Prof. Dr. Urs Jenal

Biozentrum
University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 407 Phone: +41 61 207 21 35
Email: urs.jenal-at-unibas.ch
Curriculum Vitae

Administrative Assistant

Claudia Erbel-Sieler
Biozentrum, Room 408
Phone: +41 61 207 10 84
Fax: +41 61 207 21 18
Email: claudia.erbel-at-unibas.ch

Research group Urs Jenal

Articles

2017
Sprecher, Kathrin S; Hug, Isabelle; Nesper, Jutta; Potthoff, Eva; Mahi, Mohamed-Ali; Sangermani, Matteo; Kaever, Volkhard; Schwede, Torsten; Vorholt, Julia; Jenal, Urs (2017). Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c-di-GMP Effector Protein. mBio, 8(2), e00294-17.
2016
Valentini, Martina; Laventie, Benoît-Joseph; Moscoso, Joana; Jenal, Urs; Filloux, Alain (2016). The Diguanylate Cyclase HsbD Intersects with the HptB Regulatory Cascade to Control Pseudomonas aeruginosa Biofilm and Motility. PLoS genetics, 12(10), e1006354.
Broder, Ursula N; Jaeger, Tina; Jenal, Urs (2016). LadS is a calcium-responsive kinase that induces acute-to-chronic virulence switch in Pseudomonas aeruginosa. Nature microbiology, 2, 16184.
Dubey, Badri N.; Lori, Christian; Ozaki, Shogo; Fucile, Geoffrey; Plaza-Menacho, Ivan; Jenal, Urs; Schirmer, Tilman (2016). Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking. Science Advances, 2(9), e1600823.
Reinders, Alberto; Hee, Chee-Seng; Ozaki, Shogo; Mazur, Adam; Boehm, Alex; Schirmer, Tilman; Jenal, Urs (2016). Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli. Journal of Bacteriology, 198(3), 448-62.
Rotem, Or; Nesper, Jutta; Borovok, Ilya; Gorovits, Rena; Kolot, Mikhail; Pasternak, Zohar; Shin, Irina; Glatter, Timo; Pietrokovski, Shmuel; Jenal, Urs; Jurkevitch, Edouard (2016). An extended cyclic di-GMP network in the predatory bacterium Bdellovibrio bacteriovorus. Journal of bacteriology, 198(1), 127-137.
Hengge, Regine; Galperin, Michael Y; Ghigo, Jean-Marc; Gomelsky, Mark; Green, Jeffrey; Hughes, Kelly T; Jenal, Urs; Landini, Paolo (2016). Systematic nomenclature for GGDEF and EAL domain-containing Cyclic di-GMP turnover proteins of Escherichia coli. Journal of bacteriology, 198(1), 7-11.
Hengge, Regine; Gründling, Angelika; Jenal, Urs; Ryan, Robert; Yildiz, Fitnat (2016). Bacterial signal transduction by c-di-GMP and other nucleotide second messengers. Journal of bacteriology, 198(1), 15-26.
2015
Manfredi, Pablo; Jenal, Urs (2015). Bacteria in the CF Lung: Isolation Drives Diversity. Cell host & microbe, 18(3), 268-9.
Lori, C; Ozaki, S; Steiner, S; Böhm, R; Abel, S; Dubey, B N; Schirmer, T; Hiller, S; Jenal, U (2015). Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication. Nature, 523(7559), 236-9.
Laventie, Benoît-Joseph; Nesper, Jutta; Ahrné, Erik; Glatter, Timo; Schmidt, Alexander; Jenal, Urs (2015). Capture compound mass spectrometry - a powerful tool to identify novel c-di-GMP effector proteins. Journal of visualized experiments, 97 , e51404(97), e51404.
2014
Moscoso, Joana A; Jaeger, Tina; Valentini, Martina; Hui, Kailyn; Jenal, Urs; Filloux, Alain (2014). The diguanylate cyclase SadC is a central player of the Gac/Rsm-mediated biofilm formation in Pseudomonas aeruginosa. Journal of bacteriology, 196(23), 4081-4088.
