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Ham, Daniel J; Börsch, Anastasiya; Lin, Shuo; Thürkauf, Marco; Weihrauch, Martin; Reinhard, Judith R; Delezie, Julien; Battilana, Fabienne; Wang, Xueyong; Kaiser, Marco S; Guridi, Maitea; Sinnreich, Michael; Rich, Mark M; Mittal, Nitish; Tintignac, Lionel A; Handschin, Christoph; Zavolan, Mihaela; Rüegg, Markus A (2020). The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia. Nature communications, 11 (1), 4510.

Pereira, Jorge A; Gerber, Joanne; Ghidinelli, Monica; Gerber, Daniel; Tortola, Luigi; Ommer, Andrea; Bachofner, Sven; Santarella, Francesco; Tinelli, Elisa; Lin, Shuo; Rüegg, Markus A; Kopf, Manfred; Toyka, Klaus V; Suter, Ueli (2020). Mice carrying an analogous heterozygous Dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy. Human molecular genetics, epub ahead of print, ddaa034.

Ham, Alexander S.; Chojnowska, Kathrin; Tintignac, Lionel A.; Lin, Shuo; Schmidt, Alexander; Ham, Daniel J.; Sinnreich, Michael; Rüegg, Markus A. (2020). mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice. Journal of cachexia, sarcopenia and muscle, 11 (1), 259-273.


Rion, Nathalie; Castets, Perrine; Lin, Shuo; Enderle, Leonie; Reinhard, Judith R.; Rüegg, Markus A. (2019). mTORC2 affects the maintenance of the muscle stem cell pool. Skeletal Muscle, 9 (1), 30.

Ding, Xiaolei; Willenborg, Sebastian; Bloch, Wilhelm; Wickström, Sara A; Wagle, Prerana; Brodesser, Susanne; Roers, Axel; Jais, Alexander; Brüning, Jens C; Hall, Michael N; Rüegg, Markus A; Eming, Sabine A (2019). Epidermal mTORC2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. The Journal of Allergy and Clinical Immunology, S0091-6749 (19), 31029-31102.

Castets, Perrine; Rion, Nathalie; Théodore, Marine; Falcetta, Denis; Lin, Shuo; Reischl, Markus; Wild, Franziska; Guérard, Laurent; Eickhorst, Christopher; Brockhoff, Marielle; Guridi, Maitea; Ibebunjo, Chikwendu; Cruz, Joseph; Sinnreich, Michael; Rudolf, Rüdiger; Glass, David J.; Rüegg, Markus A. (2019). mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4. Nature communications, 10 (1), 3187.

Delezie, Julien; Weihrauch, Martin; Maier, Geraldine; Tejero, Rocío; Ham, Daniel J.; Gill, Jonathan F.; Karrer-Cardel, Bettina; Rüegg, Markus A.; Tabares, Lucía; Handschin, Christoph (2019). BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America, 116 (32), 16111-16120.

Donadon, Irving; Bussani, Erica; Riccardi, Federico; Licastro, Danilo; Romano, Giulia; Pianigiani, Giulia; Pinotti, Mirko; Kostantinova, Pavlina; Evers, Melvin; Lin, Shuo; Rüegg, Markus A.; Pagani, Franco (2019). Rescue of spinal muscular atrophy mouse models with AAV9-Exon-specific U1 snRNA. Nucleic acids research, 47 (14), 7618-7632.

Rion, Nathalie; Castets, Perrine; Lin, Shuo; Enderle, Leonie; Reinhard, Judith R.; Eickhorst, Christopher; Rüegg, Markus A. (2019). mTOR controls embryonic and adult myogenesis via mTORC1. Development, 146 (7), 1-15.


Martin, S. K.; Fitter, S.; El Khawanky, N.; Grose, R. H.; Walkley, C. R.; Purton, L. E.; Rüegg, M. A.; Hall, M. N.; Gronthos, S.; Zannettino, A. C. W. (2018). mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis. Scientific Reports, 8 (1), 14501.

Zainul, Zarin; Heikkinen, Anne; Koivisto, Hennariikka; Rautalahti, Iina; Kallio, Mika; Lin, Shuo; Härönen, Heli; Norman, Oula; Rüegg, Markus A; Tanila, Heikki; Pihlajaniemi, Taina (2018). Collagen XIII Is Required for Neuromuscular Synapse Regeneration and Functional Recovery after Peripheral Nerve Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience, 38 (17), 4243-4258.

van Putten, Maaike; Aartsma-Rus, Annemieke; Grounds, Miranda D.; Kornegay, Joe N.; Mayhew, Anna; Gillingwater, Thomas H.; Takeda, Shin'ichi; Rüegg, Markus A.; De Luca, Annamaria; Nagaraju, Kanneboyina; Willmann, Raffaella (2018). Update on Standard Operating Procedures in Preclinical Research for DMD and SMA Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, The Netherlands. Journal of Neuromuscular Diseases, 5 (1), 29-34.

Boido, Marina; De Amicis, Elena; Valsecchi, Valeria; Trevisan, Marco; Ala, Ugo; Ruegg, Markus A.; Hettwer, Stefan; Vercelli, Alessandro (2018). Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy. Frontiers in cellular neuroscience, 12, 17.

Yurchenco, Peter D.; McKee, Karen K.; Reinhard, Judith R.; Rüegg, Markus A. (2018). Laminin-deficient muscular dystrophy: Molecular pathogenesis and structural repair strategies. Matrix biology : journal of the International Society for Matrix Biology, 71-72, 174-187.


Bozadjieva, Nadejda; Blandino-Rosano, Manuel; Chase, Jennifer; Dai, Xiao-Qing; Cummings, Kelsey; Gimeno, Jennifer; Dean, Danielle; Powers, Alvin C.; Gittes, George K.; Rüegg, Markus A.; Hall, Michael N.; MacDonald, Patrick E.; Bernal-Mizrachi, Ernesto (2017). Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion. The Journal of Clinical Investigation, 127 (12), 4379-4393.

Karakatsani, Andromachi; Marichal, Nicolás; Urban, Severino; Kalamakis, Georgios; Ghanem, Alexander; Schick, Anna; Zhang, Yina; Conzelmann, Karl-Klaus; Rüegg, Markus A.; Berninger, Benedikt; Ruiz de Almodovar, Carmen; Gascón, Sergio; Kröger, Stephan (2017). Neuronal LRP4 regulates synapse formation in the developing CNS. Development, 144 (24), 4604-4615.

