Prof. Dr. Markus Affolter

Biozentrum
University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 200B Phone: +41 61 207 20 72
Email: markus.affolter-at-unibas.ch
Curriculum Vitae

Administrative Assistant

Helen Preiss
Biozentrum, Room 210
Phone: +41 61 207 09 31
Fax: +41 61 207 20 78
Email: helen.preiss-at-unibas.ch

Research group Markus Affolter

Articles

2017
Harmansa, Stefan; Alborelli, Ilaria; Bieli, Dimitri; Caussinus, Emmanuel; Affolter, Markus (2017). A nanobody-based toolset to investigate the role of protein localization and dispersal in Drosophila. eLife, 6, 22549.
Nakajima, Hiroyuki; Yamamoto, Kimiko; Agarwala, Sobhika; Terai, Kenta; Fukui, Hajime; Fukuhara, Shigetomo; Ando, Koji; Miyazaki, Takahiro; Yokota, Yasuhiro; Schmelzer, Etienne; Belting, Heinz-Georg; Affolter, Markus; Lecaudey, Virginie; Mochizuki, Naoki (2017). Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance. Developmental Cell, 40(6), 523-536.
Sauteur, Loïc; Affolter, Markus; Belting, Heinz-Georg (2017). Distinct and redundant functions of Esam and VE-cadherin during vascular morphogenesis. Development, 144, 1554-1565.
Tsachaki, Maria; Meyer, Arne; Weger, Benjamin; Kratschmar, Denise V.; Tokarz, Janina; Adamski, Jerzy; Belting, Heinz-Georg; Affolter, Markus; Dickmeis, Thomas; Odermatt, Alex (2017). Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish. Journal of Endocrinology, 232(2), 323-335.
2016
Pasakarnis, Laurynas; Frei, Erich; Caussinus, Emmanuel; Affolter, Markus; Brunner, Damian (2016). Amnioserosa cell constriction but not epidermal actin cable tension autonomously drives dorsal closure. Nat Cell Biol, 18(11), 1161-1172.
Caussinus, Emmanuel; Affolter, Markus (2016). deGradFP: A System to Knockdown GFP-Tagged Proteins. Methods Mol Biol, 1478, 177-187.
Betz, Charles; Lenard, Anna; Belting, Heinz-Georg; Affolter, Markus (2016). Cell behaviors and dynamics during angiogenesis. Development, 143(13), 2249-60.
Aydogan, Vahap; Belting, Heinz-Georg; Affolter, Markus (2016). Mapping the molecular steps of secretory-lysosome-driven tracheal tube fusion. Nature Cell Biology, 18(7), 720-2.
Bieli, D; Alborelli, I; Harmansa, S; Matsuda, S; Caussinus, E; Affolter, M (2016). Development and Application of Functionalized Protein Binders in Multicellular Organisms. International Review of Cell & Molecular Biology, 325, 181-213.
Affolter, Markus (2016). Seeing is Believing, or How GFP Changed My Approach to Science. Current topics in developmental biology, 116, 1-16.
Matsuda, Shinya; Harmansa, Stefan; Affolter, Markus (2016). BMP morphogen gradients in flies. Cytokine & Growth Factor Reviews, 27, 119-27.
2015
Ittig, Simon J.; Schmutz, Christoph; Kasper, Christoph A.; Amstutz, Marlise; Schmidt, Alexander; Sauteur, Loic; Vigano, M. Alessandra; Low, Shyan Huey; Affolter, Markus; Cornelis, Guy R.; Nigg, Erich A.; Arrieumerlou, Cecile (2015). A bacterial type III secretion-based protein delivery tool for broad applications in cell biology. The Journal of cell biology, 211(4), 913-931.
Harmansa, Stefan; Hamaratoglu, Fisun; Affolter, Markus; Caussinus, Emmanuel (2015). Dpp spreading is required for medial but not for lateral wing disc growth. Nature, 527(7578), 317-22.
Bieli, Dimitri; Kanca, Oguz; Requena, David; Hamaratoglu, Fisun; Gohl, Daryl; Schedl, Paul; Affolter, Markus; Slattery, Matthew; Müller, Martin; Estella, Carlos (2015). Establishment of a Developmental Compartment Requires Interactions between Three Synergistic Cis-regulatory Modules. PLoS genetics, 11(10), e1005376.
Bürglin, Thomas R; Affolter, Markus (2015). Homeodomain proteins: an update. Chromosoma, 125(3), 497-521.
Aydogan, Vahap; Lenard, Anna; Denes, Alexandru Stefan; Sauteur, Loic; Belting, Heinz-Georg; Affolter, Markus (2015). Endothelial cell division in angiogenic sprouts of differing cellular architecture. Biology open, 4(10), 1259-69.
Affolter, Markus; Nigg, Erich A. (2015). In memoriam - Walter J. Gehring. Chromosoma, 124(3), 291-291.
Denes, Alexandru Stefan; Kanca, Oguz; Affolter, Markus (2015). A cellular process that includes asymmetric cytokinesis remodels the dorsal tracheal branches in Drosophila larvae. Development, 142(10), 1794-1805.
