Prof. Dr. Tilman Schirmer

University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 311 Phone: +41 61 207 20 89
Curriculum Vitae

Administrative Assistant

Alexandra Eberhardt
Biozentrum, Room 308
Phone: +41 61 207 20 81

Research group Tilman Schirmer


Nesper, Jutta; Hug, Isabelle; Kato, Setsu; Hee, Chee-Seng; Habazettl, Judith Maria; Manfredi, Pablo; Grzesiek, Stephan; Schirmer, Tilman; Emonet, Thierry; Jenal, Urs (2017). Cyclic di-GMP differentially tunes a bacterial flagellar motor through a novel class of CheY-like regulators. eLife, 6, 6:e28842.
Stanger, Frédéric V.; de Beer, Tjaart A. P.; Dranow, David M.; Schirmer, Tilman; Phan, Isabelle; Dehio, Christoph (2017). The BID Domain of Type IV Secretion Substrates Forms a Conserved Four-Helix Bundle Topped with a Hook. Structure, 25(1), 203-211.
Stanger, Frédéric V; Harms, Alexander; Dehio, Christoph; Schirmer, Tilman (2016). Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin. PLoS One, 11(9), e0163654.
Dubey, Badri N.; Lori, Christian; Ozaki, Shogo; Fucile, Geoffrey; Plaza-Menacho, Ivan; Jenal, Urs; Schirmer, Tilman (2016). Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking. Science Advances, 2(9), e1600823.
Schirmer, Tilman (2016). C-di-GMP Synthesis: Structural Aspects of Evolution, Catalysis and Regulation. Journal of molecular biology, 428(19), 3683-701.
Stanger, Frédéric V.; Burmann, Björn M.; Harms, Alexander; Aragão, Hugo; Mazur, Adam; Sharpe, Timothy; Dehio, Christoph; Hiller, Sebastian; Schirmer, Tilman (2016). Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification. Proceedings of the National Academy of Sciences of the United States of America, 113(5), E529-37.
Reinders, Alberto; Hee, Chee-Seng; Ozaki, Shogo; Mazur, Adam; Boehm, Alex; Schirmer, Tilman; Jenal, Urs (2016). Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli. Journal of Bacteriology, 198(3), 448-62.
Harms, Alexander; Stanger, Frédéric Valentin; Scheu, Patrick Daniel; de Jong, Imke Greet; Goepfert, Arnaud; Glatter, Timo; Gerdes, Kenn; Schirmer, Tilman; Dehio, Christoph (2015). Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology. Cell reports, 12(9), 1497-507.
Heinisch, Tillmann; Pellizzoni, Michaela; Dürrenberger, Marc; Tinberg, Christine E.; Köhler, Valentin; Häussinger, Daniel; Klehr, Juliane; Baker, David; Ward, Thomas R. (2015). Improving the catalytic performance of an artificial metalloenzyme by computational design. Journal of the American Chemical Society, 137(32), 10414-9.
Lori, C; Ozaki, S; Steiner, S; Böhm, R; Abel, S; Dubey, B N; Schirmer, T; Hiller, S; Jenal, U (2015). Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication. Nature, 523(7559), 236-9.
Bosshart, Andreas; Hee, Chee Seng; Bechtold, Matthias; Schirmer, Tilman; Panke, Sven (2015). Directed Divergent Evolution of a Thermostable D-Tagatose Epimerase towards Improved Activity for Two Hexose Substrates. ChemBioChem, 16(4), 592-601.
Munoz-Robles, Victor; Dürrenberger, Marc; Tillmann, Heinisch; Lledos, Agustí; Schirmer, Tilman; Ward, Thomas R.; Maréchal, Jean-Didier (2014). Structural, Kinetic, and Docking Studies of Artificial Imine Reductases Based on Biotin–Streptavidin Technology: An Induced Lock-and-Key Hypothesis. Journal of the American Chemical Society, 136(44), 15676-83.
Stanger, Frédéric V; Dehio, Christoph; Schirmer, Tilman (2014). Structure of the N-terminal gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysis. PloS one, 9(9), e107289.
Ozaki, Shogo; Schalch-Moser, Annina; Zumthor, Ludwig; Manfredi, Pablo; Ebbensgaard, Anna; Schirmer, Tilman; Jenal, Urs (2014). Activation and polar sequestration of PopA, a c-di-GMP effector protein involved in Caulobacter crescentus cell cycle control. Molecular Microbiology, 94(3), 580-94.
