Prof. Dr. Erich Nigg

Biozentrum
University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 180E Phone: +41 61 207 16 56
Email: erich.nigg-at-unibas.ch
Curriculum Vitae

Administrative Assistant

Nadine Iberl
Biozentrum, Room 709
Phone: +41 61 207 20 66
Fax: +41 61 207 20 78
Email: nadine.iberl-at-unibas.ch

Research group Erich Nigg

Articles

2017
Pitchai, Ganesha P; Kaulich, Manuel; Bizard, Anna H; Mesa, Pablo; Yao, Qi; Sarlos, Kata; Streicher, Werner W; Nigg, Erich A; Montoya, Guillermo; Hickson, Ian D (2017). A novel TPR-BEN domain interaction mediates PICH-BEND3 association. Nucleic acids research, , 12.
Domingues, Patrícia Henriques; Nanduri, Lalitha S. Y.; Seget, Katarzyna; Venkateswaran, Sharavan V.; Agorku, David; Viganó, Cristina; von Schubert, Conrad; Nigg, Erich A.; Swanton, Charles; Sotillo, Rocio; Bosio, Andreas; Storchová, Zuzana; Hardt, Olaf (2017). Cellular prion protein PRPC and ecto-5'-nucleotidase are markers of the cellular stress response to aneuploidy. Cancer Research, 77(11), 2914-2926.
Fava, Luca L.; Schuler, Fabian; Sladky, Valentina; Haschka, Manuel D.; Soratroi, Claudia; Eiterer, Lisa; Demetz, Egon; Weiss, Guenter; Geley, Stephan; Nigg, Erich A.; Villunger, Andreas (2017). The PIDDosome activates p53 in response to supernumerary centrosomes. Genes & Development, 31(1), 34-45.
2016
Arquint, Christian; Nigg, Erich A (2016). The PLK4-STIL-SAS-6 module at the core of centriole duplication. Biochemical Society transactions, 44(5), 1253-1263.
Redli, Patrick M.; Gasic, Ivana; Meraldi, Patrick; Nigg, Erich A.; Santamaria, Anna (2016). The Ska complex promotes Aurora B activity to ensure chromosome biorientation. The Journal of Cell Biology, 215(1), 77-93.
Abad, Maria Alba; Zou, Juan; Medina-Pritchard, Bethan; Nigg, Erich A.; Rappsilber, Juri; Santamaria, Anna; Jeyaprakash, A. Arockia (2016). Ska3 Ensures Timely Mitotic Progression by Interacting Directly With Microtubules and Ska1 Microtubule Binding Domain. Scientific Reports, 6, 34042.
Bauer, Manuel; Cubizolles, Fabien; Schmidt, Alexander; Nigg, Erich A. (2016). Quantitative analysis of human centrosome architecture by targeted proteomics and fluorescence imaging. The EMBO journal, 35(19), 2152-2166.
Ahrné, Erik; Glatter, Timo; Viganò, Cristina; Schubert, Conrad von; Nigg, Erich A.; Schmidt, Alexander (2016). Evaluation and Improvement of Quantification Accuracy in Isobaric Mass Tag-Based Protein Quantification Experiments. Journal of Proteome Research, 15(8), 2537-47.
Nigg, Erich A; Martins, Cesar (2016). 21st International Chromosome Conference-Foz do Iguaçu, Brazil. Chromosoma, 125(3), 353.
Baron, Anna P; von Schubert, Conrad; Cubizolles, Fabien; Siemeister, Gerhard; Hitchcock, Marion; Mengel, Anne; Schröder, Jens; Fernández-Montalván, Amaury; von Nussbaum, Franz; Mumberg, Dominik; Nigg, Erich A (2016). Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524. eLife, 5, e12187.
Schnerch, D; Nigg, E A (2016). Structural centrosome aberrations favor proliferation by abrogating microtubule-dependent tissue integrity of breast epithelial mammospheres. Oncogene, 35(21), 2711-22.
2015
Nielsen, Christian F; Huttner, Diana; Bizard, Anna H; Hirano, Seiki; Li, Tian-Neng; Palmai-Pallag, Timea; Bjerregaard, Victoria A; Liu, Ying; Nigg, Erich A; Wang, Lily Hui-Ching; Hickson, Ian D (2015). PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis. Nature communications, 6, 8962.
Bauer, Manuel; Ahrné, Erik; Baron, Anna P; Glatter, Timo; Fava, Luca L; Santamaria, Anna; Nigg, Erich A; Schmidt, Alexander (2015). Assessment of current mass spectrometric workflows for the quantification of low abundant proteins and phosphorylation sites. Data in brief, 5, 297-304.
Asghar, Adeel; Lajeunesse, Audrey; Dulla, Kalyan; Combes, Guillaume; Thebault, Philippe; Nigg, Erich A; Elowe, Sabine (2015). Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation. Nature communications, 6, 8364.
Arquint, Christian; Gabryjonczyk, Anna-Maria; Imseng, Stefan; Böhm, Raphael; Sauer, Evelyn; Hiller, Sebastian; Nigg, Erich A; Maier, Timm (2015). STIL binding to Polo-box 3 of PLK4 regulates centriole duplication. eLife, 4, e07888.
von Schubert, Conrad; Cubizolles, Fabien; Bracher, Jasmine M; Sliedrecht, Tale; Kops, Geert J P L; Nigg, Erich A (2015). Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells. Cell reports, 12(1), 66-78.
Affolter, Markus; Nigg, Erich A. (2015). In memoriam - Walter J. Gehring. Chromosoma, 124(3), 291-291.
Floriot, Sandrine; Vesque, Christine; Rodriguez, Sabrina; Bourgain-Guglielmetti, Florence; Karaiskou, Anthi; Gautier, Mathieu; Duchesne, Amandine; Barbey, Sarah; Fritz, Sébastien; Vasilescu, Alexandre; Bertaud, Maud; Moudjou, Mohammed; Halliez, Sophie; Cormier-Daire, Valérie; E L Hokayem, Joyce; Nigg, Erich A; Manciaux, Luc; Guatteo, Raphaël; Cesbron, Nora; Toutirais, Geraldine; Eggen, André; Schneider-Maunoury, Sylvie; Boichard, Didier; Sobczak-Thépot, Joelle; Schibler, Laurent (2015). C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle. Nature communications, 6, 6894.
Cajanek, Lukas; Glatter, Timo; Nigg, Erich A. (2015). The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis. Journal of Cell Science, 128(9), 1674-1682.
2014
Bauer, Manuel; Ahrné, Erik; Baron, Anna P; Glatter, Timo; Fava, Luca L; Santamaria, Anna; Nigg, Erich A; Schmidt, Alexander (2014). Evaluation of data-dependent and -independent mass spectrometric workflows for sensitive quantification of proteins and phosphorylation sites. Journal of proteome research, 13(12), 5973-88.
Arquint, Christian; Gabryjonczyk, Anna-Maria; Nigg, Erich A. (2014). Centrosomes as signalling centres. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 369(1650), 12.
Č ajánek, Lukáš ; Nigg, Erich A (2014). Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole. Proceedings of the National Academy of Sciences of the United States of America, 111(28), E2841-50.
Nigg, Erich A.; Cajanek, Lukas; Arquint, Christian (2014). The centrosome duplication cycle in health and disease. FEBS letters, 588(15), 2366-2372.
Nigg, Erich A (2014). Seventy-five years of Chromosoma: Ivory Towers, citation metrics, and longevity of research. Chromosoma, 123(1-2), 1-2.
Nigg, Erich A. (2014). STIL Microcephaly Mutations Interfere with APC/C-Mediated Degradation and Cause Centriole Amplification. Current biology, 24(4), 351-60.
