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Postdoc Position 100% - Structure and function of FERARI tethering complex

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

Professor Anne Spang (Biozentrum, University of Basel) is recruiting a postdoctoral fellow to elucidate the structure and function of the FERARI tethering complex.

The Project
Inter- and intracellular communication is one of the basics of eukaryotic life. Exo- and endocytic transport are essential components for this communication. Most of the endoytosed material is returned to the plasma membrane through recycling pathways. We have identified a key regulator of the Rab11 recycling pathway, the tethering complex FERARI (Solinger, Rashid et al. Nat. Cell Biol. 2020). FERARI is an unusual tether as it combines membrane fusion and membrane fission activities to promote kiss-and-run of Rab11-positive recycling vesicles with sorting endosomes. More recently, we also showed that FERARI can also promote kiss-and-run of early endocytic Rab5 positive-vesicles with sorting endosomes (Solinger et al., researchsquare). In order to understand how these processes are regulated and coordinated by FERARI, we aim to determine the structure of the FERARI tethering complex and biochemically elucidate and recapitulate FERARI function in vitro.

This project is supported by a grant from the Swiss National Science Foundation.

Your Profile
Interested candidates should hold a PhD and have a proven record in biochemistry and/or structural biology.  A background in cell biology and/or cryo EM is advantageous. High intrinsic motivation, ability to work independently as well as in a team, perseverance and creativity are expected.

We Offer
We are a highly interdisciplinary, international, divers and supportive team of scientists, committed to work at the frontier of science and to solve fundamental questions about cellular function and organization. We offer an interactive environment in which you can broaden your horizon, develop new ideas and your independence, and grow as a scientist and a professional.

The Biozentrum of the University of Basel provides a highly stimulating, international and collaborative research environment with state-or-the-art infrastructure and support facilities in a brand-new building.

Basel is an international city with people from 150 nations. Located on the border where Switzerland, Germany, and France meet, Basel is home for a large number of institutions for biomedical research, with numerous possibilities for training, networking and career development. The city provides a high standard of living and a rich and varied cultural atmosphere.

Application / Contact
Please apply online by March 1, 2022: https://biped2.biozentrum.unibas.ch/apply/postdoc-position-ferari-tethering-complex

The application should include a brief personal statement, explaining how your qualifications and experience relate to the role, together with a full, up-to-date CV and at least two reference letters. Review of applications will start immediately. Please note that only online applications will be considered.

For any informal enquiries, please contact: anne.spangunibasch.