Hutter, C. A. J.; Lehner, R.; Wirth, Ch.; Condemine, G.; Peneff, C.; Schirmer, T. (2014). Structure of the oligogalacturonate-specific KdgM porin. Acta Crystallographica Section D: Biological Crystallography, 70(Pt 6), 1770-8.
Sundriyal, Amit; Massa, Claudia; Samoray, Dietrich; Zehender, Fabian; Sharpe, Timothy; Jenal, Urs; Schirmer, Tilman (2014). Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger c-di-GMP. Journal of biological chemistry, 289(10), 6978-90.
Zähringer, Franziska; Lacanna, Egidio; Jenal, Urs; Schirmer, Tilman; Boehm, Alex (2013). Structure and signaling mechanism of a zinc-sensory diguanylate cyclase. Structure: with folding and design, 21(7), 1149-57.
Goepfert, Arnaud; Stanger, Frédéric V; Dehio, Christoph; Schirmer, Tilman (2013). Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with fic fold. PLoS one, 8(5), e64901.
Zimbron, Jeremy M.; Heinisch, Tillmann; Schmid, Maurus; Hamels, Didier; Nogueira, Elisa S.; Schirmer, Tilman; Ward, Thomas R. (2013). A Dual Anchoring Strategy for the Localization and Activation of Artificial Metalloenzymes Based on the Biotin-Streptavidin Technology. Journal of the American Chemical Society, 135(14), 5384-5388.
Goepfert, Arnaud; Harms, Alexander; Schirmer, Tilman; Dehio, Christoph: Type II Toxin-Antitoxin Loci: The fic Family, in: Gerdes, Kenn (Ed.). (2013). Prokaryotic Toxin-Antitoxins, Heidelberg: Springer Verlag , S. 177-187.
Engel, Philipp; Goepfert, Arnaud; Stanger, Frédéric V.; Harms, Alexander; Schmidt, Alexander; Schirmer, Tilman; Dehio, Christoph (2012). Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. Nature, 482(7383), 107-10.
Giri, Janhavi; Tang, John M; Wirth, Christophe; Peneff, Caroline M; Eisenberg, Bob (2012). Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli. European biophysics journal, 41(3), 259-71.
Gentner, Martin; Allan, Martin G; Zaehringer, Franziska; Schirmer, Tilman; Grzesiek, Stephan (2012). Oligomer formation of the bacterial second messenger c-di-GMP : reaction rates and equilibrium constants indicate a monomeric state at physiological concentrations. The journal of the American Chemical Society, 134(2), 1019-29.
Borer, Aline S; Wassmann, Paul; Schmidt, Margit; Hoffman, Donald R; Zhou, Jing-Jiang (2011). Crystal structure of Sol i 2 : a major allergen from fire ant venom. Journal of molecular biology, 415(4), 635-48.
Köhler, Valentin; Mao, Jincheng; Heinisch, Tillmann; Pordea, Anca; Sardo, Alessia; Wilson, Yvonne M; Knörr, Livia; Creus, Marc; Prost, Jean-Christophe; Schirmer, Tilman; Ward, Thomas R (2011). OsO4·streptavidin: a tunable hybrid catalyst for the enantioselective cis-dihydroxylation of olefins. Angewandte Chemie (International ed. in English), 50(46), 10863-6.
Abel, Sören; Chien, Peter; Wassmann, Paul; Schirmer, Tilman; Kaever, Volkhard; Laub, Michael T; Baker, Tania A; Jenal, Urs (2011). Regulatory Cohesion of Cell Cycle and Cell Differentiation through Interlinked Phosphorylation and Second Messenger Networks. Molecular cell, 43(4), 550-60.
Durrenberger, M.; Heinisch, T.; Wilson, Y.M.; Rossel, T.; Nogueira, E.; Knorr, L.; Mutschler, A.; Kersten, K.; Zimbron, M.J.; Pierron, J.; Schirmer, T.; Ward, T.R. (2011). Artificial transfer hydrogenases for the enantioselective reduction of cyclic imines. Angewandte Chemie, 50(13), 3026-3029.
