Events

Streptococcus pyogenes - the true expert of the human immune System

Prof. Mattias Collin, Lund University, Faculty of Medicine, Lund, Sweden

Host: Prof. Guy Cornelis, Biozentrum

The STRING protein-protein interaction database - what it is and how it can be used in infection research.

Prof. Christian von Mering, University of Zürich

Host: Prof. Christoph Dehio, Biozentrum

Femtosecond nanocrystallography of membrane proteins opens a new Era for Structural Biology.

Prof. Petra Fromme, Department of Chemistry and Biochemistry, Arizona State University, Tempe Arizona, USA

Femtosecond nanocrystallography provides a novel concept for structure determination, where X-ray diffraction “snapshots” are collected from a fully hydrated stream of nanocrystals, using femtosecond pulses from the world‘s first high energy X-ray free-electron laser, the Linac Coherent Light Source. Photosystem I, which is the most complex membrane that has been crystallized to date, consisting of 36 proteins and 381 cofactors, was used as the model system. The experiments show the proof of concept that diffraction of nanocrystals that contain only 100-10 000 Photosytem I molecules can be observed using femtosecond pulses that are 1012 stronger than 3rd generation synchrotron sources and destroy any material that is placed in its focus. Over 3 million diffraction patterns from individual nanocrystals (100nm- 2 µm in size) were collected and evaluated [1]. By using femtosecond pulses briefer than the time-scale of most damage processes, femtosecond nanocrystallography overcomes the problem of X-ray damage in crystallography. Data collected at the new CXI LCLS beamline at higher energy (8keV) showed that the concept of fs crystallography extends to atomic resolution. Data will be presented that show that nanocrystals of membrane proteins, which are notoriously difficult to crystallize, have extremely low mosaicity. Femtosecond crystallography also opens a new avenue for determination of protein dynamics. First experiments on time resolved X-ray crystallography have been performed on Photosystem I-ferredoxin and Photosystem II nano-crystals. The first results are very promising and pave the way for a new avenue in X-ray crystallography that may allow the determination of molecular movies of the dynamics of membrane proteins "at work" in the future.

Host: Stefanie Kauer, Biozentrum

VirtualToxLab - In silico prediction of the toxic potential of drugs and chemicals

Angelo Vedani
Pharmazentrum

Host: Paul Herrling, Torsten Schwede

Bacterial strategies to escape innate immunity.

Prof. Suzan Rooijakkers, University Medical Centre Utrecht, Utrecht, The Netherlands

Host: Prof. Jean Pieters, Biozentrum

Probabilistic models for analyzing RNAi screening data.

Prof. Niko Beerenwinkel, ETH Zurich, D-BSSE

Host: Prof. Christoph Dehio, Biozentrum

Farewell Symposium Guy R. Cornelis

Internationally renowned scientists gather in Basel for a one-day symposium celebrating the scientific achievements and contributions of Guy R. Cornelis.

For details see: www.biozentrum.unibas.ch/symposium-cornelis/

Host: Prof. Dr. Christoph Dehio

Rap proteins in cell adhesion and polarity.

Prof. Johannes L. Bos
Molecular Cancer Research
University Medical Center Utrecht, Netherlands

Host: Prof. Mike Hall, Biozentrum

Basel Muscle Club

Sreya Basu, Group Brenner, Biozentrum: A new twist in agrin's function at the NMJ: regulation of synaptic AChR density through the organization of subsynaptic microtubules.

Anne-Sophie Arnold, Group Handschin Biozentrum
A muscle-specific over-expression of PGC-1 alpha converts the whole NMJ into a slow-type phenotype by a retrograde signaling.

Host: Jerome Feige, Andrew MacKenzie, Markus Rüegg

ECCB12 - European Conference on Computational Biology

Diverse

Das Meeting wird zusammen mit der 10. BC2 stattfinden.

Host: Prof. Torsten Schwede, Biozentrum