Prof. Dr. Marek Basler

Biozentrum
University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 402 Phone: +41 61 207 21 10
Email: marek.basler-at-unibas.ch
Curriculum Vitae

Administrative Assistant

Michaela Hanisch
Biozentrum, Room 408
Phone: +41 61 207 21 21
Fax: +41 61 207 21 18
Email: michaela.hanisch-at-unibas.ch

Research Group Marek Basler

Articles

2018
Nazarov, Sergey; Schneider, Johannes P; Brackmann, Maximilian; Goldie, Kenneth N; Stahlberg, Henning; Basler, Marek (2018). Cryo-EM reconstruction of Type VI secretion system baseplate and sheath distal end. The EMBO journal, 37, e97103.
Brackmann, Maximilian; Wang, Jing; Basler, Marek (2018). Type VI secretion system sheath inter-subunit interactions modulate its contraction. EMBO reports, 19(2), 225-233.
2017
Ringel, Peter David; Hu, Di; Basler, Marek (2017). The Role of Type VI Secretion System Effectors in Target Cell Lysis and Subsequent Horizontal Gene Transfer. Cell reports, 21(13), 3927-3940.
Wang, Jing; Brackmann, Maximilian; Castaño-Díez, Daniel; Kudryashev, Mikhail; Goldie, Kenneth N.; Maier, Timm; Stahlberg, Henning; Basler, Marek (2017). Cryo-EM structure of the extended type VI secretion system sheath-tube complex. Nature Microbiology, 2(11), 1507-1512.
Vettiger, Andrea; Winter, Julius; Lin, Lin; Basler, Marek (2017). The type VI secretion system sheath assembles at the end distal from the membrane anchor. Nature Communications, 8, 16088.
Brodmann, Maj; Dreier, Roland F.; Broz, Petr; Basler, Marek (2017). Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape. Nature Communications, 8, 15853.
Brackmann, Maximilian; Nazarov, Sergey; Wang, Jing; Basler, Marek (2017). Using Force to Punch Holes: Mechanics of Contractile Nanomachines. Trends in Cell Biology, 27(9), 623-632.
2016
Schneider, Johannes P.; Basler, Marek (2016). Shedding light on biology of bacterial cells. Philosophical Transactions of the Royal Society of London, Series B : Biological Sciences, 371(1707), 20150499.
Vettiger, Andrea; Basler, Marek (2016). Type VI Secretion System Substrates Are Transferred and Reused among Sister Cells. Cell, 167(1), 99-110.e12.
Nelson, Michaeline B.; Chase, Alexander B.; Martiny, Jennifer B. H.; Stocker, Roman; Nguyen, Jen; Lloyd, Karen; Oshiro, Reid T.; Kearns, Daniel B.; Schneider, Johannes P.; Ringel, Peter D.; Basler, Marek; Olson, Christine A.; Vuong, Helen E.; Hsiao, Elaine Y.; Roller, Benjamin R. K.; Ackermann, Martin; Smillie, Chris; Chien, Diana; Alm, Eric; Jermy, Andrew J. (2016). The Microbial Olympics 2016. Nature Microbiology, 1(8), 16122.
2015
Borenstein, David Bruce; Ringel, Peter; Basler, Marek; Wingreen, Ned S. (2015). Established microbial colonies can survive type VI secretion assault. PLoS Computational Biology, 11(10), e1004520.
Basler, Marek (2015). Type VI secretion system : secretion by a contractile nanomachine. Philosophical Transactions : the Royal Society of London, 370(1679), 20150021.
Wang, Ray Yu-Ruei; Kudryashev, Mikhail; Li, Xueming; Egelman, Edward H; Basler, Marek; Cheng, Yifan; Baker, David; DiMaio, Frank (2015). De novo protein structure determination from near-atomic-resolution cryo-EM maps. Nature methods, 12(4), 335-8.
Kudryashev, Mikhail; Wang, Ray Yu-Ruei; Brackmann, Maximilian; Scherer, Sebastian; Maier, Timm; Baker, David; DiMaio, Frank; Stahlberg, Henning; Egelman, Edward H; Basler, Marek (2015). Structure of the Type VI Secretion System Contractile Sheath. Cell, 160(5), 952-62.
2013
Ho, Brian T.; Basler, Marek; Mekalanos, John J. (2013). Type 6 secretion system-mediated immunity to type 4 secretion system-mediated gene transfer. Science, 342(6155), 250-3.
Shneider, Mikhail M.; Buth, Sergey A.; Ho, Brian T.; Basler, Marek; Mekalanos, John J.; Leiman, Petr G. (2013). PAAR-repeat proteins sharpen and diversify the type VI secretion system spike. Nature, 500(7462), 350-353.
Basler, Marek; Ho, Brian T.; Mekalanos, John J. (2013). Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions. Cell, 152(4), 884-94.
2012
Horváthová, Lenka; Safaríková, Lucie; Basler, Marek; Hrdy, Ivan; Campo, Neritza B.; Shin, Jyh-Wei; Huang, Kuo-Yang; Huang, Po-Jung; Lin, Rose; Tang, Petrus; Tachezy, Jan (2012). Transcriptomic identification of iron-regulated and iron-independent gene copies within the heavily duplicated Trichomonas vaginalis genome. Genome Biology and Evolution, 4(10), 1017-29.
