Prof. Dr. Peter Scheiffele

Biozentrum
University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Raum 276A Tel.: +41 61 207 21 94
E-Mail: peter.scheiffele-at-unibas.ch
Lebenslauf

Administrative Assistent/in

Anja Streb
Biozentrum, Raum 210
Tel.: +41 61 207 21 81
Fax: +41 61 207 20 78
E-Mail: anja.streb-at-unibas.ch

Research group Peter Scheiffele

Artikel

2016
Mauger, Oriane; Lemoine, Frédéric; Scheiffele, Peter (2016). Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity. Neuron, 92(6), 1266-1278.
Nguyen, Thi-Minh; Schreiner, Dietmar; Xiao, Le; Traunmüller, Lisa; Bornmann, Caroline; Scheiffele, Peter (2016). An alternative splicing switch shapes neurexin repertoires in principal neurons versus interneurons in the mouse hippocampus. eLife, 5, e22757.
Iijima, Yoko; Behr, Katharina; Iijima, Takatoshi; Biemans, Barbara; Bischofberger, Josef; Scheiffele, Peter (2016). Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure. Scientific Reports, 6, 27400.
Furlanis, Elisabetta; Scheiffele, Peter (2016). Synaptic Ménage à Trois. Neuron, 90(4), 665-667.
Traunmüller, Lisa; Gomez, Andrea M; Nguyen, Thi-Minh; Scheiffele, Peter (2016). Control of neuronal synapse specification by a highly dedicated alternative splicing program. Science, 352(6288), 982-6.
Singh, Sandeep K; Stogsdill, Jeff A; Pulimood, Nisha S; Dingsdale, Hayley; Kim, Yong Ho; Pilaz, Louis-Jan; Kim, Il Hwan; Manhaes, Alex C; Rodrigues, Wandilson S; Pamukcu, Arin; Enustun, Eray; Ertuz, Zeynep; Scheiffele, Peter; Soderling, Scott H; Silver, Debra L; Ji, Ru-Rong; Medina, Alexandre E; Eroglu, Cagla (2016). Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. Cell, 164(1-2), 183-96.
2015
Muhammad, Karzan; Reddy-Alla, Suneel; Driller, Jan H; Schreiner, Dietmar; Rey, Ulises; Böhme, Mathias A; Hollmann, Christina; Ramesh, Niraja; Depner, Harald; Lützkendorf, Janine; Matkovic, Tanja; Götz, Torsten; Bergeron, Dominique D; Schmoranzer, Jan; Goettfert, Fabian; Holt, Mathew; Wahl, Markus C; Hell, Stefan W; Scheiffele, Peter; Walter, Alexander M; Loll, Bernhard; Sigrist, Stephan J (2015). Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function. Nature communications, 6, 8362.
Schreiner, Dietmar; Simicevic, Jovan; Ahrné, Erik; Schmidt, Alexander; Scheiffele, Peter (2015). Quantitative isoform-profiling of highly diversified recognition molecules. eLife, 4, e07794.
de la Mata, Manuel; Gaidatzis, Dimos; Vitanescu, Mirela; Stadler, Michael B; Wentzel, Corinna; Scheiffele, Peter; Filipowicz, Witold; Großhans, Helge (2015). Potent degradation of neuronal miRNAs induced by highly complementary targets. EMBO reports, 16(4), 500-11.
2014
Schreiner, Dietmar; Nguyen, Thi-Minh; Russo, Giancarlo; Heber, Steffen; Patrignani, Andrea; Ahrné, Erik; Scheiffele, Peter (2014). Targeted combinatorial alternative splicing generates brain region-specific repertoires of neurexins. Neuron, 84(2), 386-98.
Schreiner, Dietmar; Nguyen, Thi-Minh; Scheiffele, Peter (2014). Polymorphic receptors: neuronal functions and molecular mechanisms of diversification. Current opinion in neurobiology, 27, 25-30.
Iijima, Takatoshi; Iijima, Yoko; Witte, Harald; Scheiffele, Peter (2014). Neuronal cell type-specific alternative splicing is regulated by the KH domain protein SLM1. Journal of cell biology, 204(3), 331-42.
Kleijer, Kristel T E; Schmeisser, Michael J; Krueger, Dilja D; Boeckers, Tobias M; Scheiffele, Peter; Bourgeron, Thomas; Brose, Nils; Burbach, J Peter H (2014). Neurobiology of autism gene products : towards pathogenesis and drug targets. Psychopharmacology, 231(6), 1037-62.
Traunmüller, L.; Bornmann, C.; Scheiffele, P. (2014). Alternative Splicing Coupled Nonsense-Mediated Decay Generates Neuronal Cell Type-Specific Expression of SLM Proteins. Journal of Neuroscience, 34(50), 16755-61.