Lenard, Anna; Daetwyler, Stephan; Betz, Charles; Ellertsdottir, Elin; Belting, Heinz-Georg; Huisken, Jan; Affolter, Markus (2015). Endothelial Cell Self-fusion during Vascular Pruning. PLoS biology, 13(4), e1002126.
Bieli, Dimitri; Kanca, Oguz; Gohl, Daryl; Denes, Alexandru; Schedl, Paul; Affolter, Markus; Mueller, Martin (2015). The drosophila melanogaster mutants apblot and apXasta affect an essential apterous wing enhancer. G3 : Genes, Genomes, Genetics, 5(6), 1129-1143.
Phng, Li-Kun; Gebala, Véronique; Bentley, Katie; Philippides, Andrew; Wacker, Andrin; Mathivet, Thomas; Sauteur, Loïc; Stanchi, Fabio; Belting, Heinz-Georg; Affolter, Markus; Gerhardt, Holger (2015). Formin-mediated actin polymerization at endothelial junctions is required for vessel lumen formation and stabilization. Developmental cell, 32(1), 123-32.
Affolter, Markus (2015). Nachruf auf Walter J. Gehring. Zoologie: Mitteilungen der Deutschen Zoologischen Gesellschaft, 2015, 73-80.
2014
Brauchle, Michael; Hansen, Simon; Caussinus, Emmanuel; Lenard, Anna; Ochoa-Espinosa, Amanda; Scholz, Oliver; Sprecher, Simon G; Plückthun, Andreas; Affolter, Markus (2014). Protein interference applications in cellular and developmental biology using DARPins that recognize GFP and mCherry. Biology open, 3(12), 1252-61.
Belting, Heinz-Georg (2014). Cdh5/VE-cadherin Promotes Endothelial Cell Interface Elongation via Cortical Actin Polymerization during Angiogenic Sprouting. Cell reports, 9(2), 504-13.
Santos, M. Emilia; Braasch, Ingo; Boileau, Nicolas; Meyer, Britta S.; Sauteur, Loic; Boehne, Astrid; Belting, Heinz-Georg; Affolter, Markus; Salzburger, Walter (2014). The evolution of cichlid fish egg-spots is linked with a cis-regulatory change. Nature communications, 5, 5149.
De Smet, Frederik; Tembuyser, Bieke; Lenard, Anna; Claes, Filip; Zhang, Jie; Michielsen, Christof; Van Schepdael, Ann; Herbert, Jean-Marc; Bono, Françoise; Affolter, Markus; Dewerchin, Mieke; Carmeliet, Peter (2014). Fibroblast Growth Factor Signaling Affects Vascular Outgrowth and Is Required for the Maintenance of Blood Vessel Integrity. Chemistry & biology, 21(10), 1310-7.
Affolter, Markus; Wüthrich, Kurt (2014). Walter Jakob Gehring: a Master of Developmental Biology. Proceedings of the National Academy of Sciences of the United States of America, 111(35), 12574-5.
Pyrowolakis, George (2014). Dpp/BMP signaling in flies: from molecules to biology. Seminars in cell & developmental biology, 32, 128-36.
Hultin, Sara; Zheng, Yujuan; Mojallal, Mahdi; Vertuani, Simona; Gentili, Christian; Balland, Martial; Milloud, Rachel; Belting, Heinz-Georg; Affolter, Markus; Helker, Christian S M; Adams, Ralf H; Herzog, Wiebke; Uhlen, Per; Majumdar, Arindam; Holmgren, Lars (2014). AmotL2 Links VE-cadherin to Contractile Actin Fibres Necessary for Aortic Lumen Expansion. Nature communications, 5, 3743.
Kanca, Oguz; Ochoa-Espinosa, Amanda; Affolter, Markus (2014). IV. Tools and Methods for Studying Cell Migration and Cell Rearrangement in Tissue and Organ Development. Methods, 68(1), 228-32.
Kanca, Oguz; Caussinus, Emmanuel; Denes, Alexandru S; Percival-Smith, Anthony; Affolter, Markus (2014). Raeppli: a whole-tissue labeling tool for live imaging of Drosophila development. Development, 141(2), 472-80.
2013
Caussinus, Emmanuel; Kanca, Oguz; Affolter, Markus (2013). Protein knockouts in living eukaryotes using deGradFP and green fluorescent protein fusion targets. Current protocols in protein science, 73(30.2), Unit 30.2.
Lenard, Anna; Affolter, Markus (2013). Tugging organs into place. Developmental cell, 27(3), 243-244.
Kochhan, Eva; Lenard, Anna; Ellertsdottir, Elin; Herwig, Lukas; Affolter, Markus; Belting, Heinz-Georg; Siekmann, Arndt F (2013). Blood Flow Changes Coincide with Cellular Rearrangements during Blood Vessel Pruning in Zebrafish Embryos. PLoS one, 8(10), e75060.