Hodson, Nathan; McGlory, Chris; Oikawa, Sara Y.; Jeromson, Stewart; Song, Zhe; Ruegg, Markus A.; Hamilton, D. Lee; Phillips, Stuart M.; Philp, Andrew (2017). Differential localisation and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise. American Journal of Physiology - Cell Physiology, 313 (6), C604-C611.

Blandino-Rosano, M.; Barbaresso, R.; Jimenez-Palomares, M.; Bozadjieva, N.; Werneck-de-Castro, J. P.; Hatanaka, M.; Mirmira, R. G.; Sonenberg, N.; Liu, M.; Rüegg, M. A.; Hall, M. N.; Bernal-Mizrachi, E. (2017). Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing. Nature Communications, 8, 16014.

Reinhard, Judith R.; Lin, Shuo; McKee, Karen K.; Meinen, Sarina; Crosson, Stephanie C.; Sury, Maurizio; Hobbs, Samantha; Maier, Geraldine; Yurchenco, Peter D.; Rüegg, Markus A. (2017). Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice. Science Translational Medicine, 9 (396), eaal4649.

Willmann, Raffaella; Gordish-Dressman, Heather; Meinen, Sarina; Rüegg, Markus A.; Yu, Qing; Nagaraju, Kanneboyina; Kumar, Ayar; Girgenrath, Mahasweta; Coffey, Caroline B. M.; Cruz, Vivian; Van Ry, Pam M.; Bogdanik, Laurent; Lutz, Cathleen; Rutkowski, Anne; Burkin, Dean J. (2017). Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy. Journal of Neuromuscular Diseases, 4 (2), 115-126.

Kleinert, Maximilian; Parker, Benjamin L.; Fritzen, Andreas M.; Knudsen, Jonas R.; Jensen, Thomas E.; Kjøbsted, Rasmus; Sylow, Lykke; Ruegg, Markus; James, David E.; Richter, Erik A. (2017). Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice. Journal of Physiology, 595 (14), 4845-4855.

Hoffman, E. P. (2017). Facilitating orphan drug development: Proceedings of the TREAT-NMD International Conference, December 2015, Washington, DC, USA. Neuromuscular Disorders, 27 (7), 693-701.

Rion, Nathalie; Rüegg, Markus A. (2017). LncRNA-encoded peptides: More than translational noise?. Cell Research, 27 (5), 604-605.

McKee, Karen K.; Crosson, Stephanie C.; Meinen, Sarina; Reinhard, Judith R.; Rüegg, Markus A.; Yurchenco, Peter D. (2017). Chimeric protein repair of laminin polymerization ameliorates muscular dystrophy phenotype. Journal of Clinical Investigation, 127 (3), 1075-1089.

Fitter, Stephen; Matthews, Mary P.; Martin, Sally K.; Xie, Jianling; Ooi, Soo Siang; Walkley, Carl R.; Codrington, John D.; Ruegg, Markus A.; Hall, Michael N.; Proud, Christopher G.; Gronthos, Stan; Zannettino, Andrew C. W. (2017). mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation. Molecular and Cellular Biology, 37 (7), e00668-16.

Brockhoff, Marielle; Rion, Nathalie; Chojnowska, Kathrin; Wiktorowicz, Tatiana; Eickhorst, Christopher; Erne, Beat; Frank, Stephan; Angelini, Corrado; Furling, Denis; Rüegg, Markus A.; Sinnreich, Michael; Castets, Perrine (2017). Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I. Journal of Clinical Investigation, 127 (2), 549-563.


Castets, Perrine; Frank, Stephan; Sinnreich, Michael; Rüegg, Markus A. (2016). "Get the Balance Right": Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders. Journal of Neuromuscular Diseases, 3 (2), 127-155.

Ding, X.; Bloch, W.; Iden, S.; Rüegg, M. A.; Hall, M. N.; Leptin, M.; Partridge, L.; Eming, S. A. (2016). mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nature Communications, 7, 13226.

Kleinert, Maximilian; Parker, Benjamin L.; Chaudhuri, Rima; Fazakerley, Daniel J.; Serup, Annette; Thomas, Kristen C.; Krycer, James R.; Sylow, Lykke; Fritzen, Andreas M.; Hoffman, Nolan J.; Jeppesen, Jacob; Schjerling, Peter; Rüegg, Markus A.; Kiens, Bente; James, David E.; Richter, Erik A. (2016). mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3. Molecular Metabolism, 5 (8), 646-55.

Reinhard, Judith R.; Kriz, Alexander; Galic, Milos; Angliker, Nico; Rajalu, Mathieu; Vogt, Kaspar E.; Rüegg, Markus A. (2016). The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nature Communications, 7, 11613.

Grahammer, F.; Nesterov, V.; Ahmed, A.; Steinhardt, F.; Sandner, L.; Arnold, F.; Cordts, T.; Negrea, S.; Bertog, M.; Rüegg, M. A.; Hall, M. N.; Walz, G.; Korbmacher, C.; Artunc, F.; Huber, T. B. (2016). mTORC2 critically regulates renal potassium handling. Journal of Clinical Investigation, 126 (5), 1773-1782.

Guridi, Maitea; Kupr, Barbara; Romanino, Klaas; Lin, Shuo; Falcetta, Denis; Tintignac, Lionel; Rüegg, Markus A. (2016). Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism. Skeletal Muscle, 6 (13), 13.

Zhang, L.; Tschumi, B. O.; Lopez-Mejia, I. C.; Oberle, S. G.; Meyer, M.; Samson, G.; Rüegg, M. A.; Hall, M. N.; Fajas, L.; Zehn, D.; Mach, J.-P.; Donda, A.; Romero, P. (2016). Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner. Cell Reports, 14 (5), 1206-1217.

Ruegsegger, Céline; Stucki, David M.; Steiner, Silvio; Angliker, Nico; Radecke, Julika; Keller, Eva; Zuber, Benoît; Rüegg, Markus A.; Saxena, Smita (2016). Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology. Neuron, 89 (1), 129-46.

Schell, Christoph; Kretz, Oliver; Liang, Wei; Kiefer, Betina; Schneider, Simon; Sellung, Dominik; Bork, Tillmann; Leiber, Christian; Rüegg, Markus A.; Mallidis, Con; Schlatt, Stefan; Mayerhofer, Artur; Huber, Tobias B.; Grahammer, Florian (2016). The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility. American Journal of Pathology, 186 (2), 324-336.

