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G4: Chromatin and Epigenetics – 17913

(2 hrs/week; 2 CP; Spring 2021)

S. Gasser, R. Paro, D. Schübeler

This course will cover all aspects of heritable patterning of gene expression and the biological importance of "epigenomes". The modification of nucleosomes and of DNA, and the assembly of chromatin into higher order structures will be discussed. Mechanisms of inheritance will be presented as well as imprinting, X inactivation, and the role of RNA in establishing silent chromatin. Finally, the course will cover the impact of chromatin structure on differentiation, cell plasticity and development.