Prof. Dr. Tilman Schirmer

Biozentrum
University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 311 Phone: +41 61 267 20 89
Email: tilman.schirmer-at-unibas.ch
Curriculum Vitae

Administrative Assistant

Marlise Frick
Biozentrum, Room 308
Phone: +41 61 267 20 81
Fax: +41 61 267 21 09
Email: marlise.frick-at-unibas.ch

Research group Tilman Schirmer

Articles

2014
Stanger, Frédéric V; Dehio, Christoph; Schirmer, Tilman (2014). Structure of the N-Terminal Gyrase B Fragment in Complex with ADP⋅Pi Reveals Rigid-Body Motion Induced by ATP Hydrolysis. PloS one, 9(9), e107289.
Ozaki, Shogo; Schalch-Moser, Annina; Zumthor, Ludwig; Manfredi, Pablo; Ebbensgaard, Anna; Schirmer, Tilman; Jenal, Urs (2014). Activation and polar sequestration of PopA, a c-di-GMP effector protein involved in Caulobacter crescentus cell cycle control. Molecular microbiology, 94(3), 580-94.
Hutter, C A J; Lehner, R; Wirth, Ch; Condemine, G; Peneff, C; Schirmer, T (2014). Structure of the oligogalacturonate-specific KdgM porin. Acta crystallographica. Section D, Biological crystallography, 70(Pt 6), 1770-8.
Sundriyal, Amit; Massa, Claudia; Samoray, Dietrich; Zehender, Fabian; Sharpe, Timothy; Jenal, Urs; Schirmer, Tilman (2014). Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger cyclic di-GMP. The Journal of Biological Chemistry, 289, 6978-6990.
2013
Zähringer, Franziska; Lacanna, Egidio; Jenal, Urs; Schirmer, Tilman; Boehm, Alex (2013). Structure and signaling mechanism of a zinc-sensory diguanylate cyclase. Structure (London, England : 1993), 21(7), 1149-57.
Goepfert, Arnaud; Stanger, Frédéric V; Dehio, Christoph; Schirmer, Tilman (2013). Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with fic fold. PloS one, 8(5), e64901.
Zimbron, Jeremy M; Heinisch, Tillmann; Schmid, Maurus; Hamels, Didier; Nogueira, Elisa S; Schirmer, Tilman; Ward, Thomas R (2013). A dual anchoring strategy for the localization and activation of artificial metalloenzymes based on the biotin-streptavidin technology. Journal of the American Chemical Society, 135(14), 5384-8.
Goepfert, Arnaud; Harms, Alexander; Schirmer, Tilman; Dehio, Christoph: Type II Toxin-Antitoxin Loci: The fic Family, in: Kenn Gerdes (Ed.). (2013). Prokaryotic Toxin-Antitoxins, Heidelberg: Springer Verlag , S. 177-187.
2012
Engel, Philipp; Goepfert, Arnaud; Stanger, Frédéric V; Harms, Alexander; Schmidt, Alexander; Schirmer, Tilman; Dehio, Christoph (2012). Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. Nature, 482(7383), 107-110.
Giri, Janhavi; Tang, John M; Wirth, Christophe; Peneff, Caroline M; Eisenberg, Bob (2012). Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli. European biophysics journal : EBJ, 41(3), 259-71.
Gentner, Martin; Allan, Martin G; Zaehringer, Franziska; Schirmer, Tilman; Grzesiek, Stephan (2012). Oligomer formation of the bacterial second messenger c-di-GMP: reaction rates and equilibrium constants indicate a monomeric state at physiological concentrations. Journal of the American Chemical Society, 134(2), 1019-29.
Borer, Aline S; Wassmann, Paul; Schmidt, Margit; Hoffman, Donald R; Zhou, Jing-Jiang; Wright, Christine; Schirmer, Tilman; Markovic-Housley, Zora (2012). Crystal Structure of Sol i 2: A Major Allergen from Fire Ant Venom. Journal of molecular biology, 415(4), 635-48.
