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2019

Dubey, Badri N.; Agustoni, Elia; Böhm, Raphael; Kaczmarczyk, Andreas; Mangia, Francesca; von Arx, Christoph; Jenal, Urs; Hiller, Sebastian; Plaza-Menacho, Iván; Schirmer, Tilman (2019). Hybrid histidine kinase activation by cyclic di-GMP-mediated domain liberation. , BioRxiv...

Rath, Parthasarathi; Sharpe, Timothy; Kohl, Bastian; Hiller, Sebastian (2019). Two-state folding of the outer membrane protein X into a lipid bilayer membrane. Angewandte Chemie (International ed. in English), inpress.

Hiller, Sebastian (2019). Chaperone-Bound Clients: The Importance of Being Dynamic. Trends in Biochemical Sciences, inpress.

2018

Frey, Lukas; Hiller, Sebastian; Riek, Roland; Bibow, Stefan (2018). Lipid- and Cholesterol-Mediated Time-Scale-Specific Modulation of the Outer Membrane Protein X Dynamics in Lipid Bilayers. Journal of the American Chemical Society, 140 (45), 15402-15411.

Bibow, Stefan; Hiller, Sebastian (2018). A guide to quantifying membrane protein dynamics in lipids and other native-like environments by solution-state NMR spectroscopy. The FEBS journal, 1-14.

Hartmann, Jean-Baptiste; Zahn, Michael; Burmann, Irena Matecko; Bibow, Stefan; Hiller, Sebastian (2018). Sequence-Specific Solution NMR Assignments of the beta-Barrel Insertase BamA to Monitor Its Conformational Ensemble at the Atomic Level. Journal of the American Chemical Society, 140 (36), 11252-11260.

Mulvihill, Estefania; Sborgi, Lorenzo; Mari, Stefania A; Pfreundschuh, Moritz; Hiller, Sebastian; Müller, Daniel J (2018). Mechanism of membrane pore formation by human gasdermin-D. The EMBO journal, 37 (14), e98321.

Mas, Guillaume; Hiller, Sebastian (2018). Conformational plasticity of molecular chaperones involved in periplasmic and outer membrane protein folding. FEMS microbiology letters, 365 (13), fny121.

Hiller, Sebastian; Burmann, Björn M. (2018). Chaperone-client complexes: A dynamic liaison. Journal of Magnetic Resonance, 289, 142-155.

He, Lichun; Hiller, Sebastian (2018). Common Patterns in Chaperone Interactions with a Native Client Protein. Angewandte Chemie (International ed. in English), 57 (20), 5921-5924.

Heilig, Rosalie; Dick, Mathias S.; Sborgi, Lorenzo; Meunier, Etienne; Hiller, Sebastian; Broz, Petr (2018). The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice. European journal of immunology, 48 (4), 584-592.

Melo, Esther; Oertle, Philipp; Trepp, Carolyn; Meistermann, Hélène; Burgoyne, Thomas; Sborgi, Lorenzo; Cabrera, Alvaro Cortes; Chen, Chia-Yi; Hoflack, Jean-Christophe; Kam-Thong, Tony; Schmucki, Roland; Badi, Laura; Flint, Nicholas; Ghiani, Zeynep Eren; Delobel, Fréderic; Stucki, Corinne; Gromo, Giulia; Einhaus, Alfred; Hornsperger, Benoit; Golling, Sabrina; Siebourg-Polster, Juliane; Gerber, Francoise; Bohrmann, Bernd; Futter, Clare; Dunkley, Tom; Hiller, Sebastian; Schilling, Oliver; Enzmann, Volker; Fauser, Sascha; Plodinec, Marija; Iacone, Roberto (2018). HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model. EBioMedicine, 27, 258-274.