Abad, Maria Alba; Medina, Bethan; Santamaria, Anna; Zou, Juan; Plasberg-Hill, Carla; Madhumalar, Arumugam; Jayachandran, Uma; Redli, Patrick Marc; Rappsilber, Juri; Nigg, Erich A; Jeyaprakash, A Arockia (2014). Structural basis for microtubule recognition by the human kinetochore Ska complex. Nature communications, 5, 2964.
2013
Bhogaraju, Sagar; Cajanek, Lukas; Fort, Cécile; Blisnick, Thierry; Weber, Kristina; Taschner, Michael; Mizuno, Naoko; Lamla, Stefan; Bastin, Philippe; Nigg, Erich A; Lorentzen, Esben (2013). Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. Science, 341(6149), 1009-12.
Biebricher, Andreas; Hirano, Seiki; Enzlin, Jacqueline H; Wiechens, Nicola; Streicher, Werner W; Huttner, Diana; Wang, Lily H-C; Nigg, Erich A; Owen-Hughes, Tom; Liu, Ying; Peterman, Erwin; Wuite, Gijs J L; Hickson, Ian D (2013). PICH: a DNA Translocase Specially Adapted for Processing Anaphase Bridge DNA. Molecular cell, 51(5), 691-701.
Nunes Bastos, Ricardo; Gandhi, Sapan R; Baron, Ryan D; Gruneberg, Ulrike; Nigg, Erich A; Barr, Francis A (2013). Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A. Journal of cell biology, 202(4), 605-21.
Kasahara, Kousuke; Goto, Hidemasa; Izawa, Ichiro; Kiyono, Tohru; Watanabe, Nobumoto; Elowe, Sabine; Nigg, Erich A; Inagaki, Masaki (2013). PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition. Nature communications, 4, 1882.
Sonnen, Katharina F; Gabryjonczyk, Anna-Maria; Anselm, Eduard; Stierhof, York-Dieter; Nigg, Erich A (2013). Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication. Journal of cell science, 126(Pt 14), 3223-33.
von Schubert, Conrad; Nigg, Erich A. (2013). Polo-like kinases. Current biology, 23(6), R225-R227.
2012
Holland, Andrew J; Fachinetti, Daniele; Zhu, Quan; Bauer, Manuel; Verma, Inder M; Nigg, Erich A; Cleveland, Don W (2012). The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes & development, 26(24), 2684-9.
Kleylein-Sohn, Julia; Pöllinger, Bernadette; Ohmer, Michaela; Nigg, Erich A; Hemmings, Brian A; Wartmann, Markus (2012). Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET. Journal of cell science, , 38.
Kaulich, Manuel; Cubizolles, Fabien; Nigg, Erich A (2012). On the regulation, function, and localization of the DNA-dependent ATPase PICH. Chromosoma, , 14.
Jeyaprakash, A Arockia; Santamaria, Anna; Jayachandran, Uma; Chan, Ying Wai; Benda, Christian; Nigg, Erich A; Conti, Elena (2012). Structural and Functional Organization of the Ska Complex, a Key Component of the Kinetochore-Microtubule Interface. Molecular cell, , 13.
Rojas, Ana M; Santamaria, Anna; Malik, Rainer; Jensen, Thomas Skøt; Körner, Roman; Morilla, Ian; de Juan, David; Krallinger, Martin; Hansen, Daniel Aaen; Hoffmann, Robert; Lees, Jonathan; Reid, Adam; Yeats, Corin; Wehner, Anja; Elowe, Sabine; Clegg, Andrew B; Brunak, Søren; Nigg, Erich A; Orengo, Christine; Valencia, Alfonso; Ranea, Juan A G (2012). Uncovering the molecular machinery of the human spindle-an integration of wet and dry systems biology. PloS one, 7(3), e31813.
Arquint, Christian; Sonnen, Katharina F; Stierhof, York-Dieter; Nigg, Erich A (2012). Cell-cycle-regulated expression of STIL controls centriole number in human cells. Journal of cell science, 125, 1-11.
Fairley, Jennifer A; Mitchell, Louise E; Berg, Tracy; Kenneth, Niall S; von Schubert, Conrad; Silljé, Herman H W; Medema, René H; Nigg, Erich A; White, Robert J (2012). Direct Regulation of tRNA and 5S rRNA Gene Transcription by Polo-like Kinase 1. Molecular cell, , 12.
Sonnen, Katharina F; Schermelleh, Lothar; Leonhardt, Heinrich; Nigg, Erich A (2012). 3D-structured illumination microscopy provides novel insight into architecture of human centrosomes. Biology open, 1(10), 965-76.
2011
Nigg, Erich A; Stearns, Tim (2011). The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries. Nature cell biology, 13(10), 1154-60.
Fava, Luca L; Kaulich, Manuel; Nigg, Erich A; Santamaria, Anna (2011). Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint. The EMBO journal, 30(16), 3322-36.
Alexander, Jes; Lim, Daniel; Joughin, Brian A; Hegemann, Björn; Hutchins, James R A; Ehrenberger, Tobias; Ivins, Frank; Sessa, Fabio; Hudecz, Otto; Nigg, Erich A; Fry, Andrew M; Musacchio, Andrea; Stukenberg, P Todd; Mechtler, Karl; Peters, Jan-Michael; Smerdon, Stephen J; Yaffe, Michael B (2011). Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Science Signaling, 4(179), ra42.
Dou, Zhen; von Schubert, Conrad; Körner, Roman; Santamaria, Anna; Elowe, Sabine; Nigg, Erich A (2011). Quantitative Mass Spectrometry Analysis Reveals Similar Substrate Consensus Motif for Human Mps1 Kinase and Plk1. PLoS one, 6(4), e18793.
Jakobsen, Lis; Vanselow, Katja; Skogs, Marie; Toyoda, Yusuke; Lundberg, Emma; Poser, Ina; Falkenby, Lasse G; Bennetzen, Martin; Westendorf, Jens; Nigg, Erich A; Uhlen, Mathias; Hyman, Anthony A; Andersen, Jens S (2011). Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. The EMBO journal, 30(8), 1520-35.
Santamaria, Anna; Wang, Bin; Elowe, Sabine; Malik, Rainer; Zhang, Feng; Bauer, Manuel; Schmidt, Alexander; Silljé, Herman H W; Körner, Roman; Nigg, Erich A (2011). The Plk1-dependent phosphoproteome of the early mitotic spindle. Molecular & cellular proteomics, 10(1), M110.004457.
2010
von Schubert, Conrad; Xue, Gongda; Schmuckli-Maurer, Jacqueline; Woods, Kerry L; Nigg, Erich A; Dobbelaere, Dirk A E (2010). The transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells. PLoS Biology, 8(9)
Guderian, Gernot; Westendorf, Jens; Uldschmid, Andreas; Nigg, Erich A (2010). Plk4 trans-autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation. Journal of cell science, 123(Pt 13), 2163-9.
Wang, Lily Hui-Ching; Mayer, Bernd; Stemmann, Olaf; Nigg, Erich A (2010). Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division. Journal of cell science, 123(Pt 5), 806-13.
Dulla, Kalyan; Daub, Henrik; Hornberger, Renate; Nigg, Erich A; Körner, Roman (2010). Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression. Molecular & cellular proteomics, 9(6), 1167-81.
Malik, Rainer; Dulla, Kalyan; Nigg, Erich A; Körner, Roman (2010). From proteome lists to biological impact tools and strategies for the analysis of large MS data sets. Proteomics, 10(6), 1270-83.