2011
Köhler, Valentin; Mao, Jincheng; Heinisch, Tillmann; Pordea, Anca; Sardo, Alessia; Wilson, Yvonne M; Knörr, Livia; Creus, Marc; Prost, Jean-Christophe; Schirmer, Tilman; Ward, Thomas R (2011). OsO4·streptavidin: a tunable hybrid catalyst for the enantioselective cis-dihydroxylation of olefins. Angewandte Chemie (International ed. in English), 50(46), 10863-6.
Abel, S.; Chien, P.; Wassmann, P.; Schirmer, T.; Kaever, V.; Laub, M.T.; Baker, T.A.; Jenal, U. (2011). Regulatory Cohesion of Cell Cycle and Cell Differentiation through Interlinked Phosphorylation and Second Messenger Networks. Molecular Cell, 43(4), 550-60.
Durrenberger, M.; Heinisch, T.; Wilson, Y.M.; Rossel, T.; Nogueira, E.; Knorr, L.; Mutschler, A.; Kersten, K.; Zimbron, M.J.; Pierron, J.; Schirmer, T.; Ward, T.R. (2011). Artificial transfer hydrogenases for the enantioselective reduction of cyclic imines. Angewandte Chemie, 50(13), 3026-3029.
Palanivelu, D.V.; Goepfert, A.; Meury, M.; Guye, P.; Dehio, C.; Schirmer, T. (2011). Fic domain catalyzed adenylylation: Insight provided by the structural analysis of the type IV secretion system effector BepA. Protein Science, 20(3), 492-499.
Monnard, FW.; Heinisch, T.; Nogueria, ES.; Schirmer, T.; Ward, TR.;  (2011). Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor. Chem.Commun., 47(29), 8238-8240.
2010
Zimbron, J.M.; Sardo, A.; Heinisch, T.; Wohlschlager, T.; Gradinaru, J.; Massa, C.; Schirmer, T.; Creus, M.; Ward, T.R. (2010). Chemo-Genetic Optimization of DNA Recognition by Metallodrugs using a Presenter-Protein Strategy. Chemistry (Weinheim an der Bergstrasse, Germany), 16(43), 12883-12889.
Kim, D.; Hunt, J.F.; Schirmer, T.: Making, Breaking, and Sensing of Cyclic Di-GMP: Structural, Thermodynamic, and Evolutionary Principles, in: Alan J. Wolfe, Karen L. Visick (Ed.). (2010). The Second Messenger Cyclic Di-GMP, Washington, USA: ASM Press , S. 76-95.
Zahringer, F.; Massa, C.; Schirmer, T. (2010). Efficient Enzymatic Production of the Bacterial Second Messenger c-di-GMP by the Diguanylate Cyclase YdeH from E. coli. Applied Biochemistry and Biotechnology, 163(1), 71.
Mittermann, I.; Zidarn, M.; Silar, M.; Markovic-Housley, Z.; Aberer, W.; Korosec, P.; Kosnik, M.; Valenta, R. (2010). Recombinant allergen-based IgE testing to distinguish bee and wasp allergy. The Journal of Allergy and Clinical Immunology, 125(6), 1300-1307.e3.
2009
Boehm, A.; Steiner, S.; Zaehringer, F.; Casanova, A.; Hamburger, F.; Ritz, D.; Keck, W.; Ackermann, M.; Schirmer, T.; Jenal, U. (2009). Second messenger signaling governs Escherichia coli biofilm induction upon ribosomal stress. Molecular Microbiology, 72(6), 1500-1516.
Markovic-Housley, Z.; Basle, A.; Padavattan, S.; Maderegger, B.; Schirmer, T.; Hoffmann-Sommergruber, K. (2009). Structure of the major carrot allergen Dau c 1. Acta Crystallographica. Section D, Biological Crystallography, 65(Pt 11), 1206-1212.