Sborgi, Lorenzo; Ude, Johanna; Dick, Mathias S; Vesin, Johnathan; Chambon, Marc; Turcatti Gerardo,; Broz, Petr; Hiller Sebastian, (2018). Assay for high-throughput screening of inhibitors of the ASC-PYD inflammasome core filament. Cell Stress, 2, 82-90.

2017

Morgado, Leonor; Burmann, Björn M; Sharpe, Timothy; Mazur, Adam; Hiller, Sebastian (2017). The dynamic dimer structure of the chaperone Trigger Factor. Nature communications, 8 (1), 1992.

Holdbrook, Daniel A.; Burmann, Björn M.; Huber, Roland G.; Petoukhov, Maxim V.; Svergun, Dmitri I.; Hiller, Sebastian; Bond, Peter J. (2017). A Spring-Loaded Mechanism Governs the Clamp-like Dynamics of the Skp Chaperone. Structure, 25 (7), 1079-+.

Thoma, Johannes; Ritzmann, Noah; Wolf, Dominik; Mulvihill, Estefania; Hiller, Sebastian; Müller, Daniel J. (2017). Maltoporin LamB Unfolds β Hairpins along Mechanical Stress-Dependent Unfolding Pathways. Structure, 25 (7), 1139-1144.e2.

Böhm, Raphael; Wagner, Gerhard; Hiller, Sebastian: Solution NMR spectroscopy of integral membrane proteins, in: Zhou, Huan-Xiang (Ed.). (2017). Reference module in Life Sciences, New York: Elsevier, 1-25.

2016

Zhong, Franklin L.; Mamaï, Ons; Sborgi, Lorenzo; Boussofara, Lobna; Hopkins, Richard; Robinson, Kim; Szeverényi, Ildikó; Takeichi, Takuya; Balaji, Reshmaa; Lau, Aristotle; Tye, Hazel; Roy, Keya; Bonnard, Carine; Ahl, Patricia J.; Jones, Leigh Ann; Baker, Paul; Lacina, Lukas; Otsuka, Atsushi; Fournie, Pierre R.; Malecaze, François; Lane, E. Birgitte; Akiyama, Masashi; Kabashima, Kenji; Connolly, John E.; Masters, Seth L.; Soler, Vincent J.; Omar, Salma Samir; McGrath, John A.; Nedelcu, Roxana; Gribaa, Moez; Denguezli, Mohamed; Saad, Ali; Hiller, Sebastian; Reversade, Bruno (2016). Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation. Cell, 167 (1), 187-202.e17.

Sborgi, Lorenzo; Rühl, Sebastian; Mulvihill, Estefania; Pipercevic, Joka; Heilig, Rosalie; Stahlberg, Henning; Farady, Christopher J.; Müller, Daniel J.; Broz, Petr; Hiller, Sebastian (2016). GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. The EMBO Journal, 35 (16), 1766-78.

Dick, Mathias S.; Sborgi, Lorenzo; Rühl, Sebastian; Hiller, Sebastian; Broz, Petr (2016). ASC filament formation serves as a signal amplification mechanism for inflammasomes. Nature Communications, 7, 11929.

Raschle, Thomas; Rios Flores, Perla; Opitz, Christian; Müller, Daniel J.; Hiller, Sebastian (2016). Monitoring Backbone Hydrogen-Bond Formation in β-Barrel Membrane Protein Folding. Angewandte Chemie. International edition in English, 55 (20), 5952-5.

Stanger, Frédéric V.; Burmann, Björn M.; Harms, Alexander; Aragão, Hugo; Mazur, Adam; Sharpe, Timothy; Dehio, Christoph; Hiller, Sebastian; Schirmer, Tilman (2016). Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification. Proceedings of the National Academy of Sciences of the United States of America, 113 (5), E529-37.

Ravotti, Francesco; Sborgi, Lorenzo; Cadalbert, Riccardo; Huber, Matthias; Mazur, Adam; Broz, Petr; Hiller, Sebastian; Meier, Beat H.; Böckmann, Anja (2016). Sequence-specific solid-state NMR assignments of the mouse ASC PYRIN domain in its filament form. Biomolecular NMR Assignments, 10 (1), 107-15.

