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Furrer, Regula; Handschin, Christoph (2020). Lifestyle vs. pharmacological interventions for healthy aging. Aging, 12 (1), 5-7.


Krämer, Anne I.; Handschin, Christoph (2019). How Epigenetic Modifications Drive the Expression and Mediate the Action of PGC-1α in the Regulation of Metabolism. International journal of molecular sciences, 20 (21), E5449.

Panajatovic, Miljenko Valentin; Singh, François; Roos, Noëmi Johanna; Duthaler, Urs; Handschin, Christoph; Krähenbühl, Stephan; Bouitbir, Jamal (2019). PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice. Acta physiologica (Oxford, England), epub ahead of print.

Nageswara Rao, Tata; Hansen, Nils; Hilfiker, Julian; Rai, Shivam; Majewska, Julia-Magdalena; Leković, Danijela; Gezer, Deniz; Andina, Nicola; Galli, Serena; Cassel, Teresa; Geier, Florian; Delezie, Julien; Nienhold, Ronny; Hao-Shen, Hui; Beisel, Christian; Di Palma, Serena; Dimeloe, Sarah; Trebicka, Jonel; Wolf, Dominik; Gassmann, Max; Fan, Teresa W-M; Lane, Andrew N; Handschin, Christoph; Dirnhofer, Stefan; Kröger, Nicolaus; Hess, Christoph; Radimerski, Thomas; Koschmieder, Steffen; Čokić, Vladan P; Skoda, Radek C (2019). JAK2 mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms. Blood, 134 (21), 1832-46.

Delezie, Julien; Weihrauch, Martin; Maier, Geraldine; Tejero, Rocío; Ham, Daniel J.; Gill, Jonathan F.; Karrer-Cardel, Bettina; Rüegg, Markus A.; Tabares, Lucía; Handschin, Christoph (2019). BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America, 116 (32), 16111-16120.

Gill, Jonathan F.; Delezie, Julien; Santos, Gesa; McGuirk, Shawn; Schnyder, Svenia; Frank, Stephan; Rausch, Martin; St-Pierre, Julie; Handschin, Christoph (2019). Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging. Aging cell, 18 (5), e12993.

Agudelo, Leandro Z.; Ferreira, Duarte M. S.; Dadvar, Shamim; Cervenka, Igor; Ketscher, Lars; Izadi, Manizheh; Zhengye, Liu; Furrer, Regula; Handschin, Christoph; Venckunas, Tomas; Brazaitis, Marius; Kamandulis, Sigitas; Lanner, Johanna T.; Ruas, Jorge L. (2019). Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance. Nature communications, 10 (1), 2767.

Brinkkoetter, Paul T.; Bork, Tillmann; Salou, Sarah; Liang, Wei; Mizi, Athanasia; Özel, Cem; Koehler, Sybille; Hagmann, H. Henning; Ising, Christina; Kuczkowski, Alexander; Schnyder, Svenia; Abed, Ahmed; Schermer, Bernhard; Benzing, Thomas; Kretz, Oliver; Puelles, Victor G.; Lagies, Simon; Schlimpert, Manuel; Kammerer, Bernd; Handschin, Christoph; Schell, Christoph; Huber, Tobias B. (2019). Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. Cell Reports, 27 (5), 1551-1566.e5.

Leuchtmann, Aurel B; Handschin, Christoph (2019). Pharmacological targeting of age-related changes in skeletal muscle tissue. Pharmacological research, epub ahead of print.

Furrer, Regula; Handschin, Christoph (2019). Muscle Wasting Diseases: Novel Targets and Treatments. Annual review of pharmacology and toxicology, 59, 315-339.


Delezie, Julien; Handschin, Christoph (2018). Endocrine Crosstalk Between Skeletal Muscle and the Brain. Frontiers in Neurology, 9, 698.

Baum, Oliver; Aaldijk, Dea; Engeli, Anna Lena; Spree, Matthias; Summermatter, Serge; Handschin, Christoph; Zakrzewicz, Andreas (2018). Relation of nNOS isoforms to mitochondrial density and PGC-1alpha expression in striated muscles of mice. Nitric Oxide: Biology and Chemistry, 77, 35-43.