Palanivelu, D.V.; Goepfert, A.; Meury, M.; Guye, P.; Dehio, C.; Schirmer, T. (2011). Fic domain catalyzed adenylylation: Insight provided by the structural analysis of the type IV secretion system effector BepA. Protein Science, 20(3), 492-499.
Monnard, Fabien W; Heinisch, Tillmann; Nogueira, Elisa S; Schirmer, Tilman; Ward, Thomas R (2011). Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor. Chemical Communications, 47(29), 8238-40.
Zimbron, Jeremy M.; Sardo, Alessia; Heinisch, Tillmann; Wohlschlager, Therese; Gradinaru, Julieta; Massa, Claudia; Schirmer, Tilman; Creus, Marc; Ward, Thomas R. (2010). Chemo-Genetic Optimization of DNA Recognition by Metallodrugs using a Presenter-Protein Strategy. Chemistry - A European Journal, 16(43), 12883-9.
Kim, D.; Hunt, J. F.; Schirmer, T.: Making, breaking, and sensing of cyclic Di-GMP : structural, thermodynamic, and evolutionary principles, in: Alan J. Wolfe, Karen L. Visick (Ed.). (2010). The second messenger cyclic Di-GMP, Washington, D.C: ASM Press , S. S. 76-95.
Zähringer, Franziska; Massa, Claudia; Schirmer, Tilman (2010). Efficient Enzymatic Production of the Bacterial Second Messenger c-di-GMP by the Diguanylate Cyclase YdeH from E. coli. Applied biochemistry and biotechnology, 163(1), 71-9.
Mittermann, Irene; Zidarn, Mihaela; Silar, Mira; Markovic-Housley, Zora; Aberer, Werner; Korosec, Peter; Kosnik, Mitja; Valenta, Rudolf (2010). Recombinant allergen-based IgE testing to distinguish bee and wasp allergy. The Journal of Allergy and Clinical Immunology, 125(6), 1300-1307.e3.
Marković-Housley, Zora; Basle, Arnaud; Padavattan, Sivaraman; Maderegger, Bernhard (2009). Structure of the major carrot allergen Dau c 1. Acta crystallographica. Section D, Biological crystallography, 65(Pt 11), 1206-12.
Wirth, Christophe; Condemine, Guy; Boiteux, Céline; Bernèche, Simon; Schirmer, Tilman; Peneff, Caroline M (2009). NanC crystal structure, a model for outer-membrane channels of the acidic sugar-specific KdgM porin family. Journal of molecular biology, 394(4), 718-31.
Schirmer, Tilman; Jenal, Urs (2009). Structural and mechanistic determinants of c-di-GMP signalling. Nature Reviews Microbiology, 7(10), 724-35.
Boehm, Alex; Steiner, Samuel; Zaehringer, Franziska; Casanova, Alain; Hamburger, Fabienne; Ritz, Daniel; Keck, Wolfgang; Ackermann, Martin; Schirmer, Tilman; Jenal, Urs (2009). Second messenger signaling governs Escherichia coli biofilm induction upon ribosomal stress. Molecular microbiology, 72(6), 1500-1516.
Padavattan, Sivaraman; Flicker, Sabine; Schirmer, Tilman; Madritsch, Christoph; Randow, Stefanie; Reese, Gerald; Vieths, Stefan; Lupinek, Christian; Ebner, Christof; Valenta, Rudolf; Markovic-Housley, Zora (2009). High-affinity IgE recognition of a conformational epitope of the major respiratory allergen Phl p 2 as revealed by X-ray crystallography. Journal of immunology, 182(4), 2141-51.
Minasov, George; Padavattan, Sivaraman; Shuvalova, Ludmilla; Brunzelle, Joseph S; Miller, Darcie J; Baslé, Arnaud; Massa, Claudia; Collart, Frank R; Schirmer, Tilman; Anderson, Wayne F (2009). Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains. Journal of biological chemistry, 284(19), 13174-84.
Padavattan, Sivaraman; Schmidt, Margit; Hoffman, Donald R (2008). Crystal structure of the major allergen from fire ant venom, Sol i 3. Journal of molecular biology, 383(1), 178-85.
Soldatova, Lyudmila N; Tsai, Chaoming; Dobrovolskaia, Ekaterina; Marković-Housley, Zora (2007). Characterization of the N-glycans of recombinant bee venom hyaluronidase (Api m 2) expressed in insect cells. Allergy and asthma proceedings, 28(2), 210-5.
