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We study the cellular organization and regulation of metabolism by large macromolecular assemblies as well as giant microbial biosynthetic assembly lines. Our research builds on hybrid use of state-of-the-art cryo electron…

The National Center of Competence in Research (NCCR) AntiResist is a Swiss-wide research consortium funded by the Swiss National Science Foundation (SNSF). AntiResist is transforming antibiotic discovery and development…

Biozentrum Discovery Seminars Biozentrum Discovery (BZD) is a seminar series, which alternates between talks by renowned guest speakers and seminars given by graduate students and postdocs from the Biozentrum. The seminars…

Free Radical Biology and Medicine Podcast Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance Exercise training involves repeated exposure to increases in metabolic, thermal,…

Biozentrum Discovery Seminars Biozentrum Discovery (BZD) is a seminar series, which alternates between talks by renowned guest speakers and seminars given by graduate students and postdocs from the Biozentrum. Since its…

TOR signaling and control of cell growth Fig. 1: Architecture of human mTOR complex 1 Introduction Cell growth is highly regulated. Cells respond to nutrients or other appropriate growth stimuli by up-regulating…

Bruker timsTOF Ultra 2 The latest addition to the PCF. The new timsTOF Ultra MS from Bruker was just upgraded to the Ultra 2 version. With its Trapped Ion Mobility Spectrometry (TIMS) and Parallel Accumulation Serial…

FEI Tecnai G2 Spirit TEM Configuration BioTWIN lens configuration for increased contrast. 120kV TEM microscope (operated at 80kV) with a LaB6 filament and an EMSIS Veleta camera (top, side-mounted). The Camera operates using…

Host tissue responses to bacterial infection: A story of Mice and Men Bacterial infection takes place in the complex microenvironment of the host tissue. Dependent on the infection type, this environment varies dramatically…

Research Projects Biophysical Principles of Chaperone Function Molecular chaperones play a key role in cellular processes, including protein homeostasis, but also in membrane protein transport and biogenesis. We employ…