Olsen, Jesper V; Vermeulen, Michiel; Santamaria, Anna; Kumar, Chanchal; Miller, Martin L; Jensen, Lars J; Gnad, Florian; Cox, Jürgen; Jensen, Thomas S; Nigg, Erich A; Brunak, Søren; Mann, Matthias (2010). Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Science Signaling, 3(104), ra3.
Elowe, Sabine; Dulla, Kalyan; Uldschmid, Andreas; Li, Xiuling; Dou, Zhen; Nigg, Erich A (2010). Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1. Journal of cell science, 123(Pt 1), 84-94.
Hübner, Nadja C; Wang, Lily Hui-Ching; Kaulich, Manuel; Descombes, Patrick; Poser, Ina; Nigg, Erich A (2010). Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs. Chromosoma, 119(2), 149-65.
2009
Nigg, Erich A; Raff, Jordan W (2009). Centrioles, centrosomes, and cilia in health and disease. Cell, 139(4), 663-78.
Klein, Ulf R.; Nigg, Erich A. (2009). SUMO-dependent regulation of centrin-2. Journal of cell science, 122(18), 3312-3321.
Malik, Rainer; Lenobel, René; Santamaria, Anna; Ries, Albert; Nigg, Erich A; Körner, Roman (2009). Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. Journal of Proteome Research, 8(10), 4553-63.
Klein, Ulf R.; Haindl, Markus; Nigg, Erich A.; Muller, Stefan (2009). RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin. Molecular Biology of the Cell, 20(1), 410-8.
Nigg, Erich A. (2009). Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3. The EMBO journal, 28(10), 1442-52.
Chan, Ying Wai; Fava, Luca L; Uldschmid, Andreas; Schmitz, Michael H A; Gerlich, Daniel W; Nigg, Erich A; Santamaria, Anna (2009). Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. The Journal of cell biology, 185(5), 859-74.
Schmidt, Thorsten I; Kleylein-Sohn, Julia; Westendorf, Jens; Le Clech, Mikael; Lavoie, Sébastien B; Stierhof, York-Dieter; Nigg, Erich A (2009). Control of Centriole Length by CPAP and CP110. Current biology, 19(12), 1005-11.
2008
Wang, Bin; Malik, Rainer; Nigg, Erich A; Körner, Roman (2008). Evaluation of the Low-Specificity Protease Elastase for Large-Scale Phosphoproteome Analysis. Analytical chemistry, 80(24), 9526-33.
Wang, Lily Hui-Ching; Schwarzbraun, Thomas; Speicher, Michael R; Nigg, Erich A (2008). Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation. Chromosoma, 117(2), 123-35.
Chan, Eunice H Y; Santamaria, Anna; Silljé, Herman H W; Nigg, Erich A (2008). Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora. Chromosoma, 117(5), 457-69.
Malik, Rainer; Nigg, Erich A; Körner, Roman (2008). Comparative conservation analysis of the human mitotic phosphoproteome. Bioinformatics, 24(12), 1426-32.
Santamaria, Anna; Nagel, Susanna; Sillje, Herman H W; Nigg, Erich A (2008). The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle. Current biology, 18(10), 723-9.
2007
Santamaria, Anna; Neef, Rüdiger; Eberspächer, Uwe; Eis, Knut; Husemann, Manfred; Mumberg, Dominik; Prechtl, Stefan; Schulze, Volker; Siemeister, Gerhard; Wortmann, Lars; Barr, Francis A.; Nigg, Erich A. (2007). Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis. Molecular Biology of the Cell, 18(10), 4024-4036.
Thein, Kerstin H; Kleylein-Sohn, Julia; Nigg, Erich A; Gruneberg, Ulrike (2007). Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity. The Journal of cell biology, 178(3), 345-54.
Graser, Susanne; Stierhof, York-Dieter; Lavoie, Sébastien B; Gassner, Oliver S; Lamla, Stefan; Le Clech, Mikael; Nigg, Erich A (2007). Cep164, a novel centriole appendage protein required for primary cilium formation. The Journal of cell biology, 179(2), 321-30.
Baumann, Christoph; Körner, Roman; Hofmann, Kay; Nigg, Erich A (2007). PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. Cell, 128(1), 101-14.
Hergovich, Alexander; Lamla, Stefan; Nigg, Erich A; Hemmings, Brian A (2007). Centrosome-associated NDR kinase regulates centrosome duplication. Molecular cell, 25(4), 625-34.
Neef, Rüdiger; Gruneberg, Ulrike; Kopajtich, Robert; Li, Xiuling; Nigg, Erich A; Sillje, Herman; Barr, Francis A (2007). Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1. Nature Cell Biology, 9(4), 436-44.
Nigg, Erich A (2007). Centrosome duplication : of rules and licenses. Trends in cell biology, 17(5), 215-21.
Duensing, A; Liu, Y; Perdreau, S A; Kleylein-Sohn, J; Nigg, E A; Duensing, S (2007). Centriole overduplication through the concurrent formation of multiple daughter centrioles at single maternal templates. Oncogene, 26(43), 6280-8.
Ray-Gallet, Dominique; Quivy, Jean-Pierre; Silljé, Herman W W; Nigg, Erich A; Almouzni, Geneviève (2007). The histone chaperone Asf1 is dispensable for direct de novo histone deposition in Xenopus egg extracts. Chromosoma, 116(5), 487-96.
Kleylein-Sohn, Julia; Westendorf, Jens; Le Clech, Mikael; Habedanck, Robert; Stierhof, York-Dieter; Nigg, Erich A (2007). Plk4-induced centriole biogenesis in human cells. Developmental cell, 13(2), 190-202.
Elowe, Sabine; Hümmer, Stefan; Uldschmid, Andreas; Li, Xiuling; Nigg, Erich A (2007). Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions. Genes & development, 21(17), 2205-19.
Jeyaprakash, A Arockia; Klein, Ulf R; Lindner, Doris; Ebert, Judith; Nigg, Erich A; Conti, Elena (2007). Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell, 131(2), 271-85.
Graser, Susanne; Stierhof, York-Dieter; Nigg, Erich A (2007). Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion. Journal of cell science, 120(Pt 24), 4321-31.
2006
Hanisch, Anja; Wehner, Anja; Nigg, Erich A.; Silljé, Herman H. W. (2006). Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting. Molecular Biology of the Cell, 17(1), 448-59.
Yan, Xiumin; Habedanck, Robert; Nigg, Erich A. (2006). A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. Molecular Biology of the Cell, 17(2), 634-644.
Klein, Ulf R.; Nigg, Erich A.; Gruneberg, Ulrike (2006). Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP. Molecular Biology of the Cell, 17(6), 2547-58.
Gruneberg, Ulrike; Neef, Rüdiger; Li, Xiuling; Chan, Eunice H Y; Chalamalasetty, Ravindra B; Nigg, Erich A; Barr, Francis A (2006). KIF14 and citron kinase act together to promote efficient cytokinesis. The Journal of cell biology, 172(3), 363-72.
Tachibana, Kiku-e K; Nigg, Erich A (2006). Geminin regulates multiple steps of the chromosome inheritance cycle. Cell cycle, 5(2), 151-4.
Badouel, Caroline; Körner, Roman; Frank-Vaillant, Marie; Couturier, Anne; Nigg, Erich A; Tassan, Jean-Pierre (2006). M-phase MELK activity is regulated by MPF and MAPK. Cell cycle, 5(8), 883-9.
Silljé, Herman H W; Nigg, Erich A (2006). Purification of mitotic spindles from cultured human cells. Methods, 38(1), 25-8.
Nigg, Erich A (2006). Origins and consequences of centrosome aberrations in human cancers. International journal of cancer, 119(12), 2717-23.
