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PhD Fellowship in Nucleocytoplasmic Transport

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

Skilled and motivated individuals are encouraged to apply for a 4-year PhD Fellowship in the research group of Roderick Lim at the Biozentrum, University of Basel, Switzerland.

The Lim Lab is interested in nuclear pore complex (NPC) function and the regulation of nucleocytoplasmic transport (NCT). Importantly, malfunctioning NPCs and defective NCT are linked to aging as well as pathologies ranging from cancer to neurodegenerative disorders and viral pathogenesis.

Your responsibilities
In this project, we want to study novel function(s) of nuclear transport receptors, their regulation at NPCs and implications in human disease. Methods will comprise, amongst others, CRISPR-based genome editing, state-of-the art confocal imaging (including FRET, FRAP, and super-resolution techniques) and atomic force microscopy (AFM).

Besides basic research, PhD candidates will also have to contribute to undergraduate level teaching.

Your profile
Interested candidates should have a background in molecular cell biology, biophysics or related disciplines. Experience in optical/fluorescence imaging or AFM, including high-speed AFM is a plus. The successful candidate is expected to be highly interactive and capable of independent research in a team environment. A solid command of oral and written English is essential.

We offer
We are a multi-national, interdisciplinary lab that combines biophysical, molecular and cellular approaches to investigate intriguing biological problems. The successful applicant will benefit from a highly stimulating, collaborative research environment as well as state-of-the-art infrastructure and facilities at the new Biozentrum research tower.

Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany-France - it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.

Application / Contact
Please apply online The application should include a cover letter, CV, diplomas and 3 reference letters. Reviewing of applications will start immediately and continue until the position is filled. Please note that only online applications will be accepted.

For further information, please contact stephanie.gehlenunibasch