Hayashi, Makoto; Majumdar, Arindam; Li, Xiujuan; Adler, Jeremy; Sun, Zuyue; Vertuani, Simona; Hellberg, Carina; Mellberg, Sofie; Koch, Sina; Dimberg, Anna; Koh, Gou Young; Dejana, Elisabetta; Belting, Heinz-Georg; Affolter, Markus; Thurston, Gavin; Holmgren, Lars; Vestweber, Dietmar; Claesson-Welsh, Lena (2013). VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nature communications, 4, 1672.
Siekmann, Arndt F.; Affolter, Markus; Belting, Heinz-Georg (2013). The Tip Cell Concept Ten Years After : New Players Tune in for a Common Theme. Experimental cell research, 319(9), 1255-1263.
Helker, Christian S M; Schuermann, Annika; Karpanen, Terhi; Zeuschner, Dagmar; Belting, Heinz-Georg; Affolter, Markus; Schulte-Merker, Stefan; Herzog, Wiebke (2013). The Zebrafish Common Cardinal Veins Develop by a Novel Mechanism: Lumen Ensheathment. Development, 140(13), 2776-86.
Lenard, Anna; Ellertsdottir, Elin; Herwig, Lukas; Krudewig, Alice; Sauteur, Loïc; Belting, Heinz-Georg; Affolter, Markus (2013). In Vivo Analysis Reveals a Highly Stereotypic Morphogenetic Pathway of Vascular Anastomosis. Developmental cell, 25(5), 492-506.
2012
Baer, Magdalena M.; Palm, Wilhelm; Eaton, Suzanne; Leptin, Maria; Affolter, Markus (2012). Microsomal triacylglycerol transfer protein (MTP) is required cell autonomously to expand tracheal lumen in Drosophila. Journal of cell science, 125(24), 6038-6048.
Ellertsdottir, Elin; Berthold, Peter R; Bouzaffour, Mohamed; Dufourcq, Pascale; Trayer, Vincent; Gauron, Carole; Vriz, Sophie; Affolter, Markus; Rampon, Christine (2012). Developmental Role of Zebrafish Protease-Activated Receptor 1 (PAR1) in the Cardio-Vascular System. PLoS one, 7(7), e42131.
Ochoa-Espinosa, Amanda; Affolter, Markus (2012). Branching morphogenesis : from cells to organs and back. Cold Spring Harbor perspectives in biology, 4(10), Epub.
Wang, Shuoshuo; Meyer, Heiko; Ochoa-Espinosa, Amanda; Buchwald, Ulf; Onel, Susanne; Altenhein, Benjamin; Heinisch, Jürgen J; Affolter, Markus; Paululat, Achim (2012). GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis. Journal of cell science, 125(Pt 2), 461-72.
Caussinus, Emmanuel; Kanca, Oguz; Affolter, Markus (2012). Fluorescent fusion protein knockout mediated by anti-GFP nanobody. Nature structural & molecular biology, 19(1), 117-21.
Ochoa-Espinosa, Amanda; Baer, Magdalena M; Affolter, Markus (2012). Tubulogenesis: Src42A Goes to Great Lengths in Tube Elongation. Current biology, 22(11), R446-9.
2011
Gutnick, Amos; Blechman, Janna; Kaslin, Jan; Herwig, Lukas; Belting, Heinz-Georg; Affolter, Markus; Bonkowsky, Joshua L; Levkowitz, Gil (2011). The hypothalamic neuropeptide oxytocin is required for formation of the neurovascular interface of the pituitary. Developmental cell, 21(4), 642-54.
Totong, Ronald; Schell, Thomas; Lescroart, Fabienne; Ryckebüsch, Lucile; Lin, Yi-Fan; Zygmunt, Tomasz; Herwig, Lukas; Krudewig, Alice; Gershoony, Dafna; Belting, Heinz-Georg; Affolter, Markus; Torres-Vázquez, Jesús; Yelon, Deborah (2011). The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis. Development, 138(19), 4199-205.
Vermot, Julien; Affolter, Markus (2011). Modeling new conceptual interpretations of development. Development, 138(19), 4111-5.
Zygmunt, Tomasz; Gay, Carl Michael; Blondelle, Jordan; Singh, Manvendra K; Flaherty, Kathleen McCrone; Means, Paula Casey; Herwig, Lukas; Krudewig, Alice; Belting, Heinz-Georg; Affolter, Markus; Epstein, Jonathan A; Torres-Vázquez, Jesús (2011). Semaphorin-PlexinD1 Signaling Limits Angiogenic potential via the VEGF Decoy Receptor sFlt1. Developmental cell, 21(2), 301-14.
Schulz, Joachim G; Ceulemans, Helga; Caussinus, Emmanuel; Baietti, Maria F; Affolter, Markus; Hassan, Bassem A; David, Guido (2011). Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels. EMBO reports, 12(10), 1039-46.
Schwank, Gerald; Dalessi, Sascha; Yang, Schu-Fee; Yagi, Ryohei; de Lachapelle, Aitana Morton; Affolter, Markus; Bergmann, Sven; Basler, Konrad (2011). Formation of long range Dpp morphogen gradient. PLoS biology, 9(7), e1001111.