Whitehead, Natasha; Gill, Jonathan F.; Brink, Marijke; Handschin, Christoph (2018). Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart. Frontiers in Physiology, 9, 242.

Haralampieva, Deana; Salemi, Souzan; Betzel, Thomas; Dinulovic, Ivana; Krämer, Stefanie D.; Schibli, Roger; Sulser, Tullio; Handschin, Christoph; Ametamey, Simon M.; Eberli, Daniel (2018). Injected Human Muscle Precursor Cells Overexpressing PGC-1α. Enhance Functional Muscle Regeneration after Trauma. Stem cells international, 2018, 4658503.

Ruiz, Alexis; Dror, Erez; Handschin, Christoph; Furrer, Regula; Perez-Schindler, Joaquin; Bachmann, Christoph; Treves, Susan; Zorzato, Francesco (2018). Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance. Scientific Reports, 8 (1), 636.

Gill, Jonathan F.; Santos, Gesa; Schnyder, Svenia; Handschin, Christoph (2018). PGC-1α affects aging-related changes in muscle and motor function by modulating specific exercise-mediated changes in old mice. Aging Cell, 17 (1), e12697.

Weihrauch, Martin; Handschin, Christoph (2018). Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls. Biochemical pharmacology, 147, 211-220.

Pérez-Schindler, Joaquín; Handschin, Christoph: Physiological Regulation of Skeletal Muscle Mass: Resistance Exercise- Mediated Muscle Hypertrophy, in: Walrand, Stéphane(Ed.). (2018). Nutrition and Skeletal Muscle, London: Academic Press, 139-150.

Klapdor, Julie (2018). The effects of exercise and overexpression of muscle PGC-1alpha on cachexia and metabolism in cancer. .

Heim-Kupr, Barbara (2018). Molecular mechanisms of the transcriptional regulation by PGC-1α/β in skeletal muscle. .


Dinulovic, Ivana; Furrer, Regula; Handschin, Christoph (2017). Plasticity of the Muscle Stem Cell Microenvironment. Advances in experimental medicine and biology, 1041, 141-169.

Handschin, Christoph: Muskeln: mehr als nur "schön anzusehen", in: Füglister, Kurt M.; Hicklin, Martin; Mäser, Pascal(Ed.). (2017). natura obscura. 200 Naturforschende - 200 Naturphänomene - 200 Jahre Naturforschende Gesellschaft in Basel, Basel: Schwabe, 85-85.

Kupr, Barbara; Schnyder, Svenia; Handschin, Christoph (2017). Role of Nuclear Receptors in Exercise-Induced Muscle Adaptations. Cold Spring Harbor perspectives in medicine, 7 (6), a029835.

Schnyder, Svenia; Svensson, Kristoffer; Cardel, Bettina; Handschin, Christoph (2017). Muscle PGC-1α is required for long-term systemic and local adaptations to a ketogenic diet in mice. American Journal of Physiology. Endocrinology and Metabolism, 312 (5), E437-E446.

Haralampieva, Deana; Salemi, Souzan; Dinulovic, Ivana; Sulser, Tullio; Ametamey, Simon; Handschin, Christoph; Eberli, Daniel (2017). Human muscle precursor cells overexpressing PGC-1α enhance early skeletal muscle tissue formation. Cell Transplantation, 26 (6), 1103-1114.

Furrer, Regula; Eisele, Petra S.; Schmidt, Alexander; Beer, Markus; Handschin, Christoph (2017). Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP. Scientific Reports, 7, 40789.

Schnyder, Svenia; Kupr, Barbara; Handschin, Christoph (2017). Coregulator-mediated control of skeletal muscle plasticity - A mini-review. Biochimie, 136, 49-54.

Ross, Jacob Alexander; Pearson, Adam; Levy, Yotam; Cardel, Bettina; Handschin, Christoph; Ochala, Julien (2017). Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres. Journal of Cellular Physiology, 232 (6), 1270-1274.

Furrer, Regula; Handschin, Christoph: Optimized Engagement of Macrophages and Satellite Cells in the Repair and Regeneration of Exercised Muscle, in: Spiegelman, Bruce M.(Ed.). (2017). Hormones, Metabolism and the Benefits of Exercise, Cham: Springer, 57-66.


