The Biozentrum of the University of Basel (https://www.biozentrum.unibas.ch) is a leading life sciences research institute. It consists of 30 groups and 500 employees that investigate how molecules and cells create life, spanning the scales from atoms to organisms and communities.
The research group of Prof. Stephan Grzesiek at the Biozentrum seeks to appoint a PhD student in biophysics with a focus on kinase regulation, to start immediately or as per arrangement.
We are applying and developing modern NMR methods and other biophysical techniques to elucidate the functional mechanisms of disease-relevant proteins at an atomic level. For an overview of current research projects and publications, please visit https://www.biozentrum.unibas.ch/grzesiek.
The PhD project is aimed at deciphering the regulation mechanism of Abelson kinase (Abl), which is a drug target against chronic myelogeneous leukemia (CML). It is foreseen to describe Abl’s regulation, oncogenic disregulation, and reaction to cancer drugs by a combination of various biophysical techniques. As such it will also involve expression and in-cell observations in mammalian cell lines. The project will be carried in close collaboration with the group of Prof. Oliver Hantschel, Biochemisch-Pharmakologisches Centrum, University of Marburg (https://www.uni-marburg.de/de/fb20/bereiche/bpc/physiolchemie).
We are looking for a highly motivated and talented PhD student to join our lab. Candidates must have a master degree in biochemistry, physical chemistry, physics or a related scientific discipline at the time of the PhD start. They should have experience in one or several of the following fields: molecular biology or cell biology with a background in protein structure, biomolecular fluorescence spectroscopy, or macromolecular NMR.
We offer a highly interactive, multidisciplinary, and international research group with expertise in many areas of biophysics. The technical equipment includes state-of-the art high-resolution NMR spectrometers, single-molecule FRET, as well as many other biophysical technologies and an advanced protein expression lab. Moreover, the Biozentrum provides excellent internal support from various core facilities with expert staff. The PhD training will include formal education within the Biozentrum’s graduate teaching program (https://www.biozentrum.unibas.ch/education/graduate-teaching-program/teaching-cycles/).
Basel is an international city with people from 150 nations. Located on the border where Switzerland, Germany, and France meet, Basel is home for a large number of institutions for biomedical research, with numerous possibilities for training, networking, and career development. Basel provides a high standard of living and a rich and varied cultural atmosphere.
Application deadline: https://biped2.biozentrum.unibas.ch/apply/phd-grzesiek-lab.
Please note that only applications through the online form linked above will be accepted.
The application should include a brief statement of your scientific interests, your research experience, and your particular interest in this open position. In addition, a CV and the contact information of two references is required.
For any informal enquiries, please contact: stephan.grzesiekunibasch.