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The Skin I Live in

The forces that shape embryos, and how embryonic cells respond

Embryos undergo dramatic morphogenetic movements during development. For example, C. elegans embryos begin as a compact ball of cells and elongate into a thin tube. During these movements, C. elegans skin must be able to withstand the pulling and pushing of cells and tissues without coming apart at the seams. How do they do this?

We are examining the formation of the epidermis and its maturation as the embryo elongates. We have identified factors critical to make the epidermis – from transcription factors that regulate the onset of epidermal gene expression to proteins involved in polarizing and reinforcing cells. The most recent work is unpublished, but you can read the beginning of this project here: 

 

 

What got us started: 

von Stetina et al. Temporal regulation of epithelium formation. Mol Biol Cell,  2017 here

Portereiko, M. P et al., ZEN-4/MKLP1 is Required to Polarize the Foregut Epithelium. Current Biology, 2004 here

Photo: Bruce Draper, Steve von Stetina

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