Paul, Ralf; Abel, Sören; Wassmann, Paul; Beck, Andreas; Heerklotz, Heiko; Jenal, Urs (2007). Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization. Journal of biological chemistry, 282(40), 29170-7.
Wassmann, Paul; Chan, Carmen; Paul, Ralf; Beck, Andreas; Heerklotz, Heiko; Jenal, Urs; Schirmer, Tilman (2007). Structure of BeF3- -modified response regulator PleD: implications for diguanylate cyclase activation, catalysis, and feedback inhibition. Structure: with folding and design, 15(8), 915-27.
Padavattan, Sivaraman; Schirmer, Tilman; Schmidt, Margit; Akdis, Cezmi; Valenta, Rudolf; Mittermann, Irene; Soldatova, Lyudmila; Slater, Jay; Mueller, Ulrich; Markovic-Housley, Zora (2007). Identification of a B-cell epitope of hyaluronidase, a major bee venom allergen, from its crystal structure in complex with a specific Fab. Journal of molecular biology, 368(3), 742-52.
Ma, Y.; Gadermaier, G.; Bohle, B.; Bolhaar, S.; Knulst, A.; Markovic-Housley, Z.; Breiteneder, H.; Briza, P.; Hoffmann-Sommergruber, K.; Ferreira, F. (2006). Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1. International Archives of Allergy and Immunology, 139(1), 53-62.
Basle, Arnaud; Rummel, Gabriele; Storici, Paola; Rosenbusch, Juerg P.; Schirmer, Tilman (2006). Crystal structure of osmoporin OmpC from E. coli at 2.0 A. Journal of molecular biology, 362(5), 933-942.
Miedema, Henk; Vrouenraets, Maarten; Wierenga, Jenny; Eisenberg, Bob; Schirmer, Tilman; Baslé, Arnaud; Meijberg, Wim (2006). Conductance and selectivity fluctuations in D127 mutants of the bacterial porin OmpF. European biophysics journal, 36(1), 13-22.
Palanivelu, Dinesh V; Kozono, David E; Engel, Andreas; Suda, Kitaru; Lustig, Ariel; Agre, Peter; Schirmer, Tilman (2006). Co-axial association of recombinant eye lens aquaporin-0 observed in loosely packed 3D crystals. Journal of molecular biology, 355(4), 605-11.
Philippsen, A; Schirmer, T; Stein, MA; Giffhorn, F; Stetefeld, J (2005). Structure of zinc-independent sorbitol dehydrogenase from Rhodobacter sphaeroides at 2.4 A resolution. Acta Crystallographica. Section D, Biological Crystallography, 61(Pt 4), 374-379.
Schirmer, Tilman; Hoffimann-Sommergrube, Karin; Susani, Markus; Breiteneder, Heimo (2005). Crystal structure of the major celery allergen Api g 1 : molecular analysis of cross-reactivity. Journal of molecular biology, 351(5), 1101-9.
Markova, Michaela; Peneff, Caroline; Hewlins, Michael J E; Schirmer, Tilman; John, Robert A (2005). Determinants of substrate specificity in omega-aminotransferases. Journal of Biological Chemistry, 280(43), 36409-16.
Karamloo, Fariba; Schmid-Grendelmeier, Peter; Kussebi, Fatimah; Akdis, Mübeccel; Salagianni, Maria; von Beust, Barbara R; Reimers, Andrea; Zumkehr, Judith; Soldatova, Lyudmilla; Housley-Markovic, Zora; Müller, Ulrich; Kündig, Thomas; Kemeny, David M; Spangfort, Michael D; Blaser, Kurt; Akdis, Cezmi A (2005). Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes. European Journal of Immunology, 35(11), 3268-76.
Hui, Kwok-Min; Orriss, George L; Schirmer, Tilman; Magnadóttir, Bergljót; Schifferli, Jürg A; Inal, Jameel M (2005). Expression of functional recombinant von Willebrand factor-A domain from human complement C2 : a potential binding site for C4 and CRIT. The Biochemical Journal, 389(Pt 3), 863-8.