Minasov, G.; Padavattan, S.; Shuvalova, L.; Brunzelle, J.S.; Miller, D.J.; Basle, A.; Massa, C.; Collart, F.R.; Schirmer, T.; Anderson, W.F. (2009). Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains. The Journal of Biological Chemistry, 284(19), 13174-13184.
Padavattan, S.; Flicker, S.; Schirmer, T.; Madritsch, C.; Randow, S.; Reese, G.; Vieths, S.; Lupinek, C.; Ebner, C.; Valenta, R.; Markovic-Housley, Z. (2009). High-affinity IgE recognition of a conformational epitope of the major respiratory allergen Phl p 2 as revealed by X-ray crystallography. Journal of Immunology, 182(4), 2141-2151.
Wirth, C.; Condemine, G.; Boiteux, C.; Berneche, S.; Schirmer, T.; Peneff, C.M. (2009). NanC crystal structure, a model for outer-membrane channels of the acidic sugar-specific KdgM porin family. Journal of Molecular Biology, 394(4), 718-731.
Schirmer, T.; Jenal, U. (2009). Structural and mechanistic determinants of c-di-GMP signalling. Nature Reviews Microbiology, 7, 724-735.
2008
Padavattan, S.; Schmidt, M.; Hoffman, D.R.; Markovic-Housley, Z. (2008). Crystal structure of the major allergen from fire ant venom, Sol i 3. Journal of Molecular Biology, 383(1), 178-185.
2007
Soldatova, L.N.; Tsai, C.; Dobrovolskaia, E.; Markovic-Housley, Z.; Slater, J.E. (2007). Characterization of the N-glycans of recombinant bee venom hyaluronidase (Api m 2) expressed in insect cells. Allergy and Asthma Proceedings : the Official Journal of Regional and State Allergy Societies, 28(2), 210-215.
Paul, R.; Abel, S.; Wassmann, P.; Beck, A.; Heerklotz, H.; Jenal, U. (2007). Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization. The Journal of Biological Chemistry, 282(40), 29170-29177.
Wassmann, P.; Chan, C.; Paul, R.; Beck, A.; Heerklotz, H.; Jenal, U.; Schirmer, T. (2007). Structure of BeF3- -modified response regulator PleD: implications for diguanylate cyclase activation, catalysis, and feedback inhibition. Structure, 15(8), 915-927.
Padavattan, S.; Schirmer, T.; Schmidt, M.; Akdis, C.; Valenta, R.; Mittermann, I.; Soldatova, L.; Slater, J.; Mueller, U.; Markovic-Housley, Z. (2007). Identification of a B-cell epitope of hyaluronidase, a major bee venom allergen, from its crystal structure in complex with a specific Fab. Journal of Molecular Biology, 368(3), 742-752.
2006
Miedema, H.; Vrouenraets, M.; Wierenga, J.; Eisenberg, B.; Schirmer, T.; Basle, A.; Meijberg, W. (2006). Conductance and selectivity fluctuations in D127 mutants of the bacterial porin OmpF. European Biophysics Journal : EBJ, 36(1), 13-22.
Basle, A.; Rummel, G.; Storici, P.; Rosenbusch, J.P.; Schirmer, T. (2006). Crystal structure of osmoporin OmpC from E. coli at 2.0 A. Journal of Molecular Biology, 362(5), 933-942.
Ma, Y.; Gadermaier, G.; Bohle, B.; Bolhaar, S.; Knulst, A.; Markovic-Housley, Z.; Breiteneder, H.; Briza, P.; Hoffmann-Sommergruber, K.; Ferreira, F. (2006). Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1. International Archives of Allergy and Immunology, 139(1), 53-62.
Palanivelu, D.V.; Kozono, D.E.; Engel, A.; Suda, K.; Lustig, A.; Agre, P.; Schirmer, T. (2006). Co-axial association of recombinant eye lens aquaporin-0 observed in loosely packed 3D crystals. Journal of Molecular Biology, 355(4), 605-611.