He, Lichun; Sharpe, Timothy; Mazur, Adam; Hiller, Sebastian (2016). A molecular mechanism of chaperone-client recognition. Science Advances, 2 (11), e1601625.

2015

Sborgi, Lorenzo; Ravotti, Francesco; Dandey, Venkata Prasad; Dick, Mathias S.; Mazur, Adam; Reckel, Sina; Chami, Mohamed; Scherer, Sebastian; Huber, Matthias; Böckmann, Anja; Egelman, Edward H.; Stahlberg, Henning; Broz, Petr; Meier, Beat H.; Hiller, Sebastian (2015). Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy. Proceedings of the National Academy of Sciences of the United States of America, 112 (43), 13237-42.

Gruss, Fabian; Hiller, Sebastian; Maier, Timm (2015). Purification and Bicelle Crystallization for Structure Determination of the E. coli Outer Membrane Protein TamA. Methods in Molecular Biology, 1329, 259-70.

Thoma, Johannes; Burmann, Björn M.; Hiller, Sebastian; Müller, Daniel J. (2015). Impact of holdase chaperones Skp and SurA on the folding of β-barrel outer-membrane proteins. Nature structural & molecular biology, 22 (10), 795-802.

Arquint, Christian; Gabryjonczyk, Anna-Maria; Imseng, Stefan; Böhm, Raphael; Sauer, Evelyn; Hiller, Sebastian; Nigg, Erich A.; Maier, Timm (2015). STIL binding to Polo-box 3 of PLK4 regulates centriole duplication. eLife, 4, e07888.

Maier, Timm; Clantin, Bernard; Gruss, Fabian; Dewitte, Frédérique; Delattre, Anne-Sophie; Jacob-Dubuisson, Françoise; Hiller, Sebastian; Villeret, Vincent (2015). Conserved Omp85 lid-lock structure and substrate recognition in FhaC. Nature Communications, 6, 7452.

Lori, Christian; Ozaki, Shogo; Steiner, Samuel; Böhm, Raphael; Abel, Sören; Dubey, Badri N.; Schirmer, Tilman; Hiller, Sebastian; Jenal, Urs (2015). Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication. Nature, 523 (7559), 236-9.

Burmann, Björn M.; Hiller, Sebastian (2015). Chaperones and chaperone-substrate complexes: dynamic playgrounds for NMR spectroscopists. Progress in Nuclear Magnetic Resonance Spectroscopy, 86-87, 41-64.

Burmann, Björn M.; Holdbrook, Daniel A.; Callon, Morgane; Bond, Peter J.; Hiller, Sebastian (2015). Revisiting the interaction between the chaperone Skp and lipopolysaccharide. Biophysical journal, 108 (6), 1516-26.

Brahimi-Horn, M. Christiane; Lacas-Gervais, Sandra; Adaixo, Ricardo; Ilc, Karine; Rouleau, Matthieu; Notte, Annick; Dieu, Marc; Michiels, Carine; Voeltzel, Thibault; Maguer-Satta, Véronique; Pelletier, Joffrey; Ilie, Marius; Hofman, Paul; Manoury, Bénédicte; Schmidt, Alexander; Hiller, Sebastian; Pouysségur, Jacques; Mazure, Natalie M. (2015). Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia. Molecular and cellular biology, 35 (9), 1491-505.

Morgado, Leonor; Zeth, Kornelius; Burmann, Björn M.; Maier, Timm; Hiller, Sebastian (2015). Characterization of the insertase BamA in three different membrane mimetics by solution NMR spectroscopy. Journal of biomolecular NMR, 61 (3-4), 333-45.