Kussebi, Fatimah; Karamloo, Fariba; Rhyner, Claudio; Schmid-Grendelmeier, Peter; Salagianni, Maria; Mannhart, Christian; Akdis, Mübeccel; Soldatova, Lyudmilla; Markovic-Housley, Zora; Von Beust, Barbara R; Kündig, Thomas; Kemeny, David M; Blaser, Kurt; Crameri, Reto; Akdis, Cezmi A (2005). A major allergen gene-fusion protein for potential usage in allergen-specific immunotherapy. The journal of allergy and clinical immunology, 115(2), 323-9.
Storici, P; Qiu, J; Schirmer, T; Silverman, RB (2004). Mechanistic crystallography. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography. Biochemistry, 43(44), 14057-14063.
Storici, Paola; De Biase, Daniela; Bossa, Francesco; Bruno, Stefano; Mozzarelli, Andrea; Peneff, Caroline; Silverman, Richard B; Schirmer, Tilman (2004). Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin. Journal of Biological Chemistry, 279(1), 363-73.
Paul, Ralf; Weiser, Stefan; Amiot, Nicholas C; Chan, Carmen; Schirmer, Tilman; Giese, Bernd; Jenal, Urs (2004). Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain. Genes & development, 18(6), 715-27.
Chan, Carmen; Paul, Ralf; Samoray, Dietrich; Amiot, Nicolas C; Giese, Bernd; Jenal, Urs; Schirmer, Tilman (2004). Structural basis of activity and allosteric control of diguanylate cyclase. Proceedings of the National Academy of Sciences of the United States of America, 101(49), 17084-9.
Schirmer, Tilman: Structure-Function Relationships in Sugar-Specific Porins, in: Benz, R. (Ed.). (2004). Bacterial and Eukaryotic Porins: Structure, Function, Mechanism, Switzerland: Wiley-VCH Verlag GmbH & Co. KGaA , S. 169-181.
Orriss, GL; Erni, B; Schirmer, T (2003). Crystal structure of the IIB(Sor) domain of the sorbose permease from Klebsiella pneumoniae solved to 1.75A resolution. Journal of molecular biology, 327(5), 1111-1119.
Marković-Housley, Zora; Degano, Massimo; Lamba, Doriano; von Roepenack-Lahaye, Edda (2003). Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier. Journal of molecular biology, 325(1), 123-33.
Philippsen, Ansgar; Im, Wonpil; Engel, Andreas; Schirmer, Tilman; Roux, Benoit; Müller, Daniel J (2002). Imaging the electrostatic potential of transmembrane channels : atomic probe microscopy of OmpF porin. Biophysical journal, 82(3), 1667-76.
Van Gelder, Patrick; Dumas, Fabrice; Bartoldus, Ingrid; Saint, Nathalie; Prilipov, Alexei; Winterhalter, Mathias; Wang, Yanfei; Philippsen, Ansgar; Rosenbusch, Jürg P; Schirmer, Tilman (2002). Sugar transport through maltoporin of Escherichia coli : role of the greasy slide. Journal of bacteriology, 184(11), 2994-9.
Dutzler, Raimund; Schirmer, Tilman; Karplus, Martin; Fischer, Stefan (2002). Translocation mechanism of long sugar chains across the maltoporin membrane channel. Structure: with folding and design, 10(9), 1273-84.
Rodríguez-Marañón, María José; Bush, Robin M; Peterson, Ellena M; Schirmer, Tilman; de la Maza, Luis M (2002). Prediction of the membrane-spanning beta-strands of the major outer membrane protein of Chlamydia. Protein Science, 11(7), 1854-61.
Choi, Sun; Storici, Paola; Schirmer, Tilman; Silverman, Richard B (2002). Design of a conformationally restricted analogue of the antiepilepsy drug Vigabatrin that directs its mechanism of inactivation of gamma-aminobutyric acid aminotransferase. Journal of the American Chemical Society, 124(8), 1620-4.
Sauer, Oliver; Roth, Michel; Schirmer, Tilman; Rummel, Gabriele; Kratky, Christoph (2002). Low-resolution detergent tracing in protein crystals using xenon or krypton to enhance X-ray contrast. Acta Crystallographica. Section D, Biological Crystallography, 58(Pt 1), 60-9.
Schirmer, T (2001). Membrane proteins with beta-barrel fold. Chimia, 55(6), 493-496.
Phale, P S; Philippsen, A; Widmer, C; Phale, V P; Rosenbusch, J P; Schirmer, T (2001). Role of charged residues at the OmpF porin channel constriction probed by mutagenesis and simulation. Biochemistry, 40(21), 6319-25.