Dinulovic, Ivana; Furrer, Regula; Beer, Markus; Ferry, Arnaud; Cardel, Bettina; Handschin, Christoph (2016). Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche. Skeletal Muscle, 6 (1), 39.

Svensson, Kristoffer; Schnyder, Svenia; Cardel, Bettina; Handschin, Christoph (2016). Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice. PLoS ONE, 11 (7), e0158716.

Gill, Jonathan F; Delezie, Julien; Santos, Gesa; Handschin, Christoph (2016). PGC-1α expression in murine AgRP neurons regulates food intake and energy balance. Molecular metabolism, 5 (7), 580-8.

Haralampieva, Deana; Betzel, Thomas; Dinulovic, Ivana; Salemi, Souzan; Stoelting, Meline; Krämer, Stefanie D; Schibli, Roger; Sulser, Tullio; Handschin, Christoph; Eberli, Daniel; Ametamey, Simon M (2016). Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering. Journal of Nuclear Medicine, 57 (9), 1467-73.

Salatino, Silvia; Kupr, Barbara; Baresic, Mario; van Nimwegen, Erik; Handschin, Christoph (2016). The Genomic Context and Corecruitment of SP1 Affect ERRα Coactivation by PGC-1α in Muscle Cells. Molecular Endocrinology, 30 (7), 809-825.

Svensson, Kristoffer; Albert, Verena; Cardel, Bettina; Salatino, Silvia; Handschin, Christoph (2016). Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice. FASEB Journal, 30 (5), 1976-86.

Albert, V.; Svensson, K.; Shimobayashi, M.; Colombi, M.; Muñoz, S.; Jimenez, V.; Handschin, C.; Bosch, F.; Hall, M. N. (2016). mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Molecular Medicine, 8 (3), 232-246.

Stölting, Meline N. L.; Arnold, Anne Sophie; Haralampieva, Deana; Handschin, Christoph; Sulser, Tullio; Eberli, Daniel (2016). Magnetic stimulation supports muscle and nerve regeneration after trauma in mice. Muscle and Nerve, 53 (4), 598-607.

Dinulovic, Ivana; Furrer, Regula; Di Fulvio, Sabrina; Ferry, Arnaud; Beer, Markus; Handschin, Christoph (2016). PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle. Skeletal muscle, 6 (38), 38.


Handschin, Christoph (2015). Caloric restriction and exercise "mimetics'': Ready for prime time?. Pharmacological research, 103, 158-166.

Kupr, Barbara; Handschin, Christoph (2015). Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle. Frontiers in physiology, 6, 325.

Schnyder, Svenia; Handschin, Christoph (2015). Skeletal muscle as an endocrine organ : PGC-1α, myokines and exercise. Bone, 80, 115-25.

Eisele, Petra Sabine; Furrer, Regula; Beer, Markus; Handschin, Christoph (2015). The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo. Biochemical and Biophysical Research Communications, 464 (3), 692-697.

Svensson, Kristoffer; Schnyder, Svenia; Albert, Verena; Cardel, Bettina; Quagliata, Luca; Terracciano, Luigi M.; Handschin, Christoph (2015). Resveratrol and SRT1720 elicit differential effects in metabolic organs and modulate systemic parameters independently of skeletal muscle peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α). Journal of biological chemistry, 290 (26), 16059-76.

Handschin, Christoph; Mortezavi, Ashkan; Plock, Jan; Eberli, Daniel (2015). External physical and biochemical stimulation to enhance skeletal muscle bioengineering. Advanced drug delivery reviews, 82-83, 168-75.

Soler, Fernando; Fernández-Belda, Francisco; Pérez-Schindler, Joaquín; Handschin, Christoph; Fuente, Teodomiro; Hernandez-Cascales, Jesús (2015). PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects. Experimental biology and medicine, 240 (9), 1205-13.

Furrer, Regula; Handschin, Christoph (2015). Exercise and PGC-1α in inflammation and chronic disease. Deutsche Zeitschrift für Sportmedizin, 66 (12), 317-320.


Handschin, Christoph (2014). The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet. Diabetologia, 57, no. 11 (11), 2405-2412.