2005
Hui, K.-M.; Orriss, G.L.; Schirmer, T.; Magnadottir, B.; Schifferli, J.A.; Inal, J.M. (2005). Expression of functional recombinant von Willebrand factor-A domain from human complement C2: a potential binding site for C4 and CRIT. The Biochemical Journal, 389(Pt 3), 863-868.
Karamloo, F.; Schmid-Grendelmeier, P.; Kussebi, F.; Akdis, M.; Salagianni, M.; von Beust, B.R.; Reimers, A.; Zumkehr, J.; Soldatova, L.; Housley-Markovic, Z.; Muller, U.; Kundig, T.; Kemeny, D.M.; Spangfort, M.D.; Blaser, K.; Akdis, C.A. (2005). Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes. European Journal of Immunology, 35(11), 3268-3276.
Kussebi, F.; Karamloo, F.; Rhyner, C.; Schmid-Grendelmeier, P.; Salagianni, M.; Mannhart, C.; Akdis, M.; Soldatova, L.; Markovic-Housley, Z.; Von Beust, B.R.; Kundig, T.; Kemeny, D.M.; Blaser, K.; Crameri, R.; Akdis, C.A. (2005). A major allergen gene-fusion protein for potential usage in allergen-specific immunotherapy. The Journal of Allergy and Clinical Immunology, 115(2), 323-329.
Markova, M.; Peneff, C.; Hewlins, M.J.E.; Schirmer, T.; John, R.A. (2005). Determinants of substrate specificity in omega-aminotransferases. The Journal of Biological Chemistry, 280(43), 36409-36416.
Schirmer, T.; Hoffimann-Sommergrube, K.; Susani, M.; Breiteneder, H.; Markovic-Housley, Z. (2005). Crystal structure of the major celery allergen Api g 1: molecular analysis of cross-reactivity. Journal of Molecular Biology, 351(5), 1101-1109.
Philippsen, A.; Schirmer, T.; Stein, M.A.; Giffhorn, F.; Stetefeld, J. (2005). Structure of zinc-independent sorbitol dehydrogenase from Rhodobacter sphaeroides at 2.4 A resolution. Acta Crystallographica. Section D, Biological Crystallography, 61(Pt 4), 374-379.
2004
Chan, C.; Paul, R.; Samoray, D.; Amiot, N.C.; Giese, B.; Jenal, U.; Schirmer, T. (2004). Structural basis of activity and allosteric control of diguanylate cyclase. Proceedings of the National Academy of Sciences of the United States of America, 101(49), 17084-17089.
Storici, P.; Qiu, J.; Schirmer, T.; Silverman, R.B. (2004). Mechanistic crystallography. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography. Biochemistry, 43(44), 14057-14063.
Paul, R.; Weiser, S.; Amiot, N.C.; Chan, C.; Schirmer, T.; Giese, B.; Jenal, U. (2004). Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain. Genes & Development, 18(6), 715-727.
Storici, P.; De Biase, D.; Bossa, F.; Bruno, S.; Mozzarelli, A.; Peneff, C.; Silverman, R.B.; Schirmer, T. (2004). Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin. The Journal of Biological Chemistry, 279(1), 363-373.
Schirmer, Tilman: Structure-Function Relationships in Sugar-Specific Porins, in: Benz, R. (Ed.). (2004). Bacterial and Eukaryotic Porins: Structure, Function, Mechanism, Switzerland: Wiley-VCH Verlag GmbH & Co. KGaA , S. 169-181.
2003
Orriss, G.L.; Erni, B.; Schirmer, T. (2003). Crystal structure of the IIB(Sor) domain of the sorbose permease from Klebsiella pneumoniae solved to 1.75A resolution. Journal of Molecular Biology, 327(5), 1111-1119.
Markovic-Housley, Z.; Degano, M.; Lamba, D.; von Roepenack-Lahaye, E.; Clemens, S.; Susani, M.; Ferreira, F.; Scheiner, O.; Breiteneder, H. (2003). Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier. Journal of Molecular Biology, 325(1), 123-133.