Shende, P.; Xu, L.; Morandi, C.; Pentassuglia, L.; Heim, P.; Lebboukh, S.; Berthonneche, C.; Pedrazzini, T.; Kaufmann, B. A.; Hall, M. N.; Rüegg, M. A.; Brink, M. (2016). Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy. Cardiovascular Research, 109 (1), 103-114.


Willmann, Raffaella; Luca, Annamaria De; Nagaraju, Kanneboyina; Rüegg, Markus A (2015). Best Practices and Standard Protocols as a Tool to Enhance Translation for Neuromuscular Disorders. Journal of neuromuscular diseases, 2 (2), 113-117.

Aimi, F.; Georgiopoulou, S.; Kalus, I.; Lehner, F.; Hegglin, A.; Limani, P.; Gomes de Lima, V.; Rüegg, M. A.; Hall, M. N.; Lindenblatt, N.; Haas, E.; Battegay, E. J.; Humar, R. (2015). Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult. Scientific Reports, 5, 17705.

Guridi, Maitea; Tintignac, Lionel A.; Lin, Shuo; Kupr, Barbara; Castets, Perrine; Rüegg, Markus A. (2015). Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21. Science Signaling, 8 (402), ra113.

Domi, Teuta; Porrello, Emanuela; Velardo, Daniele; Capotondo, Alessia; Biffi, Alessandra; Tonlorenzi, Rossana; Amadio, Stefano; Ambrosi, Alessandro; Miyagoe-Suzuki, Yuko; Takeda, Shin'ichi; Ruegg, Markus A.; Previtali, Stefano Carlo (2015). Mesoangioblast delivery of miniagrin ameliorates murine model of merosin-deficient congenital muscular dystrophy type 1A. Skeletal Muscle, 5 (30), 30.

Angliker, Nico; Burri, Michael; Zaichuk, Mariana; Fritschy, Jean-Marc; Rüegg, Markus A. (2015). mTORC1 and mTORC2 have largely distinct functions in Purkinje cells. European Journal of Neuroscience, 42 (8), 2595-612.

Tintignac, Lionel A.; Brenner, Hans-Rudolf; Rüegg, Markus A. (2015). Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting. Physiological Reviews, 95 (3), 809-52.

Ma, S.; Venkatesh, A.; Langellotto, F.; Le, Y. Z.; Hall, M. N.; Rüegg, M. A.; Punzo, C. (2015). Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival. Experimental Eye Research, 135, 1-13.

Venkatesh, A.; Ma, S.; Le, Y. Z.; Hall, M. N.; Rüegg, M. A.; Punzo, C. (2015). Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. Journal of Clinical Investigation, 125 (4), 1446-1458.

Carr, T. D.; Feehan, R. P.; Hall, M. N.; Rüegg, M. A.; Shantz, L. M. (2015). Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors. Carcinogenesis, 36 (4), 487-497.

Martin, Sally K.; Fitter, Stephen; Dutta, Ankit K.; Matthews, Mary P.; Walkley, Carl R.; Hall, Michael N.; Ruegg, Markus A.; Gronthos, Stan; Zannettino, Andrew C. W. (2015). Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation. Stem cells, 33 (4), 1359-65.

Lopez, R. J.; Mosca, B.; Treves, S.; Maj, M.; Bergamelli, L.; Calderon, J. C.; Bentzinger, C. F.; Romanino, K.; Hall, M. N.; Rüegg, M. A.; Delbono, O.; Caputo, C.; Zorzato, F. (2015). Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. Biochemical Journal, 466 (1), 123-135.

Zhang, Yina; Lin, Shuo; Karakatsani, Andromachi; Rüegg, Markus A.; Kröger, Stephan (2015). Differential regulation of AChR clustering in the polar and equatorial region of murine muscle spindles. European Journal of Neuroscience, 41 (1), 69-78.


Norrmén, C.; Figlia, G.; Lebrun-Julien, F.; Pereira, J. A.; Trötzmüller, M.; Köfeler, H. C.; Rantanen, V.; Wessig, C.; van Deijk, A. F.; Smit, A. B.; Verheijen, M. G.; Rüegg, M. A.; Hall, M. N.; Suter, U. (2014). mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells. Cell Reports, 9 (2), 646-660.

Kleinert, Maximilian; Sylow, Lykke; Fazakerley, Daniel J.; Krycer, James R.; Thomas, Kristen C.; Oxbøll, Anne-Julie; Jordy, Andreas B.; Jensen, Thomas E.; Yang, Guang; Schjerling, Peter; Kiens, Bente; James, David E.; Ruegg, Markus A.; Richter, Erik A. (2014). Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo. Molecular Metabolism, 3 (6), 630-41.

Steiner, Esther; Enzmann, Gaby U.; Lyck, Ruth; Lin, Shuo; Rüegg, Markus A.; Kröger, Stephan; Engelhardt, Britta (2014). The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions. Cell and Tissue Research, 358 (2), 465-479.

Zhang, L.; Tschumi, B. O.; Corgnac, S.; Rüegg, M. A.; Hall, M. N.; Mach, J.-P.; Romero, P.; Donda, A. (2014). Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function. Journal of Immunology, 193 (4), 1759-1765.

Chou, Po-Chien; Oh, Won Jun; Wu, Chang-Chih; Moloughney, Joseph; Rüegg, Markus A.; Hall, Michael N.; Jacinto, Estela; Werlen, Guy (2014). Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development. Journal of Immunology, 193 (3), 1162-70.

Grahammer, F.; Haenisch, N.; Steinhardt, F.; Sander, L.; Roerden, M.; Arnold, F.; Cordts, T.; Wanner, N.; Reichardt, W.; Kerjaschki, D.; Ruegg, M. A.; Hall, M. N.; Moulin, P.; Busch, H.; Boerries, M.; Walz, G.; Artunc, F.; Huber, T. B. (2014). mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proceedings of the National Academy of Sciences of the United States of America, 111 (27), E2817-26.

Lebrun-Julien, F.; Bachmann, L.; Norrmén, C.; Trötzmüller, M.; Köfeler, H.; Rüegg, M. A.; Hall, M. N.; Suter, U. (2014). Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination. Journal of Neuroscience, 34 (25), 8432-8448.