Baresic, Mario; Salatino, Silvia; Kupr, Barbara; van Nimwegen, Erik; Handschin, Christoph (2014). Transcriptional network analysis in muscle reveals AP-1 as a partner of PGC-1α in the regulation of the hypoxic gene program. Molecular and cellular biology, 34 (16), 2996-3012.

Svensson, Kristoffer; Handschin, Christoph (2014). MicroRNAs emerge as modulators of NAD+-dependent energy metabolism in skeletal muscle. Diabetes, 63 (5), 1451-3.

Arnold, Anne-Sophie; Gill, Jonathan; Christe, Martine; Ruiz, Rocío; McGuirk, Shawn; St-Pierre, Julie; Tabares, Lucía; Handschin, Christoph (2014). Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α. Nature communications, 5, 3569.

Svensson, Kristoffer; Handschin, Christoph (2014). Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases. Drug discovery today, 19 (7), 1024-9.

Morand, Réjane; Bouitbir, Jamal; Felser, Andrea; Hench, Jürgen; Handschin, Christoph; Frank, Stephan; Krähenbühl, Stephan (2014). Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. European journal of nutrition, 53 (6), 1313-25.

Eisele, Petra S; Handschin, Christoph (2014). Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology. Seminars in immunopathology, 36 (1), 27-53.

Svensson, Kristoffer (2014). Transcriptional regulation of kidney and skeletal muscle metabolism by the coactivator PGC-1alpha. .

Dinulovic, Ivana (2014). PGC-1alpha modulates skeletal muscle regeneration by affecting immune response and satellite cell behavior. .

Salatino, Silvia (2014). Genome-wide analysis of the transcriptional network controlled by PGC-1alpha and ERRalpha in skeletal muscle from microarray and next generation sequencing data. .


Pérez-Schindler, Joaquín; Summermatter, Serge; Santos, Gesa; Zorzato, Francesco; Handschin, Christoph (2013). The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling. Proceedings of the National Academy of Sciences of the United States of America, 110 (50), 20314-9.

Summermatter, Serge; Santos, Gesa; Pérez-Schindler, Joaquín; Handschin, Christoph (2013). Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A. Proceedings of the National Academy of Sciences of the United States of America, 110 (21), 8738-43.

Bentzinger, C. F.; Lin, S.; Romanino, K.; Castets, P.; Guridi, M.; Summermatter, S.; Handschin, C.; Tintignac, L. A.; Hall, M. N.; Rüegg, M. A. (2013). Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal Muscle, 3 (1), 6.

Eisele, Petra S.; Salatino, Silvia; Sobek, Jens; Hottiger, Michael O.; Handschin, Christoph (2013). The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells. Journal of Biological Chemistry, 288 (4), 2246-2260.

Stölting, Meline Nogueira Lucena; Ferrari, Stefano; Handschin, Christoph; Becskei, Attila; Provenzano, Maurizio; Sulser, Tullio; Eberli, Daniel (2013). Myoblasts inhibit prostate cancer growth by paracrine secretion of tumor necrosis factor-α. Journal of Urology, 189 (5), 1952-9.

Summermatter, Serge; Shui, Guanghou; Maag, Daniela; Santos, Gesa; Wenk, Markus R; Handschin, Christoph (2013). PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner. Diabetes, 62 (1), 85-95.

Schnyder, Svenia (2013). The role of skeletal muscle PGC-1alpha in mediating the calorie restriction mimetic effects of resveratrol and SRT1720. .

Pérez-Schindler, Joaquín (2013). Regulation of skeletal muscle plasticity by the transcriptional coregulators PGC-1alpha and NCoR1. , 186.

Baresic, Mario (2013). The molecular dissection of the regulation of PGC-1alpha and the genome-wide activity of its transcriptional network in skeletal muscle cells. , 134.

Pérez-Schindler, Joaquín; Handschin, Christoph (2013). New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases. Drug Discovery Today. Disease Models, 10 (2), e79-e85.

Stefanie Bürgin-Wenger, (2013). Transcriptional signature of skeletal muscle hypertophy. , 52.