Affolter, Markus; Basler, Konrad (2011). Cytonemes Show Their Colors. Science, 332(6027), 312-313.
Vuilleumier, Robin; Affolter, Markus; Pyrowolakis, George (2011). Pentagone: patrolling BMP morphogen signaling. Fly, 5(3), 210-4.
Hamaratoglu, Fisun; de Lachapelle, Aitana Morton; Pyrowolakis, George; Bergmann, Sven; Affolter, Markus (2011). Dpp signaling activity requires Pentagone to scale with tissue size in the growing Drosophila wing imaginal disc. PLoS biology, 9(10), e1001182.
Herwig, Lukas; Blum, Yannick; Krudewig, Alice; Ellertsdottir, Elin; Lenard, Anna; Belting, Heinz-Georg; Affolter, Markus (2011). Distinct cellular mechanisms of blood vessel fusion in the zebrafish embryo. Current biology, 21(22), 1942-8.
2010
Oggier, Daniela M; Lenard, Anna; Küry, Michael; Hoeger, Birgit; Affolter, Markus; Fent, Karl (2010). Effects of the protein kinase inhibitor PKC412 on gene expression and link to physiological effects in zebrafish Danio rerio eleuthero-embryos. Toxicological sciences, 119(1), 104-15.
Vuilleumier, Robin; Springhorn, Alexander; Patterson, Lucy; Koidl, Stefanie; Hammerschmidt, Matthias; Affolter, Markus; Pyrowolakis, George (2010). Control of Dpp morphogen signalling by a secreted feedback regulator. Nature Cell Biology, 12(6), 611-7.
Ellertsdóttir, Elín; Lenard, Anna; Blum, Yannick; Krudewig, Alice; Herwig, Lukas; Affolter, Markus; Belting, Heinz-Georg (2010). Vascular Morphogenesis in the Zebrafish Embryo. Developmental biology, 341(1), 56-65.
Affolter, M. (2010). The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development. PLoS one, 5(4), e10245.
Ninov, Nikolay; Menezes-Cabral, Sofia; Prat-Rojo, Carla; Manjón, Cristina; Weiss, Alexander; Pyrowolakis, George; Affolter, Markus; Martín-Blanco, Enrique (2010). Dpp Signaling Directs Cell Motility and Invasiveness during Epithelial Morphogenesis. Current biology, 20(6), 513-20.
Fernandes, Isabelle; Chanut-Delalande, Hélène; Ferrer, Pierre; Latapie, Yvan; Waltzer, Lucas; Affolter, Markus; Payre, François; Plaza, Serge (2010). Zona Pellucida Domain Proteins Remodel the Apical Compartment for Localized Cell Shape Changes. Developmental cell, 18(1), 64-76.
Li, Keguo; Blum, Yannick; Verma, Anjali; Liu, Zhong; Pramanik, Kallal; Leigh, Noah R.; Chun, Chang Z.; Samant, Ganesh V.; Zhao, Baofeng; Garnaas, Maija K.; Horswill, Mark A.; Stanhope, Stephen A.; North, Paula E.; Miao, Robert Q.; Wilkinson, George A.; Affolter, Markus; Ramchandran, Ramani (2010). A non-coding antisense RNA in tie-1 locus regulates tie-1 function in vivo. Blood, 115(1), 133-139.
Weiss, Alexander; Charbonnier, Enrica; Ellertsdottir, Elin; Tsirigos, Aristotelis; Wolf, Christian; Schuh, Reinhard; Pyrowolakis, George; Affolter, Markus (2010). A conserved activation element in BMP signaling during Drosophila development. Nature structural & molecular biology, 17(1), 69-U91.
2009
Baer, Magdalena M; Bilstein, Andreas; Caussinus, Emmanuel; Csiszar, Agnes; Affolter, Markus; Leptin, Maria (2009). The role of apoptosis in shaping the tracheal system in the Drosophila embryo. Mechanisms of Development, 127(1-2), 28-35.
Affolter, Markus; Zeller, Rolf; Caussinus, Emmanuel (2009). Tissue remodelling through branching morphogenesis. Nature reviews. Molecular cell biology, 10(12), 831-42.
Hamaratoglu, Fisun; Basler, Konrad; Affolter, Markus (2009). Confronting morphogen gradients : how important are they for growth?. Science Signaling, 2(94), pe67.
Affolter, Markus; Zeller, Rolf (2009). From cells to organs : new insight into organ morphogenesis. Current opinion in genetics & development, 19(5), 421-3.
Baer, Magdalena M; Chanut-Delalande, Helene; Affolter, Markus (2009). Cellular and molecular mechanisms underlying the formation of biological tubes. Current topics in developmental biology, 89, 137-62.
Grieder, Nicole C; Morata, Gines; Affolter, Markus; Gehring, Walter J (2009). Spalt major controls the development of the notum and of wing hinge primordia of the Drosophila melanogaster wing imaginal disc. Developmental biology, 329(2), 315-26.