Goto, Hidemasa; Kiyono, Tohru; Tomono, Yasuko; Kawajiri, Aie; Urano, Takeshi; Furukawa, Koichi; Nigg, Erich A; Inagaki, Masaki (2006). Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. Nature Cell Biology, 8(2), 180-7.
Schmidt, Andreas; Rauh, Nadine R; Nigg, Erich A; Mayer, Thomas U (2006). Cytostatic factor : an activity that puts the cell cycle on hold. Journal of cell science, 119(Pt 7), 1213-8.
Nousiainen, Marjaana; Silljé, Herman H W; Sauer, Guido; Nigg, Erich A; Körner, Roman (2006). Phosphoproteome analysis of the human mitotic spindle. Proceedings of the National Academy of Sciences of the United States of America, 103(14), 5391-6.
Silljé, Herman H W; Nagel, Susanna; Körner, Roman; Nigg, Erich A (2006). HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Current biology, 16(8), 731-42.
Sayer, John A; Otto, Edgar A; O'Toole, John F; Nurnberg, Gudrun; Kennedy, Michael A; Becker, Christian; Hennies, Hans Christian; Helou, Juliana; Attanasio, Massimo; Fausett, Blake V; Utsch, Boris; Khanna, Hemant; Liu, Yan; Drummond, Iain; Kawakami, Isao; Kusakabe, Takehiro; Tsuda, Motoyuki; Ma, Li; Lee, Hwankyu; Larson, Ronald G; Allen, Susan J; Wilkinson, Christopher J; Nigg, Erich A; Shou, Chengchao; Lillo, Concepcion; Williams, David S; Hoppe, Bernd; Kemper, Markus J; Neuhaus, Thomas; Parisi, Melissa A; Glass, Ian A; Petry, Marianne; Kispert, Andreas; Gloy, Joachim; Ganner, Athina; Walz, Gerd; Zhu, Xueliang; Goldman, Daniel; Nurnberg, Peter; Swaroop, Anand; Leroux, Michel R; Hildebrandt, Friedhelm (2006). The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nature genetics, 38(6), 674-81.
Mikolajka, Aleksandra; Yan, Xiumin; Popowicz, Grzegorz M; Smialowski, Pawel; Nigg, Erich A; Holak, Tad A (2006). Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. Journal of molecular biology, 359(4), 863-75.
Chalamalasetty, Ravindra B; Hümmer, Stefan; Nigg, Erich A; Silljé, Herman H W (2006). Influence of human Ect2 depletion and overexpression on cleavage furrow formation and abscission. Journal of cell science, 119(Pt 14), 3008-19.
Nigg, Erich A (2006). Cell biology : a licence for duplication. Nature, 442(7105), 874-5.
Hanisch, Anja; Silljé, Herman H W; Nigg, Erich A (2006). Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. The EMBO journal, 25(23), 5504-15.
2005
Guarguaglini, Giulia; Duncan, Peter I.; Stierhof, York D.; Holmström, Tim; Duensing, Stefan; Nigg, Erich A. (2005). The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles. Molecular Biology of the Cell, 16(3), 1095-1107.
Mayer, Thomas U. (2005). Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity. Genes & development, 19(4), 502-13.
Mayer, Thomas U. (2005). Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation. Nature, 437(7061), 1048-52.
Khanna, Kum Kum (2005). Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Developmental cell, 9(4), 477-88.
Bahe, Susanne; Stierhof, York-Dieter; Wilkinson, Christopher J; Leiss, Florian; Nigg, Erich A (2005). Rootletin forms centriole-associated filaments and functions in centrosome cohesion. The Journal of cell biology, 171(1), 27-33.
Yamaguchi, Tomoya; Goto, Hidemasa; Yokoyama, Tomoya; Silljé, Herman; Hanisch, Anja; Uldschmid, Andreas; Takai, Yasushi; Oguri, Takashi; Nigg, Erich A; Inagaki, Masaki (2005). Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis. The Journal of cell biology, 171(3), 431-6.
Sauer, Guido; Körner, Roman; Hanisch, Anja; Ries, Albert; Nigg, Erich A; Silljé, Herman H W (2005). Proteome analysis of the human mitotic spindle. Molecular & cellular proteomics, 4(1), 35-43.
Rapley, Joseph; Baxter, Joanne E; Blot, Joelle; Wattam, Samantha L; Casenghi, Martina; Meraldi, Patrick; Nigg, Erich A; Fry, Andrew M (2005). Coordinate regulation of the mother centriole component nlp by nek2 and plk1 protein kinases. Molecular and cellular biology, 25(4), 1309-24.
Chan, Eunice H Y; Nousiainen, Marjaana; Chalamalasetty, Ravindra B; Schäfer, Anja; Nigg, Erich A; Silljé, Herman H W (2005). The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene, 24(12), 2076-86.
Tachibana, Kiku-e K; Gonzalez, Michael A; Guarguaglini, Giulia; Nigg, Erich A; Laskey, Ronald A (2005). Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects. EMBO reports, 6(11), 1052-7.
Habedanck, Robert; Stierhof, York-Dieter; Wilkinson, Christopher J; Nigg, Erich A (2005). The Polo kinase Plk4 functions in centriole duplication. Nature Cell Biology, 7(11), 1140-6.
Casenghi, Martina; Barr, Francis A; Nigg, Erich A (2005). Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome. Journal of cell science, 118(Pt 21), 5101-8.
2004
Gassmann, Reto; Carvalho, Ana; Henzing, Alexander J; Ruchaud, Sandrine; Hudson, Damien F; Honda, Reiko; Nigg, Erich A; Gerloff, Dietlind L; Earnshaw, William C (2004). Borealin : a novel chromosomal passenger required for stability of the bipolar mitotic spindle. The Journal of cell biology, 166(2), 179-91.
Gruneberg, Ulrike; Neef, Rüdiger; Honda, Reiko; Nigg, Erich A; Barr, Francis A (2004). Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. The Journal of cell biology, 166(2), 167-72.
Fletcher, Lynda; Cerniglia, George J; Nigg, Erich A; Yend, Tim J; Muschel, Ruth J (2004). Inhibition of centrosome separation after DNA damage : a role for Nek2. Radiation research, 162(2), 128-35.
Steensgaard, Peter; Garrè, Massimiliano; Muradore, Ivan; Transidico, Pietro; Nigg, Erich A; Kitagawa, Katsumi; Earnshaw, William C; Faretta, Mario; Musacchio, Andrea (2004). Sgt1 is required for human kinetochore assembly. EMBO reports, 5(6), 626-31.
Barr, Francis A; Silljé, Herman H W; Nigg, Erich A (2004). Polo-like kinases and the orchestration of cell division. Nature reviews. Molecular cell biology, 5(6), 429-40.
Meraldi, Patrick; Honda, Reiko; Nigg, Erich A (2004). Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Current opinion in genetics & development, 14(1), 29-36.
Stucke, Volker M; Baumann, Christoph; Nigg, Erich A (2004). Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1. Chromosoma, 113(1), 1-15.
Mishima, Masanori; Pavicic, Visnja; Grüneberg, Ulrike; Nigg, Erich A; Glotzer, Michael (2004). Cell cycle regulation of central spindle assembly. Nature, 430(7002), 908-13.
Krämer, Alwin; Mailand, Niels; Lukas, Claudia; Syljuåsen, Randi G; Wilkinson, Christopher J; Nigg, Erich A; Bartek, Jiri; Lukas, Jiri (2004). Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nature cell biology, 6(9), 884-91.