Pérez-Schindler, Joaquín; Summermatter, Serge; Salatino, Silvia; Zorzato, Francesco; Beer, Markus; Balwierz, Piotr J; van Nimwegen, Erik; Feige, Jérôme N; Auwerx, Johan; Handschin, Christoph (2012). The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism. Molecular and cellular biology, 32 (24), 4913-24.

Arnold, Anne-Sophie; Christe, Martine; Handschin, Christoph (2012). A functional motor unit in the culture dish : co-culture of spinal cord explants and muscle cells. Journal of visualized experiments, 62, e3616.

Egger, A.; Samardzija, M.; Sothilingam, V.; Tanimoto, N.; Lange, C.; Salatino, S.; Fang, L.; Garcia-Garrido, M.; Beck, S.; Okoniewski, M. J.; Neutzner, A.; Seeliger, M. W.; Grimm, C.; Handschin, C. (2012). PGC-1α determines light damage susceptibility of the murine retina. PLoS ONE, 7 (2), e31272.

Summermatter, S; Handschin, C (2012). PGC-1α and exercise in the control of body weight. International journal of obesity and related metabolic disorders, 36 (11), 1428-35.

Summermatter, Serge; Thurnheer, Raphael; Santos, Gesa; Mosca, Barbara; Baum, Oliver; Treves, Susan; Hoppeler, Hans; Zorzato, Francesco; Handschin, Christoph (2012). Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type. American Journal of Physiology, 302 (1), C88-99.

Eisele, Petra (2012). The role of PGC-1alpha and PGC-1beta during inflammatory processes in skeletal muscle. .

Handschin, Christoph; Meyer, Urs A. (2012). Warum reagiert mein Patient anders auf dieses Medikament? : Pharmakogenomik und personalisierte Medizin in der Praxis. Swiss medical forum = Schweizerisches Medizin-Forum, 12 (22), 425-433.


Romanino, Klaas; Mazelin, Laetitia; Albert, Verena; Conjard-Duplany, Agnès; Lin, Shuo; Bentzinger, C Florian; Handschin, Christoph; Puigserver, Pere; Zorzato, Francesco; Schaeffer, Laurent; Gangloff, Yann-Gaël; Rüegg, Markus A (2011). Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America, 108 (51), 20808-13.

Summermatter, Serge; Troxler, Heinz; Santos, Gesa; Handschin, Christoph (2011). Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity. Biochemical and biophysical research communications, 408 (1), 180-5.

Handschin, Christoph; Spiegelman, Bruce M (2011). PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination. Cell metabolism, 13 (4), 351;authorreply352.

Handschin, C (2011). Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) improves skeletal muscle mitochondrial function and insulin sensitivity. Diabetologia, 54 (6), 1270-2.

Arnold, Anne-Sophie; Egger, Anna; Handschin, Christoph (2011). PGC-1α and Myokines in the aging muscle : a mini-review. Gerontology, 57 (1), 37-43.

Egger, A. (2011). The role of the coactivators PGC-1alpha and PGC-1beta in retina and skeletal muscle. , 111.


Stein, S.; Lohmann, C.; Handschin, C.; Stenfeldt, E.; Boren, J.; Luscher, T. F.; Matter, C. M. (2010). ApoE−/− PGC-1α−/− mice display reduced IL-18 levels and do not develop enhanced atherosclerosis. PLoS ONE, Vol. 5, H. 10 , e13539.

Summermatter, S.; Baum, O.; Santos, G.; Hoppeler, H.; Handschin, C. (2010). Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway. Journal of Biological Chemistry, 285 (43), 32793-32800.

Stein, Sokrates; Schaefer, Nicola; Breitenstein, Alexander; Besler, Christian; Winnik, Stephan; Lohmann, Christine; Heinrich, Kathrin; Brokopp, Chad E.; Handschin, Christoph; Landmesser, Ulf; Tanner, Felix C.; Luescher, Thomas F.; Matter, Christian M. (2010). SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice. Aging, 2 (6), 353-360.

Burch, N.; Arnold, A. S.; Item, F.; Summermatter, S.; Brochmann Santana Santos, G.; Christe, M.; Boutellier, U.; Toigo, M.; Handschin, C. (2010). Electric pulse stimulation of cultured murine muscle cells reproduces gene expression changes of trained mouse muscle. PLoS ONE, 5 (6), e10970.