Kleaveland, Benjamin; Zheng, Xiangjian; Liu, Jian J; Blum, Yannick; Tung, Jennifer J; Zou, Zhiying; Sweeney, Shawn M; Chen, Mei; Guo, Lili; Lu, Min-min; Zhou, Diane; Kitajewski, Jan; Affolter, Markus; Ginsberg, Mark H; Kahn, Mark L (2009). Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nature medicine, 15(2), 169-76.
Affolter, Markus: The Dawn of Life - Cells into Organs, 04-022009 (Link).
2008
Gohl, Daryl; Müller, Martin; Pirrotta, Vincenzo; Affolter, Markus; Schedl, Paul (2008). Enhancer blocking and transvection at the Drosophila apterous locus. Genetics, 178(1), 127-43.
Affolter, Markus; Slattery, Matthew; Mann, Richard S. (2008). A lexicon for homeodomain-DNA recognition. Cell, 133(7), 1133-1135.
Grieder, Nicole C; Caussinus, Emmanuel; Parker, David S; Cadigan, Kenneth; Affolter, Markus; Luschnig, Stefan (2008). gammaCOP is required for apical protein secretion and epithelial morphogenesis in Drosophila melanogaster. PLoS one, 3(9), e3241.
Blum, Yannick; Belting, Heinz-Georg; Ellertsdottir, Elin; Herwig, Lukas; Lüders, Florian; Affolter, Markus (2008). Complex cell rearrangements during intersegmental vessel sprouting and vessel fusion in the zebrafish embryo. Developmental biology, 316(2), 312-22.
Affolter, Markus; Caussinus, Emmanuel (2008). Tracheal branching morphogenesis in Drosophila : new insights into cell behaviour and organ architecture. Development, 135(12), 2055-64.
Affolter, Markus; Pyrowolakis, George; Weiss, Alexander; Basler, Konrad (2008). Signal-induced repression : the exception or the rule in developmental signaling?. Developmental cell, 15(1), 11-22.
Caussinus, Emmanuel; Colombelli, Julien; Affolter, Markus (2008). Tip-cell migration controls stalk-cell intercalation during Drosophila tracheal tube elongation. Current biology, 18(22), 1727-34.
2007
Affolter, Markus; Barde, Yves (2007). Self-renewal in the fly kidney. Developmental cell, 13(3), 321-322.
Affolter, Markus; Basler, Konrad (2007). The Decapentaplegic morphogen gradient : from pattern formation to growth regulation. Nature Reviews. Genetics, 8(9), 663-74.
Merabet, Samir; Saadaoui, Mehdi; Sambrani, Nagraj; Hudry, Bruno; Pradel, Jacques; Affolter, Markus; Graba, Yacine (2007). A unique Extradenticle recruitment mode in the Drosophila Hox protein Ultrabithorax. Proceedings of the National Academy of Sciences of the United States of America, 104(43), 16946-51.
Belting, Heinz-Georg; Affolter, Markus (2007). It takes guts to make a single lumen. Nature Cell Biology, 9(8), 880-1.
Chanut-Delalande, Hélène; Jung, Alain C; Lin, Li; Baer, Magdalena M; Bilstein, Andreas; Cabernard, Clemens; Leptin, Maria; Affolter, Markus (2007). A genetic mosaic analysis with a repressible cell marker screen to identify genes involved in tracheal cell migration during Drosophila air sac morphogenesis. Genetics, 176(4), 2177-87.
2006
Cordier, Florence; Hartmann, Britta; Rogowski, Marco; Affolter, Markus; Grzesiek, Stephan (2006). DNA recognition by the brinker repressor - an extreme case of coupling between binding and folding. Journal of molecular biology, 361(4), 659-72.
Affolter, Markus; Pyrowolakis, George (2006). eIF4A goes beyond translation. Nature Cell Biology, 8(12), 1319-21.
Affolter, Markus (2006). Markus Affolter. Interview. Current biology, 16(4), R111-R112.
Affolter, M. (2006). Polychaetoid/ZO-1 is required for cell specification and rearrangement during Drosophila tracheal morphogenesis. Current biology, 16(12), 1224-31.
Affolter, Markus; Mann, Richard: Hyped-up for Hox in Hyderabad : workshop on upstream and downstream of Hox genes, in: (2006). EMBO reports, London: Nature Publishing Group (= 7).
Neumann, Marc; Affolter, Markus (2006). Remodelling epithelial tubes through cell rearrangements : from cells to molecules. EMBO reports, 7(1), 36-40.
2005
Affolter, M. (2005). The Drosophila Extradenticle and Homothorax selector proteins control branchless/FGF expression in mesodermal bridge-cells. EMBO reports, 6(8), 762-8.
Affolter, Markus; Weijer, Cornelis J (2005). Signaling to cytoskeletal dynamics during chemotaxis. Developmental cell, 9(1), 19-34.
Cabernard, Clemens; Affolter, Markus (2005). Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila. Developmental cell, 9(6), 831-42.
Merabet, S. (2005). Recognition of distinct target sites by a unique Labial/Extradenticle/Homothorax complex. Development, 132(7), 1591-600.
Jung, Alain C; Denholm, Barry; Skaer, Helen; Affolter, Markus (2005). Renal tubule development in Drosophila : a closer look at the cellular level. Journal of the American Society of Nephrology, 16(2), 322-8.