2002
Sauer, O.; Roth, M.; Schirmer, T.; Rummel, G.; Kratky, C. (2002). Low-resolution detergent tracing in protein crystals using xenon or krypton to enhance X-ray contrast. Acta Crystallographica. Section D, Biological Crystallography, 58(Pt 1), 60-69.
Choi, S.; Storici, P.; Schirmer, T.; Silverman, R.B. (2002). Design of a conformationally restricted analogue of the antiepilepsy drug Vigabatrin that directs its mechanism of inactivation of gamma-aminobutyric acid aminotransferase. Journal of the American Chemical Society, 124(8), 1620-1624.
Rodriguez-Maranon, M.J.; Bush, R.M.; Peterson, E.M.; Schirmer, T.; de la Maza, L.M. (2002). Prediction of the membrane-spanning beta-strands of the major outer membrane protein of Chlamydia. Protein Science : a Publication of the Protein Society, 11(7), 1854-1861.
Dutzler, R.; Schirmer, T.; Karplus, M.; Fischer, S. (2002). Translocation mechanism of long sugar chains across the maltoporin membrane channel. Structure, 10(9), 1273-1284.
Van Gelder, P.; Dumas, F.; Bartoldus, I.; Saint, N.; Prilipov, A.; Winterhalter, M.; Wang, Y.; Philippsen, A.; Rosenbusch, J.P.; Schirmer, T. (2002). Sugar transport through maltoporin of Escherichia coli: role of the greasy slide. Journal of Bacteriology, 184(11), 2994-2999.
Philippsen, A.; Im, W.; Engel, A.; Schirmer, T.; Roux, B.; Muller, D.J. (2002). Imaging the electrostatic potential of transmembrane channels: atomic probe microscopy of OmpF porin. Biophysical Journal, 82(3), 1667-1676.
2001
Schirmer, T.; Roschenbusch, J.P. (2001). Membrane proteins with beta-barrel fold. Chimia, 55, 493-496.
Van Gelder, P.; Dutzler, R.; Dumas, F.; Koebnik, R.; Schirmer, T. (2001). Sucrose transport through maltoporin mutants of Escherichia coli. Protein Engineering, 14(11), 943-948.
Phale, P.S.; Philippsen, A.; Widmer, C.; Phale, V.P.; Rosenbusch, J.P.; Schirmer, T. (2001). Role of charged residues at the OmpF porin channel constriction probed by mutagenesis and simulation. Biochemistry, 40(21), 6319-6325.
2000
Markovic-Housley, Z.; Miglierini, G.; Soldatova, L.; Rizkallah, P.J.; Muller, U.; Schirmer, T. (2000). Crystal structure of hyaluronidase, a major allergen of bee venom. Structure (London, England : 1993), 8(10), 1025-1035.
1999
Schirmer, T.; Phale, P.S. (1999). Brownian dynamics simulation of ion flow through porin channels. Journal of Molecular Biology, 294(5), 1159-1167.
Storici, P.; Capitani, G.; De Biase, D.; Moser, M.; John, R.A.; Jansonius, J.N.; Schirmer, T. (1999). Crystal structure of GABA-aminotransferase, a target for antiepileptic drug therapy. Biochemistry, 38(27), 8628-8634.
Dutzler, R.; Rummel, G.; Alberti, S.; Hernandez-Alles, S.; Phale, P.; Rosenbusch, J.; Benedi, V.; Schirmer, T. (1999). Crystal structure and functional characterization of OmpK36, the osmoporin of Klebsiella pneumoniae. Structure (London, England : 1993), 7(4), 425-434.
Storici, P.; Capitani, G.; Muller, R.; Schirmer, T.; Jansonius, J.N. (1999). Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine. Journal of Molecular Biology, 285(1), 297-309.
1998
Penel, S.; Pebay-Peyroula, E.; Rosenbusch, J.; Rummel, G.; Schirmer, T.; Timmins, P.A. (1998). Detergent binding in trigonal crystals of OmpF porin from Escherichia coli. Biochimie, 80(5-6), 543-551.
