A5: Infection Biology – From in vitro models to human patients – 30638
(1 hrs/week; 1 CP; Fall 2021)
Dirk Bumann, Christoph Dehio
This introductory course to Systems Biology of Infection will focus on data and knowled ge-based modeling and model-driven analysis of microbial infection processes. We will discuss recent advances in understanding the interaction of the host with bacterial and viral pathogens by integrative analysis of genome-wide and spatio-temporal data sets using computational approaches that can employ this data to generate models of host -pathogen interaction. We will further discuss how such systems-level approaches may facilitate the identification of diagnostic biomarkers and potential drug targets for novel anti-infectives and possibly allow exploring novel strategies for personalized therapy.