Jakob, Roman P.; Koch, Johanna R.; Burmann, Björn M.; Schmidpeter, Philipp A. M.; Hunkeler, Moritz; Hiller, Sebastian; Schmid, Franz X.; Maier, Timm (2015). Dimeric structure of the bacterial extracellular foldase PrsA. Journal of Biological Chemistry, 290 (6), 3278-92.

2014

Kentner, David; Martano, Giuseppe; Callon, Morgane; Chiquet, Petra; Brodmann, Maj; Burton, Olga; Wahlander, Asa; Nanni, Paolo; Delmotte, Nathanaël; Grossmann, Jonas; Limenitakis, Julien; Schlapbach, Ralph; Kiefer, Patrick; Vorholt, Julia A.; Hiller, Sebastian; Bumann, Dirk (2014). Shigella reroutes host cell central metabolism to obtain high-flux nutrient supply for vigorous intracellular growth. Proceedings of the National Academy of Sciences of the United States of America, 111 (27), 9929-34.

Schnarwiler, Felix; Niemann, Moritz; Doiron, Nicholas; Harsman, Anke; Käser, Sandro; Mani, Jan; Chanfon, Astrid; Dewar, Caroline E.; Oeljeklaus, Silke; Jackson, Christopher B.; Pusnik, Mascha; Schmidt, Oliver; Meisinger, Chris; Hiller, Sebastian; Warscheid, Bettina; Schnaufer, Achim C.; Ochsenreiter, Torsten; Schneider, André (2014). Trypanosomal TAC40 constitutes a novel subclass of mitochondrial β-barrel proteins specialized in mitochondrial genome inheritance. Proceedings of the National Academy of Sciences of the United States of America, 111 (21), 7624-9.

Callon, Morgane; Burmann, Björn M.; Hiller, Sebastian (2014). Structural mapping of a chaperone-substrate interaction surface. Angewandte Chemie. International edition in English, 53 (20), 5069-72.

Etzkorn, Manuela; Zoonens, Manuel; Catoire, Laurent J.; Popot, Jean-Luc; Hiller, Sebastian (2014). How amphipols embed membrane proteins : global solvent accessibility and interaction with a flexible protein terminus. The journal of membrane biology, 247 (9-10), 965-970.

2013

Burmann, Björn M; Wang, Congwei; Hiller, Sebastian (2013). Conformation and dynamics of the periplasmic membrane-protein-chaperone complexes OmpX-Skp and tOmpA-Skp. Nature structural & molecular biology, 20, 1265-1272.

Gruss, Fabian; Zähringer, Franziska; Jakob, Roman P.; Burmann, Björn M.; Hiller, Sebastian; Maier, Timm (2013). The structural basis of autotransporter translocation by TamA. Nature structural & molecular biology, 20 (11), 1318-U247.

Hiller, Sebastian (2013). The functional heart of the M2 channel. Biophysical journal, 104 (8), 1639-1640.

Reckel, Sina; Hiller, Sebastian (2013). Perspectives of Solution NMR Spectroscopy for Structural and Functional Studies of Integral Membrane Proteins. Molecular physics, 111 (7), 843-849.

2012

Burmann, Björn M; Hiller, Sebastian (2012). Solution NMR studies of membrane-protein-chaperone complexes. Chimia, 66, 759-63.

Bühler, Marc; Hiller, Sebastian (2012). Dynamic nature of heterochromatin highlighted by a HP1(Swi6)-dependent gene silencing mechanism. Cell cycle, 11 (21), 3907-3908.

Harsman, Anke; Niemann, Moritz; Pusnik, Mascha; Schmidt, Oliver; Burmann, Björn M.; Hiller, Sebastian; Meisinger, Chris; Schneider, André; Wagner, Richard (2012). Bacterial origin of a mitochondrial outer membrane protein translocase : new perspectives from comparative single channel electrophysiology. Journal of biological chemistry, 287 (37), 31437-45.

