(2020). Lifestyle vs. pharmacological interventions for healthy aging. Aging, 12 (1), 5-7.
(2019). How Epigenetic Modifications Drive the Expression and Mediate the Action of PGC-1α in the Regulation of Metabolism. International journal of molecular sciences, 20 (21), E5449.
(2019). PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice. Acta physiologica (Oxford, England), epub ahead of print.
(2019). JAK2 mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms. Blood, 134 (21), 1832-46.
(2019). BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America, 116 (32), 16111-16120.
(2019). Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging. Aging cell, 18 (5), e12993.
(2019). Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance. Nature communications, 10 (1), 2767.
(2019). Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. Cell Reports, 27 (5), 1551-1566.e5.
(2019). Pharmacological targeting of age-related changes in skeletal muscle tissue. Pharmacological research, epub ahead of print.
(2019). Muscle Wasting Diseases: Novel Targets and Treatments. Annual review of pharmacology and toxicology, 59, 315-339.
(2018). Endocrine Crosstalk Between Skeletal Muscle and the Brain. Frontiers in Neurology, 9, 698.
(2018). Relation of nNOS isoforms to mitochondrial density and PGC-1alpha expression in striated muscles of mice. Nitric Oxide: Biology and Chemistry, 77, 35-43.
(2018). Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart. Frontiers in Physiology, 9, 242.
(2018). Injected Human Muscle Precursor Cells Overexpressing PGC-1Î±. Enhance Functional Muscle Regeneration after Trauma. Stem cells international, 2018, 4658503.
(2018). Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance. Scientific Reports, 8 (1), 636.
(2018). PGC-1α affects aging-related changes in muscle and motor function by modulating specific exercise-mediated changes in old mice. Aging Cell, 17 (1), e12697.
(2018). Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls. Biochemical pharmacology, 147, 211-220.
: Physiological Regulation of Skeletal Muscle Mass: Resistance Exercise- Mediated Muscle Hypertrophy, in: Walrand, Stéphane(Ed.). (2018). Nutrition and Skeletal Muscle, London: Academic Press, 139-150.
(2017). Plasticity of the Muscle Stem Cell Microenvironment. Advances in experimental medicine and biology, 1041, 141-169.
: Muskeln: mehr als nur "schön anzusehen", in: Füglister, Kurt M.; Hicklin, Martin; Mäser, Pascal(Ed.). (2017). natura obscura. 200 Naturforschende - 200 Naturphänomene - 200 Jahre Naturforschende Gesellschaft in Basel, Basel: Schwabe, 85-85.
(2017). Role of Nuclear Receptors in Exercise-Induced Muscle Adaptations. Cold Spring Harbor perspectives in medicine, 7 (6), a029835.
(2017). Muscle PGC-1α is required for long-term systemic and local adaptations to a ketogenic diet in mice. American Journal of Physiology. Endocrinology and Metabolism, 312 (5), E437-E446.
(2017). Human muscle precursor cells overexpressing PGC-1α enhance early skeletal muscle tissue formation. Cell Transplantation, 26 (6), 1103-1114.
(2017). Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP. Scientific Reports, 7, 40789.
(2017). Coregulator-mediated control of skeletal muscle plasticity - A mini-review. Biochimie, 136, 49-54.
(2017). Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres. Journal of Cellular Physiology, 232 (6), 1270-1274.
: Optimized Engagement of Macrophages and Satellite Cells in the Repair and Regeneration of Exercised Muscle, in: Spiegelman, Bruce M.(Ed.). (2017). Hormones, Metabolism and the Benefits of Exercise, Cham: Springer, 57-66.
(2016). Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche. Skeletal Muscle, 6 (1), 39.
(2016). Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice. PLoS ONE, 11 (7), e0158716.
(2016). PGC-1α expression in murine AgRP neurons regulates food intake and energy balance. Molecular metabolism, 5 (7), 580-8.
(2016). Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering. Journal of Nuclear Medicine, 57 (9), 1467-73.
(2016). The Genomic Context and Corecruitment of SP1 Affect ERRα Coactivation by PGC-1α in Muscle Cells. Molecular Endocrinology, 30 (7), 809-825.
(2016). Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice. FASEB Journal, 30 (5), 1976-86.
(2016). mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Molecular Medicine, 8 (3), 232-246.
(2016). Magnetic stimulation supports muscle and nerve regeneration after trauma in mice. Muscle and Nerve, 53 (4), 598-607.
(2016). PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle. Skeletal muscle, 6 (38), 38.
(2015). Caloric restriction and exercise "mimetics'': Ready for prime time?. Pharmacological research, 103, 158-166.
(2015). Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle. Frontiers in physiology, 6, 325.