Ozaki, Shogo; Schalch-Moser, Annina; Zumthor, Ludwig; Manfredi, Pablo; Ebbensgaard, Anna; Schirmer, Tilman; Jenal, Urs (2014). Activation and polar sequestration of PopA, a c-di-GMP effector protein involved in Caulobacter crescentus cell cycle control. Molecular Microbiology, 94(3), 580-94.
Fei, Na; Häussinger, Daniel; Blümli, Seraina; Laventie, Benoît-Joseph; Bizzini, Lorenzo D; Zimmermann, Kaspar; Jenal, Urs; Gillingham, Dennis (2014). Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides. Chemical Communications, 50(62), 8499-502.
Fumeaux, Coralie; Radhakrishnan, Sunish Kumar; Ardissone, Silvia; Théraulaz, Laurence; Frandi, Antonio; Martins, Daniel; Nesper, Jutta; Abel, Sören; Jenal, Urs; Viollier, Patrick H. (2014). Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators. Nature Communications, 5, 4081.
Sundriyal, Amit; Massa, Claudia; Samoray, Dietrich; Zehender, Fabian; Sharpe, Timothy; Jenal, Urs; Schirmer, Tilman (2014). Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger c-di-GMP. Journal of biological chemistry, 289(10), 6978-90.
2013
Zähringer, Franziska; Lacanna, Egidio; Jenal, Urs; Schirmer, Tilman; Boehm, Alex (2013). Structure and signaling mechanism of a zinc-sensory diguanylate cyclase. Structure: with folding and design, 21(7), 1149-57.
Wegrzyn, Katarzyna; Witosinska, Monika; Schweiger, Pawel; Bury, Katarzyna; Jenal, Urs; Konieczny, Igor (2013). RK2 plasmid dynamics in Caulobacter crescentus cells - two modes of DNA replication initiation. Microbiology, 159(Pt 6), 1010-22.
Renggli, Sabine; Keck, Wolfgang; Jenal, Urs; Ritz, Daniel (2013). The role of auto-fluorescence in flow-cytometric analysis of Escherichia coli treated with bactericidal antibiotics. Journal of bacteriology, 195(18), 4067-4073.
Steiner, Samuel; Lori, Christian; Boehm, Alex; Jenal, Urs (2013). Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein-protein interaction. The EMBO journal, 32(3), 354-68.
Renggli, Sabine; Keck, Wolfgang; Jenal, Urs; Ritz, Daniel (2013). Role of autofluorescence in flow cytometric analysis of Escherichia coli treated with bactericidal antibiotics. Journal of bacteriology, 195(18), 4067-73.
Abel, Sören; Bucher, Tabitha; Nicollier, Micaël; Hug, Isabelle; Kaever, Volkhard; Abel Zur Wiesch, Pia; Jenal, Urs (2013). Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the caulobacter cell cycle. PLoS genetics, 9(9), e1003744.
Jenal, Urs (2013). Think globally, act locally: how bacteria integrate local decisions with their global cellular programme. The EMBO journal, 32(14), 1972-4.
Davis, NJ; Cohen, Y; Sanselicio, S; Fumeaux, C; Ozaki, S; Luciano, J; Guerrero-Ferreira, RC; Wright, ER; Jenal, U; Viollier, PH;  (2013). De- and repolarization mechanism of flagellar morphogenesis during a bacterial cell cycle. Genes Dev., 27(18 (Note: Erratum in Genes Dev.;27(20):2292)), 2049-62.
2012
Nesper, Jutta; Reinders, Alberto; Glatter, Timo; Schmidt, Alexander; Jenal, Urs (2012). A novel capture compound for the identification and analysis of cyclic di-GMP binding proteins. Journal of proteomics, 75(15), 4874-8.
Petters, Tobias; Zhang, Xin; Nesper, Jutta; Treuner-Lange, Anke; Gomez-Santos, Nuria; Hoppert, Michael; Jenal, Urs; Søgaard-Andersen, Lotte (2012). The orphan histidine protein kinase SgmT is a c-di-GMP receptor and regulates composition of the extracellular matrix together with the orphan DNA binding response regulator DigR in Myxococcus xanthus. Molecular Microbiology, 84(1), 147-65.
