Navigation mit Access Keys

Main Content

2018

Zihlmann, Pascal; Silbermann, Marleen; Sharpe, Timothy; Jiang, Xiaohua; Mühlethaler, Tobias; Jakob, Roman P; Rabbani, Said; Sager, Christoph P; Frei, Priska; Pang, Lijuan; Maier, Timm; Ernst, Beat (2018). KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists. Chemistry (Weinheim an der Bergstrasse, Germany), 24, 1-10.

Kuenzl, Tilmann; Li-Blatter, Xiaochun; Srivastava, Puneet; Herdewijn, Piet; Sharpe, Timothy; Panke, Sven (2018). Mutant Variants of the Substrate-Binding Protein DppA from Escherichia coli Enhance Growth on Nonstandard γ-Glutamyl Amide-Containing Peptides. Applied and Environmental Microbiology, 84 (13), e00340-18.

Canning, Peter; Park, Kwangjin; Gonçalves, João; Li, Chunmei; Howard, Conor J.; Sharpe, Timothy D.; Holt, Liam J.; Pelletier, Laurence; Bullock, Alex N.; Leroux, Michel R. (2018). CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Cell Reports, 22 (4), 885-894.

2017

Morgado, Leonor; Burmann, Björn M; Sharpe, Timothy; Mazur, Adam; Hiller, Sebastian (2017). The dynamic dimer structure of the chaperone Trigger Factor. Nature communications, 8 (1), 1992.

Dixon-Clarke, Sarah E.; Shehata, Saifeldin N.; Krojer, Tobias; Sharpe, Timothy D.; von Delft, Frank; Sakamoto, Kei; Bullock, Alex N. (2017). Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16. Biochemical Journal, 474 (5), 699-713.

2016

Benjamin, D.; Colombi, M.; Hindupur, S. K.; Betz, C.; Lane, H. A.; El-Shemerly, M. Y. M.; Lu, M.; Quagliata, L.; Terracciano, L.; Moes, S.; Sharpe, T.; Wodnar-Filipowicz, A.; Moroni, C.; Hall, M. N. (2016). Syrosingopine sensitizes cancer cells to killing by metformin. Science Advances, 2 (12), e1601756.

Moschetti, Tommaso; Sharpe, Timothy; Fischer, Gerhard; Marsh, May E.; Ng, Hong Kin; Morgan, Matthew; Scott, Duncan E.; Blundell, Tom L.; R. Venkitaraman, Ashok; Skidmore, John; Abell, Chris; Hyvönen, Marko (2016). Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. Journal of Molecular Biology, 428 (23), 4589-4607.

Stanger, Frédéric V.; Burmann, Björn M.; Harms, Alexander; Aragão, Hugo; Mazur, Adam; Sharpe, Timothy; Dehio, Christoph; Hiller, Sebastian; Schirmer, Tilman (2016). Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification. Proceedings of the National Academy of Sciences of the United States of America, 113 (5), E529-37.

He, Lichun; Sharpe, Timothy; Mazur, Adam; Hiller, Sebastian (2016). A molecular mechanism of chaperone-client recognition. Science Advances, 2 (11), e1601625.

2015

Kleeb, Simon; Pang, Lijuan; Mayer, Katharina; Eris, Deniz; Sigl, Anja; Preston, Roland C.; Zihlmann, Pascal; Sharpe, Timothy; Jakob, Roman P.; Abgottspon, Daniela; Hutter, Aline S.; Scharenberg, Meike; Jiang, Xiaohua; Navarra, Giulio; Rabbani, Said; Smiesko, Martin; Lüdin, Nathalie; Bezençon, Jacqueline; Schwardt, Oliver; Maier, Timm; Ernst, Beat (2015). FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile. Journal of Medicinal Chemistry, 58 (5), 2221-39.

2014

Sundriyal, Amit; Massa, Claudia; Samoray, Dietrich; Zehender, Fabian; Sharpe, Timothy; Jenal, Urs; Schirmer, Tilman (2014). Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger c-di-GMP. Journal of Biological Chemistry, 289 (10), 6978-90.

2013

Smith, Clive A.; Li, Xin; Mize, Todd H.; Sharpe, Timothy D.; Graziani, Edmund I.; Abell, Chris; Huck, Wilhelm T. S. (2013). Sensitive, high throughput detection of proteins in individual, surfactant-stabilized picoliter droplets using nanoelectrospray ionization mass spectrometry. Analytical Chemistry, 85 (8), 3812-6.

2012

Adams, Cassandra J.; Pike, Ashley C. W.; Maniam, Sandra; Sharpe, Timothy D.; Coutts, Amanda S.; Knapp, Stefan; La Thangue, Nicholas B.; Bullock, Alex N. (2012). The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure. Proceedings of the National Academy of Sciences, 109 (10), 3778-3783.