Miloslavski, Rachel; Cohen, Elad; Avraham, Adam; Iluz, Yifat; Hayouka, Zvi; Kasir, Judith; Mudhasani, Rajini; Jones, Stephen N.; Cybulski, Nadine; Rüegg, Markus A.; Larsson, Ola; Gandin, Valentina; Rajakumar, Arjuna; Topisirovic, Ivan; Meyuhas, Oded (2014). Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. Journal of Molecular Cell Biology, 6 (3), 255-66.

Hettwer, Stefan; Lin, Shuo; Kucsera, Stefan; Haubitz, Monika; Oliveri, Filippo; Fariello, Ruggero G.; Ruegg, Markus A.; Vrijbloed, Jan W. (2014). Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction. PLoS ONE, 9 (2), e88739.

Chen, J.; Tu, X.; Esen, E.; Joeng, K. S.; Lin, C.; Arbeit, J. M.; Rüegg, M. A.; Hall, M. N.; Ma, L.; Long, F. (2014). WNT7B promotes bone formation in part through mTORC1. PLoS Genetics, 10 (1), e1004145.


Angliker, Nico; Rüegg, Markus A. (2013). In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons. Bioarchitecture, 3 (4), 113-8.

Castets, Perrine; Rüegg, Markus A. (2013). MTORC1 determines autophagy through ULK1 regulation in skeletal muscle. Autophagy, 9 (9), 1435-7.

Song, Jian; Lokmic, Zerina; Lämmermann, Tim; Rolf, Julia; Wu, Chuan; Zhang, Xueli; Hallmann, Rupert; Hannocks, Melanie-Jane; Horn, Nathalie; Ruegg, Markus A.; Sonnenberg, Arnoud; Georges-Labouesse, Elisabeth; Winkler, Thomas H.; Kearney, John F.; Cardell, Susanna; Sorokin, Lydia (2013). Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proceedings of the National Academy of Sciences of the United States of America, 110 (31), E2915-24.

Cloëtta, Dimitri; Thomanetz, Venus; Baranek, Constanze; Lustenberger, Regula M; Lin, Shuo; Oliveri, Filippo; Atanasoski, Suzana; Rüegg, Markus A (2013). Inactivation of mTORC1 in the Developing Brain Causes Microcephaly and Affects Gliogenesis. Journal of neuroscience, 33 (18), 7799-810.

Castets, Perrine; Lin, Shuo; Rion, Nathalie; Di Fulvio, Sabrina; Romanino, Klaas; Guridi, Maitea; Frank, Stephan; Tintignac, Lionel A.; Sinnreich, Michael; Ruegg, Markus A. (2013). Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy. Cell metabolism, 17 (5), 731-44.

Thomanetz, Venus; Angliker, Nico; Cloëtta, Dimitri; Lustenberger, Regula M; Schweighauser, Manuel; Oliveri, Filippo; Suzuki, Noboru; Rüegg, Markus A (2013). Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology. The journal of cell biology, 201 (2), 293-308.

Bentzinger, C. F.; Lin, S.; Romanino, K.; Castets, P.; Guridi, M.; Summermatter, S.; Handschin, C.; Tintignac, L. A.; Hall, M. N.; Rüegg, M. A. (2013). Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal Muscle, 3 (1), 6.


Meinen, Sarina; Lin, Shuo; Rüegg, Markus A.; Punga, Anna Rostedt (2012). Fatigue and Muscle Atrophy in a Mouse Model of Myasthenia Gravis Is Paralleled by Loss of Sarcolemmal nNOS. PLoS ONE, 7 (8), e44148.

Meinen, Sarina; Lin, Shuo; Ruegg, Markus A (2012). Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A). Skeletal muscle, 2 (1), 18.

Steiner, Esther; Enzmann, Gaby U.; Lin, Shuo; Ghavampour, Sharang; Hannocks, Melanie-Jane; Zuber, Benoît; Rüegg, Markus A.; Sorokin, Lydia; Engelhardt, Britta (2012). Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. Glia, 60 (11), 1646-59.

Blättler, Sharon M.; Verdeguer, Francisco; Liesa, Marc; Cunningham, John T.; Vogel, Rutger O.; Chim, Helen; Liu, Huifei; Romanino, Klaas; Shirihai, Orian S.; Vazquez, Francisca; Rüegg, Markus A.; Shi, Yang; Puigserver, Pere (2012). Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Molecular and cellular biology, 32 (16), 3333-46.

Hagiwara, Asami; Cornu, Marion; Cybulski, Nadine; Polak, Pazit; Betz, Charles; Trapani, Francesca; Terracciano, Luigi; Heim, Markus H.; Rüegg, Markus A.; Hall, Michael N. (2012). Hepatic mTORC2 activates glycolysis and lipogenesis through akt, glucokinase, and SREBP1c. Cell Metabolism, 15 (5), 725-38.

Blättler, Sharon M.; Cunningham, John T.; Verdeguer, Francisco; Chim, Helen; Haas, Wilhelm; Liu, Huifei; Romanino, Klaas; Rüegg, Markus A.; Gygi, Steven P.; Shi, Yang; Puigserver, Pere (2012). Yin yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling. Cell Metabolism, 15 (4), 505-17.

Punga, Anna Rostedt; Ruegg, Markus A. (2012). Signaling and aging at the neuromuscular synapse : lessons learnt from neuromuscular diseases. Current Opinion in Pharmacology, 12 (3), 340-6.


Romanino, Klaas; Mazelin, Laetitia; Albert, Verena; Conjard-Duplany, Agnès; Lin, Shuo; Bentzinger, C Florian; Handschin, Christoph; Puigserver, Pere; Zorzato, Francesco; Schaeffer, Laurent; Gangloff, Yann-Gaël; Rüegg, Markus A (2011). Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America, 108 (51), 20808-13.

Rieker, Claus; Dev, Kumlesh K.; Lehnhoff, Katja; Barbieri, Samuel; Ksiazek, Iwona; Kauffmann, Sabine; Danner, Simone; Schell, Heinrich; Boden, Cindy; Ruegg, Markus A.; Kahle, Philipp J.; van der Putten, Herman; Shimshek, Derya R. (2011). Neuropathology in mice expressing mouse alpha-synuclein. PLoS ONE, 6 (9), e24834.

Meinen, Sarina; Lin, Shuo; Thurnherr, Raphael; Erb, Michael; Meier, Thomas; Rüegg, Markus A. (2011). Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. EMBO Molecular Medicine, 3 (8), 465-79.