Handschin, Christoph (2010). Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor gamma coactivator 1alpha. Journal of receptors and signal transduction, 30 (6), 376-84.

Handschin, Christoph; Summermatter, Serge; LeBrasseur, Nathan K.; Lin, Jiandie; Spiegelman, Bruce M. (2010). For a pragmatic approach to exercise studies. Journal of Applied Physiology, 108 (1), 223-223.


Handschin, Christoph (2009). Peroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation. Clinical and experimental pharmacology and physiology, 36 (12), 1139-43.

Handschin, C (2009). PGC-1a in muscle links metabolism to inflammation. Proceedings of the Australian Physiological Society, 40, 11-16.

Zenhaeusern, G.; Gubser, P.; Eisele, P.; Gasser, O.; Steinhuber, A.; Trampuz, A.; Handschin, C.; Luster, A. D.; Hess, C. (2009). A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells. Blood, 113 (1), 95-99.

Handschin, C. (2009). The biology of PGC-1α and its therapeutic potential. Trends in Pharmacological Sciences, 30 (6), 322-329.

Burch, N. (2009). Development of a new cell culture model to study the role of PGC-1alpha in exercise. .


Handschin, Christoph; Spiegelman, Bruce M (2008). The role of exercise and PGC1alpha in inflammation and chronic disease. Nature, 454 (7203), 463-9.

Choi, Cheol Soo; Befroy, Douglas E; Codella, Roberto; Kim, Sheene; Reznick, Richard M; Hwang, Yu-Jin; Liu, Zhen-Xiang; Lee, Hui-Young; Distefano, Alberto; Samuel, Varman T; Zhang, Dongyan; Cline, Gary W; Handschin, Christoph; Lin, Jiandie; Petersen, Kitt F; Spiegelman, Bruce M; Shulman, Gerald I (2008). Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America, 105 (50), 19926-31.

Handschin, Christoph: Induction of drug metabolism : role for nuclear receptors, in: Ottow , Eckhard; Weinmann, Hilmar(Ed.). (2008). Nuclear Receptors as Drug Targets (Methods and Principles in Medicinal Chemistry, Vol. 39), Weinheim: Wiley-VCH, 453-468.


Rohas, L. M.; St-Pierre, J.; Uldry, M.; Jager, S.; Handschin, C.; Spiegelman, B. M. (2007). A fundamental system of cellular energy homeostasis regulated by PGC-1α. Proceedings of the National Academy of Sciences of the United States of America, 104 (19), 7933-7938.

Matter, C. M.; Handschin, C. (2007). RANTES (regulated on activation, normal T cell expressed and secreted), inflammation, obesity, and the metabolic syndrome. Circulation, 115 (8), 946-8.

Jäger, Sibylle; Handschin, Christoph; St-Pierre, Julie; Spiegelman, Bruce M (2007). AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α. Proceedings of the National Academy of Sciences of the United States of America, 104 (29), 12017-22.

Handschin, Christoph; Kobayashi, Yvonne M; Chin, Sherry; Seale, Patrick; Campbell, Kevin P; Spiegelman, Bruce M (2007). PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes & development, 21 (7), 770-83.

Handschin, C.; Choi, C. S.; Chin, S.; Kim, S.; Kawamori, D.; Kurpad, A. J.; Neubauer, N.; Hu, J.; Mootha, V. K.; Kim, Y. -B.; Kulkarni, R. N.; Shulman, G. I.; Spiegelman, B. M. (2007). Abnormal glucose homeostasis in skeletal muscle-specific PGC-1α knockout mice reveals skeletal muscle-pancreatic β cell crosstalk. Journal of Clinical Investigation, 117 (11), 3463-74.

Handschin, C.; Chin, S.; Li, P.; Liu, F.; Maratos-Flier, E.; Lebrasseur, N. K.; Yan, Z.; Spiegelman, B. M. (2007). Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals. Journal of Biological Chemistry, 282 (41), 30014-21.


Wu, Z.; Huang, X.; Feng, Y.; Handschin, C.; Gullicksen, P. S.; Bare, O.; Labow, M.; Spiegelman, B.; Stevenson, S. C. (2006). Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells. Proceedings of the National Academy of Sciences of the United States of America, 103 (39), 14379-84.

