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\b 2013\b0 \par \par \par Summermatter, Serge; Santos, Gesa; P\'e9rez-Schindler, Joaqu\'edn; Handschin, Christoph\'a0(2013). Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A. Proceedings of the National Academy of Sciences of the United States of America, 110(21), 8738-43.\par \par \par Bentzinger, C Florian; Lin, Shuo; Romanino, Klaas; Castets, Perrine; Guridi, Maitea; Summermatter, Serge; Handschin, Christoph; Tintignac, Lionel A; Hall, Michael N; R\'fcegg, Markus A\'a0(2013). Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal muscle, 3(1), 6.\par \par \par Eisele, Petra S; Salatino, Silvia; Sobek, Jens; Hottiger, Michael O; Handschin, Christoph\'a0(2013). The Peroxisome Proliferator-activated Receptor γ Coactivator 1α/β (PGC-1) Coactivators Repress the Transcriptional Activity of NF-κB in Skeletal Muscle Cells. The Journal of biological chemistry, 288(4), 2246-60.\par \par \par St\'f6lting, Meline Nogueira Lucena; Ferrari, Stefano; Handschin, Christoph; Becskei, Attila; Provenzano, Maurizio; Sulser, Tullio; Eberli, Daniel\'a0(2013). Myoblasts Inhibit Prostate Cancer Growth by Paracrine Secretion of Tumor Necrosis Factor-α. The Journal of urology, 189(5), 1952-1959.\par \par \par Summermatter, Serge; Shui, Guanghou; Maag, Daniela; Santos, Gesa; Wenk, Markus R; Handschin, Christoph\'a0(2013). PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner. Diabetes, 62(1), 85-95.\par \par \par \b 2012\b0 \par \par \par P\'e9rez-Schindler, Joaqu\'edn; Summermatter, Serge; Salatino, Silvia; Zorzato, Francesco; Beer, Markus; Balwierz, Piotr J; van Nimwegen, Erik; Feige, J\'e9r\'f4me N; Auwerx, Johan; Handschin, Christoph\'a0(2012). The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism. Molecular and cellular biology, 32(24), 4913-24.\par \par \par Handschin, Christoph; Meyer, Urs A.\'a0(2012). Warum reagiert mein Patient anders auf dieses Medikament? Pharmakogenomik und Personalisierte Medizin in der Praxis. Swiss Medical Forum, 12(22), 425-433.\par \par \par Arnold, Anne-Sophie; Christe, Martine; Handschin, Christoph\'a0(2012). A Functional Motor Unit in the Culture Dish: Co-culture of Spinal Cord Explants and Muscle Cells. Journal of visualized experiments : JoVE, (62), e3616.\par \par \par Egger, Anna; Samardzija, Marijana; Sothilingam, Vithiyanjali; Tanimoto, Naoyuki; Lange, Christina; Salatino, Silvia; Fang, Lei; Garcia-Garrido, Marina; Beck, Susanne; Okoniewski, Michal J; Neutzner, Albert; Seeliger, Mathias W; Grimm, Christian; Handschin, Christoph\'a0(2012). PGC-1alpha Determines Light Damage Susceptibility of the Murine Retina. PloS one, 7(2), e31272.\par \par \par Summermatter, S; Handschin, C\'a0(2012). PGC-1alpha and exercise in the control of body weight. International journal of obesity, 36(11), 1428-35.\par \par \par Summermatter, Serge; Thurnheer, Raphael; Santos, Gesa; Mosca, Barbara; Baum, Oliver; Treves, Susan; Hoppeler, Hans; Zorzato, Francesco; Handschin, Christoph\'a0(2012). Remodeling of calcium handling in skeletal muscle through PGC-1alpha: impact on force, fatigability, and fiber type. American journal of physiology. Cell physiology, 302(1), C88-99.\par \par \par \b 2011\b0 \par \par \par Romanino, Klaas; Mazelin, Laetitia; Albert, Verena; Conjard-Duplany, Agn\'e8s; Lin, Shuo; Bentzinger, C Florian; Handschin, Christoph; Puigserver, Pere; Zorzato, Francesco; Schaeffer, Laurent; Gangloff, Yann-Ga\'ebl; R\'fcegg, Markus A\'a0(2011). Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America, 108(51), 20808-13.\par \par \par Summermatter, S.; Troxler, H.; Santos, G.; Handschin, C.\'a0(2011). Coordinated balancing of muscle oxidative metabolism through PGC-1alpha increases metabolic flexibility and preserves insulin sensitivity. Biochemical and Biophysical Research Communications, 408(1), 180-185.\par \par \par Handschin, Christoph;\'a0Spiegelman, Bruce M: PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination, in: Cell metabolism 13, 2011, H. 4, S. 351; author reply 352.