2010

Arbely, Eyal; Rutherford, Trevor J.; Neuweiler, Hannes; Sharpe, Timothy D.; Ferguson, Neil; Fersht, Alan R. (2010). Carboxyl pK(a) values and acid denaturation of BBL. Journal of Molecular Biology, 403 (2), 313-27.

Filippakopoulos, Panagis; Low, Andrew; Sharpe, Timothy D.; Uppenberg, Jonas; Yao, Shenggen; Kuang, Zhihe; Savitsky, Pavel; Lewis, Rowena S.; Nicholson, Sandra E.; Norton, Raymond S.; Bullock, Alex N. (2010). Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4. Journal of Molecular Biology, 401 (3), 389-402.

Arbely, Eyal; Neuweiler, Hannes; Sharpe, Timothy D.; Johnson, Christopher M.; Fersht, Alan R. (2010). The human peripheral subunit-binding domain folds rapidly while overcoming repulsive Coulomb forces. Protein Science, 19 (9), 1704-1713.

2009

Arbely, Eyal; Rutherford, Trevor J.; Sharpe, Timothy D.; Ferguson, Neil; Fersht, Alan R. (2009). Downhill versus barrier-limited folding of BBL 1: energetic and structural perturbation effects upon protonation of a histidine of unusually low pKa. Journal of Molecular Biology, 387 (4), 986-92.

Neuweiler, Hannes; Sharpe, Timothy D.; Johnson, Christopher M.; Teufel, Daniel P.; Ferguson, Neil; Fersht, Alan R. (2009). Downhill versus barrier-limited folding of BBL 2: mechanistic insights from kinetics of folding monitored by independent tryptophan probes. Journal of Molecular Biology, 387 (4), 975-85.

Neuweiler, Hannes; Sharpe, Timothy D.; Rutherford, Trevor J.; Johnson, Christopher M.; Allen, Mark D.; Ferguson, Neil; Fersht, Alan R. (2009). The folding mechanism of BBL: Plasticity of transition-state structure observed within an ultrafast folding protein family. Journal of Molecular Biology, 390 (5), 1060-1073.

2008

Sharpe, Timothy D.; Ferguson, Neil; Johnson, Christopher M.; Fersht, Alan R. (2008). Conservation of transition state structure in fast folding peripheral subunit-binding domains. Journal of Molecular Biology, 383 (1), 224-37.

2007

Ferguson, Neil; Sharpe, Timothy D.; Johnson, Christopher M.; Schartau, Pamela J.; Fersht, Alan R. (2007). Structural biology: analysis of `downhill` protein folding. Nature, 445 (7129), E14-5;discussionE17-8.

Huang, Fang; Sato, Satoshi; Sharpe, Timothy D.; Ying, Liming; Fersht, Alan R. (2007). Distinguishing between cooperative and unimodal downhill protein folding. Proceedings of the National Academy of Sciences of the United States of America, 104 (1), 123-7.

Sharpe, Tim; Jonsson, Amanda L.; Rutherford, Trevor J.; Daggett, Valerie; Fersht, Alan R. (2007). The role of the turn in b-hairpin formation during WW domain folding. Protein Science, 1, 2233-2239.

2006

Ferguson, Neil; Sharpe, Timothy D.; Johnson, Christopher M.; Fersht, Alan R. (2006). The transition state for folding of a peripheral subunit-binding domain contains robust and ionic-strength dependent characteristics. Journal of Molecular Biology, 356 (5), 1237-1247.

Ferguson, Neil; Becker, Johanna; Tidow, Henning; Tremmel, Sandra; Sharpe, Timothy D.; Krause, Gerd; Flinders, Jeremy; Petrovich, Miriana; Berriman, John; Oschkinat, Hartmut; Fersht, Alan R. (2006). General structural motifs of amyloid protofilaments. Proceedings of the National Academy of Sciences of the United States of America, 103 (44), 16248-53.

2005

Ferguson, Neil; Sharpe, Timothy D.; Schartau, Pamela J.; Sato, Satoshi; Allen, Mark D.; Johnson, Christopher M.; Rutherford, Trevor J.; Fersht, Alan R. (2005). Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family. Journal of Molecular Biology, 353 (2), 427-46.

2004

Ferguson, Neil; Schartau, Pamela J.; Sharpe, Timothy D.; Sato, Satoshi; Fersht, Alan R. (2004). One-state downhill versus conventional protein folding. Journal of Molecular Biology, 344 (2), 295-301.

2003

Ferguson, Neil; Berriman, John; Petrovich, Miriana; Sharpe, Timothy D.; Finch, John T.; Fersht, Alan R. (2003). Rapid amyloid fiber formation from the fast-folding WW domain FBP28. Proceedings of the National Academy of Sciences of the United States of America, 100 (17), 9814-9.


Get list as pdf

Get list as text (rtf)

Main Content