The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.
Skilled and motivated individuals are encouraged to apply for a 4-year PhD Fellowship in the research group of Roderick Lim at the Biozentrum, University of Basel, Switzerland.
The Lim Lab is interested in understanding how mechanotransduction and nucleocytoplasmic transport (NCT) work in unison to achieve gene expression and cellular phenotypic changes such as during developmental progression, stem cell differentiation and cell transformation.
In this project, we want to study how mechanical force impacts on the nuclear pore complexes (NPCs) that mediate NCT. Methods will comprise, amongst others, CRISPR-based genome editing, state-of-the art confocal imaging (including FRET, FRAP, and super-resolution techniques) and atomic force microscopy (AFM).
Besides basic research, PhD candidates will also have to contribute to undergraduate level teaching.
Interested candidates should have a background in molecular cell biology, biophysics or related disciplines. Experience in optical/fluorescence imaging or AFM, is a plus. The successful candidate is expected to be highly interactive and capable of independent research in a team environment. A solid command of oral and written English is essential.
We are a multi-national, interdisciplinary lab that combines biophysical, molecular and cellular approaches to investigate intriguing biological problems. The successful applicant will benefit from a highly stimulating, collaborative research environment as well as state-of-the-art infrastructure and facilities at the new Biozentrum research tower.
Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany-France - it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.
Application / Contact
Please apply online https://biped2.biozentrum.unibas.ch/apply/phd-fellowship-in-mechanobiology. The application should include a cover letter, CV, diplomas and 3 reference letters. Reviewing of applications will start immediately and continue until the position is filled. Please note that only online applications will be accepted.
For further information, please contact stephanie.gehlenunibasch.