Inoki, K.; Mori, H.; Wang, J.; Suzuki, T.; Hong, S.; Yoshida, S.; Blattner, S. M.; Ikenoue, T.; Ruegg, M. A.; Hall, M. N.; Kwiatkowski, D. J.; Rastaldi, M. P.; Huber, T. B.; Kretzler, M.; Holzman, L. B.; Wiggins, R. C.; Guan, K. -L. (2011). mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. Journal of Clinical Investigation, 121 (6), 2181-2196.

Gödel, M.; Hartleben, B.; Herbach, N.; Liu, S.; Zschiedrich, S.; Lu, S.; Debreczeni-Mor, A.; Lindenmeyer, M. T.; Rastaldi, M. -P.; Hartleben, G.; Wiech, T.; Fornoni, A.; Nelson, R. G.; Kretzler, M.; Wanke, R.; Pavenstadt, H.; Kerjaschki, D.; Cohen, C. D.; Hall, M. N.; Ruegg, M. A.; Inoki, K.; Walz, G.; Huber, T. B. (2011). Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. Journal of Clinical Investigation, 121 (6), 2197-2209.

Punga, A. R.; Lin, S.; Oliveri, F.; Meinen, S.; Ruegg, M. A. (2011). Muscle-selective synaptic disassembly and reorganization in MuSK antibody positive MG mice. Experimental Neurology, 230 (2), 207-17.

Shende, P.; Plaisance, I.; Morandi, C.; Pellieux, C.; Berthonneche, C.; Zorzato, F.; Krishnan, J.; Lerch, R.; Hall, M. N.; Ruegg, M. A.; Pedrazzini, T.; Brink, M. (2011). Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice. Circulation, 123 (10), 1073-82.

Punga, A. R.; Maj, M.; Lin, S.; Meinen, S.; Ruegg, M. A. (2011). MuSK levels differ between adult skeletal muscles and influence postsynaptic plasticity. The European journal of neuroscience, 33 (5), 890-8.


Rüegg, Markus A.; Glass, David J. (2010). Molecular mechanisms and treatment options for muscle wasting eiseases. Annual Review of Pharmacology and Toxicology, 51, 373-95.

Escher, Claudia; Lochmüller, Hanns; Fischer, Dirk; Frank, Stephan; Reimann, Jens; Walter, Maggie C.; Ehrat, Markus; Ruegg, Markus A.; Gygax, Daniel (2010). Reverse protein arrays as novel approach for protein quantification in muscular dystrophies. Neuromuscular disorders, 20 (5), 302-9.


Risson, Valérie; Mazelin, Laetitia; Roceri, Mila; Sanchez, Hervé; Moncollin, Vincent; Corneloup, Claudine; Richard-Bulteau, Hélène; Vignaud, Alban; Baas, Dominique; Defour, Aurélia; Freyssenet, Damien; Tanti, Jean-François; Le-Marchand-Brustel, Yannick; Ferrier, Bernard; Conjard-Duplany, Agnès; Romanino, Klaas; Bauché, Stéphanie; Hantaï, Daniel; Mueller, Matthias; Kozma, Sara C; Thomas, George; Rüegg, Markus A; Ferry, Arnaud; Pende, Mario; Bigard, Xavier; Koulmann, Nathalie; Schaeffer, Laurent; Gangloff, Yann-Gaël (2009). Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy. The Journal of cell biology, 187 (6), 859-74.

Erb, M.; Meinen, S.; Barzaghi, P.; Sumanovski, L. T.; Courdier-Fruh, I.; Ruegg, M. A.; Meier, T. (2009). Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-α2 deficiency. Journal of pharmacology and experimental therapeutics, 331 (3), 787-95.

Huze, C.; Bauche, S.; Richard, P.; Chevessier, F.; Goillot, E.; Gaudon, K.; Ben Ammar, A.; Chaboud, A.; Grosjean, I.; Lecuyer, H. -A.; Bernard, V.; Rouche, A.; Alexandri, N.; Kuntzer, T.; Fardeau, M.; Fournier, E.; Brancaccio, A.; Ruegg, M. A.; Koenig, J.; Eymard, B.; Schaeffer, L.; Hantai, D. (2009). Identification of an agrin mutation that causes congenital myasthenia and affects synapse function. American Journal of Human Genetics, 85 (2), 155-67.

Willmann, Raffaella; Possekel, Stefanie; Dubach-Powell, Judith; Meier, Thomas; Rüegg, Markus A. (2009). Mammalian animal models for Duchenne muscular dystrophy. Neuromuscular Disorders, 19 (4), 241-9.

Patursky-Polischuk, I.; Stolovich-Rain, M.; Hausner-Hanochi, M.; Kasir, J.; Cybulski, N.; Avruch, J.; Ruegg, M. A.; Hall, M. N.; Meyuhas, O. (2009). The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Molecular and cellular biology, 29 (3), 640-649.

Cybulski, N.; Polak, P.; Auwerx, J.; Ruegg, M. A.; Hall, M. N. (2009). mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proceedings of the National Academy of Sciences of the United States of America, 106 (24), 9902-7.


Polak, P.; Cybulski, N.; Feige, J. N.; Auwerx, J.; Ruegg, M. A.; Hall, M. N. (2008). Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration. Cell Metabolism, 8 (5), 399-410.

Bentzinger, C. F.; Romanino, K.; Cloetta, D.; Lin, S.; Mascarenhas, J. B.; Oliveri, F.; Xia, J.; Casanova, E.; Costa, C. F.; Brink, M.; Zorzato, F.; Hall, M. N.; Ruegg, M. A. (2008). Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metabolism, 8 (5), 411-24.

Lin, S.; Maj, M.; Bezakova, G.; Magyar, J. P.; Brenner, H. R.; Ruegg, M. A. (2008). Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice. Proceedings of the National Academy of Sciences of the United States of America, 105 (32), 11406-11.

Lin, Shuo; Landmann, Lukas; Ruegg, Markus A; Brenner, Hans Rudolf (2008). The role of nerve- versus muscle-derived factors in mammalian neuromuscular junction formation. Journal of neuroscience, 28 (13), 3333-40.

Reiterer, V.; Maier, S.; Sitte, H. H.; Kriz, A.; Ruegg, M. A.; Hauri, H. P.; Freissmuth, M.; Farhan, H. (2008). Sec24- and ARFGAP1-dependent trafficking of GABA transporter-1 is a prerequisite for correct axonal targeting. Journal of Neuroscience, 28 (47), 12453-64.