Sasai, Kaori; Katayama, Hiroshi; Stenoien, David L; Fujii, Satoshi; Honda, Reiko; Kimura, Masashi; Okano, Yukio; Tatsuka, Masaaki; Suzuki, Fumio; Nigg, Erich A; Earnshaw, William C; Brinkley, William R; Sen, Subrata (2004). Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motility And The Cytoskeleton, 59(4), 249-63.
2003
Honda, Reiko; Körner, Roman; Nigg, Erich A. (2003). Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Molecular Biology of the Cell, 14(8), 3325-41.
Neef, Rüdiger; Preisinger, Christian; Sutcliffe, Josephine; Kopajtich, Robert; Nigg, Erich A; Mayer, Thomas U; Barr, Francis A (2003). Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. The Journal of cell biology, 162(5), 863-75.
Casenghi, Martina; Meraldi, Patrick; Weinhart, Ulrike; Duncan, Peter I; Körner, Roman; Nigg, Erich A (2003). Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Developmental cell, 5(1), 113-25.
Silljé, Herman H W; Nigg, Erich A (2003). Capturing polo kinase. Science, 299(5610), 1190-1.
Jackman, Mark; Lindon, Catherine; Nigg, Erich A; Pines, Jonathon (2003). Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nature Cell Biology, 5(2), 143-8.
Goto, Hidemasa; Yasui, Yoshihiro; Kawajiri, Aie; Nigg, Erich A; Terada, Yasuhiko; Tatsuka, Masaaki; Nagata, Koh-ichi; Inagaki, Masaki (2003). Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. Journal of biological chemistry, 278(10), 8526-30.
Groth, Anja; Lukas, Jiri; Nigg, Erich A; Silljé, Herman H W; Wernstedt, Christer; Bartek, Jiri; Hansen, Klaus (2003). Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. The EMBO journal, 22(7), 1676-87.
Gruneberg, Ulrike; Nigg, Erich A (2003). Regulation of cell division : stop the SIN!. Trends in cell biology, 13(4), 159-62.
Krause, Darren R; Jonnalagadda, Jyoti C; Gatei, Magtouf H; Sillje, Herman H W; Zhou, Bin-Bing; Nigg, Erich A; Khanna, Kumkum (2003). Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. Oncogene, 22(38), 5927-37.
Carrera, Pilar; Moshkin, Yuri M; Gronke, Sebastian; Sillje, Herman H W; Nigg, Erich A; Jackle, Herbert; Karch, Francois (2003). Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions. Genes & development, 17(20), 2578-90.
Cheng, Kin-Yip; Lowe, Edward D; Sinclair, John; Nigg, Erich A; Johnson, Louise N (2003). The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex. The EMBO journal, 22(21), 5757-68.
Kufer, Thomas A; Nigg, Erich A; Silljé, Herman H W (2003). Regulation of Aurora-A kinase on the mitotic spindle. Chromosoma, 112(4), 159-63.
Andersen, Jens S; Wilkinson, Christopher J; Mayor, Thibault; Mortensen, Peter; Nigg, Erich A; Mann, Matthias (2003). Proteomic characterization of the human centrosome by protein correlation profiling. Nature, 426(6966), 570-4.
2002
Nigg, Erich A. (2002). Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science, 297(5590), 2267-70.
Nigg, Erich A. (2002). Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. The EMBO journal, 21(4), 483-492.
Heitlinger, E; Peter, M; Lustig, A; Villiger, W; Nigg, E A; Aebi, U (2002). The role of the head and tail domain in lamin structure and assembly : analysis of bacterially expressed chicken lamin A and truncated B2 lamins. Journal of structural biology, 108(1), 74-89.
Meraldi, P; Nigg, E A (2002). The centrosome cycle. FEBS letters, 521(1-3), 9-13.
Kufer, Thomas A; Silljé, Herman H W; Körner, Roman; Gruss, Oliver J; Meraldi, Patrick; Nigg, Erich A (2002). Human TPX2 is required for targeting Aurora-A kinase to the spindle. The Journal of cell biology, 158(4), 617-23.
Gruneberg, U; Glotzer, M; Gartner, A; Nigg, EA (2002). The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo. The Journal of cell biology, 158(5), 901-914.
Wind, Mathias; Kelm, Olaf; Nigg, Erich A; Lehmann, Wolf D (2002). Identification of phosphorylation sites in the polo-like kinases Plx1 and Plk1 by a novel strategy based on element and electrospray high resolution mass spectrometry. Proteomics, 2(11), 1516-23.
Nigg, Erich A (2002). Centrosome aberrations : cause or consequence of cancer progression?. Nature reviews. Cancer, 2(11), 815-25.
Goto, Hidemasa; Yasui, Yoshihiro; Nigg, Erich A; Inagaki, Masaki (2002). Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. Genes to cells, 7(1), 11-7.
Mello, Jill A; Silljé, Herman H W; Roche, Daniele M J; Kirschner, Doris B; Nigg, Erich A; Almouzni, Geneviève (2002). Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway. EMBO reports, 3(4), 329-34.
Stucke, Volker M; Silljé, Herman H W; Arnaud, Lionel; Nigg, Erich A (2002). Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication. The EMBO journal, 21(7), 1723-32.
Sumara, Izabela; Vorlaufer, Elisabeth; Stukenberg, P Todd; Kelm, Olaf; Redemann, Norbert; Nigg, Erich A; Peters, Jan-Michael (2002). The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Molecular cell, 9(3), 515-25.
Kelm, Olaf; Wind, Mathias; Lehmann, Wolf D; Nigg, Erich A (2002). Cell cycle-regulated phosphorylation of the Xenopus polo-like kinase Plx1. Journal of biological chemistry, 277(28), 25247-56.
Mayor, Thibault; Hacker, Ulrike; Stierhof, York-Dieter; Nigg, Erich A (2002). The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles. Journal of cell science, 115(Pt 16), 3275-84.
2001
Nigg, E A (2001). Cell cycle regulation by protein kinases and phosphatases. Ernst Schering Research Foundation workshop, 1(34), 19-46.
Araújo, S J; Nigg, E A; Wood, R D (2001). Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome. Molecular and cellular biology, 21(7), 2281-91.
Nigg, E A (2001). Mitotic kinases as regulators of cell division and its checkpoints. Nature reviews. Molecular cell biology, 2(1), 21-32.
Silljé, H H; Nigg, E A (2001). Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. Current biology, 11(13), 1068-73.
Donaldson, M M; Tavares, A A; Hagan, I M; Nigg, E A; Glover, D M (2001). The mitotic roles of Polo-like kinase. Journal of cell science, 114(Pt 13), 2357-8.
Duncan, P I; Pollet, N; Niehrs, C; Nigg, E A (2001). Cloning and characterization of Plx2 and Plx3, two additional Polo-like kinases from Xenopus laevis. Experimental cell research, 270(1), 78-87.
Meraldi, P; Nigg, E A (2001). Centrosome cohesion is regulated by a balance of kinase and phosphatase activities. Journal of cell science, 114(Pt 20), 3749-57.
2000
Mayor, T; Stierhof, YD; Tanaka, K; Fry, AM; Nigg, EA (2000). The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion. The Journal of cell biology, 151(4), 837-846.
Pahlavan, G; Polanski, Z; Kalab, P; Golsteyn, R; Nigg, E A; Maro, B (2000). Characterization of polo-like kinase 1 during meiotic maturation of the mouse oocyte. Developmental biology, 220(2), 392-400.
Fry, A M; Mayor, T; Nigg, E A (2000). Regulating centrosomes by protein phosphorylation. Current topics in developmental biology, 49, 291-312.