2004
Cabernard, Clemens; Neumann, Marc; Affolter, Markus (2004). Cellular and molecular mechanisms involved in branching morphogenesis of the Drosophila tracheal system. Journal of applied physiology, 97(6), 2347-53.
Pyrowolakis, George; Hartmann, Britta; Müller, Bruno; Basler, Konrad; Affolter, Markus (2004). A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Developmental cell, 7(2), 229-40.
Ribeiro, Carlos; Neumann, Marc; Affolter, Markus (2004). Genetic control of cell intercalation during tracheal morphogenesis in Drosophila. Current biology, 14(24), 2197-207.
Leptin, Maria; Affolter, Markus (2004). Drosophila gastrulation : identification of a missing link. Current biology, 14(12), R480-2.
Petit, Valérie; Nussbaumer, Ute; Dossenbach, Caroline; Affolter, Markus (2004). Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation. Molecular and cellular biology, 24(9), 3769-81.
Jaźwińska, Anna (2004). A family of genes encoding zona pellucida (ZP) domain proteins is expressed in various epithelial tissues during Drosophila embryogenesis. Gene Expression Patterns, 4(4), 413-21.
2003
Groppe, Jay; Greenwald, Jason; Wiater, Ezra; Rodriguez-Leon, Joaquin; Economides, Aris N; Kwiatkowski, Witek; Baban, Kandan; Affolter, Markus; Vale, Wylie W; Izpisua Belmonte, Juan Carlos; Choe, Senyon (2003). Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein. The Journal of bone and joint surgery, 85-A Suppl 3, 52-8.
Basler, K. (2003). Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. Cell, 113(2), 221-33.
Affolter, Markus; Bellusci, Savério; Itoh, Nobuyuki; Shilo, Benny; Thiery, Jean-Paul; Werb, Zena (2003). Tube or not tube : remodeling epithelial tissues by branching morphogenesis. Developmental cell, 4(1), 11-8.
Ribeiro, Carlos; Petit, Valérie; Affolter, Markus (2003). Signaling systems, guided cell migration, and organogenesis : insights from genetic studies in Drosophila. Developmental biology, 260(1), 1-8.
Jaźwińska, Anna; Ribeiro, Carlos (2003). Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein. Nature Cell Biology, 5(10), 895-901.
2002
Groppe, Jay; Greenwald, Jason; Wiater, Ezra; Rodriguez-Leon, Joaquin; Economides, Aris N; Kwiatkowski, Witek; Affolter, Markus; Vale, Wylie W; Izpisua Belmonte, Juan Carlos; Choe, Senyon (2002). Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature, 420(6916), 636-42.
Muller, F. (2002). Conserved regulation of the Caenorhabditis elegans labial/Hox1 gene ceh-13. Developmental biology, 242(2), 96-108.
Petit, Valérie; Ribeiro, Carlos; Ebner, Andreas; Affolter, Markus (2002). Regulation of cell migration during tracheal development in Drosophila melanogaster. The International Journal of Developmental Biology, 46(1), 125-32.
Ebner, Andreas; Kiefer, Fabrice N; Ribeiro, Carlos; Petit, Valérie; Nussbaumer, Ute; Affolter, Markus (2002). Tracheal development in Drosophila melanogaster as a model system for studying the development of a branched organ. Gene, 287(1-2), 55-66.
Ribeiro, Carlos; Ebner, Andreas; Affolter, Markus (2002). In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis. Developmental cell, 2(5), 677-83.
2001
Dossenbach, C; Röck, S; Affolter, M (2001). Specificity of FGF signaling in cell migration in Drosophila. Development, 128(22), 4563-72.
Affolter, M; Marty, T; Vigano, M A (2001). Nuclear interpretation of Dpp signaling in Drosophila. The EMBO journal, 20(13), 3298-305.
Marty, T; Vigano, M A; Ribeiro, C; Nussbaumer, U; Grieder, N C; Affolter, M (2001). A HOX complex, a repressor element and a 50 bp sequence confer regional specificity to a DPP-responsive enhancer. Development, 128(14), 2833-45.
Affolter, M; Mann, R (2001). Development : legs, eyes, or wings - selectors and signals make the difference. Science, 292(5519), 1080-1.
2000
Sivasankaran, R; Vigano, M A; Müller, B; Affolter, M; Basler, K (2000). Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker. The EMBO journal, 19(22), 6162-72.
Montagne, J. (2000). Expression of the blistered/DSRF gene is controlled by different morphogens during Drosophila trachea and wing development. Mechanisms of Development, 96(1), 27-36.
Affolter, M; Shilo, B Z (2000). Genetic control of branching morphogenesis during Drosophila tracheal development. Current opinion in cell biology, 12(6), 731-5.
Affolter, M (2000). Cell-cell interaction during Drosophila embryogenesis : novel mechanisms and molecules. Ernst Schering Research Foundation Workshop, 29(29), 65-79.
