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2020

Brunner, Janine D; Jakob, Roman P; Schulze, Tobias; Neldner, Yvonne; Moroni, Anna; Thiel, Gerhard; Maier, Timm; Schenck, Stephan (2020). Structural basis for ion selectivity in TMEM175 K; +; channels. eLife, 9, ahead of print.

Perez, Camilo; Maier, Timm (2020). Expression, Purification, and Structural Biology of Membrane Proteins. New York: Humana Press, 2127. , 423.

2019

Kaur, Hundeep; Hartmann, Jean-Baptiste; Jakob, Roman P.; Zahn, Michael; Zimmermann, Iwan; Maier, Timm; Seeger, Markus A.; Hiller, Sebastian (2019). Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach. Journal of Biomolecular NMR, 73 (6-7), 375-384.

Schönemann, Wojciech; Cramer, Jonathan; Mühlethaler, Tobias; Fiege, Brigitte; Silbermann, Marleen; Rabbani, Said; Dätwyler, Philipp; Zihlmann, Pascal; Jakob, Roman P.; Sager, Christoph P.; Smiesko, Martin; Schwardt, Oliver; Maier, Timm; Ernst, Beat (2019). Improvement of Aglycone π-Stacking Yields Nano- to Subnanomolar FimH Antagonists. ChemMedChem, 14 (7), 749-757.

Sauer, Maximilian M.; Jakob, Roman P.; Luber, Thomas; Canonica, Fabia; Navarra, Giulio; Ernst, Beat; Unverzagt, Carlo; Maier, Timm; Glockshuber, Rudi (2019). Binding of the bacterial adhesin FimH to its natural, multivalent high-mannose type glycan targets. Journal of the American Chemical Society, 141 (2), 936-944.

2018

Vigano, M. Alessandra; Bieli, Dimitri; Schaefer, Jonas V.; Jakob, Roman P.; Matsuda, Shinya; Maier, Timm; Plückthun, Andreas; Affolter, Markus (2018). Correction:DARPins recognizing mTFP1 as novel reagents for in vitro; and in vivo protein manipulations. Biology open, 7 (12), bio036749.

Vigano, M. Alessandra; Bieli, Dimitri; Schaefer, Jonas V.; Jakob, Roman Peter; Matsuda, Shinya; Maier, Timm; Plückthun, Andreas; Affolter, Markus (2018). DARPins recognizing mTFP1 as novel reagents for in vitro and in vivo protein manipulations. Biology open, 7 (11), bio036749.

Zihlmann, Pascal; Silbermann, Marleen; Sharpe, Timothy; Jiang, Xiaohua; Mühlethaler, Tobias; Jakob, Roman P.; Rabbani, Said; Sager, Christoph P.; Frei, Priska; Pang, Lijuan; Maier, Timm; Ernst, Beat (2018). KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists. Chemistry (Weinheim an der Bergstrasse, Germany), 24 (49), 13049-13057.

Hunkeler, Moritz; Hagmann, Anna; Stuttfeld, Edward; Chami, Mohamed; Guri, Yakir; Stahlberg, Henning; Maier, Timm (2018). Structural basis for regulation of human acetyl-CoA carboxylase. Nature, 558 (7710), 470-474.

Maier, Timm; Weissman, Kira J. (2018). Macromolecular assemblies: Assembly, dynamics and control of activity. Current Opinion in Structural Biology, 49, vi-vii.

Bauer, Daniela; Meinhold, Sarah; Jakob, Roman P.; Stigler, Johannes; Merkel, Ulrich; Maier, Timm; Rief, Matthias; Žoldák, Gabriel (2018). A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy. Proceedings of the National Academy of Sciences of the United States of America, 115 (18), 4666-4671.

Imseng, Stefan; Aylett, Christopher Hs; Maier, Timm (2018). Architecture and activation of phosphatidylinositol 3-kinase related kinases. Current opinion in structural biology, 49, 177-189.

Herbst, Dominik A.; Huitt-Roehl, Callie R.; Jakob, Roman P.; Kravetz, Jacob M.; Storm, Philip A.; Alley, Jamie R.; Townsend, Craig A.; Maier, Timm (2018). The structural organization of substrate loading in iterative polyketide synthases. Nature Chemical Biology, 14 (5), 474-479.