Basler, M.; Mekalanos, J. J. (2012). Type 6 secretion dynamics within and between bacterial cells. Science, 337(6096), 815.
Fiser, Radovan; Masin, Jiri; Bumba, Ladislav; Pospisilova, Eva; Fayolle, Catherine; Basler, Marek; Sadilkova, Lenka; Adkins, Irena; Kamanova, Jana; Cerny, Jan; Konopasek, Ivo; Osicka, Radim; Leclerc, Claude; Sebo, Peter (2012). Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores. PLoS Pathogens, 8(4), e1002580.
Basler, M.; Pilhofer, M.; Henderson, G. P.; Jensen, G. J.; Mekalanos, J. J. (2012). Type VI secretion requires a dynamic contractile phage tail-like structure. Nature, 483(7388), 182-6.
2011
Rao, Jayasimha; Damron, F. Heath; Basler, Marek; Digiandomenico, Antonio; Sherman, Nicholas E.; Fox, Jay W.; Mekalanos, John J.; Goldberg, Joanna B. (2011). Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient. Frontiers in Microbiology, 2, 162.
2010
Linhartová, Irena; Bumba, Ladislav; Mašín, Jiří; Basler, Marek; Osička, Radim; Kamanová, Jana; Procházková, Kateřina; Adkins, Irena; Hejnová-Holubová, Jana; Sadílková, Lenka; Morová, Jana; Sebo, Peter (2010). RTX proteins: a highly diverse family secreted by a common mechanism. FEMS Microbiology Reviews, 34(6), 1076-112.
Osickova, Adriana; Masin, Jiri; Fayolle, Catherine; Krusek, Jan; Basler, Marek; Pospisilova, Eva; Leclerc, Claude; Osicka, Radim; Sebo, Peter (2010). Adenylate cyclase toxin translocates across target cell membrane without forming a pore. Molecular Microbiology, 75(6), 1550-62.
2009
Vojtova-Vodolanova, Jana; Basler, Marek; Osicka, Radim; Knapp, Oliver; Maier, Elke; Cerny, Jan; Benada, Oldrich; Benz, Roland; Sebo, Peter (2009). Oligomerization is involved in pore formation by Bordetella adenylate cyclase toxin. FASEB Journal, 23(9), 2831-43.
Leiman, Petr G.; Basler, Marek; Ramagopal, Udupi A.; Bonanno, Jeffrey B.; Sauder, J. Michael; Pukatzki, Stefan; Burley, Stephen K.; Almo, Steven C.; Mekalanos, John J. (2009). Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin. Proceedings of the National Academy of Sciences, 106(11), 4154-9.
2008
Pánek, Josef; Bobek, Jan; Mikulík, Karel; Basler, Marek; Vohradský, Jirí (2008). Biocomputational prediction of small non-coding RNAs in Streptomyces. BMC Genomics, 9, 217.
2007
Frýdlová, Ivana; Basler, Marek; Vasicová, Pavla; Malcová, Ivana; Hasek, Jirí (2007). Special type of pheromone-induced invasive growth in Saccharomyces cerevisiae. Current Genetics, 52(2), 87-95.
Sasková, Lenka; Nováková, Linda; Basler, Marek; Branny, Pavel (2007). Eukaryotic-type serine/threonine protein kinase StkP is a global regulator of gene expression in Streptococcus pneumoniae. Journal of Bacteriology, 189(11), 4168-79.
Basler, Marek; Knapp, Oliver; Masin, Jiri; Fiser, Radovan; Maier, Elke; Benz, Roland; Sebo, Peter; Osicka, Radim (2007). Segments crucial for membrane translocation and pore-forming activity of Bordetella adenylate cyclase toxin. Journal of Biological Chemistry, 282(17), 12419-29.
Fiser, Radovan; Masín, Jirí; Basler, Marek; Krusek, Jan; Spuláková, Veronika; Konopásek, Ivo; Sebo, Peter (2007). Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities. Journal of Biological Chemistry, 282(5), 2808-20.
2006
Basler, Marek; Linhartová, Irena; Halada, Petr; Novotná, Jana; Bezousková, Silvia; Osicka, Radim; Weiser, Jaroslav; Vohradský, Jirí; Sebo, Peter (2006). The iron-regulated transcriptome and proteome of Neisseria meningitidis serogroup C. Proteomics, 6(23), 6194-6206.
Linhartova, Irena; Basler, Marek; Ichikawa, Jeffrey; Pelicic, Vladimir; Osicka, Radim; Lory, Stephen; Nassif, Xavier; Sebo, Peter (2006). Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells. FEMS Microbiology Letters, 263(1), 109-18.
Basler, Marek; Masin, Jiri; Osicka, Radim; Sebo, Peter (2006). Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes. Infection and Immunity, 74(4), 2207-14.
2005
Masin, Jiri; Basler, Marek; Knapp, Oliver; El-Azami-El-Idrissi, Mohammed; Maier, Elke; Konopasek, Ivo; Benz, Roland; Leclerc, Claude; Sebo, Peter (2005). Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells. Biochemistry, 44(38), 12759-66.

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