St-Pierre, J.; Drori, S.; Uldry, M.; Silvaggi, J. M.; Rhee, J.; Jager, S.; Handschin, C.; Zheng, K.; Lin, J.; Yang, W.; Simon, D. K.; Bachoo, R.; Spiegelman, B. M. (2006). Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell, 127 (2), 397-408.

Sandri, Marco; Lin, Jiandie; Handschin, Christoph; Yang, Wenli; Arany, Zoltan P; Lecker, Stewart H; Goldberg, Alfred L; Spiegelman, Bruce M (2006). PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proceedings of the National Academy of Sciences of the United States of America, 103 (44), 16260-5.

Rhee, J.; Ge, H.; Yang, W.; Fan, M.; Handschin, C.; Cooper, M.; Lin, J.; Li, C.; Spiegelman, B. M. (2006). Partnership of PGC-1α and HNF4α in the regulation of lipoprotein metabolism. Journal of Biological Chemistry, 281 (21), 14683-90.

Handschin, Christophe; Spiegelman, Bruce M (2006). Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism. Endocrine reviews, 27 (7), 728-35.


Handschin, C.; Gnerre, C.; Fraser, D. J.; Martinez-Jimenez, C.; Jover, R.; Meyer, U. A. (2005). Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Archives of Biochemistry and Biophysics, 434 (1), 75-85.

Gnerre, C.; Schuster, G. U.; Roth, A.; Handschin, C.; Johansson, L.; Looser, R.; Parini, P.; Podvinec, M.; Robertsson, K.; Gustafsson, J. -A.; Meyer, U. A. (2005). LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver. Journal of Lipid Research, 46 (8), 1633-42.

Lin, J.; Yang, R.; Tarr, P. T.; Wu, P. -H.; Handschin, C.; Li, S.; Yang, W.; Pei, L.; Uldry, M.; Tontonoz, P.; Newgard, C. B.; Spiegelman, B. M. (2005). Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP. Cell, 120 (2), 261-73.

Lin, Jiandie; Handschin, Christoph; Spiegelman, Bruce M (2005). Metabolic control through the PGC-1 family of transcription coactivators. Cell Metabolism, 1 (6), 361-70.

Handschin, C.; Meyer, U. A. (2005). Regulatory network of lipid-sensing nuclear receptors: : roles for CAR, PXR, LXR, and FXR. Archives of Biochemistry and Biophysics, 433 (2), 387-96.

Handschin, Christoph; Lin, Jiandie; Rhee, James; Peyer, Anne-Kathrin; Chin, Sherry; Wu, Pei-Hsuan; Meyer, Urs A; Spiegelman, Bruce M (2005). Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α. Cell, 122 (4), 505-15.

Arany, Z.; He, H.; Lin, J.; Hoyer, K.; Handschin, C.; Toka, O.; Ahmad, F.; Matsui, T.; Chin, S.; Wu, P. -H.; Rybkin, I. I.; Shelton, J. M.; Manieri, M.; Cinti, S.; Schoen, F. J.; Bassel-Duby, R.; Rosenzweig, A.; Ingwall, J. S.; Spiegelman, B. M. (2005). Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle. Cell Metabolism, Vol. 1, H. 4, 259-271.

Handschin, C.; Mootha, V. K. (2005). Estrogen-related receptor α (ERRα) : a novel target in type 2 diabetes. Drug Discovery Today. Therapeutic Strategies, 2 (2), 151-156.

Handschin, C.; Meyer, U. A.: PXR and CAR: more than meets the eyeProceedings of the 15th Int. symposium on microsomes and drug oxidation, Bologna: medimond Int. Poc. Div. Monduzzi Editore, 17-21.


Mootha, Vamsi K.; Handschin, Christoph; Arlow, Dan; Xie, Xiaohui; St Pierre, Julie; Sihag, Smita; Yang, Wenli; Altshuler, David; Puigserver, Pere; Patterson, Nick; Willy, Patricia J.; Schulman, Ira G.; Heyman, Richard A.; Lander, Eric S.; Spiegelman, Bruce M. (2004). Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proceedings of the National Academy of Sciences of the United States of America, 101 (17), 6570-5.