Amherd, R; Hintermann, E; Walz, D; Affolter, M; Meyer, U A (2000). Purification, cloning, and characterization of a second arylalkylamine N-acetyltransferase from Drosophila melanogaster. DNA and cell biology, 19(11), 697-705.
Marty, T; Müller, B; Basler, K; Affolter, M (2000). Schnurri mediates Dpp-dependent repression of brinker transcription. Nature Cell Biology, 2(10), 745-9.
Udagawa, Y; Hanai, J; Tada, K; Grieder, N C; Momoeda, M; Taketani, Y; Affolter, M; Kawabata, M; Miyazono, K (2000). Schnurri interacts with Mad in a Dpp-dependent manner. Genes to cells, 5(5), 359-69.
1999
Mann, R. S. (1999). Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex. Development, 126(22), 5137-48.
Affolter, M; Marty, T; Vigano, M A (1999). Balancing import and export in development. Genes & development, 13(8), 913-5.
1998
Chen, C K; Kühnlein, R P; Eulenberg, K G; Vincent, S; Affolter, M; Schuh, R (1998). The transcription factors KNIRPS and KNIRPS RELATED control cell migration and branch morphogenesis during Drosophila tracheal development. Development, 125(24), 4959-68.
Groppe, J; Rumpel, K; Economides, A N; Stahl, N; Sebald, W; Affolter, M (1998). Biochemical and biophysical characterization of refolded Drosophila DPP : a homolog of bone morphogenetic proteins 2 and 4. Journal of Biological Chemistry, 273(44), 29052-65.
Brodbeck, D; Amherd, R; Callaerts, P; Hintermann, E; Meyer, U A; Affolter, M (1998). Molecular and biochemical characterization of the aaNAT1 (Dat) locus in Drosophila melanogaster : differential expression of two gene products. DNA and cell biology, 17(7), 621-33.
Vincent, S; Wilson, R; Coelho, C; Affolter, M; Leptin, M (1998). The Drosophila protein Dof is specifically required for FGF signaling. Molecular cell, 2(4), 515-25.
Mann, R S; Affolter, M (1998). Hox proteins meet more partners. Current opinion in genetics & development, 8(4), 423-9.
1997
Vincent, S; Ruberte, E; Grieder, N C; Chen, C K; Haerry, T; Schuh, R; Affolter, M (1997). DPP controls tracheal cell migration along the dorsoventral body axis of the Drosophila embryo. Development, 124(14), 2741-50.
Yamamoto, Y; Girard, F; Bello, B; Affolter, M; Gehring, W J (1997). The cramped gene of Drosophila is a member of the Polycomb-group, and interacts with mus209, the gene encoding Proliferating Cell Nuclear Antigen. Development, 124(17), 3385-94.
Affolter, M. (1997). Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling. The EMBO journal, 16(24), 7402-10.
1996
Montagne, J; Groppe, J; Guillemin, K; Krasnow, M A; Gehring, W J; Affolter, M (1996). The Drosophila Serum Response Factor gene is required for the formation of intervein tissue of the wing and is allelic to blistered. Development, 122(9), 2589-97.
Guillemin, K; Groppe, J; Ducker, K; Treisman, R; Hafen, E; Affolter, M; Krasnow, M A (1996). The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system. Development, 122(5), 1353-62.
1995
Grieder, N C; Nellen, D; Burke, R; Basler, K; Affolter, M (1995). Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1. Cell, 81(5), 791-800.
Ruberte, E; Marty, T; Nellen, D; Affolter, M; Basler, K (1995). An absolute requirement for both the type II and type I receptors, punt and thick veins, for dpp signaling in vivo. Cell, 80(6), 889-97.
1994
Basler, K. (1994). Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesis. Development, 120(11), 3105-17.
Gehring, W.J.; Affolter, M.; Burglin, T. (1994). Homeodomain proteins. Annual review of biochemistry, 63, 487-526.
GEHRING, WJ; QIAN, YQ; BILLETER, M; FURUKUBOTOKUNAGA, K; SCHIER, AF; RESENDEZPEREZ, D; AFFOLTER, M; OTTING, G; WUTHRICH, K (1994). Homeodomain-DNA recognition. Cell, 78(2), 211-223.
Affolter, M; Montagne, J; Walldorf, U; Groppe, J; Kloter, U; LaRosa, M; Gehring, W J (1994). The Drosophila SRF homolog is expressed in a subset of tracheal cells and maps within a genomic region required for tracheal development. Development, 120(4), 743-53.
Basler, K. (1994). Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. Cell, 78(2), 225-37.
Dorn, A; Affolter, M; Gehring, W J; Leupin, W (1994). Homeodomain proteins in development and therapy. Pharmacology & therapeutics, 61(1-2), 155-84.
1993
Affolter, M; Walldorf, U; Kloter, U; Schier, A F; Gehring, W J (1993). Regional repression of a Drosophila POU box gene in the endoderm involves inductive interactions between germ layers. Development, 117(4), 1199-210.
1992
Qian, Y Q; Otting, G; Furukubo-Tokunaga, K; Affolter, M; Gehring, W J; Wüthrich, K (1992). NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein. Proceedings of the National Academy of Sciences of the United States of America, 89(22), 10738-42.
