Postdoc position to analyze single cell gene expression
The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.
A postdoc position is available in the research group of Prof. Zavolan at the Biozentrum, University of Basel to uncover drivers of gene expression in single cells during immune responses, and as a function of organism age.
Currently, technologies are available to probe gene expression globally and with the resolution of single cells. How the heterogeneity of gene expression in single cells impacts the dynamics of collections of cells within organs and within the confines of specific processes remains to be understood. Many efforts are dedicated to this aim worldwide. Our group, which is part of the Biozentrum and the Swiss Institute of Bioinformatics, is composed of experimental and theoretical scientists that study various aspects of cell fate determination, in relation to aging and diseases. In recent projects we have obtained single cell gene expression profiles from mice of various ages and genetic backgrounds, subjected or not to anti-aging treatments. We would now like to recruit a postdoctoral researcher to study the basis of variability in single cell expression and its relation to cellular phenotypes.
1: Rzepiela AJ, Ghosh S, Breda J, Vina‐Vilaseca A, Syed AP, Gruber AJ, Eschbach K, Beisel C, van Nimwegen E, Zavolan M. Single‐cell mRNA profiling reveals the hierarchical response of miRNA targets to miRNA induction. Molecular systems biology 14 (8), e8266.
2. Mittal N, Guimaraes JC, Gross T, Schmidt A, Vina-Vilaseca A, Nedialkova DD, Aeschimann F, Leidel SA, Spang A, Zavolan M. The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan. Nat Commun. 2017 Sep 6;8(1):457.
3: Balwierz PJ, Pachkov M, Arnold P, Gruber AJ, Zavolan M, van Nimwegen E. ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs. Genome Res. 24(5):869-84 (2014).
We are looking for candidates with knowledge of molecular biology and a strong quantitative background, i.e. in physics, mathematics, computer science or computational biology. Candidates should have experience in computational model development and programming, and be familiar with high-throughput biological dataanalysis.
The salary is set according to the guidelines of the Swiss National Science Foundation.
Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany- France -, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.
Application / Contact
Please send your completed application as a single pdf-file - including application letter, a statement of research interests, CV, diplomas and contact information of at least two referees – to the following e-mail address (also for informal information)
Prof. Mihaela Zavolan
Biozentrum, Universität Basel
SIB - Swiss Institute of Bioinformatics Klingelbergstrasse 50-70
4056 Basel Switzerland