Malone, Jacob G; Jaeger, Tina; Manfredi, Pablo; Dötsch, Andreas; Blanka, Andrea; Bos, Raphael; Cornelis, Guy R; Häussler, Susanne; Jenal, Urs (2012). The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent pseudomonas aeruginosa in cystic fibrosis airways. PLoS pathogens, 8(6), e1002760.
Hardwick, SW; Gubbey, T; Hug, I; Jenal, U; Luisi, BF;  (2012). Crystal structure of Caulobacter crescentus polynucleotide phosphorylase reveals a mechanism of RNA substrate channelling and RNA degradosome assembly. Open Biol, 2(4), 120028.
2011
Abel, Sören; Chien, Peter; Wassmann, Paul; Schirmer, Tilman; Kaever, Volkhard; Laub, Michael T; Baker, Tania A; Jenal, Urs (2011). Regulatory Cohesion of Cell Cycle and Cell Differentiation through Interlinked Phosphorylation and Second Messenger Networks. Molecular cell, 43(4), 550-60.
Habazettl, Judith; Allan, Martin G; Jenal, Urs; Grzesiek, Stephan (2011). Solution structure of the PilZ domain protein PA4608 complex with cyclic di-GMP identifies charge clustering as molecular readout. Journal of biological chemistry, 286(16), 14304-14.
Levi, A.; Folcher, M.; Jenal, U.; Shuman, H.A. (2011). Cyclic Diguanylate Signaling Proteins Control Intracellular Growth of Legionella pneumophila. mBio, 2(1), e00316-10.
2010
Abgottspon, Daniela; Rölli, Gina; Hosch, Lucie; Steinhuber, Andrea; Jiang, Xiaohua; Schwardt, Oliver; Cutting, Brian; Smiesko, Martin; Jenal, Urs; Ernst, Beat; Trampuz, Andrej (2010). Development of an aggregation assay to screen FimH antagonists. Journal of Microbiological Methods, 82(3), 249-55.
Diepold, Andreas; Amstutz, Marlise; Abel, Sören; Sorg, Isabel; Jenal, Urs; Cornelis, Guy R (2010). Deciphering the assembly of the Yersinia type III secretion injectisome. The EMBO journal, 29(11), 1928-40.
Spangler, Christian; Böhm, Alex; Jenal, Urs; Seifert, Roland; Kaever, Volkhard (2010). A liquid chromatography-coupled tandem mass spectrometry method for quantitation of cyclic di-guanosine monophosphate. Journal of Microbiological Methods, 81(3), 226-31.
Boehm, Alex; Kaiser, Matthias; Li, Hui; Spangler, Christian; Kasper, Christoph Alexander; Ackermann, Martin; Kaever, Volkhard; Sourjik, Victor; Roth, Volker; Jenal, Urs (2010). Second Messenger-Mediated Adjustment of Bacterial Swimming Velocity. Cell, 141(1), 107-16.
Malone, Jacob G; Jaeger, Tina; Spangler, Christian; Ritz, Daniel; Spang, Anne; Arrieumerlou, Cécile; Kaever, Volkhard; Landmann, Regine; Jenal, Urs (2010). YfiBNR Mediates Cyclic di-GMP Dependent Small Colony Variant Formation and Persistence in Pseudomonas aeruginosa. PLoS Pathogens, 6(3), e1000804.
2009
Schirmer, Tilman; Jenal, Urs (2009). Structural and mechanistic determinants of c-di-GMP signalling. Nature reviews microbiology, 7(10), 724-35.
Duerig, Anna; Abel, Sören; Folcher, Marc; Nicollier, Micael; Schwede, Torsten; Amiot, Nicolas; Giese, Bernd; Jenal, Urs (2009). Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression. Genes & development, 23(1), 93-104.
Jenal, Urs; Galperin, Michael Y (2009). Single domain response regulators : molecular switches with emerging roles in cell organization and dynamics. Current opinion in microbiology, 12(2), 152-60.