Schauder, S.; Nunn, R.S.; Lanz, R.; Erni, B.; Schirmer, T. (1998). Crystal structure of the IIB subunit of a fructose permease (IIBLev) from Bacillus subtilis. Journal of Molecular Biology, 276(3), 591-602.
Phale, P.S.; Philippsen, A.; Kiefhaber, T.; Koebnik, R.; Phale, V.P.; Schirmer, T.; Rosenbusch, J.P. (1998). Stability of trimeric OmpF porin: the contributions of the latching loop L2. Biochemistry, 37(45), 15663-15670.
Schirmer, T. (1998). General and specific porins from bacterial outer membranes. Journal of Structural Biology, 121(2), 101-109.
Shen, B.W.; Hennig, M.; Hohenester, E.; Jansonius, J.N.; Schirmer, T. (1998). Crystal structure of human recombinant ornithine aminotransferase. Journal of Molecular Biology, 277(1), 81-102.
1997
Wang, Y.F.; Dutzler, R.; Rizkallah, P.J.; Rosenbusch, J.P.; Schirmer, T. (1997). Channel specificity: structural basis for sugar discrimination and differential flux rates in maltoporin. Journal of Molecular Biology, 272(1), 56-63.
Phale, P.S.; Schirmer, T.; Prilipov, A.; Lou, K.L.; Hardmeyer, A.; Rosenbusch, J.P. (1997). Voltage gating of Escherichia coli porin channels: role of the constriction loop. Proceedings of the National Academy of Sciences of the United States of America, 94(13), 6741-6745.
1996
Chan, W.C.; Schirmer, T.; Ferenci, T. (1996). Combinatorial mutagenesis analysis of residues in the channel constriction loop L3 and neighbouring beta-strands in the LamB glycoporin of Escherichia coli. Molecular Membrane Biology, 13(1), 41-48.
Dutzler, R.; Wang, Y.F.; Rizkallah, P.; Rosenbusch, J.P.; Schirmer, T. (1996). Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway. Structure (London, England : 1993), 4(2), 127-134.
Lou, K.L.; Saint, N.; Prilipov, A.; Rummel, G.; Benson, S.A.; Rosenbusch, J.P.; Schirmer, T. (1996). Structural and functional characterization of OmpF porin mutants selected for larger pore size. I. Crystallographic analysis. The Journal of Biological Chemistry, 271(34), 20669-20675.
Saint, N.; Lou, K.L.; Widmer, C.; Luckey, M.; Schirmer, T.; Rosenbusch, J.P. (1996). Structural and functional characterization of OmpF porin mutants selected for larger pore size. II. Functional characterization. The Journal of Biological Chemistry, 271(34), 20676-20680.
Nunn, R.S.; Markovic-Housley, Z.; Genovesio-Taverne, J.C.; Flukiger, K.; Rizkallah, P.J.; Jansonius, J.N.; Schirmer, T.; Erni, B. (1996). Structure of the IIA domain of the mannose transporter from Escherichia coli at 1.7 angstroms resolution. Journal of Molecular Biology, 259(3), 502-511.
Markovic-Housley, Z.; Schirmer, T.; Hohenester, E.; Khomutov, A.R.; Khomutov, R.M.; Karpeisky, M.Y.; Sandmeier, E.; Christen, P.; Jansonius, J.N. (1996). Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase. European Journal of Biochemistry / FEBS, 236(3), 1025-1032.
Saint, N.; Prilipov, A.; Hardmeyer, A.; Lou, K.L.; Schirmer, T.; Rosenbusch, J.P. (1996). Replacement of the sole histidinyl residue in OmpF porin from E. coli by threonine (H21T) does not affect channel structure and function. Biochemical and Biophysical Research Communications, 223(1), 118-122.
1995
Alberti, S.; Rodriquez-Quinones, F.; Schirmer, T.; Rummel, G.; Tomas, J.M.; Rosenbusch, J.P.; Benedi, V.J. (1995). A porin from Klebsiella pneumoniae: sequence homology, three-dimensional model, and complement binding. Infection and Immunity, 63(3), 903-910.
