| 2013 |
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Bentzinger, C Florian; Lin, Shuo; Romanino, Klaas; Castets, Perrine; Guridi, Maitea; Summermatter, Serge; Handschin, Christoph; Tintignac, Lionel A; Hall, Michael N; Rüegg, Markus A (2013). Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal muscle, 3(1), 6.
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Eisele, Petra S; Salatino, Silvia; Sobek, Jens; Hottiger, Michael O; Handschin, Christoph (2013). The Peroxisome Proliferator-activated Receptor γ Coactivator 1α/β (PGC-1) Coactivators Repress the Transcriptional Activity of NF-κB in Skeletal Muscle Cells. The Journal of biological chemistry, 288(4), 2246-60.
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Stölting, Meline Nogueira Lucena; Ferrari, Stefano; Handschin, Christoph; Becskei, Attila; Provenzano, Maurizio; Sulser, Tullio; Eberli, Daniel (2013). Myoblasts Inhibit Prostate Cancer Growth by Paracrine Secretion of Tumor Necrosis Factor-α. The Journal of urology, 189(5), 1952-1959.
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Summermatter, Serge; Shui, Guanghou; Maag, Daniela; Santos, Gesa; Wenk, Markus R; Handschin, Christoph (2013). PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner. Diabetes, 62(1), 85-95.
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| 2012 |
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Pérez-Schindler, Joaquín; Summermatter, Serge; Salatino, Silvia; Zorzato, Francesco; Beer, Markus; Balwierz, Piotr J; van Nimwegen, Erik; Feige, Jérôme N; Auwerx, Johan; Handschin, Christoph (2012). The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism. Molecular and cellular biology, 32(24), 4913-24.
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Handschin, Christoph; Meyer, Urs A. (2012). Warum reagiert mein Patient anders auf dieses Medikament? Pharmakogenomik und Personalisierte Medizin in der Praxis. Swiss Medical Forum, 12(22), 425-433.
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Arnold, Anne-Sophie; Christe, Martine; Handschin, Christoph (2012). A Functional Motor Unit in the Culture Dish: Co-culture of Spinal Cord Explants and Muscle Cells. Journal of visualized experiments : JoVE, (62), e3616.
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Egger, Anna; Samardzija, Marijana; Sothilingam, Vithiyanjali; Tanimoto, Naoyuki; Lange, Christina; Salatino, Silvia; Fang, Lei; Garcia-Garrido, Marina; Beck, Susanne; Okoniewski, Michal J; Neutzner, Albert; Seeliger, Mathias W; Grimm, Christian; Handschin, Christoph (2012). PGC-1alpha Determines Light Damage Susceptibility of the Murine Retina. PloS one, 7(2), e31272.
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Summermatter, S; Handschin, C (2012). PGC-1alpha and exercise in the control of body weight. International journal of obesity, 36(11), 1428-35.
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Summermatter, Serge; Thurnheer, Raphael; Santos, Gesa; Mosca, Barbara; Baum, Oliver; Treves, Susan; Hoppeler, Hans; Zorzato, Francesco; Handschin, Christoph (2012). Remodeling of calcium handling in skeletal muscle through PGC-1alpha: impact on force, fatigability, and fiber type. American journal of physiology. Cell physiology, 302(1), C88-99.
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| 2011 |
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Romanino, Klaas; Mazelin, Laetitia; Albert, Verena; Conjard-Duplany, Agnès; Lin, Shuo; Bentzinger, C Florian; Handschin, Christoph; Puigserver, Pere; Zorzato, Francesco; Schaeffer, Laurent; Gangloff, Yann-Gaël; Rüegg, Markus A (2011). Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America, 108(51), 20808-13.
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Summermatter, S.; Troxler, H.; Santos, G.; Handschin, C. (2011). Coordinated balancing of muscle oxidative metabolism through PGC-1alpha increases metabolic flexibility and preserves insulin sensitivity. Biochemical and Biophysical Research Communications, 408(1), 180-185.
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Handschin, Christoph; Spiegelman, Bruce M: PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination, in: Cell metabolism 13, 2011, H. 4, S. 351; author reply 352.
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Handschin, C. (2011). Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta) improves skeletal muscle mitochondrial function and insulin sensitivity. Diabetologia, 54(6), 1270-1272.