Abel, Sören; Jenal, Urs: Role of cyclic di-GMP in Caulobacter crescentus development and cell cycle control, in: Wolfe, Alan J.; Visick, Karen L. (Ed.). (2009). Second messenger cyclic Di-GMP, Washington DC: ASM Press , S. S. 120-136.
Jenal, Urs; Dorman, Charles J. (2009). Small molecule signaling. Current opinion in microbiology, 12(2), 125-128.
Boehm, Alex; Steiner, Samuel; Zaehringer, Franziska; Casanova, Alain; Hamburger, Fabienne; Ritz, Daniel; Keck, Wolfgang; Ackermann, Martin; Schirmer, Tilman; Jenal, Urs (2009). Second messenger signaling governs Escherichia coli biofilm induction upon ribosomal stress. Molecular microbiology, 72(6), 1500-1516.
2008
Paul, Ralf; Jaeger, Tina; Abel, Sören; Wiederkehr, Irene; Folcher, Marc; Biondi, Emanuele G; Laub, Michael T; Jenal, Urs (2008). Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate. Cell, 133(3), 452-61.
2007
Christen, Matthias; Christen, Beat; Allan, Martin G; Folcher, Marc; Jenö, Paul; Grzesiek, Stephan; Jenal, Urs (2007). DgrA is a member of a new family of cyclic diguanosine monophosphate receptors and controls flagellar motor function in Caulobacter crescentus. Proceedings of the National Academy of Sciences of the United States of America, 104(10), 4112-7.
Ackermann, Martin; Schauerte, Alexandra; Stearns, Stephen C; Jenal, Urs (2007). Experimental evolution of aging in a bacterium. BMC evolutionary biology, 7, 126.
Malone, J G; Williams, R; Christen, M; Jenal, U; Spiers, A J; Rainey, P B (2007). The structure-function relationship of WspR, a Pseudomonas fluorescens response regulator with a GGDEF output domain. Microbiology, 153(Pt 4), 980-94.
Stephens, Craig; Christen, Beat; Watanabe, Kelly; Fuchs, Thomas; Jenal, Urs (2007). Regulation of D-xylose metabolism in Caulobacter crescentus by a LacI-type repressor. Journal of bacteriology, 189(24), 8828-34.
Stephens, Craig; Christen, Beat; Fuchs, Thomas; Sundaram, Vidyodhaya; Watanabe, Kelly; Jenal, Urs (2007). Genetic analysis of a novel pathway for D-xylose metabolism in Caulobacter crescentus. Journal of bacteriology, 189(5), 2181-5.
Paul, Ralf; Abel, Sören; Wassmann, Paul; Beck, Andreas; Heerklotz, Heiko; Jenal, Urs (2007). Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization. Journal of biological chemistry, 282(40), 29170-7.
Wassmann, Paul; Chan, Carmen; Paul, Ralf; Beck, Andreas; Heerklotz, Heiko; Jenal, Urs; Schirmer, Tilman (2007). Structure of BeF3- -modified response regulator PleD: implications for diguanylate cyclase activation, catalysis, and feedback inhibition. Structure: with folding and design, 15(8), 915-27.
2006
Christen, Beat; Christen, Matthias; Paul, Ralf; Schmid, Franziska; Folcher, Marc; Jenoe, Paul; Meuwly, Markus; Jenal, Urs (2006). Allosteric control of cyclic di-GMP signaling. Journal of Biological Chemistry, 281(42), 32015-24.
Levi, Assaf; Jenal, Urs (2006). Holdfast formation in motile swarmer cells optimizes surface attachment during Caulobacter crescentus development. Journal of bacteriology, 188(14), 5315-8.
Jenal, Urs; Malone, Jacob (2006). Mechanisms of cyclic-di-GMP signaling in bacteria. Annual Review of Genetics, 40, 385-407.
2005
Jenal, Urs; Silversmith, Ruth E; Sogaard-Andersen, Lotte; Sockett, Liz: Sense and sensibility in bacteria : VIIIth International Conference on Bacterial Locomotion and Sensory Transduction, in: (2005). EMBO reports, London: Nature Publishing Group (= 6).