Meinen, Sarina; Barzaghi, Patrizia; Lin, Shuo; Lochmüller, Hanns; Ruegg, Markus A (2007). Linker molecules between laminins and dystroglycan ameliorate laminin-alpha2-deficient muscular dystrophy at all disease stages. The Journal of cell biology, 176 (7), 979-93.

Plachta, N.; Annaheim, C.; Bissiere, S.; Lin, S.; Ruegg, M.; Hoving, S.; Muller, D.; Poirier, F.; Bibel, M.; Barde, Y. -A. (2007). Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells. Nature neuroscience, 10 (6), 712-9.

Ksiazek, Iwona; Burkhardt, Constanze; Lin, Shuo; Seddik, Riad; Maj, Marcin; Bezakova, Gabriela; Jucker, Mathias; Arber, Silvia; Caroni, Pico; Sanes, Joshua R.; Bettler, Bernhard; Ruegg, Markus A. (2007). Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death. Journal of Neuroscience, 27 (27), 7183-95.

Hausser, Heinz-Juergen; Ruegg, Markus A.; Brenner, Rolf E.; Ksiazek, Iwona (2007). Agrin is highly expressed by chondrocytes and is required for normal growth. Histochemistry and Cell Biology, 127 (4), 363-74.

Camilleri, A. A.; Willmann, R.; Sadasivam, G.; Lin, S.; Ruegg, M. A.; Gesemann, M.; Fuhrer, C. (2007). Tyrosine phosphatases such as SHP-2 act in a balance with Src-family kinases in stabilization of postsynaptic clusters of acetylcholine receptors. BMC Neuroscience, 8 (46), 46.


Meinen, S; Ruegg, M A (2006). Congenital muscular dystrophy: mini-agrin delivers in mice. Gene Therapy, 13 (11), 869-70.

Scotton, P.; Bleckmann, D.; Stebler, M.; Sciandra, F.; Brancaccio, A.; Meier, T.; Stetefeld, J.; Ruegg, M. A. (2006). Activation of muscle-specific receptor tyrosine kinase and binding to dystroglycan are regulated by alternative mRNA splicing of agrin. Journal of Biological Chemistry, 281 (48), 36835-45.

Jokic, N.; Gonzalez de Aguilar, J. -L.; Dimou, L.; Lin, S.; Fergani, A.; Ruegg, M. A.; Schwab, M. E.; Dupuis, L.; Loeffler, J. -P. (2006). The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model. EMBO reports, 7 (11), 1162-1167.

Annies, M.; Bittcher, G.; Ramseger, R.; Loschinger, J.; Woll, S.; Porten, E.; Abraham, C.; Ruegg, M. A.; Kroger, S. (2006). Clustering transmembrane-agrin induces filopodia-like processes on axons and dendrites. Molecular and cellular neuroscience, 31 (3), 515-24.

Ruegg, M. A.: Commonalities and differences in muscular dystrophies : mechanisms and molecules involved in merosin-deficient congenital muscular dystrophy, in: Winder, Steve J.(Ed.). (2006). Molecular mechanisms of muscular dystrophies, Georgetown, Tex.:, 74-81.

Possekel, S.; Meier, T.; Ruegg, M. A.: Peripheral signaling pathways involved in muscle lossPharmacotherapy of Cachexia, Boca Raton, FL, USA: CRC Press, 543-564.


Mascarenhas, J. B.; Ruegg, M. A.; Sasaki, T.; Eble, J. A.; Engel, J.; Stetefeld, J. (2005). Structure and laminin-binding specificity of the NtA domain expressed in eukaryotic cells. Matrix Biology, 23 (8), 507-13.

Ruegg, M. A. (2005). Organization of synaptic myonuclei by Syne proteins and their role during the formation of the nerve-muscle synapse. Proceedings of the National Academy of Sciences of the United States of America, 102 (16), 5643-4.

Bentzinger, C. F.; Barzaghi, P.; Lin, S.; Ruegg, M. A. (2005). Overexpression of mini-agrin in skeletal muscle increases muscle integrity and regenerative capacity in laminin-alpha2-deficient mice. FASEB Journal, 19 (8), 934-42.

Stetefeld, J.; Ruegg, M. A. (2005). Structural and functional diversity generated by alternative mRNA splicing. Trends in biochemical sciences, 30 (9), 515-21.

Smirnov, S. P.; Barzaghi, P.; McKee, K. K.; Ruegg, M. A.; Yurchenco, P. D. (2005). Conjugation of LG domains of agrins and perlecan to polymerizing laminin-2 promotes acetylcholine receptor clustering. Journal of Biological Chemistry, 280 (50), 41449-57.

Sadasivam, G.; Willmann, R.; Lin, S.; Erb-Vogtli, S.; Kong, X. C.; Ruegg, M. A.; Fuhrer, C. (2005). Src-family kinases stabilize the neuromuscular synapse in vivo via protein interactions, phosphorylation, and cytoskeletal linkage of acetylcholine receptors. Journal of Neuroscience, 25 (45), 10479-93.

Madhavan, R.; Zhao, X. T.; Ruegg, M. A.; Peng, H. B. (2005). Tyrosine phosphatase regulation of MuSK-dependent acetylcholine receptor clustering. Molecular and cellular neuroscience, 28 (3), 403-16.


Jacinto, E.; Loewith, R.; Schmidt, A.; Lin, S.; Ruegg, M. A.; Hall, A.; Hall, M. N. (2004). Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nature Cell Biology, 6 (11), 1122-8.

Kong, X. C.; Barzaghi, P.; Ruegg, M. A. (2004). Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference. EMBO reports, 5 (2), 183-8.

Stetefeld, J.; Alexandrescu, A. T.; Maciejewski, M. W.; Jenny, M.; Rathgeb-Szabo, K.; Schulthess, T.; Landwehr, R.; Frank, S.; Ruegg, M. A.; Kammerer, R. A. (2004). Modulation of agrin function by alternative splicing and Ca2+ binding. Structure: with folding and design, 12 (3), 503-15.

Ruegg, M. A.; McMahan, U. J.: AgrinEncyclopedia of Neuroscience, Amsterdam: Elsevier.


Mascarenhas, J. B.; Ruegg, M. A.; Winzen, U.; Halfter, W.; Engel, J.; Stetefeld, J. (2003). Mapping of the laminin-binding site of the N-terminal agrin domain (NtA). The EMBO Journal, 22 (3), 529-36.