Fry, A M; Descombes, P; Twomey, C; Bacchieri, R; Nigg, E A (2000). The NIMA-related kinase X-Nek2B is required for efficient assembly of the zygotic centrosome in Xenopus laevis. Journal of cell science, 113 ( Pt 11)(11), 1973-84.
Smits, V A; Klompmaker, R; Arnaud, L; Rijksen, G; Nigg, E A; Medema, R H (2000). Polo-like kinase-1 is a target of the DNA damage checkpoint. Nature Cell Biology, 2(9), 672-6.
1999
Tanaka, K; Nigg, E A (1999). Cloning and characterization of the murine Nek3 protein kinase, a novel member of the NIMA family of putative cell cycle regulators. Journal of biological chemistry, 274(19), 13491-7.
Fry, A M; Arnaud, L; Nigg, E A (1999). Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motif. Journal of biological chemistry, 274(23), 16304-10.
Mayor, T; Meraldi, P; Stierhof, Y D; Nigg, E A; Fry, A M (1999). Protein kinases in control of the centrosome cycle. FEBS letters, 452(1-2), 92-5.
Silljé, H H; Takahashi, K; Tanaka, K; Van Houwe, G; Nigg, E A (1999). Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. The EMBO journal, 18(20), 5691-702.
Meraldi, P; Lukas, J; Fry, A M; Bartek, J; Nigg, E A (1999). Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nature Cell Biology, 1(2), 88-93.
1998
Nigg, E. A. (1998). GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes. Chromosoma, 107(6-7), 424-9.
Nigg, E A (1998). Polo-like kinases : positive regulators of cell division from start to finish. Current opinion in cell biology, 10(6), 776-83.
Fry, A M; Mayor, T; Meraldi, P; Stierhof, Y D; Tanaka, K; Nigg, E A (1998). C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. The Journal of cell biology, 141(7), 1563-74.
Fry, A M; Meraldi, P; Nigg, E A (1998). A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators. The EMBO journal, 17(2), 470-81.
Marshall, C J; Nigg, E A (1998). Oncogenes and cell proliferation cancer genes : lessons from genetics and biochemistry. Current opinion in genetics & development, 8(1), 11-3.
Descombes, P; Nigg, E A (1998). The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts. The EMBO journal, 17(5), 1328-35.
Blangy, A; Chaussepied, P; Nigg, E A (1998). Rigor-type mutation in the kinesin-related protein HsEg5 changes its subcellular localization and induces microtubule bundling. Cell Motility And The Cytoskeleton, 40(2), 174-82.
1997
Fry, A M; Nigg, E A (1997). Characterization of mammalian NIMA-related kinases. Methods in enzymology, 283, 270-82.
Lane, H A; Nigg, E A (1997). Cell-cycle control : POLO-like kinases join the outer circle. Trends in cell biology, 7(2), 63-8.
Nigg, E A (1997). Nucleocytoplasmic transport : signals, mechanisms and regulation. Nature, 386(6627), 779-87.
Blangy, A; Arnaud, L; Nigg, E A (1997). Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150. Journal of biological chemistry, 272(31), 19418-24.
Mundt, K E; Golsteyn, R M; Lane, H A; Nigg, E A (1997). On the regulation and function of human polo-like kinase 1 (PLK1) : effects of overexpression on cell cycle progression. Biochemical and Biophysical Research Communications, 239(2), 377-85.
Tanaka, K; Parvinen, M; Nigg, E A (1997). The in vivo expression pattern of mouse Nek2, a NIMA-related kinase, indicates a role in both mitosis and meiosis. Experimental cell research, 237(2), 264-74.
1996
Leclerc, V.; Tassan, J. P.; O'Farrell, P. H.; Nigg, E. A.; Léopold, P. (1996). Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II. Molecular Biology of the Cell, 7(4), 505-13.
Gold, M. O.; Tassan, J. P.; Nigg, E. A.; Rice, A. P.; Herrmann, C. H. (1996). Viral transactivators E1A and VP16 interact with a large complex that is associated with CTD kinase activity and contains CDK8. Nucleic Acids Research, 24(19), 3771-7.
Lane, H A; Nigg, E A (1996). Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes. The Journal of cell biology, 135(6 Pt 2), 1701-13.
Nigg, E A (1996). Cyclin-dependent kinase 7 : at the cross-roads of transcription, DNA repair and cell cycle control?. Current opinion in cell biology, 8(3), 312-7.
Golsteyn, R M; Lane, H A; Mundt, K E; Arnaud, L; Nigg, E A (1996). The family of polo-like kinases. Progress in cell cycle research, 2, 107-14.
Adamczewski, J P; Rossignol, M; Tassan, J P; Nigg, E A; Moncollin, V; Egly, J M (1996). MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH. The EMBO journal, 15(8), 1877-84.
Nigg, E A; Blangy, A; Lane, H A (1996). Dynamic changes in nuclear architecture during mitosis : on the role of protein phosphorylation in spindle assembly and chromosome segregation. Experimental cell research, 229(2), 174-80.
1995
Golsteyn, R M; Mundt, K E; Fry, A M; Nigg, E A (1995). Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function. The Journal of cell biology, 129(6), 1617-28.
DEVAULT, A; MARTINEZ, AM; FESQUET, D; LABBE, JC; MORIN, N; TASSAN, JP; NIGG, EA; CAVADORE, JC; DOREE, M (1995). MAT1 ('menage à trois') a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK. The EMBO journal, 14(20), 5027-5036.
Gallant, P; Fry, A M; Nigg, E A (1995). Protein kinases in the control of mitosis : focus on nucleocytoplasmic trafficking. Journal of cell science. Supplement, 19, 21-8.
Zucca, E; Nigg, E A (1995). Cell cycle regulation and the function of cancer genes. Annals of oncology, 6(10), 975-8.
Fry, A M; Nigg, E A (1995). Cell cycle : the NIMA kinase joins forces with Cdc2. Current biology, 5(10), 1122-5.
Fry, A M; Schultz, S J; Bartek, J; Nigg, E A (1995). Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans. Journal of biological chemistry, 270(21), 12899-905.
Nigg, E A (1995). Cyclin-dependent protein kinases : key regulators of the eukaryotic cell cycle. Bioessays, 17(6), 471-80.
Tassan, J P; Jaquenoud, M; Léopold, P; Schultz, S J; Nigg, E A (1995). Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. Proceedings of the National Academy of Sciences of the United States of America, 92(19), 8871-5.
Ossipow, V; Tassan, J P; Nigg, E A; Schibler, U (1995). A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation. Cell, 83(1), 137-46.
Tassan, J P; Jaquenoud, M; Fry, A M; Frutiger, S; Hughes, G J; Nigg, E A (1995). In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein. The EMBO journal, 14(22), 5608-17.
Blangy, A; Lane, H A; d'Hérin, P; Harper, M; Kress, M; Nigg, E A (1995). Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell, 83(7), 1159-69.
1994
Tassan, J P; Schultz, S J; Bartek, J; Nigg, E A (1994). Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase). The Journal of cell biology, 127(2), 467-78.
Schultz, S J; Fry, A M; Sütterlin, C; Ried, T; Nigg, E A (1994). Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. Cell growth & differentiation, 5(6), 625-35.
Gallant, P; Nigg, E A (1994). Identification of a novel vertebrate cyclin : cyclin B3 shares properties with both A- and B-type cyclins. The EMBO journal, 13(3), 595-605.
Hennekes, H; Nigg, E A (1994). The role of isoprenylation in membrane attachment of nuclear lamins : a single point mutation prevents proteolytic cleavage of the lamin A precursor and confers membrane binding properties. Journal of cell science, 107 ( Pt 4), 1019-29.