2013
Sylwestrak, Emily; Scheiffele, Peter (2013). Neuroscience: Sculpting neuronal connectivity. Nature, 503(7474), 42-3.
Kiebler, Michael A; Scheiffele, Peter; Ule, Jernej (2013). What, where, and when: the importance of post-transcriptional regulation in the brain. Frontiers in neuroscience, 7, 192.
Wentzel, Corinna; Sommer, Julia E; Nair, Ramya; Stiefvater, Adeline; Sibarita, Jean-Baptiste; Scheiffele, Peter (2013). mSYD1A, a Mammalian Synapse-Defective-1 Protein, Regulates Synaptogenic Signaling and Vesicle Docking. Neuron, 78(6), 1012-23.
Scheiffele, Peter (2013). Preparing for your future as you grow. Neuron, 78(5), 751-2.
Burch, Patrick; Binaghi, Massimo; Scherer, Manuel; Wentzel, Corinna; Bossert, David; Eberhardt, Luc; Neuburger, Markus; Scheiffele, Peter; Gademann, Karl (2013). Total Synthesis of Gelsemiol. Chemistry, 19(8), 2589-2591.
Budreck, Elaine C; Kwon, Oh-Bin; Jung, Jung Hoon; Baudouin, Stephane; Thommen, Albert; Kim, Hye-Sun; Fukazawa, Yugo; Harada, Harumi; Tabuchi, Katsuhiko; Shigemoto, Ryuichi; Scheiffele, Peter; Kim, Joung-Hun (2013). Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling. Proceedings of the National Academy of Sciences of the United States of America, 110(2), 725-30.
2012
Feltrin, Daniel; Fusco, Ludovico; Witte, Harald; Moretti, Francesca; Martin, Katrin; Letzelter, Michel; Fluri, Erika; Scheiffele, Peter; Pertz, Olivier (2012). Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation. PLoS biology, 10(12), e1001439.
Scheiffele, Peter; Iijima, Takatoshi (2012). Choreographing the axo-dendritic dance. Developmental cell, 23(5), 923-924.
Baudouin, Stéphane J; Gaudias, Julien; Gerharz, Stefan; Hatstatt, Laetitia; Zhou, Kuikui; Punnakkal, Pradeep; Tanaka, Kenji F; Spooren, Will; Hen, Rene; De Zeeuw, Chris I; Vogt, Kaspar; Scheiffele, Peter (2012). Shared synaptic pathophysiology in syndromic and non-syndromic rodent models of autism. Science, 338(6103), 128-32.
2011
Iijima, Takatoshi; Wu, Karen; Witte, Harald; Hanno-Iijima, Yoko; Glatter, Timo; Richard, Stéphane; Scheiffele, Peter (2011). SAM68 regulates neuronal activity-dependent alternative splicing of Neurexin-1. Cell, 147(7), 1601-14.
Panzanelli, Patrizia; Gunn, Benjamin G; Schlatter, Monika C; Benke, Dietmar; Tyagarajan, Shiva K; Scheiffele, Peter; Belelli, Delia; Lambert, Jeremy J; Rudolph, Uwe; Fritschy, Jean-Marc (2011). Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells. The Journal of Physiology, 589(Pt 20), 4959-80.
Kalinovsky, Anna; Boukhtouche, Fatiha; Blazeski, Richard; Bornmann, Caroline; Suzuki, Noboru; Mason, Carol A; Scheiffele, Peter (2011). Development of axon-target specificity of ponto-cerebellar afferents. PLoS Biology, 9(2), e1001013.
2010
Scheiffele, Peter; Beg, Asim A (2010). Neuroscience : Angelman syndrome connections. Nature, 468(7326), 907-8.
Asante, Curtis Oware; Chu, Amy; Fisher, Mark; Benson, Leora; Beg, Asim; Scheiffele, Peter; Martin, John (2010). Cortical control of adaptive locomotion in wild type mice and mutant mice lacking the Ephrin-Eph effector protein alpha2-Chimaerin. Journal of Neurophysiology, 104(6), 3189-202.
Scheiffele, Peter; Yuzaki, Michizuke (2010). Recent excitements about excitatory synapses. The European journal of neuroscience, 32(2), 179-80.
Baudouin, Stephane; Scheiffele, Peter (2010). SnapShot: Neuroligin-neurexin complexes. Cell, 141(5), 908-U187.
Shen, Kang; Scheiffele, Peter (2010). Genetics and cell biology of building specific synaptic connectivity. Annual Review of Neuroscience, 33, 473-507.
Tanaka, Kenji F; Ahmari, Susanne E; Leonardo, E David; Richardson-Jones, Jesse W; Budreck, Elaine C; Scheiffele, Peter; Sugio, Shouta; Inamura, Naoko; Ikenaka, Kazuhiro; Hen, René (2010). Flexible Accelerated STOP Tetracycline Operator-knockin (FAST) : a versatile and efficient new gene modulating system. Biological Psychiatry, 67(8), 770-3.