Stuttfeld, E.; Aylett, C. H. S.; Imseng, S.; Boehringer, D.; Scaiola, A.; Sauer, E.; Hall, M. N.; Maier, T.; Ban, N. (2018). Architecture of the human mTORC2 core complex. eLife, 7, e33101.

Rabbani, Said; Fiege, Brigitte; Eris, Deniz; Silbermann, Marleen; Jakob, Roman Peter; Navarra, Giulio; Maier, Timm; Ernst, Beat (2018). Conformational Switch of the Bacterial Adhesin FimH in the Absence of the Regulatory Domain: Engineering a Minimalistic Allosteric System. Journal of Biological Chemistry, 293 (5), 1835-1849.

Herbst, Dominik A.; Townsend, Craig A.; Maier, Timm (2018). The architectures of iterative type I PKS and FAS. Natural Product Reports, 35 (10), 1046-1069.

Vigano, M. Alessandra; Bieli, Dimitri; Schaefer, Jonas V; Jakob, Roman P; Matsuda, Shinya; Maier, Timm; Plueckthun, Andreas; Affolter, Markus (2018). DARPins recognizing mTFP1 as novel reagents for in vitro and in vivo protein manipulations. bioRxiv, onlineonly.

Sager, Christoph P.; Fiege, Brigitte; Zihlmann, Pascal; Vannam, Raghu; Rabbani, Said; Jakob, Roman P.; Preston, Roland C.; Zalewski, Adam; Maier, Timm; Peczuh, Mark W.; Ernst, Beat (2018). The price of flexibility - a case study on septanoses as pyranose mimetics. Chemical Science, 9 (3), 646-654.

2017

Benning, Friederike M. C.; Sakiyama, Yusuke; Mazur, Adam; Bukhari, Habib S. T.; Lim, Roderick Y. H.; Maier, Timm (2017). High-Speed Atomic Force Microscopy Visualization of the Dynamics of the Multienzyme Fatty Acid Synthase. ACS Nano, 11 (11), 10852-10859.

Wang, Jing; Brackmann, Maximilian; Castaño-Díez, Daniel; Kudryashev, Mikhail; Goldie, Kenneth N.; Maier, Timm; Stahlberg, Henning; Basler, Marek (2017). Cryo-EM structure of the extended type VI secretion system sheath-tube complex. Nature Microbiology, 2 (11), 1507-1512.

Maier, Timm (2017). Fatty acid synthases: Re-engineering biofactories. Nature Chemical Biology, 13 (4), 344-345.

Stuttfeld, Edward; Imseng, Stefan; Maier, Timm (2017). A central role for a region in the middle. eLife, 6, e25700.

Storm, Philip A; Herbst, Dominik A; Maier, Timm; Townsend, Craig A (2017). Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin. Cell chemical biology, 24 (3), 316-325.

Navarra, Giulio; Zihlmann, Pascal; Jakob, Roman P.; Stangier, Katia; Preston, Roland C.; Rabbani, Said; Smiesko, Martin; Wagner, Bea; Maier, Timm; Ernst, Beat (2017). Carbohydrate-Lectin Interactions - An Unexpected Contribution to Affinity. ChemBioChem, 18 (6), 539-544.

Roth, Christian; Weizenmann, Nicole; Bexten, Nicola; Saenger, Wolfram; Zimmermann, Wolfgang; Maier, Timm; Sträter, Norbert (2017). Amylose recognition and ring-size determination of amylomaltase. Science Advances, 3 (1), e1601386.

2016

Hagmann, Anna; Hunkeler, Moritz; Stuttfeld, Edward; Maier, Timm (2016). Hybrid Structure of a Dynamic Single-Chain Carboxylase from Deinococcus radiodurans. Structure, 24 (8), 1227-1236.

Jakob, Roman P.; Schmidpeter, Philipp A. M.; Koch, Johanna R.; Schmid, Franz X.; Maier, Timm (2016). Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps. PLoS ONE, 11 (6), e0157070.

Silván, Unai; Hyotyla, Janne; Mannherz, Hans-Georg; Ringler, Philippe; Müller, Shirley A; Aebi, Ueli; Maier, Timm; Schoenenberger, Cora-Ann (2016). Contributions of the lower dimer to supramolecular actin patterning revealed by TIRF microscopy. Journal of structural biology, 195 (2), 159-66.