Cowan, S.W.; Garavito, R.M.; Jansonius, J.N.; Jenkins, J.A.; Karlsson, R.; Konig, N.; Pai, E.F.; Pauptit, R.A.; Rizkallah, P.J.; Rosenbusch, J.P. (1995). The structure of OmpF porin in a tetragonal crystal form. Structure (London, England : 1993), 3(10), 1041-1050.
Schirmer, T.; Keller, T.A.; Wang, Y.F.; Rosenbusch, J.P. (1995). Structural basis for sugar translocation through maltoporin channels at 3.1 A resolution. Science (New York, N.Y.), 267(5197), 512-514.
1994
Cowan, S.W.; Schirmer, T. (1994). Structures of non-specific diffusion pores from E.coli In Bacterial Cell Wall, J.-M. Guysen and R. Hakenbeck, ed. Amsterdam: Elsevier Science B.V., , 353-361.
Jeanteur, D.; Schirmer, T.; Fourel, D.; Simonet, V.; Rummel, G.; Widmer, C.; Rosenbusch, J.P.; Pattus, F.; Pages, J.M. (1994). Structural and functional alterations of a colicin-resistant mutant of OmpF porin from Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, 91(22), 10675-10679.
Karshikoff, A.; Spassov, V.; Cowan, S.W.; Ladenstein, R.; Schirmer, T. (1994). Electrostatic properties of two porin channels from Escherichia coli. Journal of Molecular Biology, 240(4), 372-384.
1993
Schirmer, T.; Cowan, S.W. (1993). Prediction of membrane-spanning beta-strands and its application to maltoporin. Protein Science : a Publication of the Protein Society, 2(8), 1361-1363.
Pflugl, G.; Kallen, J.; Schirmer, T.; Jansonius, J.N.; Zurini, M.G.; Walkinshaw, M.D. (1993). X-ray structure of a decameric cyclophilin-cyclosporin crystal complex. Nature, 361(6407), 91-94.
1992
Cowan, S.W.; Schirmer, T.; Rummel, G.; Steiert, M.; Ghosh, R.; Pauptit, R.A.; Jansonius, J.N.; Rosenbusch, J.P. (1992). Crystal structures explain functional properties of two E. coli porins. Nature, 358(6389), 727-733.
1991
Schirmer, T.; Roschenbusch, J.P. (1991). Prokaryotic and Eukaryotic porins. Current Opinion in Struct. Biol.1, , 539-545.
1990
Schirmer, T.; Evans, P.R. (1990). Structural basis of the allosteric behaviour of phosphofructokinase. Nature, 343(6254), 140-145.
1987
Schirmer, T.; Vincent, M.G. (1987). Polarized absorption and fluorescence spectra of single crystals of C-phycocyanin. Biochim. Biophys. Acta, 893, 379-385.
Schirmer, T.; Bode, W.; Huber, R. (1987). Refined three-dimensional structures of two cyanobacterial C-phycocyanins at 2.1 and 2.5 A resolution. A common principle of phycobilin-protein interaction. Journal of Molecular Biology, 196(3), 677-695.
1986
Schirmer, T.; Huber, R.; Schneider, M.; Bode, W.; Miller, M.; Hackert, M.L. (1986). Crystal structure analysis and refinement at 2.5 A of hexameric C-phycocyanin from the cyanobacterium Agmenellum quadruplicatum. The molecular model and its implications for light-harvesting. Journal of Molecular Biology, 188(4), 651-676.
1985
Schirmer, T.; Bode, W.; Huber, R.; Sidler, W.; Zuber, H. (1985). X-ray crystallographic structure of the light-harvesting biliprotein C-phycocyanin from the thermophilic cyanobacterium Mastigocladus laminosus and its resemblance to globin structures. Journal of Molecular Biology, 184(2), 257-277.

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