Six of these SNSF supported research projects are being carried out at the University of Basel and the University Hospital Basel and are being funded with 2.79 million Swiss francs.
At the Biozentrum, the two research groups led by Sebastian Hiller and Urs Jenal are each carrying out a project in this program. Sebastian Hiller’s team is investigating the functional mechanism employed by many pathogenic bacteria to protect themselves with an external membrane. The aim is to understand the mechanism leading to the formation of the membrane proteins in order to be able to block it and to apply this knowledge to develop new antibiotics.
Urs Jenal and his group are investigating the basics of antibiotic tolerance and its role in the development of resistant pathogens. The background for this study is the increasing number of pathogens that survive antibiotic therapy even without developing resistance. The goal is to investigate the molecular and metabolic mechanisms of antibiotic tolerance. This will enable the development of new diagnostic tools to help monitor and control the occurrence of antibiotic tolerance in the clinical setting.