class ll-restricted antigen processing and presentation. Immunol, 75, 159-208.
1999
Eynon, E.E.; Schlax, C.; Pieters, J. (1999). A Secreted form of the MHC Class ll Associated Invariant Chain Inhibiting T cell Activation. J. Biol. Chem., 274, 26266-71.
Pieters, J.: Processing and presentation of phagocytosed antigens to the immune system, in: S. Gordon (Ed.). (1999). Phagocytosis: The Host, JAI Press Inc. , S. 379-406.
Cella, M.; Salio, M.; Scheidegger, D.; Engering, A.; Pieters, J.; Sallusto, A.; Lanzavecchia, A.: Regulation of antigen capture, MHC biosynthesis and degradation optimizes presentation of infectious antigens in maturing dendritic cells, in: Lotze, Michael T; Thomson, Angus W. (Ed.). (1999). Dendritic cells : biology and clinical applications, San Diego: Academic Press , S. 631-636.
Ferrari, G.; Langen, H.; Naito, M.; Pieters, J. (1999). A coat protein on phagosomes involved in the intracellular survival of mycobacteria. Cell, 97(4), 435-447.
1998
Engering, A.J.; Richters, C.D.; Fluitsma, D.M.; van Pelt, A.M.; Kamperdijk, E.W.; Hoefsmit, E.C.; Pieters, J. (1998). MHC class II and invariant chain biosynthesis and transport during maturation of human precursor dendritic cells. Int Immunol, 10, 1713-1723.
Hasan, Z.; Pieters, J. (1998). Subcellular fractionation by organelle electrophoresis: Separation of phagosomes containing heat-killed yeast particles. Electrophoresis, 19, 1179-84.
1997
Cella, M.; Engering, A.; Pinet, V.; Pieters, J.; Lanzavecchia, A. (1997). Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature, 388, 782-7.
Engering, A.; Lefkovits, I.; Pieters, J. (1997). Analysis of subcellular organelles involved in major histocompatibility complex (MHC) class II-restricted antigen presentation by electrophoresis. Electrophoresis, 18(14), 2523-2530.
Engering, A.J.; Cella, M.; Fluitsma, D.; Brockhaus, M.; Hoefsmit, E.C.; Lanzavecchia, A.; Pieters, J. (1997). The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells. European Journal of Immunology, 27(9), 2417-2425.
Hasan, Z.; Schlax, C.; Kuhn, L.; Lefkovits, I.; Young, D.; Thole, J.; Pieters, J. (1997). Isolation and characterization of the mycobacterial phagosome: segregation from the endosomal/lysosomal pathway. Molecular Microbiology, 24(3), 545-553.
Pieters, J. (1997). MHC class ll compartments: specialized organelles of the endocytic pathway in antigen presenting cells. Biol Chem, 378, 751-8.
Engering, A.J.; Cella, M.; Fluitsma, D.M.; Hoefsmit, E.C.; Lanzavecchia, A.; Pieters, J. (1997). Mannose receptor mediated antigen uptake and presentation in human dendritic cells. Advances in Experimental Medicine and Biology, 417, 183-187.
Ferrari, G.; Knight, A.M.; Watts, C.; Pieters, J. (1997). Distinct Intracellular Compartments Involved in Invariant Chain Degradation and Antigenic Peptide Loading of Major Histocompatibility Complex (MHC) Class II Molecules. J Cell Biol, 139, 1433-46.
1994
Tulp, A.; Verwoerd, D.; Dobberstein, B.; Ploegh, HL.; Pieters, J. (1994). Isolation and characterization of the intracellular MHC class II compartment. Nature, 369, 120-6.
1993
Pieters, J.; Bakke, O.; Dobberstein, B. (1993). The MHC class ll-associated Invariant chain contains two endosomal sorting signals within its cytoplasmic tail. J. Cell Sci., 106, 831-46.
Tulp, A.; Verwoerd, D.; Pieters, J. (1993). Application of an improved density gradient electrophoresis apparatus to the separation of proteins, cells and subcellular organelles. Electrophoresis, 14(12), 1295-1301.
1991
Pieters, J.; Horstmann, H.; Bakke, O.; Griffiths, G.; Lipp, J. (1991). Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain. J Cell Biol, 115, 1213-23.
1990
Pieters, J.; Lindhout, T.; Willems, G. (1990). Heparin-stimulated inhibition of factor lXa generation and factor lXa neutralization in plasma. Blood, 76, 549-54.
1989
Pieters, J.; Lindhout, T.; Hemker, H.C. (1989). In situ-generated thrombin is the only enzyme that effectively activates factor VIII and factor V in thromboplastin-activated plasma. Blood, 74(3), 1021-1024.
Hemker, H.C.; Beguin, S.; Pieters, J.; Lindhout, T. (1989). The ex vivo correlate of the antithrombotic action of heparin. Annals of the New York Academy of Sciences, 556, 146-157.
1988
Pieters, J.; Lindhout, T. (1988). The limited importance of factor Xa inhibition to the anticoagulant property of heparin in thromboplastin-activated plasma. Blood, 72(6), 2048-2052.
Pieters, J.; Willems, G.; Hemker, H.C; Lindhout, T. (1988). Inhibition of faxtor lXa and factor Xa by antithrombin lll/heparin during factor X activation. J. Biol. Chem., 263, 15313-8.
Maurer-Fogy, I.; Reutelingsperger, C.P.; Pieters, J.; Bodo, G.; Stratowa, C.; Hauptmann, R. (1988). Cloning and expression of cDNA for human vascular anticoagulant, a Ca2+-dependent phospholipid-binding protein. European Journal of Biochemistry / FEBS, 174(4), 585-592.
1987
Pieters, J.; Franssen, J.; Visch, C.; Lindhout, T. (1987). Neutralization of heparin by prothrombin activation products. Thrombosis Research, 45(5), 573-580.

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