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Arnold, A.-S.; Egger, A.; Handschin, C. (2011). PGC-1alpha and Myokines in the Aging Muscle - A Mini-Review. Gerontology, 57(1), 37-43.
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| 2010 |
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Stein, S.; Lohmann, C.; Handschin, C.; Stenfeldt, E.; Boren, J.; Luscher, T.F.; Matter, C.M. (2010). ApoE-/- PGC-1alpha-/- Mice Display Reduced IL-18 Levels and Do Not Develop Enhanced Atherosclerosis. PloS one, 5(10), e13539.
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Summermatter, S.; Baum, O.; Santos, G.; Hoppeler, H.; Handschin, C. (2010). Peroxisome Proliferator-activated Receptor gamma Coactivator 1alpha (PGC-1alpha) Promotes Skeletal Muscle Lipid Refueling in Vivo by Activating de Novo Lipogenesis and the Pentose Phosphate Pathway. The Journal of Biological Chemistry, 285(43), 32793-32800.
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Stein, S.; Schafer, N.; Breitenstein, A.; Besler, C.; Winnik, S.; Lohmann, C.; Heinrich, K.; Brokopp, C.E.; Handschin, C.; Landmesser, U.; Tanner, F.C.; Luscher, T.F.; Matter, C.M. (2010). SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice. Aging, 2(6), 353-360.
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Burch, N.; Arnold, A.S.; Item, F.; Summermatter, S.; Brochmann Santana Santos, G.; Christe, M.; Boutellier, U.; Toigo, M.; Handschin, C. (2010). Electric Pulse Stimulation of Cultured Murine Muscle Cells Reproduces Gene Expression Changes of Trained Mouse Muscle. PloS one, 5(6), e10970.
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Handschin, C. (2010). Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor gamma coactivator 1alpha. Journal of Receptor and Signal Transduction Research, 30(6), 376-384.
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| 2009 |
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Handschin, C. (2009). PGC-1alpha in muscle links metabolism to inflammation. Clinical and Experimental Pharmacology & Physiology, 36, 1139-1143.
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Handschin, C. (2009). The biology of PGC-1alpha and its therapeutic potential. Trends in Pharmacological Sciences, 30(6), 322-329.
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Zenhaeusern, G.; Gubser, P.; Eisele, P.; Gasser, O.; Steinhuber, A.; Trampuz, A.; Handschin, C.; Luster, A.D.; Hess, C. (2009). A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells. Blood, 113(1), 95-99.
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| 2008 |
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Choi, C.S.; Befroy, D.E.; Codella, R.; Kim, S.; Reznick, R.M.; Hwang, Y.-J.; Liu, Z.-X.; Lee, H.-Y.; Distefano, A.; Samuel, V.T.; Zhang, D.; Cline, G.W.; Handschin, C.; Lin, J.; Petersen, K.F.; Spiegelman, B.M.; Shulman, G.I. (2008). Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America, 105(50), 19926-19931.
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Handschin, C.; Spiegelman, B.M. (2008). The role of exercise and PGC1alpha in inflammation and chronic disease. Nature, 454(7203), 463-469.
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Handschin, C.: Nuclear Receptors as Drug Targets, in: Ottow, E. (Ed.). (2008). Methods and Principles in Medicinal Chemistry, Weinheim: Wiley-VCH , S. 453-458.
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| 2007 |
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Handschin, C.; Chin, S.; Li, P.; Liu, F.; Maratos-Flier, E.; Lebrasseur, N.K.; Yan, Z.; Spiegelman, B.M. (2007). Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. The Journal of Biological Chemistry, 282(41), 30014-30021.
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Handschin, C.; Choi, C.S.; Chin, S.; Kim, S.; Kawamori, D.; Kurpad, A.J.; Neubauer, N.; Hu, J.; Mootha, V.K.; Kim, Y.-B.; Kulkarni, R.N.; Shulman, G.I.; Spiegelman, B.M. (2007). Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. The Journal of Clinical Investigation, 117(11), 3463-3474.
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Handschin, C.; Kobayashi, Y.M.; Chin, S.; Seale, P.; Campbell, K.P.; Spiegelman, B.M. (2007). PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes & Development, 21(7), 770-783.
