Main Content
2020
(2020). Regulation of α-synuclein by chaperones in mammalian cells. Nature, 577 (7788), 127-132.
2019
: An integrative protocol for the structure determination of the mouse ASC-PYD filament, in: Sohn, Jungsan(Ed.). (2019). Methods in Enzymology, New York: Elsevier, 625, 205-222.
2017
(2017). The dynamic dimer structure of the chaperone Trigger Factor. Nature communications, 8 (1), 1992.
(2017). High-Speed Atomic Force Microscopy Visualization of the Dynamics of the Multienzyme Fatty Acid Synthase. ACS Nano, 11 (11), 10852-10859.
2016
(2016). Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification. Proceedings of the National Academy of Sciences of the United States of America, 113 (5), E529-37.
(2016). A Rigorous and Efficient Method To Reweight Very Large Conformational Ensembles Using Average Experimental Data and To Determine Their Relative Information Content. Journal of chemical theory and computation, 12 (1), 383-394.
(2016). The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases. Nucleic acids research, 44 (D1), D27-D37.
(2016). Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli. Journal of Bacteriology, 198 (3), 448-62.
(2016). Sequence-specific solid-state NMR assignments of the mouse ASC PYRIN domain in its filament form. Biomolecular NMR Assignments, 10 (1), 107-15.
(2016). A molecular mechanism of chaperone-client recognition. Science Advances, 2 (11), e1601625.
(2016). Spatiotemporal dynamics of the nuclear pore complex transport barrier resolved by high-speed atomic force microscopy. Nature Nanotechnology, 11 (8), 719-23.
2015
(2015). Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy. Proceedings of the National Academy of Sciences of the United States of America, 112 (43), 13237-42.
2014
(2014). Simultaneous analysis of large-scale RNAi screens for pathogen entry. BMC Genomics, 15, 1162.
2012
(2012). iBRAIN2: automated analysis and data handling for RNAi screens. Studies in health technology and informatics, 175, 205-13.
2010
(2010). Novel Inhibitors of Dengue Virus Methyltransferase : discovery by in vitro-driven virtual screening on a Desktop Computer Grid. Journal of Medicinal Chemistry, 53 (4), 1483-95.
2009
(2009). The protein structure initiative structural genomics knowledgebase. Nucleic Acids Research, 37 (1Supplement), D365-D368.
(2009). The protein model portal. Journal of structural and functional genomics, 10 (1), 1-8.
2008
: Docking for neglected diseases as community efforts, in: Schwede T,; Peitsch MC,(Ed.). (2008). Computational structural biology, Singapore: World Scientific Publishing, S.683-704.
(2008). Identification of androgen-selective androgen-response elements in the human aquaporin-5 and Rad9 genes. The Biochemical Journal, 411 (3), 679-86.
2007
(2007). Tandem mass spectrometry protein identification on a PC grid. Studies in health technology and informatics, 126, 3-12.
(2007). Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity : a combined virtual screening and biological assay approach. Molecular pharmacology, 71 (2), 398-406.
: SWISS-TANDEM : a Web-based workspace for MS/MS protein identification on PC grid, in: Kokol, P; Podgorelec, V; MiceticTurk, D; Zorman, M; Verlic, M(Ed.). (2007). Twentieth IEEE international symposium on computer-based medical systems, Los Alamitos, Calif.: IEEE Computer Society, CBMS 2007.
2006
: The SwissBioGrid Project : objectives, preliminary results and lessons learnede-Science 2006 : 2nd IEEE International Conference on e-Science and Grid Computing, Los Alamitos, Calif.: IEEE Computer Society, e-Science 2006, 148.
(2006). Prediction of cis-regulatory elements for drug-activated transcription factors in the regulation of drug-metabolising enzymes and drug transporters. Expert Opinion on Drug Metabolism & Toxicology, 2 (3), 367-79.
2005
(2005). LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver. Journal of Lipid Research, 46 (8), 1633-42.
2004
(2004). Identification of the xenosensors regulating human 5-aminolevulinate synthase. Proceedings of the National Academy of Sciences of the United States of America, 101 (24), 9127-32.
(2004). The evolution of drug-activated nuclear receptors : one ancestral gene diverged into two xenosensor genes in mammals. Nuclear Receptor, 2 (1), 7.
(2004). The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis. Proceedings of the National Academy of Sciences of the United States of America, 101 (17), 6472-7.
2003
(2003). Molecular cloning and characterization of chicken orphan nuclear receptor cTR2. General and Comparative Endocrinology, 132 (3), 474-84.
(2003). In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism. Drug news & perspectives, 16 (7), 423-434.
2002
(2002). NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Molecular endocrinology, 16 (6), 1269-79.
(2002). Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. Journal of Biological Chemistry, 277 (33), 29561-7.
(2002). Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptorw. Gastroenterology, 122 (7), 1954-1966.
(2002). Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR). Journal of biological chemistry, 277 (38), 34717-26.
(2002). Cytochrome P450 CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme. Molecular pharmacology, 62 (5), 1061-7.
2001
(2001). Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. Molecular endocrinology, 15 (9), 1571-85.
(2001). Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor. Molecular pharmacology, 60 (4), 681-9.
2000
(2000). CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR). Proceedings of the National Academy of Sciences of the United States of America, 97 (20), 10769-74.