Kanbe, M; Shibata, S; Umino, Y; Jenal, U; Aizawa, S-I (2005). Protease susceptibility of the Caulobacter crescentus flagellar hook-basal body : a possible mechanism of flagellar ejection during cell differentiation. Microbiology, 151(Pt 2), 433-8.
Christen, Matthias; Christen, Beat; Folcher, Marc; Schauerte, Alexandra; Jenal, Urs (2005). Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP. Journal of Biological Chemistry, 280(35), 30829-37.
Armitage, JP; Holland, IB; Jenal, U; Kenny, B (2005). "Neural networks" in bacteria : making connections. Journal of bacteriology, 187(1), 26-36.
2004
Jenal, Urs (2004). Cyclic di-guanosine-monophosphate comes of age : a novel secondary messenger involved in modulating cell surface structures in bacteria?. Current opinion in microbiology, 7(2), 185-91.
Grünenfelder, Björn; Tawfilis, Sherif; Gehrig, Stefanie; ØSterås, Magne; Eglin, Daniel; Jenal, Urs (2004). Identification of the protease and the turnover signal responsible for cell cycle-dependent degradation of the Caulobacter FliF motor protein. Journal of bacteriology, 186(15), 4960-71.
Paul, Ralf; Weiser, Stefan; Amiot, Nicholas C; Chan, Carmen; Schirmer, Tilman; Giese, Bernd; Jenal, Urs (2004). Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain. Genes & development, 18(6), 715-27.
Chan, Carmen; Paul, Ralf; Samoray, Dietrich; Amiot, Nicolas C; Giese, Bernd; Jenal, Urs; Schirmer, Tilman (2004). Structural basis of activity and allosteric control of diguanylate cyclase. Proceedings of the National Academy of Sciences of the United States of America, 101(49), 17084-9.
2003
Aldridge, Phillip; Paul, Ralf; Goymer, Patrick; Rainey, Paul; Jenal, Urs (2003). Role of the GGDEF regulator PleD in polar development of Caulobacter crescentus. Molecular microbiology, 47(6), 1695-708.
Grünenfelder, Björn; Gehrig, Stefanie; Jenal, Urs (2003). Role of the cytoplasmic C terminus of the FliF motor protein in flagellar assembly and rotation. Journal of bacteriology, 185(5), 1624-33.
Jenal, Urs; Hengge-Aronis, Regine (2003). Regulation by proteolysis in bacterial cells. Current opinion in microbiology, 6(2), 163-72.
Ackermann, Martin; Stearns, Stephen C; Jenal, Urs (2003). Senescence in a bacterium with asymmetric division. Science, 300(5627), 1920.
Vohradsky, Jiri; Janda, Ivan; Grünenfelder, Björn; Berndt, Peter; Röder, Daniel; Langen, Hanno; Weiser, Jaroslav; Jenal, Urs (2003). Proteome of Caulobacter crescentus cell cycle publicly accessible on SWICZ server. Proteomics, 3(10), 1874-82.
2002
Fischer, B; Rummel, G; Aldridge, P; Jenal, Urs (2002). The FtsH protease is involved in development, stress response and heat shock control in Caulobacter crescentus. Molecular microbiology, 44(2), 461-78.
Jenal, Urs; Stephens, Craig (2002). The Caulobacter cell cycle : timing, spatial organization and checkpoints. Current opinion in microbiology, 5(6), 558-63.
Potocka, Isabel; Thein, Melanie; ØSterås, Magne; Jenal, Urs; Alley, M R K (2002). Degradation of a Caulobacter soluble cytoplasmic chemoreceptor is ClpX dependent. Journal of bacteriology, 184(23), 6635-41.
2001
Fuchs, T; Wiget, P; Osterås, M; Jenal, U (2001). Precise amounts of a novel member of a phosphotransferase superfamily are essential for growth and normal morphology in Caulobacter crescentus. Molecular microbiology, 39(3), 679-92.
