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E9: Computational Biology II – Sequence Modeling and Analysis – 27247

(2 hrs/week, plus 1h exercises; 4 CP; Spring 2021, Lectures and Exercises)

Mihaela Zavolan

This course will introduce students to fundamental problems in Bioinformatics/Computational Biology such as:

  • Evolution: Mathematical models for the evolution of DNA sequences.
  • Alignment and Phylogeny reconstruction: inferring evolutionary relationships between sequences.
  • Functional annotation: Finding genes and regulatory sequences in fully sequenced genomes.
  • Families of coding sequences: Hidden Markov models of protein domains
  • Gene expression networks: Inferring regulatory factors driving gene expression.

Students should have a good understanding of calculus, linear algebra, combinatorics and algorithms and should be familiar with concepts of molecular biology.