2009
Dean, Camin; Scheiffele, Peter (2009). Imaging synaptogenesis by measuring accumulation of synaptic proteins. Cold Spring Harbor Protocols, 2009(11), pdb.prot5315.
2008
Gascón, Sergio; Paez-Gomez, Juan A; Díaz-Guerra, Margarita; Scheiffele, Peter; Scholl, Francisco G (2008). Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons. Journal of neuroscience methods, 168(1), 104-12.
Koehnke, Jesko; Jin, Xiangshu; Trbovic, Nikola; Katsamba, Phinikoula S; Brasch, Julia; Ahlsen, Goran; Scheiffele, Peter; Honig, Barry; Palmer, Arthur G; Shapiro, Lawrence (2008). Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4. Structure: with folding and design, 16(3), 410-21.
Robakis, Thalia; Bak, Beata; Lin, Shu-huei; Bernard, Daniel J; Scheiffele, Peter (2008). An internal signal sequence directs intramembrane proteolysis of a cellular immunoglobulin-domain protein. Journal of Biological Chemistry, 283(52), 36369-76.
Huang, Z Josh; Scheiffele, Peter (2008). GABA and neuroligin signaling : linking synaptic activity and adhesion in inhibitory synapse development. Current Opinion in Neurobiology, 18(1), 77-83.
Koehnke, Jesko; Jin, Xiangshu; Budreck, Elaine C; Posy, Shoshana; Scheiffele, Peter; Honig, Barry; Shapiro, Lawrence (2008). Crystal structure of the extracellular cholinesterase-like domain from neuroligin-2. Proceedings of the National Academy of Sciences of the United States of America, 105(6), 1873-8.
Kim, Juhyun; Jung, Sang-Yong; Lee, Yeon Kyung; Park, Sangki; Choi, June-Seek; Lee, C Justin; Kim, Hye-Sun; Choi, Yun-Beom; Scheiffele, Peter; Bailey, Craig H; Kandel, Eric R; Kim, Joung-Hun (2008). Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals. Proceedings of the National Academy of Sciences of the United States of America, 105(26), 9087-92.
Caroni, Pico; Scheiffelle, Peter (2008). Editorial overview. Current opinion in neurobiology, 18(5), 469-471.
2007
Budreck, Elaine C; Scheiffele, Peter (2007). Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses. The European journal of neuroscience, 26(7), 1738-48.
Beg, Asim A; Sommer, Julia E; Martin, John H; Scheiffele, Peter (2007). alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits. Neuron, 55(5), 768-78.
Biederer, Thomas; Scheiffele, Peter (2007). Mixed-culture assays for analyzing neuronal synapse formation. Nature protocols, 2(3), 670-6.
Taniguchi, H.; Gollan, L.; Scholl, F. G.; Mahadomrongkul, V.; Dobler, E.; Limthong, N.; Peck, M.; Aoki, C.; Scheiffele, P. (2007). Silencing of neuroligin function by postsynaptic neurexins. Journal of Neuroscience, 27(11), 2815-24.
Futai, Kensuke; Kim, Myung Jong; Hashikawa, Tsutomu; Scheiffele, Peter; Sheng, Morgan; Hayashi, Yasunori (2007). Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin. Nature neuroscience, 10(2), 186-95.
2006
Chih, Ben; Gollan, Leora; Scheiffele, Peter (2006). Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex. Neuron, 51(2), 171-8.
Beg, Asim A; Scheiffele, Peter (2006). SUMO wrestles the synapse. Science, 311(5763), 962-3.
Buttery, Philip; Beg, Asim A; Chih, Ben; Broder, Arkady; Mason, Carol A; Scheiffele, Peter (2006). The diacylglycerol-binding protein alpha1-chimaerin regulates dendritic morphology. Proceedings of the National Academy of Sciences of the United States of America, 103(6), 1924-9.
2005
Rosales, Carlos R; Osborne, Kyle D; Zuccarino, Griselda V; Scheiffele, Peter; Silverman, Michael A (2005). A cytoplasmic motif targets neuroligin-1 exclusively to dendrites of cultured hippocampal neurons. The European journal of neuroscience, 22(9), 2381-6.
Chih, Ben; Engelman, Holly; Scheiffele, Peter (2005). Control of excitatory and inhibitory synapse formation by neuroligins. Science, 307(5713), 1324-8.
