University of Basel

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Postdoc position available in the Spang lab

Remodeling of mRNA content and translational control in stress response

Our lab is interested in membrane dynamics and intracellular protein and mRNA trafficking and metabolism. One of the current research focus is on the fate mRNA upon cellular stresses. When a cell encounters stress, translation is attenuated and mRNA is stored and eventually degraded in processing bodies (PBs). We found that dependent on the stress condition, a subset of mRNA is transported to PBs, while another set is more heavily translated. At the same time, the cell needs to respond by translating a subset of mRNAs that will be beneficial in counteracting the stress.  

We have an opening for a creative and highly motivated postdoctoral fellow to work on the translational control of protein expression under different stress conditions in yeast. Experience in live cell imaging, molecular biology, biochemistry and/or RNA biology (RNAseq/Riboseq) is advantageous. Postdoc applicants should have a proven record as successful researcher demonstrated by high impact publications. The successful applicant will join an enthusiastic, creative and collaborative group using interdisciplinary approaches.

The Biozentrum offers an international and competitive research environment with state-of-the-art facilities. The Biozentrum is part of the University of Basel. 

To apply please send your CV, a research statement, and the name and address of 3 referees to: anne.spang-at-unibas.ch

Related publications:

Wang, C., F. Schmich, J. Weidner, N. Beerenwinkel and A. Spang. (2017) Context-dependent deposition and regulation of mRNAs in P-bodies. bioRxiv

Mittal, N., J. Guimaraes, T. Gross, A. Schmidt, A. Vina-Vilaseca, D. Nedialkova, F. Aeschimann, S. Leidel, A. Spang, and M. Zavolan. (2017). The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan. Nat. Comm. (in press)

Ritz, A., M. Trautwein, F. Grassinger, and A. Spang. (2014). The prion domain in the exomer-dependent cargo Pin2p serves as a trans-Golgi retention motif. Cell Rep. 7:249-60

Weidner, J., C. Wang, C. Prescianotto-Baschong, A. F. Estrada and A. Spang. (2014). The polysome-associated proteins Scp160 and Bfr1 prevent P-body formation under normal growth conditions. J. Cell Sci. 137:1992-2004

Kilchert, C. and A. Spang. (2011). Co-translational localization of ABP140 mRNA to the distal pole of yeast cells. EMBO J. 30: 3567-80

Kilchert, C., J. Weidner, C. Prescianotto-Baschong, and A. Spang. (2010). Defects in the secretory pathway and high Ca2+ induce multiple P-bodies. Mol. Biol. Cell. 21: 2624-38





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