(2015). Skeletal muscle as an endocrine organ : PGC-1α, myokines and exercise. Bone, 80, 115-25.
(2015). The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo. Biochemical and Biophysical Research Communications, 464 (3), 692-697.
(2015). Resveratrol and SRT1720 elicit differential effects in metabolic organs and modulate systemic parameters independently of skeletal muscle peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α). Journal of biological chemistry, 290 (26), 16059-76.
(2015). External physical and biochemical stimulation to enhance skeletal muscle bioengineering. Advanced drug delivery reviews, 82-83, 168-75.
(2015). PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects. Experimental biology and medicine, 240 (9), 1205-13.
(2015). Exercise and PGC-1α in inflammation and chronic disease. Deutsche Zeitschrift für Sportmedizin, 66 (12), 317-320.
(2014). The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet. Diabetologia, 57, no. 11 (11), 2405-2412.
(2014). Transcriptional network analysis in muscle reveals AP-1 as a partner of PGC-1α in the regulation of the hypoxic gene program. Molecular and cellular biology, 34 (16), 2996-3012.
(2014). MicroRNAs emerge as modulators of NAD+-dependent energy metabolism in skeletal muscle. Diabetes, 63 (5), 1451-3.
(2014). Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α. Nature communications, 5, 3569.
(2014). Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases. Drug discovery today, 19 (7), 1024-9.
(2014). Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. European journal of nutrition, 53 (6), 1313-25.
(2014). Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology. Seminars in immunopathology, 36 (1), 27-53.
(2013). The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling. Proceedings of the National Academy of Sciences of the United States of America, 110 (50), 20314-9.
(2013). Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A. Proceedings of the National Academy of Sciences of the United States of America, 110 (21), 8738-43.
(2013). Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal Muscle, 3 (1), 6.
(2013). The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells. Journal of Biological Chemistry, 288 (4), 2246-2260.
(2013). Myoblasts inhibit prostate cancer growth by paracrine secretion of tumor necrosis factor-α. Journal of Urology, 189 (5), 1952-9.
(2013). PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner. Diabetes, 62 (1), 85-95.
(2013). New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases. Drug Discovery Today. Disease Models, 10 (2), e79-e85.
(2012). The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism. Molecular and cellular biology, 32 (24), 4913-24.
(2012). A functional motor unit in the culture dish : co-culture of spinal cord explants and muscle cells. Journal of visualized experiments, 62, e3616.
(2012). PGC-1α determines light damage susceptibility of the murine retina. PLoS ONE, 7 (2), e31272.
(2012). PGC-1α and exercise in the control of body weight. International journal of obesity and related metabolic disorders, 36 (11), 1428-35.
(2012). Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type. American Journal of Physiology, 302 (1), C88-99.
(2012). Warum reagiert mein Patient anders auf dieses Medikament? : Pharmakogenomik und personalisierte Medizin in der Praxis. Swiss medical forum = Schweizerisches Medizin-Forum, 12 (22), 425-433.
(2011). Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America, 108 (51), 20808-13.
(2011). Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity. Biochemical and biophysical research communications, 408 (1), 180-5.
(2011). Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) improves skeletal muscle mitochondrial function and insulin sensitivity. Diabetologia, 54 (6), 1270-2.
(2011). PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination. Cell metabolism, 13 (4), 351;authorreply352.
(2011). PGC-1α and Myokines in the aging muscle : a mini-review. Gerontology, 57 (1), 37-43.
(2010). ApoE−/− PGC-1α−/− mice display reduced IL-18 levels and do not develop enhanced atherosclerosis. PLoS ONE, Vol. 5, H. 10 , e13539.
(2010). Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway. Journal of Biological Chemistry, 285 (43), 32793-32800.
(2010). SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice. Aging, 2 (6), 353-360.
(2010). Electric pulse stimulation of cultured murine muscle cells reproduces gene expression changes of trained mouse muscle. PLoS ONE, 5 (6), e10970.
(2010). Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor gamma coactivator 1alpha. Journal of receptors and signal transduction, 30 (6), 376-84.
(2010). For a pragmatic approach to exercise studies. Journal of Applied Physiology, 108 (1), 223-223.
(2009). Peroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation. Clinical and experimental pharmacology and physiology, 36 (12), 1139-43.
(2009). PGC-1a in muscle links metabolism to inflammation. Proceedings of the Australian Physiological Society, 40, 11-16.
(2009). A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells. Blood, 113 (1), 95-99.
(2009). The biology of PGC-1α and its therapeutic potential. Trends in Pharmacological Sciences, 30 (6), 322-329.
(2008). The role of exercise and PGC1alpha in inflammation and chronic disease. Nature, 454 (7203), 463-9.