Golsteyn, R M; Schultz, S J; Bartek, J; Ziemiecki, A; Ried, T; Nigg, E A (1994). Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5. Journal of cell science, 107 ( Pt 6), 1509-17.
Mäkelä, T P; Tassan, J P; Nigg, E A; Frutiger, S; Hughes, G J; Weinberg, R A (1994). A cyclin associated with the CDK-activating kinase MO15. Nature, 371(6494), 254-7.
Roy, R; Adamczewski, J P; Seroz, T; Vermeulen, W; Tassan, J P; Schaeffer, L; Nigg, E A; Hoeijmakers, J H; Egly, J M (1994). The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor. Cell, 79(6), 1093-101.
1993
Hennekes, H; Peter, M; Weber, K; Nigg, E A (1993). Phosphorylation on protein kinase C sites inhibits nuclear import of lamin B2. The Journal of cell biology, 120(6), 1293-304.
Nigg, E A (1993). Targets of cyclin-dependent protein kinases. Current opinion in cell biology, 5(2), 187-93.
Schmidt-Zachmann, M S; Nigg, E A (1993). Protein localization to the nucleolus : a search for targeting domains in nucleolin. Journal of cell science, 105 ( Pt 3), 799-806.
Schmidt-Zachmann, M S; Dargemont, C; Kühn, L C; Nigg, E A (1993). Nuclear export of proteins : the role of nuclear retention. Cell, 74(3), 493-504.
Nigg, E A (1993). Cellular substrates of p34(cdc2) and its companion cyclin-dependent kinases. Trends in cell biology, 3(9), 296-301.
Schultz, S J; Nigg, E A (1993). Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. Cell growth & differentiation, 4(10), 821-30.
Maridor, G; Gallant, P; Golsteyn, R; Nigg, E A (1993). Nuclear localization of vertebrate cyclin A correlates with its ability to form complexes with cdk catalytic subunits. Journal of cell science, 106 ( Pt 2), 535-44.
1992
Sanghera, J. S.; Peter, M.; Nigg, E. A.; Pelech, S. L. (1992). Immunological characterization of avian MAP kinases : evidence for nuclear localization. Molecular Biology of the Cell, 3(7), 775-87.
Krek, W; Maridor, G; Nigg, E A (1992). Casein kinase II is a predominantly nuclear enzyme. The Journal of cell biology, 116(1), 43-55.
NIGG E A (1992). Assembly-disassembly of the nuclear lamina. Current opinion in cell biology, 4(1), 105-109.
Gallant, P; Nigg, E A (1992). Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells. The Journal of cell biology, 117(1), 213-24.
Nigg, E A; Kitten, G T; Vorburger, K (1992). Targeting lamin proteins to the nuclear envelope: the role of CaaX box modifications. Biochemical Society transactions, 20(2), 500-4.
Nigg, E A; Gallant, P; Krek, W (1992). Regulation of p34cdc2 protein kinase activity by phosphorylation and cyclin binding. Ciba Foundation symposium, 170, 72-84; discussion 84-96.
Krek, W; Nigg, E A (1992). Cell cycle regulation of vertebrate p34cdc2 activity: identification of Thr161 as an essential in vivo phosphorylation site. The New Biologist, 4(4), 323-9.
Peter, M; Sanghera, J S; Pelech, S L; Nigg, E A (1992). Mitogen-activated protein kinases phosphorylate nuclear lamins and display sequence specificity overlapping that of mitotic protein kinase p34cdc2. European journal of biochemistry, 205(1), 287-94.
Krek, W; Marks, J; Schmitz, N; Nigg, E A; Simanis, V (1992). Vertebrate p34cdc2 phosphorylation site mutants : effects upon cell cycle progression in the fission yeast Schizosaccharomyces pombe. Journal of cell science, 102 ( Pt 1), 43-53.
Nigg, E A (1992). Assembly and cell cycle dynamics of the nuclear lamina. Seminars in cell biology, 3(4), 245-53.
Peter, M; Chavrier, P; Nigg, E A; Zerial, M (1992). Isoprenylation of rab proteins on structurally distinct cysteine motifs. Journal of cell science, 102 ( Pt 4), 857-65.
1991
Nigg, E. A. (1991). Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle : identification of major phosphorylation sites. The EMBO journal, 10(2), 305-16.
KITTEN, GT; NIGG, EA (1991). The CaaX motif is required for isoprenylation, carboxyl methylation, and nuclear membrane association of lamin B2. The Journal of cell biology, 113(1), 13-23.
Bailer, S M; Eppenberger, H M; Griffiths, G; Nigg, E A (1991). Characterization of A 54-kD protein of the inner nuclear membrane : evidence for cell cycle-dependent interaction with the nuclear lamina. The Journal of cell biology, 114(3), 389-400.
Heitlinger, E; Peter, M; Häner, M; Lustig, A; Aebi, U; Nigg, E A (1991). Expression of chicken lamin B2 in Escherichia coli : characterization of its structure, assembly, and molecular interactions. The Journal of cell biology, 113(3), 485-95.
Nigg, E A (1991). The substrates of the cdc2 kinase. Seminars in cell biology, 2(4), 261-70.
Nigg, E A; Krek, W; Peter, M (1991). Vertebrate cdc2 kinase : its regulation by phosphorylation and its mitotic targets. Cold Spring Harbor Symposia on Quantitative Biology, 56, 539-47.
Enoch, T; Peter, M; Nurse, P; Nigg, E A (1991). p34cdc2 acts as a lamin kinase in fission yeast. The Journal of cell biology, 112(5), 797-807.
Pearson, D; Nigg, E A; Nagamine, Y; Jans, D A; Hemmings, B A (1991). Mechanisms of cAMP-mediated gene induction : examination of renal epithelial cell mutants affected in the catalytic subunit of the cAMP-dependent protein kinase. Experimental cell research, 192(1), 315-8.
Maridor, G; Park, W; Krek, W; Nigg, E A (1991). Casein kinase II : cDNA sequences, developmental expression, and tissue distribution of mRNAs for alpha, alpha', and beta subunits of the chicken enzyme. Journal of biological chemistry, 266(4), 2362-8.
Peter, M; Heitlinger, E; Häner, M; Aebi, U; Nigg, E A (1991). Disassembly of in vitro formed lamin head-to-tail polymers by CDC2 kinase. The EMBO journal, 10(6), 1535-44.
Nigg, E A; Baeuerle, P A; Lührmann, R (1991). Nuclear import-export : in search of signals and mechanisms. Cell, 66(1), 15-22.
Krek, W; Nigg, E A (1991). Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells : evidence for a double block to p34cdc2 kinase activation in vertebrates. The EMBO journal, 10(11), 3331-41.
Peter, M; Nigg, E A (1991). Ectopic expression of an A-type lamin does not interfere with differentiation of lamin A-negative embryonal carcinoma cells. Journal of cell science, 100 ( Pt 3), 589-98.
1990
Maridor, G.; Nigg, E. A. (1990). cDNA sequences of chicken nucleolin/C23 and NO38/B23 : two major nucleolar proteins. Nucleic Acids Research, 18(5), 1286.
Nigg, E A (1990). Mechanisms of signal transduction to the cell nucleus. Advances in cancer research, 55, 271-310.
Peter, M; Nakagawa, J; Dorée, M; Labbé, J C; Nigg, E A (1990). Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase. Cell, 60(5), 791-801.
Peter, M; Nakagawa, J; Dorée, M; Labbé, J C; Nigg, E A (1990). In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase. Cell, 61(4), 591-602.
Maridor, G; Krek, W; Nigg, E A (1990). Structure and developmental expression of chicken nucleolin and NO38 : coordinate expression of two abundant non-ribosomal nucleolar proteins. Biochimica et biophysica acta, 1049(2), 126-33.
