Research group Kaspar Vogt

The function of interneurons

Electrophysiological measurements and the use of voltage-dependent dyes allow us to investigate the functions of the great variety of inhibitory interneurons, even in disease states.

Inhibitory interneurons in this brain appear green.

The function of our brain depends on a precisely balanced equilibrium between excitatory and inhibitory signaling. Disturbance of this balance may lead to diseases such as epilepsy, anxiety states, and schizophrenia. Inhibitory signals are sent out by about 20% of the nerve cells in the brain, known as inhibitory interneurons. One important feature of these nerve cells or neurons is their great functional and morphological variety, although there has been little research so far into the significance of this diversity.

The effects of different inhibitory signals

We are investigating the effects of different interneurons on their target cells. The different effects they can trigger in the target cells and the interactions between excitatory and inhibitory signals are of particular interest to us.

Nerve cells are complex geometric entities with many cell processes, known as dendrites, which receive signals from other nerve cells. Various interneurons send their signals to very specific sites on these dendrites. We are especially interested in how the complex geometry influences signal processing. Voltage-dependent dyes should enable us to demonstrate these signals at a high spatial resolution.

Understanding and using the variety

Many medications (e.g. sleeping tablets) target the functions or effects of the interneurons because of their key role in cerebral function. Research into their variety contributes to better understanding of neuronal diseases and will allow us to develop novel medicines.