Hunkeler, Moritz; Stuttfeld, Edward; Hagmann, Anna; Imseng, Stefan; Maier, Timm (2016). The dynamic organization of fungal acetyl-CoA carboxylase. Nature Communications, 7, 11196.

Herbst, Dominik A; Jakob, Roman P; Zähringer, Franziska; Maier, Timm (2016). Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases. Nature, 531 (7595), 533-537.

Sauer, Maximilian M; Jakob, Roman P; Eras, Jonathan; Baday, Sefer; Eriş, Deniz; Navarra, Giulio; Bernèche, Simon; Ernst, Beat; Maier, Timm; Glockshuber, Rudi (2016). Catch-bond mechanism of the bacterial adhesin FimH. Nature communications, 7, 10738.

Aylett, C. H. S.; Sauer, E.; Imseng, S.; Boehringer, D.; Hall, M. N; Ban, N.; Maier, T. (2016). Architecture of human mTOR complex 1. Science, 351 (6268), 48-52.

Preston, Roland C.; Jakob, Roman P.; Binder, Florian P. C.; Sager, Christoph P.; Ernst, Beat; Maier, Timm (2016). E-selectin ligand complexes adopt an extended high-affinity conformation. Journal of Molecular Cell Biology, 8 (1), 62-72.

2015

Gruss, Fabian; Hiller, Sebastian; Maier, Timm (2015). Purification and Bicelle Crystallization for Structure Determination of the E. coli Outer Membrane Protein TamA. Methods in Molecular Biology, 1329, 259-70.

Arquint, Christian; Gabryjonczyk, Anna-Maria; Imseng, Stefan; Böhm, Raphael; Sauer, Evelyn; Hiller, Sebastian; Nigg, Erich A.; Maier, Timm (2015). STIL binding to Polo-box 3 of PLK4 regulates centriole duplication. eLife, 4, e07888.

Maier, Timm; Clantin, Bernard; Gruss, Fabian; Dewitte, Frédérique; Delattre, Anne-Sophie; Jacob-Dubuisson, Françoise; Hiller, Sebastian; Villeret, Vincent (2015). Conserved Omp85 lid-lock structure and substrate recognition in FhaC. Nature Communications, 6, 7452.

Blatter, Markus; Dunin-Horkawicz, Stanislaw; Grishina, Irma; Maris, Christophe; Thore, Stephane; Maier, Timm; Bindereif, Albrecht; Bujnicki, Janusz M.; Allain, Frederic H. -T. (2015). The signature of the five-stranded vRRM fold defined by functional, structural and computational analysis of the hnRNP L protein. Journal of molecular biology, 427 (19), 3001-3022.

Fiege, Brigitte; Rabbani, Said; Preston, Roland C.; Jakob, Roman P.; Zihlmann, Pascal; Schwardt, Oliver; Jiang, Xiaohua; Maier, Timm; Ernst, Beat (2015). The Tyrosine Gate of the Bacterial Lectin FimH : a Conformational Analysis by NMR Spectroscopy and X-ray Crystallography. ChemBioChem, 16 (8), 1235-1246.

Kleeb, Simon; Pang, Lijuan; Mayer, Katharina; Eris, Deniz; Sigl, Anja; Preston, Roland C.; Zihlmann, Pascal; Sharpe, Timothy; Jakob, Roman P.; Abgottspon, Daniela; Hutter, Aline S.; Scharenberg, Meike; Jiang, Xiaohua; Navarra, Giulio; Rabbani, Said; Smiesko, Martin; Lüdin, Nathalie; Bezençon, Jacqueline; Schwardt, Oliver; Maier, Timm; Ernst, Beat (2015). FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile. Journal of Medicinal Chemistry, 58 (5), 2221-39.

Morgado, Leonor; Zeth, Kornelius; Burmann, Björn M.; Maier, Timm; Hiller, Sebastian (2015). Characterization of the insertase BamA in three different membrane mimetics by solution NMR spectroscopy. Journal of biomolecular NMR, 61 (3-4), 333-45.

Jakob, Roman P.; Koch, Johanna R.; Burmann, Björn M.; Schmidpeter, Philipp A. M.; Hunkeler, Moritz; Hiller, Sebastian; Schmid, Franz X.; Maier, Timm (2015). Dimeric structure of the bacterial extracellular foldase PrsA. Journal of Biological Chemistry, 290 (6), 3278-92.

