University of Basel

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Research-assistant position: “Development of Bioassays for Measuring Nanoparticle - Protein interactions” (100%)

Research-assistant position: “Development of Bioassays for Measuring Nanoparticle - Protein interactions” (100%)

The Biozentrum of the University of Basel, Switzerland is one of the leading institutes worldwide for molecular and biomedical basic research and teaching. It is home to more than 30 research groups with scientists from over 40 countries. Research at the Biozentrum focuses on the areas of Cell Growth & Development, Infection Biology, Neurobiology, Structural Biology & Biophysics and Computational & Systems Biology. With its more than 550 employees, the Biozentrum is the largest department at the University of Basel’s Faculty of Science.

We are offering a 1-year research-assistant position on the topic of “Development of Bioassays for Measuring Nanoparticle - protein interactions” in the research group of Prof. Torsten Schwede. This project is embedded within the Nanoscreen Consortium, an excellent international collaborative network of industrial and academic partners in engineered nanomaterials design, production, characterization, in vitro testing and measurement-science.

Your responsibilities

The goal of this specific research project is the investigation of binding mechanisms of proteins to nanoparticles of different materials and sizes. You will produce recombinant proteins and develop analytical tools to study protein-nanoparticle interactions systematically. Some of your analytical work will be carried out in specialized partner-laboratories around Switzerland. The aim of the study is to correlate the nanoparticle interaction patterns in vitro with bio-responses observed within the consortium. This work is expected to contribute to predictive nanotoxicology, with numerous potential applications in the design of novel nanomaterials.

Your profile

  • Excellent practical knowledge in protein biochemistry, bioassays and analytics
  • Solid theoretical background and technical experience in biochemistry, chemistry, nanoscience, material science or similar
  • Interdisciplinary mindset, hands-on and high motivation for collaborative work

Applicants should have very strong practical research experience, particularly in protein biochemistry and bio-analytics, including developing ELISA or similar assays. Attention to detail, systematic, self-organized working style, motivation to take on new challenges, good team-working and communication skills are essential for this collaborative project.

The workplace

The Schwede group is renowned for SWISS-MODEL (, a widely used automated protein structure homology-modelling server. The molecular modelling activities of the group are complemented with a well-equipped experimental laboratory at the Biozentrum, where most of the work will be performed.

Application Instructions

The position is available immediately and is limited to one year. The University of Basel is an
equal opportunity employer and encourages applications from both female and male candidates.

Please submit your application online through the Biozentrum website including a CV, a letter of motivation highlighting your personal interests and contributions to the field of protein biochemistry and bioassays, as well as contact information of referees. Incoming applications will be evaluated continuously until the position is filled.