Keller, Claudia; Adaixo, Ricardo; Stunnenberg, Rieka; Woolcock, Katrina Jane; Hiller, Sebastian; Bühler, Marc (2012). HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts. Molecular cell, 47 (2), 215-27.

Huber, Matthias; Böckmann, Anja; Hiller, Sebastian; Meier, Beat H. (2012). 4D solid-state NMR for protein structure determination. Physical Chemistry, Chemical Physics, 14 (15), 5239-46.

Yu, Tsyr-Yan; Raschle, Thomas; Hiller, Sebastian; Wagner, Gerhard (2012). Solution NMR spectroscopic characterization of human VDAC-2 in detergent micelles and lipid bilayer nanodiscs. Biochimica et biophysica acta. BBA. Biomembranes, 1818 (6), 1562-9.

Hiller, Sebastian; Wider, Gerhard (2012). Automated projection spectroscopy and its applications. Topics in current chemistry, 316, 21-47.

Hiller, Sebastian; Wagner, Gerhard: Solution NMR Spectroscopy of Integral Membrane ProteinsComprehensive Biophysics, Burlington: Elsevier, 5, 120-138.

2011

Krähenbühl, Barbara; Hiller, Sebastian; Wider, Gerhard (2011). 4D APSY-HBCB(CG)CDHD experiment for automated assignment of aromatic amino acid side chains in proteins. Journal of biomolecular NMR, 51 (3), 313-8.

Huber, Matthias; Hiller, Sebastian; Schanda, Paul; Ernst, Matthias; Böckmann, Anja; Verel, René; Meier, Beat H. (2011). A proton-detected 4D solid-state NMR experiment for protein structure determination. ChemPhysChem, 12 (5), 915-918.

Gossert, Alvar D.; Hiller, Sebastian; Fernández, César (2011). Automated NMR resonance assignment of large proteins for protein-ligand interaction studies. Journal of the American Chemical Society, 133 (2), 210-3.

2010

Hiller, Sebastian; Abramson, Jeff; Mannella, Carmen; Wagner, Gerhard; Zeth, Kornelius (2010). The 3D structures of VDAC represent a native conformation. Trends in biochemical sciences, 35 (9), 514-521.

Raschle, Thomas; Hiller, Sebastian; Etzkorn, Manuel; Wagner, Gerhard (2010). Nonmicellar systems for solution NMR spectroscopy of membrane proteins. Current Opinion in Structural Biology, 20 (4), 471-9.

Hiller, Sebastian; Malia, Thomas J.; Garces, Robert G.; Orekhov, Vladislav Y.; Wagner, Gerhard (2010). Backbone and ILV side chain methyl group assignments of the integral human membrane protein VDAC-1. Biomolecular NMR Assignments, 4 (1), 29-32.

Takeuchi, Koh; Frueh, Dominique P.; Sun, Zhen-Yu J.; Hiller, Sebastian; Wagner, Gerhard (2010). CACA-TOCSY with alternate 13C-12C labeling: a 13Calpha direct detection experiment for mainchain resonance assignment, dihedral angle information, and amino acid type identification. Journal of biomolecular NMR, 47 (1), 55-63.

Kräutler, Vincent; Hiller, Sebastian; Hünenberger, Philippe H. (2010). Residual structure in a peptide fragment of the outer membrane protein X under denaturing conditions: a molecular dynamics study. European biophysics journal, 39 (10), 1421-32.

2009

Raschle, Thomas; Hiller, Sebastian; Yu, Tsyr-Yan; Rice, Amanda J.; Walz, Thomas; Wagner, Gerhard (2009). Structural and functional characterization of the integral membrane protein VDAC-1 in lipid bilayer nanodiscs. The journal of the American Chemical Society, 131 (49), 17777-9.

Hiller, Sebastian; Ibraghimov, Ilghis; Wagner, Gerhard; Orekhov, Vladislav Y. (2009). Coupled decomposition of four-dimensional NOESY spectra. The journal of the American Chemical Society, 131 (36), 12970-8.