Bezakova, G.; Ruegg, M. A. (2003). New insights into the roles of agrin. Nature reviews. Molecular cell biology, 4 (4), 295-308.

Eusebio, A.; Oliveri, F.; Barzaghi, P.; Ruegg, M. A. (2003). Expression of mouse agrin in normal, denervated and dystrophic muscle. Neuromuscular Disorders, 13 (5), 408-15.

Guo, L. T.; Zhang, X. U.; Kuang, W.; Xu, H.; Liu, L. A.; Vilquin, J. -T.; Miyagoe-Suzuki, Y.; Takeda, S.; Ruegg, M. A.; Wewer, U. M.; Engvall, E. (2003). Laminin alpha2 deficiency and muscular dystrophy : genotype-phenotype correlation in mutant mice. Neuromuscular Disorders, 13 (3), 207-15.

Bartoccioni, E.; Marino, M.; Evoli, A.; Ruegg, M. A.; Scuderi, F.; Provenzano, C. (2003). Identification of disease-specific autoantibodies in seronegative myasthenia gravis. Annals of the New York Academy of Sciences, 998, 356-8.


Pun, S.; Sigrist, M.; Santos, A. F.; Ruegg, M. A.; Sanes, J. R.; Jessell, T. M.; Arber, S.; Caroni, P. (2002). An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles. Neuron, 34 (3), 357-370.

Bixby, J. L.; Baerwald-De la Torre, K.; Wang, C.; Rathjen, F. G.; Ruegg, M. A. (2002). A neuronal inhibitory domain in the N-terminal half of agrin. Journal of Neurobiology, 50 (2), 164-179.

Abicht, A.; Stucka, R.; Schmidt, C.; Briguet, A.; Hopfner, S.; Song, I. -H.; Pongratz, D.; Muller-Felber, W.; Ruegg, M. A.; Lochmuller, H. (2002). A newly identified chromosomal microdeletion and an N-box mutation of the AChR epsilon gene cause a congenital myasthenic syndrome. Brain, 125 (5), 1005-1013.


Neumann, Frank R.; Bittcher, Godela; Annies, Maik; Schumacher, Beat; Kroger, Stephan; Ruegg, Markus A. (2001). An alternative amino-terminus expressed in the central nervous system converts agrin to a type II transmembrane protein. Molecular and cellular neuroscience, 17 (1), 208-225.

Ruegg, M. A. (2001). Molecules involved in the formation of synaptic connections in muscle and brain. Matrix Biology, 20 (1), 3-12.

Stetefeld, J.; Jenny, M.; Schulthess, T.; Landwehr, R.; Schumacher, B.; Frank, S.; Ruegg, M. A.; Engel, J.; Kammerer, R. A. (2001). The laminin-binding domain of agrin is structurally related to N-TIMP-1. Nature Structural biology, 8 (8), 705-709.

Moll, J.; Barzaghi, P.; Lin, S.; Bezakova, G.; Lochmuller, H.; Engvall, E.; Muller, U.; Ruegg, M. A. (2001). An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy. Nature, 413 (6853), 302-307.

Alexandrescu, A. T.; Maciejewski, M. W.; Ruegg, M. A.; Engel, J.; Kammerer, R. A. (2001). 1H, 13C and 15N backbone assignments for the C-terminal globular domain of agrin. Journal of Biomolecular NMR, 20 (3), 295-6.


Briguet, A.; Ruegg, M. A. (2000). The Ets transcription factor GABP is required for postsynaptic differentiation in vivo. Journal of neuroscience, Vol. 20, H. 16, 5989-5996.

Meier, Thomas; Ruegg, Markus A. (2000). The Role of Dystroglycan and Its Ligands in Physiology and Disease. News in physiological sciences, 15, 255-259.

van der Putten, H.; Wiederhold, K. H.; Probst, A.; Barbieri, S.; Mistl, C.; Danner, S.; Kauffmann, S.; Hofele, K.; Spooren, W. P.; Ruegg, M. A.; Lin, S.; Caroni, P.; Sommer, B.; Tolnay, M.; Bilbe, G. (2000). Neuropathology in mice expressing human alpha-synuclein. Journal of Neuroscience, 20 (16), 6021-9.

Sommer, B.; Barbieri, S.; Hofele, K.; Wiederhold, K.; Probst, A.; Mistl, C.; Danner, S.; Kauffmann, S.; Spooren, W.; Tolnay, M.; Bilbe, G.; Kafmann, S.; Caromi, P.; Ruegg, M. A. (2000). Mouse models of alpha-synucleinopathy and Lewy pathology. Experimental gerontology, 35 (9-10), 1389-403.

Halfter, W.; Dong, S.; Schurer, B.; Osanger, A.; Schneider, W.; Ruegg, M.; Cole, G. J. (2000). Composition, synthesis, and assembly of the embryonic chick retinal basal lamina. Developmental biology, 220 (2), 111-28.


Kammerer, R. A.; Schulthess, T.; Landwehr, R.; Schumacher, B.; Lustig, A.; Yurchenco, P. D.; Ruegg, M. A.; Engel, J.; Denzer, A. J. (1999). Interaction of agrin with laminin requires a coiled-coil conformation of the agrin-binding site within the laminin gamma1 chain. The EMBO Journal, 18 (23), 6762-70.


Gesemann, M.; Brancaccio, A.; Schumacher, B.; Ruegg, M. A. (1998). Agrin is a high-affinity binding protein of dystroglycan in non-muscle tissue. Journal of Biological Chemistry, 273 (1), 600-5.

Denzer, A. J.; Schulthess, T.; Fauser, C.; Schumacher, B.; Kammerer, R. A.; Engel, J.; Ruegg, M. A. (1998). Electron microscopic structure of agrin and mapping of its binding site in laminin-1. The EMBO Journal, 17 (2), 335-43.

Ruegg, M. A.; Bixby, J. L. (1998). Agrin orchestrates synaptic differentiation at the vertebrate neuromuscular junction. Trends in Neurosciences, 21 (1), 22-7.

Sieb, J. P.; Dorfler, P.; Tzartos, S.; Wewer, U. M.; Ruegg, M. A.; Meyer, D.; Baumann, I.; Lindemuth, R.; Jakschik, J.; Ries, F. (1998). Congenital myasthenic syndromes in two kinships with end-plate acetylcholine receptor and utrophin deficiency. Neurology, 50 (1), 54-61.