Furukubo-Tokunaga, K; Müller, M; Affolter, M; Pick, L; Kloter, U; Gehring, W J (1992). In vivo analysis of the helix-turn-helix motif of the fushi tarazu homeo domain of Drosophila melanogaster. Genes & development, 6(6), 1082-96.
Dorn, A; Affolter, M; Müller, M; Gehring, W J; Leupin, W (1992). Distamycin-induced inhibition of homeodomain-DNA complexes. The EMBO journal, 11(1), 279-86.
1991
Affolter, M; Percival-Smith, A; Müller, M; Billeter, M; Qian, Y Q; Otting, G; Wüthrich, K; Gehring, W J (1991). Similarities between the homeodomain and the Hin recombinase DNA-binding domain. Cell, 64(5), 879-80.
1990
Affolter, M; Schier, A; Gehring, W J (1990). Homeodomain proteins and the regulation of gene expression. Current opinion in cell biology, 2(3), 485-95.
Affolter, M; Percival-Smith, A; Müller, M; Leupin, W; Gehring, W J (1990). DNA binding properties of the purified Antennapedia homeodomain. Proceedings of the National Academy of Sciences of the United States of America, 87(11), 4093-7.
Percival-Smith, A; Müller, M; Affolter, M; Gehring, W J (1990). The interaction with DNA of wild-type and mutant fushi tarazu homeodomains. The EMBO journal, 9(12), 3967-74.
Gehring, W J; Müller, M; Affolter, M; Percival-Smith, A; Billeter, M; Qian, Y Q; Otting, G; Wüthrich, K (1990). The structure of the homeodomain and its functional implications. Trends in Genetics, 6(10), 323-9.
Otting, G; Qian, Y Q; Billeter, M; Müller, M; Affolter, M; Gehring, W J; Wüthrich, K (1990). Protein - DNA contacts in the structure of a homeodomain - DNA complex determined by nuclear magnetic resonance spectroscopy in solution. The EMBO journal, 9(10), 3085-92.
Pick, L; Schier, A; Affolter, M; Schmidt-Glenewinkel, T; Gehring, W J (1990). Analysis of the ftz upstream element : germ layer-specific enhancers are independently autoregulated. Genes & development, 4(7), 1224-39.
1988
Müller, M; Affolter, M; Leupin, W; Otting, G; Wüthrich, K; Gehring, W J (1988). Isolation and sequence-specific DNA binding of the Antennapedia homeodomain. The EMBO journal, 7(13), 4299-304.
Otting, G; Qian, Y Q; Müller, M; Affolter, M; Gehring, W; Wüthrich, K (1988). Secondary structure determination for the Antennapedia homeodomain by nuclear magnetic resonance and evidence for a helix-turn-helix motif. The EMBO journal, 7(13), 4305-9.
1987
Affolter, M; Côté, J; Renaud, J; Ruiz-Carrillo, A (1987). Regulation of histone and beta A-globin gene expression during differentiation of chicken erythroid cells. Molecular and cellular biology, 7(10), 3663-72.
1986
Affolter, M; Ruiz-Carrillo, A (1986). Transcription unit of the chicken histone H5 gene and mapping of H5 pre-mRNA sequences. Journal of biological chemistry, 261(25), 11496-502.
Affolter, M; Labbé, D; Jean, A; Raymond, M; Noël, D; Labelle, Y; Parent-Vaugeois, C; Lambert, M; Bojanowski, R; Anderson, A (1986). cDNA clones for liver cytochrome P-450s from individual aroclor-treated rats : constitutive expression of a new P-450 gene related to phenobarbital-inducible forms. DNA, 5(3), 209-18.
1985
ANDERSON, A; WAITHE, W; LABBE, D; AFFOLTER, M; LABELLE, Y (1985). Diversité des cytochromes P-450 hépatiques : rôle dans la cancérogénèse chimique. L'Union médicale du Canada, 114(9), 731-732.
Affolter, M; Ruiz-Carrillo, A (1985). L'expression des gènes et ses conséquences dans les maladies génétiques. L'Union médicale du Canada, 114(9), 724-6.
1984
Affolter, M; Anderson, A (1984). Segmental homologies in the coding and 3' non-coding sequences of rat liver cytochrome P-450e and P-450b cDNAs and cytochrome P-450e-like genes. Biochemical and Biophysical Research Communications, 118(2), 655-62.
1983
Ruiz-Carrillo, A; Affolter, M; Renaud, J (1983). Genomic organization of the genes coding for the six main histones of the chicken : complete sequence of the H5 gene. Journal of molecular biology, 170(4), 843-59.
Affolter, M; Parent-Vaugeois, C; Anderson, A (1983). Curing and induction of the Fels 1 and Fels 2 prophages in the Ames mutagen tester strains of Salmonella typhimurium. Mutation research, 110(2), 243-62.
Affolter, M; Parent-Vaugeois, C; Anderson, A (1983). Mutagenic response of Ames strains cured of their inducible Fels 1 and Fels 2 prophages. Cancer research, 43(2), 653-9.

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