Van Gelder, P; Dutzler, R; Dumas, F; Koebnik, R; Schirmer, T (2001). Sucrose transport through maltoporin mutants of Escherichia coli. Protein engineering, 14(11), 943-8.
Marković-Housley, Z; Miglierini, G; Soldatova, L; Rizkallah, P J (2000). Crystal structure of hyaluronidase, a major allergen of bee venom. Structure: with folding and design, 8(10), 1025-35.
Dutzler, R; Rummel, G; Albertí, S; Hernández-Allés, S; Phale, P; Rosenbusch, J; Benedí, V; Schirmer, T (1999). Crystal structure and functional characterization of OmpK36, the osmoporin of Klebsiella pneumoniae. Structure: with folding and design, 7(4), 425-34.
Storici, P; Capitani, G; Müller, R; Schirmer, T; Jansonius, J N (1999). Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine. Journal of molecular biology, 285(1), 297-309.
Storici, P; Capitani, G; De Biase, D; Moser, M; John, R A; Jansonius, J N; Schirmer, T (1999). Crystal structure of GABA-aminotransferase, a target for antiepileptic drug therapy. Biochemistry, 38(27), 8628-34.
Schirmer, T; Phale, P S (1999). Brownian dynamics simulation of ion flow through porin channels. Journal of molecular biology, 294(5), 1159-67.
Shen, B W; Hennig, M; Hohenester, E; Jansonius, J N; Schirmer, T (1998). Crystal structure of human recombinant ornithine aminotransferase. Journal of molecular biology, 277(1), 81-102.
Penel, S; Pebay-Peyroula, E; Rosenbusch, J; Rummel, G; Schirmer, T; Timmins, P A (1998). Detergent binding in trigonal crystals of OmpF porin from Escherichia coli. Biochimie, 80(5-6), 543-51.
Schirmer, T (1998). General and specific porins from bacterial outer membranes. Journal of Structural Biology, 121(2), 101-9.
Phale, P S; Philippsen, A; Kiefhaber, T; Koebnik, R; Phale, V P; Schirmer, T; Rosenbusch, J P (1998). Stability of trimeric OmpF porin : the contributions of the latching loop L2. Biochemistry, 37(45), 15663-70.
Schauder, S; Nunn, R S; Lanz, R; Erni, B; Schirmer, T (1998). Crystal structure of the IIB subunit of a fructose permease (IIBLev) from Bacillus subtilis. Journal of molecular biology, 276(3), 591-602.
Phale, P S; Schirmer, T; Prilipov, A; Lou, K L; Hardmeyer, A; Rosenbusch, J P (1997). Voltage gating of Escherichia coli porin channels : role of the constriction loop. Proceedings of the National Academy of Sciences of the United States of America, 94(13), 6741-5.
Wang, Y F; Dutzler, R; Rizkallah, P J; Rosenbusch, J P; Schirmer, T (1997). Channel specificity : structural basis for sugar discrimination and differential flux rates in maltoporin. Journal of molecular biology, 272(1), 56-63.
Nunn, RS; MarkovicHousley, Z; GenovesioTaverne, JC; Flukiger, K; Rizkallah, PJ; Jansonius, JN; Schirmer, T; Erni, B (1996). Structure of the IIA domain of the mannose transporter from Escherichia coli at 1.7 angstroms resolution. Journal of molecular biology, 259(3), 502-511.
Marković-Housley, Z; Schirmer, T; Hohenester, E; Khomutov, A R (1996). Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase. European journal of biochemistry, 236(3), 1025-32.
Dutzler, R; Wang, Y F; Rizkallah, P; Rosenbusch, J P; Schirmer, T (1996). Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway. Structure, 4(2), 127-34.
Chan, W C; Schirmer, T; Ferenci, T (1996). Combinatorial mutagenesis analysis of residues in the channel constriction loop L3 and neighbouring beta-strands in the LamB glycoporin of Escherichia coli. Molecular Membrane Biology, 13(1), 41-48.
Saint, N; Prilipov, A; Hardmeyer, A; Lou, K L; Schirmer, T; Rosenbusch, J P (1996). Replacement of the sole histidinyl residue in OmpF porin from E. coli by threonine (H21T) does not affect channel structure and function. Biochemical and Biophysical Research Communications, 223(1), 118-22.