(2008). Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America, 105 (50), 19926-31.
: Induction of drug metabolism : role for nuclear receptors, in: Ottow , Eckhard; Weinmann, Hilmar(Ed.). (2008). Nuclear Receptors as Drug Targets (Methods and Principles in Medicinal Chemistry, Vol. 39), Weinheim: Wiley-VCH, 453-468.
(2007). A fundamental system of cellular energy homeostasis regulated by PGC-1α. Proceedings of the National Academy of Sciences of the United States of America, 104 (19), 7933-7938.
(2007). RANTES (regulated on activation, normal T cell expressed and secreted), inflammation, obesity, and the metabolic syndrome. Circulation, 115 (8), 946-8.
(2007). AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α. Proceedings of the National Academy of Sciences of the United States of America, 104 (29), 12017-22.
(2007). PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes & development, 21 (7), 770-83.
(2007). Abnormal glucose homeostasis in skeletal muscle-specific PGC-1α knockout mice reveals skeletal muscle-pancreatic β cell crosstalk. Journal of Clinical Investigation, 117 (11), 3463-74.
(2007). Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals. Journal of Biological Chemistry, 282 (41), 30014-21.
(2006). Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells. Proceedings of the National Academy of Sciences of the United States of America, 103 (39), 14379-84.
(2006). Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell, 127 (2), 397-408.
(2006). PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proceedings of the National Academy of Sciences of the United States of America, 103 (44), 16260-5.
(2006). Partnership of PGC-1α and HNF4α in the regulation of lipoprotein metabolism. Journal of Biological Chemistry, 281 (21), 14683-90.
(2006). Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism. Endocrine reviews, 27 (7), 728-35.
(2005). Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Archives of Biochemistry and Biophysics, 434 (1), 75-85.
(2005). LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver. Journal of Lipid Research, 46 (8), 1633-42.
(2005). Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP. Cell, 120 (2), 261-73.
(2005). Metabolic control through the PGC-1 family of transcription coactivators. Cell Metabolism, 1 (6), 361-70.
(2005). Regulatory network of lipid-sensing nuclear receptors: : roles for CAR, PXR, LXR, and FXR. Archives of Biochemistry and Biophysics, 433 (2), 387-96.
(2005). Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α. Cell, 122 (4), 505-15.
(2005). Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle. Cell Metabolism, Vol. 1, H. 4, 259-271.
(2005). Estrogen-related receptor α (ERRα) : a novel target in type 2 diabetes. Drug Discovery Today. Therapeutic Strategies, 2 (2), 151-156.
(2004). Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proceedings of the National Academy of Sciences of the United States of America, 101 (17), 6570-5.
(2004). Identification of the xenosensors regulating human 5-aminolevulinate synthase. Proceedings of the National Academy of Sciences of the United States of America, 101 (24), 9127-32.
(2004). The evolution of drug-activated nuclear receptors : one ancestral gene diverged into two xenosensor genes in mammals. Nuclear Receptor, 2 (1), 7.
(2004). Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α : modulation by p38 MAPK. Genes & development, 18 (3), 278-89.
(2003). Induction of drug metabolism: the role of nuclear receptors. Pharmacological reviews, 55 (4), 649-73.
(2003). Molecular cloning and characterization of chicken orphan nuclear receptor cTR2. General and Comparative Endocrinology, 132 (3), 474-84.
(2003). In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism. Drug news & perspectives, 16 (7), 423-434.
(2003). An An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle. Proceedings of the National Academy of Sciences of the United States of America, 100 (12), 7111-6.
: The molecular mechanism of induction of cytochromes P450 by drugs and other xenobioticsMolecular Investigation of Metabolism and Transport of Drugs - from Animal to Human Tissue, Halle (Saale): Deutsche Akademie der Naturforscher Leopoldina, 87, 205-211.
(2002). A Link between cholesterol levels and phenobarbital induction of cytochromes P450. Biochemical and Biophysical Research Communications, 291 (2), 378-384.
(2002). NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Molecular endocrinology, 16 (6), 1269-79.
(2002). Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. Journal of Biological Chemistry, 277 (33), 29561-7.
(2001). A regulatory network of nuclear receptors for hepatic cytochrome P450 induction by drugs: Interactions between the xenobiotic-, the cholesterol- and the bile acid-sensors CXR, LXR and FXR in chicken liver. .
(2001). Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. Molecular endocrinology, 15 (9), 1571-85.
(2001). Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor. Molecular pharmacology, 60 (4), 681-9.
(2000). A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line. Journal of Biological Chemistry, 275 (18), 13362-13369.
(2000). CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR). Proceedings of the National Academy of Sciences of the United States of America, 97 (20), 10769-74.