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Jager, S.; Handschin, C.; St-Pierre, J.; Spiegelman, B.M. (2007). AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proceedings of the National Academy of Sciences of the United States of America, 104(29), 12017-12022.
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Matter, C.M.; Handschin, C. (2007). RANTES (regulated on activation, normal T cell expressed and secreted), inflammation, obesity, and the metabolic syndrome. Circulation, 115(8), 946-948.
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Rohas, L.M.; St-Pierre, J.; Uldry, M.; Jager, S.; Handschin, C.; Spiegelman, B.M. (2007). A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proceedings of the National Academy of Sciences of the United States of America, 104(19), 7933-7938.
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| 2006 |
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Handschin, C.; Spiegelman, B.M. (2006). Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocrine Reviews, 27(7), 728-735.
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Rhee, J.; Ge, H.; Yang, W.; Fan, M.; Handschin, C.; Cooper, M.; Lin, J.; Li, C.; Spiegelman, B.M. (2006). Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism. The Journal of Biological Chemistry, 281(21), 14683-14690.
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Sandri, M.; Lin, J.; Handschin, C.; Yang, W.; Arany, Z.P.; Lecker, S.H.; Goldberg, A.L.; Spiegelman, B.M. (2006). PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proceedings of the National Academy of Sciences of the United States of America, 103(44), 16260-16265.
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St-Pierre, J.; Drori, S.; Uldry, M.; Silvaggi, J.M.; Rhee, J.; Jager, S.; Handschin, C.; Zheng, K.; Lin, J.; Yang, W.; Simon, D.K.; Bachoo, R.; Spiegelman, B.M. (2006). Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell, 127(2), 397-408.
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Wu, Z.; Huang, X.; Feng, Y.; Handschin, C.; Gullicksen, P.S.; Bare, O.; Labow, M.; Spiegelman, B.; Stevenson, S.C. (2006). Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proceedings of the National Academy of Sciences of the United States of America, 103(39), 14379-14384.
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| 2005 |
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Handschin, C.; Meyer, U.A. (2005). Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Archives of Biochemistry and Biophysics, 433(2), 387-396.
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Lin, J.; Handschin, C.; Spiegelman, B.M. (2005). Metabolic control through the PGC-1 family of transcription coactivators. Cell Metabolism, 1(6), 361-370.
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Lin, J.; Yang, R.; Tarr, P.T.; Wu, P.-H.; Handschin, C.; Li, S.; Yang, W.; Pei, L.; Uldry, M.; Tontonoz, P.; Newgard, C.B.; Spiegelman, B.M. (2005). Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell, 120(2), 261-273.
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Gnerre, C.; Schuster, G.U.; Roth, A.; Handschin, C.; Johansson, L.; Looser, R.; Parini, P.; Podvinec, M.; Robertsson, K.; Gustafsson, J.-A.; Meyer, U.A. (2005). LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver. Journal of Lipid Research, 46(8), 1633-1642.
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Handschin, C.; Gnerre, C.; Fraser, D.J.; Martinez-Jimenez, C.; Jover, R.; Meyer, U.A. (2005). Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Archives of Biochemistry and Biophysics, 434(1), 75-85.
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Handschin, C.; Mootha, V.K. (2005). Estrogen-related receptor alpha (ERRalpha): a novel target in type 2 diabetes. Drug Discovery Today Therapeutic Strategies, 2(2), 151-156.
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Arany, Z.; He, H.; Lin, J.; Hoyer, K.; Handschin, C.; Toka, O.; Ahmad, F.; Matsui, T.; Chin, S.; Wu, P.-H.; Rybkin, I.I.; Shelton, J.M.; Manieri, M.; Cinti, S.; Schoen, F.J.; Bassel-Duby, R.; Rosenzweig, A.; Ingwall, J.S.; Spiegelman, B.M. (2005). Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metabolism, 1(4), 259-271.
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Handschin, C.; Lin, J.; Rhee, J.; Peyer, A.-K.; Chin, S.; Wu, P.-H.; Meyer, U.A.; Spiegelman, B.M. (2005). Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell, 122(4), 505-515.