Kudryashev, Mikhail; Wang, Ray Yu-Ruei; Brackmann, Maximilian; Scherer, Sebastian; Maier, Timm; Baker, David; DiMaio, Frank; Stahlberg, Henning; Egelman, Edward H; Basler, Marek (2015). Structure of the Type VI Secretion System Contractile Sheath. Cell, 160 (5), 952-62.

Fujieda, Nobutaka; Schaetti, Jonas; Stuttfeld, Edward; Ohkubo, Kei; Maier, Timm; Fukuzumi, Shunichi; Ward, Thomas R. (2015). Enzyme repurposing of a hydrolase as an emergent peroxidase upon metal binding. Chemical Science, 6 (7), 4060-4065.

2014

Bukhari, Habib S. T.; Jakob, Roman P.; Maier, Timm (2014). Evolutionary origins of the multienzyme architecture of giant fungal Fatty Acid synthase. Structure, 22 (12), 1775-1785.

2013

Gruss, Fabian; Zähringer, Franziska; Jakob, Roman P.; Burmann, Björn M.; Hiller, Sebastian; Maier, Timm (2013). The structural basis of autotransporter translocation by TamA. Nature structural & molecular biology, 20 (11), 1318-U247.

Sauer, Evelyn; Imseng, Stefan; Maier, Timm; Hall, Michael N; 4 Sauer, E.; Imseng, S.; Maier, T.; Hall, M. N. (2013). Conserved sequence motifs and the structure of the mTOR kinase domain. Biochemical Society transactions, 41 (4), 889-95.

2010

Maier, T.; Leibundgut, M.; Boehringer, D.; Ban, N. (2010). Structure and function of eukaryotic fatty acid synthases. Quarterly Reviews of Biophysics, 43 (3), 373-422.

Mocibob, Marko; Ivic, Nives; Bilokapic, Silvija; Maier, Timm; Luic, Marija; Ban, Nenad; Weygand-Durasevic, Ivana (2010). Homologs of aminoacyl-tRNA synthetases acylate carrier proteins and provide a link between ribosomal and nonribosomal peptide synthesis. Proceedings of the National Academy of Sciences of the United States of America, 107 (33), 14585-90.

Mocibob, M.; Ivic, N.; Bilokapic, S.; Maier, T.; Luic, M.; Ban, N.; Weygand-Durasevic, I. (2010). New links between protein biosynthesis and nonribosomal peptide synthesis. The FEBS journal, 277, 260-261.

2009

Mueller, M.; Grauschopf, U.; Maier, T.; Glockshuber, R.; Ban, N. (2009). The structure of a cytolytic alpha-helical toxin pore reveals its assembly mechanism. Nature, 459 (7247), 726-U135.

2008

Rossmann, M.; Schultz-Heienbrok, R.; Behlke, J.; Remmel, N.; Alings, C.; Sandhoff, K.; Saenger, W.; Maier, T. (2008). Crystal structures of human saposins C and D: Implications for lipid recognition and membrane interactions. Structure, 16 (5), 809-817.

Merz, F.; Boehringer, D.; Schaffitzel, C.; Preissler, S.; Hoffmann, A.; Maier, T.; Rutkowska, A.; Lozza, J.; Ban, N.; Bukau, B.; Deuerling, E. (2008). Molecular mechanism and structure of Trigger Factor bound to the translating ribosome. The EMBO Journal, 27 (11), 1622-32.

Maier, T.; Leibundgut, M.; Ban, N. (2008). The crystal structure of a mammalian fatty acid synthase. Science, 321 (5894), 1315-1322.

Leibundgut, M.; Maier, T.; Jenni, S.; Ban, N. (2008). The multienzyme architecture of eukaryotic fatty acid synthases. Current Opinion in Structural Biology, 18 (6), 714-725.

Bingel-Erlenmeyer, R.; Kohler, R.; Kramer, G.; Sandikci, A.; Antolic, S.; Maier, T.; Schaffitzel, C.; Wiedmann, B.; Bukau, B.; Ban, N. (2008). A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing. Nature, 452 (7183), 108-U13.

2006

Schultz-Heienbrok, Robert; Remmel, Natascha; Klingenstein, R; Rossocha, Maksim; Sandhoff, Konrad; Saenger, Wolfram; Maier, Timm (2006). Crystallization and preliminary characterization of three different crystal forms of human saposin C heterologously expressed in Pichia pastoris. Acta Crystallographica Section F, 62 (Pt2), 117-20.