Hiller, Sebastian; Wagner, Gerhard (2009). The role of solution NMR in the structure determinations of VDAC-1 and other membrane proteins. Current opinion in structural biology, 19 (4), 396-401.

Hiller, Sebastian; Arthanari, Haribabu; Wagner, Gerhard (2009). The T-lock: automated compensation of radio-frequency induced sample heating. Journal of biomolecular NMR, 44 (2), 69-76.

2008

Hiller, Sebastian; Wider, Gerhard; Wüthrich, Kurt (2008). APSY-NMR with proteins: practical aspects and backbone assignment. Journal of biomolecular NMR, 42 (3), 179-95.

Hiller, Sebastian; Garces, Robert G.; Malia, Thomas J.; Orekhov, Vladislav Y.; Colombini, Marco; Wagner, Gerhard (2008). Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science, 321 (5893), 1206-10.

Hiller, Sebastian; Joss, Rosmarie; Wider, Gerhard (2008). Automated NMR assignment of protein side chain resonances using automated projection spectroscopy (APSY). The journal of the American Chemical Society, 130 (36), 12073-9.

Suzuki, Chikako; Garces, Robert G.; Edmonds, Katherine A.; Hiller, Sebastian; Hyberts, Sven G.; Marintchev, Assen; Wagner, Gerhard (2008). PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Proceedings of the National Academy of Sciences of the United States of America, 105 (9), 3274-9.

Hiller, Sebastian; Wider, Gerhard; Imbach, Lukas L.; Wüthrich, Kurt (2008). Interactions with hydrophobic clusters in the urea-unfolded membrane protein OmpX. Angewandte Chemie. International edition in English, 47 (5), 977-81.

2007

Etezady-Esfarjani, Touraj; Hiller, Sebastian; Villalba, Cristina; Wüthrich, Kurt (2007). Cell-free protein synthesis of perdeuterated proteins for NMR studies. Journal of biomolecular NMR, 39 (3), 229-38.

Hiller, Sebastian; Wasmer, Christian; Wider, Gerhard; Wüthrich, Kurt (2007). Sequence-specific resonance assignment of soluble nonglobular proteins by 7D APSY-NMR spectroscopy. The journal of the American Chemical Society, 129 (35), 10823-8.

Gossert, Alvar D.; Hiller, Sebastian; Fiorito, Francesco; Wüthrich, Kurt (2007). NMR assignment of the E. coli type 1 pilus protein FimF. Journal of biomolecular NMR, 38 (2), 195.

2006

Fiorito, Francesco; Hiller, Sebastian; Wider, Gerhard; Wüthrich, Kurt (2006). Automated resonance assignment of proteins: 6D APSY-NMR. Journal of biomolecular NMR, 35 (1), 27-37.

2005

Hiller, Sebastian; Fiorito, Francesco; Wüthrich, Kurt; Wider, Gerhard (2005). Automated projection spectroscopy (APSY). Proceedings of the National Academy of Sciences of the United States of America, 102 (31), 10876-81.

Hiller, Sebastian; Wider, Gerhard; Etezady-Esfarjani, Touraj; Horst, Reto; Wüthrich, Kurt (2005). Managing the solvent water polarization to obtain improved NMR spectra of large molecular structures. Journal of biomolecular NMR, 32 (1), 61-70.

2004

Tafer, Hakim; Hiller, Sebastian; Hilty, Christian; Fernández, César; Wüthrich, Kurt (2004). Nonrandom structure in the urea-unfolded Escherichia coli outer membrane protein X (OmpX). Biochemistry, 43 (4), 860-9.

2003

Hiller, Sebastian; Kohl, Andreas; Fiorito, Francesco; Herrmann, Thorsten; Wider, Gerhard; Tschopp, Jürg; Grütter, Markus G.; Wüthrich, Kurt (2003). NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. Structure, 11 (10), 1199-205.


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