\par \par \par Handschin, C.\'a0(2011). Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta) improves skeletal muscle mitochondrial function and insulin sensitivity. Diabetologia, 54(6), 1270-1272.\par \par \par Arnold, A.-S.; Egger, A.; Handschin, C.\'a0(2011). PGC-1alpha and Myokines in the Aging Muscle - A Mini-Review. Gerontology, 57(1), 37-43.\par \par \par \b 2010\b0 \par \par \par Stein, S.; Lohmann, C.; Handschin, C.; Stenfeldt, E.; Boren, J.; Luscher, T.F.; Matter, C.M.\'a0(2010). ApoE-/- PGC-1alpha-/- Mice Display Reduced IL-18 Levels and Do Not Develop Enhanced Atherosclerosis. PloS one, 5(10), e13539.\par \par \par Summermatter, S.; Baum, O.; Santos, G.; Hoppeler, H.; Handschin, C.\'a0(2010). Peroxisome Proliferator-activated Receptor gamma Coactivator 1alpha (PGC-1alpha) Promotes Skeletal Muscle Lipid Refueling in Vivo by Activating de Novo Lipogenesis and the Pentose Phosphate Pathway. The Journal of Biological Chemistry, 285(43), 32793-32800.\par \par \par Stein, S.; Schafer, N.; Breitenstein, A.; Besler, C.; Winnik, S.; Lohmann, C.; Heinrich, K.; Brokopp, C.E.; Handschin, C.; Landmesser, U.; Tanner, F.C.; Luscher, T.F.; Matter, C.M.\'a0(2010). SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice. Aging, 2(6), 353-360.\par \par \par Burch, N.; Arnold, A.S.; Item, F.; Summermatter, S.; Brochmann Santana Santos, G.; Christe, M.; Boutellier, U.; Toigo, M.; Handschin, C.\'a0(2010). Electric Pulse Stimulation of Cultured Murine Muscle Cells Reproduces Gene Expression Changes of Trained Mouse Muscle. PloS one, 5(6), e10970.\par \par \par Handschin, C.\'a0(2010). Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor gamma coactivator 1alpha. Journal of Receptor and Signal Transduction Research, 30(6), 376-384.\par \par \par \b 2009\b0 \par \par \par Handschin, C.\'a0(2009). PGC-1alpha in muscle links metabolism to inflammation. Clinical and Experimental Pharmacology & Physiology, 36, 1139-1143.\par \par \par Handschin, C.\'a0(2009). The biology of PGC-1alpha and its therapeutic potential. Trends in Pharmacological Sciences, 30(6), 322-329.\par \par \par Zenhaeusern, G.; Gubser, P.; Eisele, P.; Gasser, O.; Steinhuber, A.; Trampuz, A.; Handschin, C.; Luster, A.D.; Hess, C.\'a0(2009). A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells. Blood, 113(1), 95-99.\par \par \par \b 2008\b0 \par \par \par Choi, C.S.; Befroy, D.E.; Codella, R.; Kim, S.; Reznick, R.M.; Hwang, Y.-J.; Liu, Z.-X.; Lee, H.-Y.; Distefano, A.; Samuel, V.T.; Zhang, D.; Cline, G.W.; Handschin, C.; Lin, J.; Petersen, K.F.; Spiegelman, B.M.; Shulman, G.I.\'a0(2008). Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America, 105(50), 19926-19931.\par \par \par Handschin, C.; Spiegelman, B.M.\'a0(2008). The role of exercise and PGC1alpha in inflammation and chronic disease. Nature, 454(7203), 463-469.\par \par \par Handschin, C.: Nuclear Receptors as Drug Targets, in:  Ottow, E.\'a0(Ed.). (2008). Methods and Principles in Medicinal Chemistry, Weinheim: Wiley-VCH , S. 453-458.\par \par \par \b 2007\b0 \par \par \par Handschin, C.; Chin, S.; Li, P.; Liu, F.; Maratos-Flier, E.; Lebrasseur, N.K.; Yan, Z.; Spiegelman, B.M.\'a0(2007). Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. The Journal of Biological Chemistry, 282(41), 30014-30021.\par \par \par Handschin, C.; Choi, C.S.; Chin, S.; Kim, S.; Kawamori, D.; Kurpad, A.J.; Neubauer, N.; Hu, J.; Mootha, V.K.; Kim, Y.-B.; Kulkarni, R.N.; Shulman, G.I.; Spiegelman, B.M.\'a0(2007). Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. The Journal of Clinical Investigation, 117(11), 3463-3474.\par \par \par Handschin, C.; Kobayashi, Y.M.; Chin, S.; Seale, P.; Campbell, K.P.; Spiegelman, B.M.\'a0(2007). PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes & Development, 21(7), 770-783.\par \par \par Jager, S.; Handschin, C.; St-Pierre, J.; Spiegelman, B.M.