Grünenfelder, B; Rummel, G; Vohradsky, J; Röder, D; Langen, H; Jenal, U (2001). Proteomic analysis of the bacterial cell cycle. Proceedings of the National Academy of Sciences of the United States of America, 98(8), 4681-6.
2000
Osteras, M; Jenal, U (2000). Regulatory circuits in Caulobacter. Current opinion in microbiology, 3(2), 171-176.
Jenal, U (2000). Signal transduction mechanisms in Caulobacter crescentus development and cell cycle control. FEMS microbiology reviews, 24(2), 177-91.
1999
Osterås, M; Stotz, A; Schmid Nuoffer, S; Jenal, U (1999). Identification and transcriptional control of the genes encoding the Caulobacter crescentus ClpXP protease. Journal of bacteriology, 181(10), 3039-50.
Aldridge, P; Jenal, U (1999). Cell cycle-dependent degradation of a flagellar motor component requires a novel-type response regulator. Molecular microbiology, 32(2), 379-91.
1998
Jenal, U.: Recent progress in understanding the bacterial cell cycle, in: (1998). Mikrobielle Evolution und Infektion, Reinbek: Einhorn Presse Verlag .
Jenal, U; Fuchs, T (1998). An essential protease involved in bacterial cell-cycle control. The EMBO journal, 17(19), 5658-69.
1997
Meisenzahl, A C; Shapiro, L; Jenal, U (1997). Isolation and characterization of a xylose-dependent promoter from Caulobacter crescentus. Journal of bacteriology, 179(3), 592-600.
1996
Mohr, C D; Jenal, U; Shapiro, L (1996). Flagellar assembly in Caulobacter crescentus : a basal body P-ring null mutation affects stability of the L-ring protein. Journal of bacteriology, 178(3), 675-82.
Jenal, U; Stephens, C (1996). Bacterial differentiation : sizing up sporulation. Current biology, 6(2), 111-4.
Jenal, U; Shapiro, L (1996). Cell cycle-controlled proteolysis of a flagellar motor protein that is asymmetrically distributed in the Caulobacter predivisional cell. The EMBO journal, 15(10), 2393-406.
1995
Jenal, U; Stephens, C; Shapiro, L (1995). Regulation of asymmetry and polarity during the Caulobacter cell cycle. Advances in Enzymology and Related Areas of Molecular Biology, 71, 1-39.
1994
Jenal, U; White, J; Shapiro, L (1994). Caulobacter flagellar function, but not assembly, requires FliL, a non-polarly localized membrane protein present in all cell types. Journal of molecular biology, 243(2), 227-44.
Gast, D A; Jenal, U; Wasserfallen, A; Leisinger, T (1994). Regulation of tryptophan biosynthesis in Methanobacterium thermoautotrophicum Marburg. Journal of bacteriology, 176(15), 4590-6.
1993
Jenal, U; Thurner, C; Leisinger, T (1993). Transcription of the ileS operon in the archaeon Methanobacterium thermoautotrophicum Marburg. Journal of bacteriology, 175(18), 5945-52.
1991
Jenal, U; Rechsteiner, T; Tan, P Y; Bühlmann, E; Meile, L; Leisinger, T (1991). Isoleucyl-tRNA synthetase of Methanobacterium thermoautotrophicum Marburg : cloning of the gene, nucleotide sequence, and localization of a base change conferring resistance to pseudomonic acid. Journal of biological chemistry, 266(16), 10570-7.
1989
Meile, L.; Rechsteiner, T.; Jenal, U.; Jordan, M.; Leisinger, T.: Approaches to the development of gene transfer systems in Methanobacterium thermoautotrophicum, in: M. S. DaCosta; J. C. Duarte; R. A. D. Williams (Ed.). (1989). Microbiology of extreme environments and its potential for biotechnology, London: Elseier Appl. Science , S. S. 253-257.
MEILE, L; JENAL, U; STUDER, D; JORDAN, M; LEISINGER, T (1989). Characterization of M1, a virulent phage of Methanobacterium thermoautotrophicum Marburg. Archives of microbiology, 152(2), 105-110.

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