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Biozentrum Lectures 2015

Navigating the cellular landscape with new imaging approaches

Jennifer Lippincott-Schwartz, Eugene Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
November 23, 2015, Time: 16:15, Hörsaal 1, Pharmazentrum, Klingelbergstrasse 50-70, Basel

 

 

Emerging visualization technologies are playing an increasingly important role in the study of numerous aspects of cell biology, capturing processes at the level of whole organisms down to single molecules. While developments in probes and microscopes are dramatically expanding the areas of productive imaging, there are still significant roadblocks. Primary challenges include fluorophore bleed-through, which limits the number of fluorophores that can be simultaneously imagined, as well as imaging speeds that are too slow, and finally labeling densities that are too low for deciphering fine subcellular architecture. New imaging methods can overcome these roadblocks and help clarifying subcellular organelle dynamics.

We combine cutting edge microscopy techniques to visualize several organelles such as the endoplasmatic reticulum (ER), the lysosome or the mitochondria simultaneously within cells. This allows us to track these organelles through time and analyze their inter-organelle contacts. Furthermore, we employ different imaging technologies to visualize organelle dynamics at very high temporal-spatial resolution. Examining the ER, we could observe that the peripheral ER sheets represent a complex meshwork of tightly cross-linked ER tubules.

In the Biozentrum Lecture Jennifer Lippincott-Schwartz will focus on new imaging approaches and on possible roles of the complex ER structural organization for diverse cellular functions.

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Jennifer Lippincott-Schwartz is Distinguished NIH Investigator and Chief of the Section on Organelle Biology in the Cell Biology and Metabolism Branch of the NICHD. She studied Biology at Stanford University and obtained her PhD in Biochemistry at Johns Hopkins University in 1986.After four years post-doctoral training at the National Institutes of Health (NIH) in Bethesda, Maryland, she established her own lab at the NIH. Using live cell imaging approaches, Jennifer Lippincott-Schwartz studies the spatio-temporal behavior and dynamic interactions of molecules in cells. In 2008 she was elected to the National Academy of Sciences and in 2010, she was awarded the Pearse Prize of the Royal Microscopy Society.