2004
Washbourne, Philip; Dityatev, Alexander; Scheiffele, Peter; Biederer, Thomas; Weiner, Joshua A; Christopherson, Karen S; El-Husseini, Alaa (2004). Cell adhesion molecules in synapse formation. Journal of neuroscience, 24(42), 9244-9.
Kalinovsky, A.; Scheiffele, P. (2004). Transcriptional control of synaptic differentiation by retrograde signals. Current Opinion in Neurobiology, 14(3), 272-9.
Chih, Ben; Afridi, Shehla Khan; Clark, Lorraine; Scheiffele, Peter (2004). Disorder-associated mutations lead to functional inactivation of neuroligins. Human molecular genetics, 13(14), 1471-7.
2003
Scholl, Francisco G; Scheiffele, Peter (2003). Making connections : cholinesterase-domain proteins in the CNS. Trends in neurosciences, 26(11), 618-24.
Chih, Ben; Scheiffele, Peter (2003). Is reelin the answer to synapse elimination at the neuromuscular junction?. Science's STKE, 2003(205), pe45.
Dean, Camin; Scholl, Francisco G.; Choih, Jenny; DeMaria, Shannon; Berger, James; Isacoff, Ehud; Scheiffele, Peter (2003). Neurexin mediates the assembly of presynaptic terminals. Nature Neuroscience, 6(7), 708-16.
Scheiffele, Peter (2003). Cell-cell signaling during synapse formation in the CNS. Annual Review of Neuroscience, 26, 485-508.
2002
Breuza, Lionel; Corby, Séverine; Arsanto, Jean-Pierre; Delgrossi, Marie-Hélène; Scheiffele, Peter; Le Bivic, André (2002). The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco-2 cells. Journal of cell science, 115(Pt 23), 4457-67.
Diaz, E.; Ge, Y.; Yang, Y. H.; Loh, K. C.; Serafini, T. A.; Okazaki, Y.; Hayashizaki, Y.; Speed, T. P.; Ngai, J.; Scheiffele, P. (2002). Molecular analysis of gene expression in the developing pontocerebellar projection system. Neuron, 36(3), 417-34.
2000
Scheiffele, P; Fullekrug, J (2000). Glycosylation and protein transport. Essays in Biochemistry, 36, 27-35.
Scheiffele, P.; Fan, J.; Choih, J.; Fetter, R.; Serafini, T. (2000). Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell, 101(6), 657-69.
1999
Fullekrug, J.; Scheiffele, P.; Simons, K. (1999). VIP36 localisation to the early secretory pathway. Journal of Cell Science, 112 ( Pt 17)(17), 2813-21.
Brückner, K; Pablo Labrador, J; Scheiffele, P; Herb, A; Seeburg, P H; Klein, R (1999). EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron, 22(3), 511-24.
Scheiffele, P; Rietveld, A; Wilk, T; Simons, K (1999). Influenza viruses select ordered lipid domains during budding from the plasma membrane. Journal of Biological Chemistry, 274(4), 2038-44.
1998
Harder, T.; Scheiffele, Peter; Verkade, P.; Simons, K. (1998). Lipid domain structure of the plasma membrane revealed by patching of membrane components. Journal of Cell Biology, 141(4), 929-42.
Scheiffele, P; Verkade, P; Fra, A M; Virta, H; Simons, K; Ikonen, E (1998). Caveolin-1 and -2 in the exocytic pathway of MDCK cells. The Journal of cell biology, 140(4), 795-806.
1997
Shevchenko, A; Keller, P; Scheiffele, P; Mann, M; Simons, K (1997). Identification of components of trans-Golgi network-derived transport vesicles and detergent-insoluble complexes by nanoelectrospray tandem mass spectrometry. Electrophoresis, 18(14), 2591-600.
Scheiffele, P.; Roth, M. G.; Simons, K. (1997). Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain. The EMBO Journal, 16(18), 5501-8.
1995
Scheiffele, P.; Peranen, J.; Simons, K. (1995). N-glycans as apical sorting signals in epithelial cells. Nature, 378(6552), 96-8.
Scheiffele, Peter; Pansegrau, W.; Lanka, E. (1995). Initiation of Agrobacterium tumefaciens T-DNA processing: purified proteins VirD1 and VirD2 catalyze site- and strand-specific cleavage of superhelical T-border DNA in vitro. Journal of Biological Chemistry, 270(3), 1269-76.

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