The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.
Professor Médéric Diard (Biozentrum, University of Basel) is recruiting a postdoctoral researcher to study the dynamics of intestinal colonization, adaptation and transmission of multiresistant clinical isolates of Esherichia coli.
The Diard Lab at Basel University’s Biozentrum is a young and international team with expertise in experimental evolution and molecular biology of bacteria. Its mission is to understand fundamental principles of microbial evolution and design innovative approaches to fight against pathogens.
This four-year position is fully funded by an ERC consolidator grant.
Starting date: January 1, 2022.
The project is an ambitious endeavor aimed at understanding the population structure of multresistant E. coli focusing on traits enhancing the fitness of these strains during intestinal colonization. Since the intestinal tract of mammals represents a major ecological niche for E. coli we hypothesize that superior gut colonization ability could predispose certain clones to evolutionary success. This will be addressed by genome-wide screening for specific determinants enhancing intestinal fitness in strains of multiresistant E. coli that are highly prevalent in the human population. The role of the colonization resistance mediated by the host microbiota in selecting prevalent E. coli clones will be explored using gnotobiotic mouse lines. Host transmission dynamics will be investigated in different clinically relevant contexts and new strategies to limit the spread of multiresistant E. coli will be designed.
Interested candidates should have completed a PhD and have a track record in microbial molecular biology and/or in experimental evolution. A background in experimental infection biology is of advantage. Team spirit, perseverance and a taste for multidisciplinary projects are expected.
What We Offer
The Biozentrum offers an exciting and stimulating work environment in a friendly and collaborative atmosphere. The team is embedded in the research area Infection Biology, which provides strong synergies between internationally-recognized and complementary research groups. We provide competitive salaries.
Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany- France -, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.
Application / Contact
Candidates should send CV and motivation statement as well as the contact details of at least two references to Médéric Diard (mederic.diardunibasch).