Events

Observing single-cell gene regulation in real time

Biozentrum InHouse Seminar, Prof. Erik van Nimwegen, Focal Area: Computational & Systems Biology

• Host: Biozentrum

8:00 EMBO at Basel Life: Genomes in biology and medicine

The conference will take place from September 10 – 13 2017 at the Congress Center Basel. 
It aims to foster fruitful exchange between academic and clinical researchers and the pharmaceutical and biotech industry, and it will promote excellence in the life sciences to a wide audience.

Confirmed speakers include:

Opening lecture:
Sir Paul Nurse

Keynote lectures:
Jennifer Doudna, Svante Pääbo

As well as:
René Bernards
Peer Bork
Pascale Cossart
Titia de Lange
John Hardy
Jennifer Lippincott-Schwartz
Joan Steitz

Discount for University of Basel Students and Postdocs  
Students and Postdocs from the University of Basel who register until June 2^nd will receive a discount of CHF 50. In order to obtain the discount, please choose the ‘Unibas’ ticket category.

Registration: www.basellife.org/embo

Call for abstracts
You are cordially invited to submit abstracts for poster and/or oral presentations. The submission deadline is Monday, 3 July 2017 (11:59h CEST).

[BC]2 Basel Computational Biology Conference 2017

12. - 15.9.2017

Hosts: 

Marc Robinson-Rechavi (scientific program chair), University of Lausanne & SIB
Erik van Nimwegen (scientific program chair), Biozentrum University of Basel & SIB
Torsten Schwede (conference series chair), Biozentrum University of Basel & SIB 

https://www.bc2.ch/2017/

The activation mechanism and drug discovery of G protein-coupled receptors

Guests@Biozentrum, Dr. Shuguang Yuan, Actelion Pharmaceutical Ltd, one of the leading scientists in the area of G protein-coupled receptors (GPCRs)

• Host: Tilman Schirmer

Watching bacterial gene transfer

Seminar Series: Infection Biology - From in vitro models to human patients, Prof. Berenike Maier, University of Cologne.

 

Transport of macromolecules through nanometer-sized membrane pores is a ubiquitous theme in cell biology. Examples include the linear import of precurser proteins into mitochondria and DNA transport during bacterial gene transfer. However, little is known about the biophysical mechanisms that bias the direction of macromolecular movement within membrane pores. Here, I will focus on DNA uptake through the bacterial cell envelope. DNA uptake is a key step of bacterial transformation. Combining single molecule manipulation and fluorescence techniques, we showed that the force-dependent kinetics of DNA uptake are in remarkable agreement with a translocation ratchet model, whereby the periplasmic ComE protein acts as a chaperone that rectifies DNA diffusion through the outer membrane by reversible binding. We propose a model for DNA uptake wherein a fairly weak molecular motor transports the transforming DNA through the outer membrane and a stronger motor pulls the DNA through the cytoplasmic membrane.

• Host: Prof. Dirk Bumann

Differential rhythmicity: age-related changes in the diurnal transcriptomes of mouse liver and kidney

Seminar Series: Growth & Development, Dr. Pål Westermark, Bioinformatics and Biomathematics Leibniz Institute for Farm Animal Biology, Leibnitz

• Host: Prof. Christoph Handschin