\'a0(2007). AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proceedings of the National Academy of Sciences of the United States of America, 104(29), 12017-12022.\par \par \par Matter, C.M.; Handschin, C.\'a0(2007). RANTES (regulated on activation, normal T cell expressed and secreted), inflammation, obesity, and the metabolic syndrome. Circulation, 115(8), 946-948.\par \par \par Rohas, L.M.; St-Pierre, J.; Uldry, M.; Jager, S.; Handschin, C.; Spiegelman, B.M.\'a0(2007). A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proceedings of the National Academy of Sciences of the United States of America, 104(19), 7933-7938.\par \par \par \b 2006\b0 \par \par \par Handschin, C.; Spiegelman, B.M.\'a0(2006). Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocrine Reviews, 27(7), 728-735.\par \par \par Rhee, J.; Ge, H.; Yang, W.; Fan, M.; Handschin, C.; Cooper, M.; Lin, J.; Li, C.; Spiegelman, B.M.\'a0(2006). Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism. The Journal of Biological Chemistry, 281(21), 14683-14690.\par \par \par Sandri, M.; Lin, J.; Handschin, C.; Yang, W.; Arany, Z.P.; Lecker, S.H.; Goldberg, A.L.; Spiegelman, B.M.\'a0(2006). PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proceedings of the National Academy of Sciences of the United States of America, 103(44), 16260-16265.\par \par \par St-Pierre, J.; Drori, S.; Uldry, M.; Silvaggi, J.M.; Rhee, J.; Jager, S.; Handschin, C.; Zheng, K.; Lin, J.; Yang, W.; Simon, D.K.; Bachoo, R.; Spiegelman, B.M.\'a0(2006). Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell, 127(2), 397-408.\par \par \par Wu, Z.; Huang, X.; Feng, Y.; Handschin, C.; Gullicksen, P.S.; Bare, O.; Labow, M.; Spiegelman, B.; Stevenson, S.C.\'a0(2006). Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proceedings of the National Academy of Sciences of the United States of America, 103(39), 14379-14384.\par \par \par \b 2005\b0 \par \par \par Handschin, C.; Meyer, U.A.\'a0(2005). Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Archives of Biochemistry and Biophysics, 433(2), 387-396.\par \par \par Lin, J.; Handschin, C.; Spiegelman, B.M.\'a0(2005). Metabolic control through the PGC-1 family of transcription coactivators. Cell Metabolism, 1(6), 361-370.\par \par \par Lin, J.; Yang, R.; Tarr, P.T.; Wu, P.-H.; Handschin, C.; Li, S.; Yang, W.; Pei, L.; Uldry, M.; Tontonoz, P.; Newgard, C.B.; Spiegelman, B.M.\'a0(2005). Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell, 120(2), 261-273.\par \par \par Gnerre, C.; Schuster, G.U.; Roth, A.; Handschin, C.; Johansson, L.; Looser, R.; Parini, P.; Podvinec, M.; Robertsson, K.; Gustafsson, J.-A.; Meyer, U.A.\'a0(2005). LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver. Journal of Lipid Research, 46(8), 1633-1642.\par \par \par Handschin, C.; Gnerre, C.; Fraser, D.J.; Martinez-Jimenez, C.; Jover, R.; Meyer, U.A.\'a0(2005). Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Archives of Biochemistry and Biophysics, 434(1), 75-85.\par \par \par Handschin, C.; Mootha, V.K.\'a0(2005). Estrogen-related receptor alpha (ERRalpha): a novel target in type 2 diabetes. Drug Discovery Today Therapeutic Strategies, 2(2), 151-156.\par \par \par Arany, Z.; He, H.; Lin, J.; Hoyer, K.; Handschin, C.; Toka, O.; Ahmad, F.; Matsui, T.; Chin, S.; Wu, P.-H.; Rybkin, I.I.; Shelton, J.M.; Manieri, M.; Cinti, S.; Schoen, F.J.; Bassel-Duby, R.; Rosenzweig, A.; Ingwall, J.S.; Spiegelman, B.M.\'a0(2005). Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metabolism, 1(4), 259-271.\par \par \par Handschin, C.; Lin, J.; Rhee, J.; Peyer, A.-K.; Chin, S.; Wu, P.-H.; Meyer, U.A.; Spiegelman, B.M.\'a0(2005). Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell, 122(4), 505-515.\par \par \par Handschin, C.;\'a0Meyer, U.A.: PXR and CAR: more than meets the eye, in:  Oesch, F.\'a0(Ed.). (2005). Proceedings of the 15th Int. Symposium on Microsomes and Drug Oxidation, Bologna: Medimond Int. Poc. Div. Monduzzi Editore , S. 17-21.