Saint, N; Lou, K L; Widmer, C; Luckey, M; Schirmer, T; Rosenbusch, J P (1996). Structural and functional characterization of OmpF porin mutants selected for larger pore size. II.. Functional characterization. Journal of Biological Chemistry, 271(34), 20676-80.
Lou, K L; Saint, N; Prilipov, A; Rummel, G; Benson, S A; Rosenbusch, J P; Schirmer, T (1996). Structural and functional characterization of OmpF porin mutants selected for larger pore size. I.. Crystallographic analysis. Journal of Biological Chemistry, 271(34), 20669-75.
Schirmer, T.; Keller, T.A.; Wang, Y.F.; Rosenbusch, J.P. (1995). Structural basis for sugar translocation through maltoporin channels at 3.1 A resolution. Science, 267(5197), 512-514.
Cowan, S W; Garavito, R M; Jansonius, J N; Jenkins, J A; Karlsson, R; König, N; Pai, E F; Pauptit, R A; Rizkallah, P J; Rosenbusch, J P (1995). The structure of OmpF porin in a tetragonal crystal form. Structure, 3(10), 1041-50.
Albertí, S; Rodríquez-Quiñones, F; Schirmer, T; Rummel, G; Tomás, J M; Rosenbusch, J P; Benedí, V J (1995). A porin from Klebsiella pneumoniae : sequence homology, three-dimensional model, and complement binding. Infection and immunity, 63(3), 903-10.
Jeanteur, D; Schirmer, T; Fourel, D; Simonet, V; Rummel, G; Widmer, C; Rosenbusch, J P; Pattus, F; Pagès, J M (1994). Structural and functional alterations of a colicin-resistant mutant of OmpF porin from Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, 91(22), 10675-9.
Cowan, S.W.; Schirmer, T. (1994). Structures of non-specific diffusion pores from E.coli. New comprehensive biochemistry, 27, 353-361.
Karshikoff, A; Spassov, V; Cowan, S W; Ladenstein, R; Schirmer, T (1994). Electrostatic properties of two porin channels from Escherichia coli. Journal of molecular biology, 240(4), 372-84.
Pflügl, G; Kallen, J; Schirmer, T; Jansonius, J N; Zurini, M G; Walkinshaw, M D (1993). X-ray structure of a decameric cyclophilin-cyclosporin crystal complex. Nature, 361(6407), 91-4.
Schirmer, T; Cowan, S W (1993). Prediction of membrane-spanning beta-strands and its application to maltoporin. Protein Science, 2(8), 1361-3.
Cowan, S W; Schirmer, T; Rummel, G; Steiert, M; Ghosh, R; Pauptit, R A; Jansonius, J N; Rosenbusch, J P (1992). Crystal structures explain functional properties of two E. coli porins. Nature, 358(6389), 727-33.
Schirmer, T.; Roschenbusch, J.P. (1991). Prokaryotic and eukaryotic porins. Current Opinion in Structural Biology, 1, H. 4, 539-545.
Schirmer, T; Evans, P R (1990). Structural basis of the allosteric behaviour of phosphofructokinase. Nature, 343(6254), 140-5.
Schirmer, T.; Bode, W.; Huber, R. (1987). Refined three-dimensional structures of two cyanobacterial C-phycocyanins at 2.1 and 2.5 A resolution : a common principle of phycobilin-protein interaction. Journal of molecular biology, 196(3), 677-695.
SCHIRMER, T; VINCENT, MG (1987). Polarized absorption and fluorescence spectra of single crystals of C-phycocyanin. Biochimica et biophysica acta, 893(3), 379-385.
Schirmer, T.; Huber, R.; Schneider, M.; Bode, W.; Miller, M.; Hackert, M.L. (1986). Crystal structure analysis and refinement at 2.5 A of hexameric C-phycocyanin from the cyanobacterium Agmenellum quadruplicatum : the molecular model and its implications for light-harvesting. Journal of molecular biology, 188(4), 651-676.
Schirmer, T; Bode, W; Huber, R; Sidler, W; Zuber, H (1985). X-ray crystallographic structure of the light-harvesting biliprotein C-phycocyanin from the thermophilic cyanobacterium Mastigocladus laminosus and its resemblance to globin structures. Journal of molecular biology, 184(2), 257-77.

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