Podvinec, M.; Handschin, C.; Looser, R.; Meyer, U. A. (2004). Identification of the xenosensors regulating human 5-aminolevulinate synthase. Proceedings of the National Academy of Sciences of the United States of America, 101 (24), 9127-32.

Handschin, Christoph; Blättler, Sharon; Roth, Adrian; Looser, Renate; Oscarson, Mikael; Kaufmann, Michel R; Podvinec, Michael; Gnerre, Carmela; Meyer, Urs A (2004). The evolution of drug-activated nuclear receptors : one ancestral gene diverged into two xenosensor genes in mammals. Nuclear Receptor, 2 (1), 7.

Fan, Melina; Rhee, James; St-Pierre, Julie; Handschin, Christoph; Puigserver, Pere; Lin, Jiandie; Jäeger, Sibylle; Erdjument-Bromage, Hediye; Tempst, Paul; Spiegelman, Bruce M (2004). Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α : modulation by p38 MAPK. Genes & development, 18 (3), 278-89.


Handschin, C.; Meyer, U. A. (2003). Induction of drug metabolism: the role of nuclear receptors. Pharmacological reviews, 55 (4), 649-73.

Sanyal, S.; Handschin, C.; Podvinec, M.; Song, K. -H.; Kim, H. -J.; Kim, J. -Y.; Seo, Y. -W.; Kim, S. -A.; Kwon, H. -B.; Lee, K.; Kim, W. -S.; Meyer, U. A.; Choi, H. -S. (2003). Molecular cloning and characterization of chicken orphan nuclear receptor cTR2. General and Comparative Endocrinology, 132 (3), 474-84.

Handschin, Christoph; Podvinec, Michael; Meyer, Urs A. (2003). In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism. Drug news & perspectives, 16 (7), 423-434.

Handschin, Christoph; Rhee, James; Lin, Jiandie; Tarr, Paul T; Spiegelman, Bruce M (2003). An An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle. Proceedings of the National Academy of Sciences of the United States of America, 100 (12), 7111-6.

Handschin, C.; Meyer, U. A.: The molecular mechanism of induction of cytochromes P450 by drugs and other xenobioticsMolecular Investigation of Metabolism and Transport of Drugs - from Animal to Human Tissue, Halle (Saale): Deutsche Akademie der Naturforscher Leopoldina, 87, 205-211.


Ourlin, J. -C.; Handschin, C.; Kaufmann, M.; Meyer, U. A. (2002). A Link between cholesterol levels and phenobarbital induction of cytochromes P450. Biochemical and Biophysical Research Communications, 291 (2), 378-384.

Podvinec, Michael; Kaufmann, Michel R; Handschin, Christoph; Meyer, Urs A (2002). NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Molecular endocrinology, 16 (6), 1269-79.

Handschin, C.; Podvinec, M.; Amherd, R.; Looser, R.; Ourlin, J. -C.; Meyer, U. A. (2002). Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. Journal of Biological Chemistry, 277 (33), 29561-7.


Handschin, C; Podvinec, M; Stöckli, J; Hoffmann, K; Meyer, U A (2001). Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. Molecular endocrinology, 15 (9), 1571-85.

Handschin, C.; Podvinec, M.; Looser, R.; Amherd, R.; Meyer, U. A. (2001). Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor. Molecular pharmacology, 60 (4), 681-9.

Handschin, C (2001). A regulatory network of nuclear receptors for hepatic cytochrome P450 induction by drugs: Interactions between the xenobiotic-, the cholesterol- and the bile acid-sensors CXR, LXR and FXR in chicken liver. .


Handschin, C.; Meyer, U. A. (2000). A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line. Journal of Biological Chemistry, 275 (18), 13362-13369.

Handschin, C; Podvinec, M; Meyer, U A (2000). CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR). Proceedings of the National Academy of Sciences of the United States of America, 97 (20), 10769-74.


Handschin, C (1996). Interactions of alpha-melanocyte-stimulating hormone (alpha-MSH), melanin-concentrating hormone (MCH) and melatonin in B16F1 mouse melanoma cells. .

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