Griffiths, G; Hollinshead, R; Hemmings, B A; Nigg, E A (1990). Ultrastructural localization of the regulatory (RII) subunit of cyclic AMP-dependent protein kinase to subcellular compartments active in endocytosis and recycling of membrane receptors. Journal of cell science, 96 ( Pt 4), 691-703.
1989
Nigg, E. A. (1989). The nuclear envelope. Current opinion in cell biology, Vol. 1, H. 3, S. 435-40.
Vorburger, K; Lehner, C F; Kitten, G T; Eppenberger, H M; Nigg, E A (1989). A second higher vertebrate B-type lamin : cDNA sequence determination and in vitro processing of chicken lamin B2. Journal of molecular biology, 208(3), 405-15.
Peter, M; Kitten, G T; Lehner, C F; Vorburger, K; Bailer, S M; Maridor, G; Nigg, E A (1989). Cloning and sequencing of cDNA clones encoding chicken lamins A and B1 and comparison of the primary structures of vertebrate A- and B-type lamins. Journal of molecular biology, 208(3), 393-404.
Borer, R A; Lehner, C F; Eppenberger, H M; Nigg, E A (1989). Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell, 56(3), 379-90.
Krek, W; Nigg, E A (1989). Structure and developmental expression of the chicken CDC2 kinase. The EMBO journal, 8(10), 3071-8.
Nakagawa, J; Kitten, G T; Nigg, E A (1989). A somatic cell-derived system for studying both early and late mitotic events in vitro. Journal of cell science, 94 ( Pt 3), 449-62.
Vorburger, K; Kitten, G T; Nigg, E A (1989). Modification of nuclear lamin proteins by a mevalonic acid derivative occurs in reticulocyte lysates and requires the cysteine residue of the C-terminal CXXM motif. The EMBO journal, 8(13), 4007-13.
1988
Nigg, E A (1988). Nuclear function and organization : the potential of immunochemical approaches. International review of cytology, 110, 27-92.
Stick, R; Angres, B; Lehner, C F; Nigg, E A (1988). The fates of chicken nuclear lamin proteins during mitosis : evidence for a reversible redistribution of lamin B2 between inner nuclear membrane and elements of the endoplasmic reticulum. The Journal of cell biology, 107(2), 397-406.
1987
Lehner, C F; Stick, R; Eppenberger, H M; Nigg, E A (1987). Differential expression of nuclear lamin proteins during chicken development. The Journal of cell biology, 105(1), 577-87.
1986
Lehner, C F; Fürstenberger, G; Eppenberger, H M; Nigg, E A (1986). Biogenesis of the nuclear lamina : in vivo synthesis and processing of nuclear protein precursors. Proceedings of the National Academy of Sciences of the United States of America, 83(7), 2096-9.
Lehner, C F; Kurer, V; Eppenberger, H M; Nigg, E A (1986). The nuclear lamin protein family in higher vertebrates : identification of quantitatively minor lamin proteins by monoclonal antibodies. Journal of biological chemistry, 261(28), 13293-301.
Lehner, C F; Eppenberger, H M; Fakan, S; Nigg, E A (1986). Nuclear substructure antigens : monoclonal antibodies against components of nuclear matrix preparations. Experimental cell research, 162(1), 205-19.
Nigg, E A; Sefton, B M; Singer, S J; Vogt, P K (1986). Cytoskeletal organization, vinculin-phosphorylation, and fibronectin expression in transformed fibroblasts with different cell morphologies. Virology, 151(1), 50-65.
Reuter, R; Lehner, C F; Nigg, E A; Lührmann, R (1986). A monoclonal antibody specific for snRNPs U1 and U2. FEBS letters, 201(1), 25-30.
1985
Nigg, E A; Schäfer, G; Hilz, H; Eppenberger, H M (1985). Cyclic-AMP-dependent protein kinase type II is associated with the Golgi complex and with centrosomes. Cell, 41(3), 1039-51.
Nigg, E A; Hilz, H; Eppenberger, H M; Dutly, F (1985). Rapid and reversible translocation of the catalytic subunit of cAMP-dependent protein kinase type II from the Golgi complex to the nucleus. The EMBO journal, 4(11), 2801-6.
1983
NIGG, EA; COOPER, JA; HUNTER, T (1983). Immunofluorescent localization of a 39,000-dalton substrate of tyrosine protein kinases to the cytoplasmic surface of the plasma membrane. The Journal of cell biology, 96(6), 1601-1609.
Papkoff, J; Nigg, E A; Hunter, T (1983). The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein. Cell, 33(1), 161-72.
1982
Sefton, B M; Hunter, T; Nigg, E A; Singer, S J; Walter, G (1982). Cytoskeletal targets for viral transforming proteins with tyrosine protein kinase activity. Cold Spring Harbor symposia on quantitative biology, 46 Pt 2, 939-51.
Nigg, E A; Sefton, B M; Hunter, T; Walter, G; Singer, S J (1982). Immunofluorescent localization of the transforming protein of Rous sarcoma virus with antibodies against a synthetic src peptide. Proceedings of the National Academy of Sciences of the United States of America, 79(17), 5322-6.
Nigg, E A; Walter, G; Singer, S J (1982). On the nature of crossreactions observed with antibodies directed to defined epitopes. Proceedings of the National Academy of Sciences of the United States of America, 79(19), 5939-43.
1981
Cherry, R J; Nigg, E A (1981). Rotational diffusion of erythrocyte membrane proteins. Progress in clinical and biological research, 51, 59-77.
1980
Nigg, E A; Bron, C; Girardet, M; Cherry, R J (1980). Band 3-glycophorin A association in erythrocyte membrane demonstrated by combining protein diffusion measurements with antibody-induced cross-linking. Biochemistry, 19(9), 1887-93.
Nigg, E A; Cherry, R J (1980). Anchorage of a band 3 population at the erythrocyte cytoplasmic membrane surface : protein rotational diffusion measurements. Proceedings of the National Academy of Sciences of the United States of America, 77(8), 4702-6.
Nigg, E A; Gahmberg, C G; Cherry, R J (1980). Rotational diffusion of band 3 proteins in membranes from En(a-) and neuraminidase-treated normal human erythrocytes. Biochimica et biophysica acta, 600(3), 636-42.
Cherry, R J; Nigg, E A; Beddard, G S (1980). Oligosaccharide motion in erythrocyte membranes investigated by picosecond fluorescence polarization and microsecond dichroism of an optical probe. Proceedings of the National Academy of Sciences of the United States of America, 77(10), 5899-903.
Nigg, E A; Cherry, R J; Bächi, T (1980). Influence of influenza and Sendai virus on the rotational mobility of Band 3 proteins in human erythrocyte membranes. Virology, 107(2), 552-6.
1979
Cherry, R J; Nigg, E (1979). Rotational diffusion of band 3 in the red cell membrane : measurements using triplet probes. Progress in clinical and biological research, 30, 475-81.
Nigg, E; Cherry, R J (1979). Dimeric association of band 3 in the erythrocyte membrane demonstrated by protein diffusion measurements. Nature, 277(5696), 493-4.
Nigg, E; Kessler, M; Cherry, R J (1979). Labeling of human erythrocyte membranes with eosin probes used for protein diffusion measurements : inhibition of anion transport and photo-oxidative inactivation of acetylcholinesterase. Biochimica et biophysica acta, 550(2), 328-40.
Nigg, E A; Cherry, R J (1979). Influence of temperature and cholesterol on the rotational diffusion of band 3 in the human erythrocyte membrane. Biochemistry, 18(16), 3457-65.

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