\par \par \par \b 2004\b0 \par \par \par Fan, M.; Rhee, J.; St-Pierre, J.; Handschin, C.; Puigserver, P.; Lin, J.; Jaeger, S.; Erdjument-Bromage, H.; Tempst, P.; Spiegelman, B.M.\'a0(2004). Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes & Development, 18(3), 278-289.\par \par \par Handschin, C.; Blattler, S.; Roth, A.; Looser, R.; Oscarson, M.; Kaufmann, M.R.; Podvinec, M.; Gnerre, C.; Meyer, U.A.\'a0(2004). The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals. Nuclear Receptor, 2(1), 7.\par \par \par Podvinec, M.; Handschin, C.; Looser, R.; Meyer, U.A.\'a0(2004). Identification of the xenosensors regulating human 5-aminolevulinate synthase. Proceedings of the National Academy of Sciences of the United States of America, 101(24), 9127-9132.\par \par \par Mootha, Vamsi K; Handschin, Christoph; Arlow, Dan; Xie, Xiaohui; St Pierre, Julie; Sihag, Smita; Yang, Wenli; Altshuler, David; Puigserver, Pere; Patterson, Nick; Willy, Patricia J; Schulman, Ira G; Heyman, Richard A; Lander, Eric S; Spiegelman, Bruce M\'a0(2004). Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proceedings of the National Academy of Sciences of the United States of America, 101(17), 6570-5.\par \par \par \b 2003\b0 \par \par \par Handschin, C.; Rhee, J.; Lin, J.; Tarr, P.T.; Spiegelman, B.M.\'a0(2003). An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proceedings of the National Academy of Sciences of the United States of America, 100(12), 7111-7116.\par \par \par Handschin, C.; Podvinec, M.; Meyer, U.A.\'a0(2003). In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism. Drug News & Perspectives, 16(7), 423-434.\par \par \par Sanyal, S.; Handschin, C.; Podvinec, M.; Song, K.-H.; Kim, H.-J.; Kim, J.-Y.; Seo, Y.-W.; Kim, S.-A.; Kwon, H.-B.; Lee, K.; Kim, W.-S.; Meyer, U.A.; Choi, H.-S.\'a0(2003). Molecular cloning and characterization of chicken orphan nuclear receptor cTR2. General and Comparative Endocrinology, 132(3), 474-484.\par \par \par Handschin, C.; Meyer, U.A.\'a0(2003). Induction of drug metabolism: the role of nuclear receptors. Pharmacological Reviews, 55(4), 649-673.\par \par \par Handschin, C.;\'a0Meyer, U.A.: The molecular mechanism of induction of cytochromes P450 by drugs and other xenobiotics, in:  D\'f6hmer, J.\'a0(Ed.). (2003). Nova Acta Leopoldina, Halle: Deutsche Akad. der Naturforscher Leopoldina , S. 205-211.\par \par \par \b 2002\b0 \par \par \par Handschin, C.; Podvinec, M.; Amherd, R.; Looser, R.; Ourlin, J.-C.; Meyer, U.A.\'a0(2002). Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. The Journal of Biological Chemistry, 277(33), 29561-29567.\par \par \par Podvinec, M.; Kaufmann, M.R.; Handschin, C.; Meyer, U.A.\'a0(2002). NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Molecular Endocrinology (Baltimore, Md.), 16(6), 1269-1279.\par \par \par Ourlin, J.-C.; Handschin, C.; Kaufmann, M.; Meyer, U.A.\'a0(2002). A Link between cholesterol levels and phenobarbital induction of cytochromes P450. Biochemical and Biophysical Research Communications, 291(2), 378-384.\par \par \par \b 2001\b0 \par \par \par Handschin, C.; Podvinec, M.; Looser, R.; Amherd, R.; Meyer, U.A.\'a0(2001). Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor. Molecular Pharmacology, 60(4), 681-689.\par \par \par Handschin, C.; Podvinec, M.; Stockli, J.; Hoffmann, K.; Meyer, U.A.\'a0(2001). Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. Molecular Endocrinology (Baltimore, Md.), 15(9), 1571-1585.\par \par \par \b 2000\b0 \par \par \par Handschin, C.; Podvinec, M.; Meyer, U.A.\'a0(2000). CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR). Proceedings of the National Academy of Sciences of the United States of America, 97(20), 10769-10774.\par \par \par Handschin, C.; Meyer, U.A.\'a0(2000). A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line. The Journal of Biological Chemistry, 275(18), 13362-13369.\par \par \par }Empty Filename.