Nano-diffraction of biological specimens The Abrahams group develops new approaches for using diffraction to determine the atomic structures of proteins and other radiation sensitive nano-size samples. We use diffraction…

Join us! Are you interested in becoming part of the team? Feel free to contact us anytime! We are looking for highly motivated and curious PhD students with a background in theoretical physics, computational biology, applied…

Computational structure biology Protein structure modeling The main interest of our group is the development of methods and algorithms for molecular modeling and simulations of three-dimensional protein structures and their…

TOR signaling and the control of cell growth Cell growth is a highly regulated, plastic process controlled by TOR-dependent pathways in response to nutrients, growth factors and energy. TOR is a major controller of cell…

IMCF guidelines 1. General booking Rules: The user can book a microscope only after having received the appropriate introduction. The instruments can be booked up to 14 days in advance. During daily working hours (9-17h),…

Electron Tomography Application To obtain a 3D model for objects that are too thick or vary too much in size and shape for single particle electron microscopy (≥ 1 micrometer thick), e.g., small cells, cellular organelles…

Uropathogenic Escherichia coli (UPEC) and urinary tract infections (UTIs) Deciphering UPEC in-vivo physiology To truly understand how UPEC behave inside the human bladder, we go straight to the source – analyzing urine…

Research Projects Biophysical Principles of Chaperone Function Molecular chaperones play a key role in cellular processes, including protein homeostasis, but also in membrane protein transport and biogenesis. We employ…

Applications Single particle analysis is generally used to determine the 3D structure of globular proteins and protein complexes at high resolution. Method Grids holding purified protein samples are plunge-frozen in liquid…

Prof. Anissa Kempf on sleep We do it every night and from time to time during the day, too. We sleep. But why actually? And what makes us fall asleep, how does the brain control our sleep? Prof. Anissa Kempf investigates…