Navigation mit Access Keys

Main Content

An integrated structural biology approach for a molecular understanding of TRP ion channels

Transient receptor potential (TRP) channels are a large eukaryotic ion channel family with remarkable functional diversity. They consist of six mammalian subfamilies. TRPV1, a member of the vanilloid channel subfamily in particular has gained wide recognition as the first TRP channel member to be characterized by cryo electron microscopy and for heralding the “resolution revolution”.
TRP channels play important roles in e.g. temperature and pain sensation or organ development and thus mutations can lead to devastating diseases. Intriguingly, regulatory partners such as cytosolic proteins or lipids often interact with the proximal TRP channel termini, which despite the recent technological advances in structural biology, often remain functionally and structurally orphaned, presumably because they are unstructured and/or very dynamic. We use a combination of biophysical approaches to characterize the interaction of TRP channel termini with their protein and lipid partners for a more detailed understanding of the molecular details of TRP channel regulation. A particular focus lies on members of the TRP vanilloid (TRPV) and TRP mucolipin (TRPML) families due to their complex lipid-based regulation patterns and involvement in neurodegenerative diseases.

Main Content