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Handschin, C.; Meyer, U.A.: PXR and CAR: more than meets the eye, in: Oesch, F. (Ed.). (2005). Proceedings of the 15th Int. Symposium on Microsomes and Drug Oxidation, Bologna: Medimond Int. Poc. Div. Monduzzi Editore , S. 17-21.
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| 2004 |
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Fan, M.; Rhee, J.; St-Pierre, J.; Handschin, C.; Puigserver, P.; Lin, J.; Jaeger, S.; Erdjument-Bromage, H.; Tempst, P.; Spiegelman, B.M. (2004). Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes & Development, 18(3), 278-289.
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Handschin, C.; Blattler, S.; Roth, A.; Looser, R.; Oscarson, M.; Kaufmann, M.R.; Podvinec, M.; Gnerre, C.; Meyer, U.A. (2004). The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals. Nuclear Receptor, 2(1), 7.
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Podvinec, M.; Handschin, C.; Looser, R.; Meyer, U.A. (2004). Identification of the xenosensors regulating human 5-aminolevulinate synthase. Proceedings of the National Academy of Sciences of the United States of America, 101(24), 9127-9132.
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Mootha, Vamsi K; Handschin, Christoph; Arlow, Dan; Xie, Xiaohui; St Pierre, Julie; Sihag, Smita; Yang, Wenli; Altshuler, David; Puigserver, Pere; Patterson, Nick; Willy, Patricia J; Schulman, Ira G; Heyman, Richard A; Lander, Eric S; Spiegelman, Bruce M (2004). Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proceedings of the National Academy of Sciences of the United States of America, 101(17), 6570-5.
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| 2003 |
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Handschin, C.; Rhee, J.; Lin, J.; Tarr, P.T.; Spiegelman, B.M. (2003). An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proceedings of the National Academy of Sciences of the United States of America, 100(12), 7111-7116.
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Handschin, C.; Podvinec, M.; Meyer, U.A. (2003). In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism. Drug News & Perspectives, 16(7), 423-434.
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Sanyal, S.; Handschin, C.; Podvinec, M.; Song, K.-H.; Kim, H.-J.; Kim, J.-Y.; Seo, Y.-W.; Kim, S.-A.; Kwon, H.-B.; Lee, K.; Kim, W.-S.; Meyer, U.A.; Choi, H.-S. (2003). Molecular cloning and characterization of chicken orphan nuclear receptor cTR2. General and Comparative Endocrinology, 132(3), 474-484.
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Handschin, C.; Meyer, U.A. (2003). Induction of drug metabolism: the role of nuclear receptors. Pharmacological Reviews, 55(4), 649-673.
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Handschin, C.; Meyer, U.A.: The molecular mechanism of induction of cytochromes P450 by drugs and other xenobiotics, in: Döhmer, J. (Ed.). (2003). Nova Acta Leopoldina, Halle: Deutsche Akad. der Naturforscher Leopoldina , S. 205-211.
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| 2002 |
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Handschin, C.; Podvinec, M.; Amherd, R.; Looser, R.; Ourlin, J.-C.; Meyer, U.A. (2002). Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. The Journal of Biological Chemistry, 277(33), 29561-29567.
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Podvinec, M.; Kaufmann, M.R.; Handschin, C.; Meyer, U.A. (2002). NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Molecular Endocrinology (Baltimore, Md.), 16(6), 1269-1279.
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Ourlin, J.-C.; Handschin, C.; Kaufmann, M.; Meyer, U.A. (2002). A Link between cholesterol levels and phenobarbital induction of cytochromes P450. Biochemical and Biophysical Research Communications, 291(2), 378-384.
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| 2001 |
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Handschin, C.; Podvinec, M.; Looser, R.; Amherd, R.; Meyer, U.A. (2001). Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor. Molecular Pharmacology, 60(4), 681-689.
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Handschin, C.; Podvinec, M.; Stockli, J.; Hoffmann, K.; Meyer, U.A. (2001). Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. Molecular Endocrinology (Baltimore, Md.), 15(9), 1571-1585.
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| 2000 |
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Handschin, C.; Podvinec, M.; Meyer, U.A. (2000). CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR). Proceedings of the National Academy of Sciences of the United States of America, 97(20), 10769-10774.
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Handschin, C.; Meyer, U.A. (2000). A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line. The Journal of Biological Chemistry, 275(18), 13362-13369.
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