Wendeler, M.; Werth, N.; Maier, T.; Schwarzmann, G.; Kolter, T.; Schoeniger, M.; Hoffmann, D.; Lemm, T.; Saenger, W.; Sandhoff, K. (2006). The enzyme-binding region of human GM2-activator protein. FEBS Journal, 273 (5), 982-991.

Maier, T.; Jenni, S.; Ban, N. (2006). Architecture of mammalian fatty acid synthase at 4.5 angstrom resolution. Science, 311 (5765), 1258-1262.

Jenni, S.; Leibundgut, M.; Maier, T.; Ban, N. (2006). Architecture of a fungal fatty acid synthase at 5 angstrom resolution. Science, 311 (5765), 1263-1267.

Bilokapic, S.; Maier, T.; Ahel, D.; Gruic-Sovulj, I.; Soll, D.; Weygand-Durasevic, I.; Ban, N. (2006). Structure of the unusual seryl-tRNA synthetase reveals a distinct zinc-dependent mode of substrate recognition. The EMBO Journal, 25 (11), 2498-509.

2005

Schultz-Heienbrok, R.; Maier, T.; Strater, N. (2005). A large hinge bending domain rotation is necessary for the catalytic function of Escherichia coli 5 `-nucleotidase. Biochemistry, 44 (7), 2244-2252.

Maier, T.; Przylas, I.; Strater, N.; Herdewijn, P.; Saenger, W. (2005). Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid. Journal of the American Chemical Society, 127 (9), 2937-43.

Maier, T.; Ferbitz, L.; Deuerling, E.; Ban, N. (2005). A cradle for new proteins: trigger factor at the ribosorne. Current Opinion in Structural Biology, 15 (2), 204-212.

Ferbitz, L.; Maier, T.; Patzelt, H.; Bukau, B.; Ban, N.; Deuerling, E. (2005). Cytosolic proteins at birth: The chaperone trigger factor forms a molecular cradle for newborn proteins. Cell Structure And Function, 30, 9-9.

2004

Schultz-Heienbrok, R.; Maier, Timm; Strater, N. (2004). Trapping a 96 degrees domain rotation in two distinct conformations by engineered disulfide bridges. Protein Science, 13 (7), 1811-22.

Ferbitz, L.; Maier, Timm; Patzelt, H.; Bukau, B.; Deuerling, E.; Ban, N. (2004). Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins. Nature, 431 (7008), 590-6.

2003

Lodge, Jacinta A; Maier, Timm; Liebl, Wolfgang; Hoffmann, Volker; Sträter, Norbert (2003). Crystal Structure of Thermotoga maritima α-Glucosidase AglA Defines a New Clan of NAD+-dependent Glycosidases. Journal of Biological Chemistry, 278 (21), 19151-8.

Maier, T.; Strater, N.; Schuette, C. G.; Klingenstein, R.; Sandhoff, K.; Saenger, W. (2003). The X-ray crystal structure of human beta-hexosaminidase B provides new insights into Sandhoff disease. Journal of Molecular Biology, 328 (3), 669-681.

2001

Niere, M.; Dettloff, M.; Maier, T.; Ziegler, M.; Wiesner, A. (2001). Insect immune activation by apolipophorin III is correlated with the lipid-binding properties of this protein. Biochemistry, 40 (38), 11502-8.

2000

Voelter, W.; Wacker, R.; Franz, M.; Maier, T.; Stoeva, S. (2000). Complete structural characterization of a chitin-binding lectin from mistletoe extracts. Journal für praktische Chemie, 342 (8), 812-818.

1999

Stoeva, S.; Maier, T.; Soler, M.; Voelter, W. (1999). Carbohydrate Chains and Their Binding Sites in Mistletoe Lectin I. Polish Journal of Chemistry, 73 (1), 125-133.

Krauspenhaar, R.; Eschenburg, S.; Perbandt, M.; Kornilov, V.; Konareva, N.; Mikailova, I.; Stoeva, S.; Wacker, R.; Maier, T.; Singh, T.; Mikhailov, A.; Voelter, W.; Betzel, C. (1999). Crystal structure of mistletoe lectin I from Viscum album. Biochemical and Biophysical Research Communications, 257 (2), 418-24.


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