Nawrotzki, R.; Loh, N. Y.; Ruegg, M. A.; Davies, K. E.; Blake, D. J. (1998). Characterisation of alpha-dystrobrevin in muscle. Journal of Cell Science, 111 (17), 2595-2605.

Meier, T.; Ruegg, M. A.; Wallace, B. G. (1998). Muscle-specific agrin isoforms reduce phosphorylation of AChR gamma and delta subunits in cultured muscle cells. Molecular and cellular neuroscience, 11 (4), 206-16.

Meier, T.; Marangi, P. A.; Moll, J.; Hauser, D. M.; Brenner, H. R.; Ruegg, M. A. (1998). A minigene of neural agrin encoding the laminin-binding and acetylcholine receptor-aggregating domains is sufficient to induce postsynaptic differentiation in muscle fibres. The European journal of neuroscience, 10 (10), 3141-3152.

Groffen, A. J.; Ruegg, M. A.; Dijkman, H.; van de Velden, T. J.; Buskens, C. A.; van den Born, J.; Assmann, K. J.; Monnens, L. A.; Veerkamp, J. H.; van den Heuvel, L. P. (1998). Agrin is a major heparan sulfate proteoglycan in the human glomerular basement membrane. Journal of Histochemistry and Cytochemistry, 46 (1), 19-27.


Denzer, A J; Brandenberger, R; Gesemann, M; Chiquet, M; Ruegg, M A (1997). Agrin binds to the nerve-muscle basal lamina via laminin. The Journal of cell biology, 137 (3), 671-83.

Denzer, A. J.; Hauser, D. M.; Gesemann, M.; Ruegg, M. A. (1997). Synaptic differentiation : the role of agrin in the formation and maintenance of the neuromuscular junction. Cell and Tissue Research, 290 (2), 357-65.

Meier, T.; Hauser, D. M.; Chiquet, M.; Landmann, L.; Ruegg, M. A.; Brenner, H. R. (1997). Neural agrin induces ectopic postsynaptic specializations in innervated muscle fibers. Journal of neuroscience, 17 (17), 6534-44.

Campagna, J. A.; Ruegg, M. A.; Bixby, J. L. (1997). Evidence that agrin directly influences presynaptic differentiation at neuromuscular junctions in vitro. The European journal of neuroscience, 9 (11), 2269-83.


Ruegg, M. A. (1996). Agrin, laminin beta 2 (s-laminin) and ARIA : their role in neuromuscular development. Current Opinion in Neurobiology, 6 (1), 97-103.

Yamada, H.; Denzer, A. J.; Hori, H.; Tanaka, T.; Anderson, L. V.; Fujita, S.; Fukuta-Ohi, H.; Shimizu, T.; Ruegg, M. A.; Matsumura, K. (1996). Dystroglycan is a dual receptor for agrin and laminin-2 in Schwann cell membrane. Journal of Biological Chemistry, 271 (38), 23418-23.

Meier, T.; Gesemann, M.; Cavalli, V.; Ruegg, M. A.; Wallace, B. G. (1996). AChR phosphorylation and aggregation induced by an agrin fragment that lacks the binding domain for alpha-dystroglycan. The EMBO Journal, 15 (11), 2625-31.

Jones, G.; Herczeg, A.; Ruegg, M. A.; Lichtsteiner, M.; Kroger, S.; Brenner, H. R. (1996). Substrate-bound agrin induces expression of acetylcholine receptor epsilon-subunit gene in cultured mammalian muscle cells. Proceedings of the National Academy of Sciences of the United States of America, 93 (12), 5985-90.

Gesemann, M.; Cavalli, V.; Denzer, A. J.; Brancaccio, A.; Schumacher, B.; Ruegg, M. A. (1996). Alternative splicing of agrin alters its binding to heparin, dystroglycan, and the putative agrin receptor. Neuron, 16 (4), 755-67.


Gesemann, M; Denzer, A J; Ruegg, M A (1995). Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site. The Journal of cell biology, 128 (4), 625-36.

DENZER, AJ; GESEMANN, M; SCHUMACHER, B; RUEGG, MA (1995). An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix. The Journal of cell biology, 131 (6), 1547-1560.

Campagna, J. A.; Ruegg, M. A.; Bixby, J. L. (1995). Agrin is a differentiation-inducing "stop signal" for motoneurons in vitro. Neuron, 15 (6), 1365-1374.

Brancaccio, A.; Ruegg, M. A.; Engel, J. (1995). Cloning and sequencing of mouse skeletal muscle alpha-dystroglycan. Matrix biology, 14 (8), 681-5.


Tsim, K. W.; Ruegg, M. A.; Escher, G.; Kroger, S.; McMahan, U. J. (1992). cDNA that encodes active agrin. Neuron, 8 (4), 677-89.

Ruegg, M. A.; Tsim, K. W.; Horton, S. E.; Kroger, S.; Escher, G.; Gensch, E. M.; McMahan, U. J. (1992). The agrin gene codes for a family of basal lamina proteins that differ in function and distribution. Neuron, 8 (4), 691-699.

McMahan, U. J.; Horton, S. E.; Werle, M. J.; Honig, L. S.; Kroger, S.; Ruegg, M. A.; Escher, G. (1992). Agrin isoforms and their role in synaptogenesis. Current opinion in cell biology, 4 (5), 869-74.


Stoeckli, E. T.; Kuhn, T. B.; Duc, C. O.; Ruegg, M. A.; Sonderegger, P. (1991). The axonally secreted protein axonin-1 is a potent substratum for neurite growth. Journal of Cell Biology, 112 (3), 449-455.


Stoeckli, E. T.; Lemkin, P. F.; Kuhn, T. B.; Ruegg, M. A.; Heller, M.; Sonderegger, P. (1989). Identification of proteins secreted from axons of embryonic dorsal-root-ganglia neurons. European Journal of Biochemistry, 180 (2), 249-58.

Ruegg, M. A.; Stoeckli, E. T.; Kuhn, T. B.; Heller, M.; Zuellig, R.; Sonderegger, P. (1989). Purification of axonin-1, a protein that is secreted from axons during neurogenesis. The EMBO Journal, 8 (1), 55-63.

Ruegg, M.A.; Stoeckli, E.T.; Lanz, R.B.; Streit, P.; Sonderegger, P.; , (1989). A homologue of the axonally secreted protein axonin-1 is an integral membrane protein of nerve fiber tracts involved in neurite fasciculation. The Journal of cell biology, 109 ((5)), 2363-78.

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