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Heat stress reduces lifetime of mRNA molecules

The coronavirus pandemic and the development of the novel vaccines has brought mRNA into the public eye. mRNAs are transcripts of DNA. They serve as a template for protein production and are degraded after a certain time.…


Architecture of cellular control center mTORC2 elucidated

The protein complex mTORC2 plays a crucial role in the regulation of cellular metabolism. It stimulates, for example, the production of lipids and fatty acids, but it also controls carbohydrate metabolism. In the past,…


How neuromuscular connections are maintained after nerve lesions

The protein complex mTORC1 promotes muscle growth and is important for the self-cleaning process of the muscle cells. The role of mTORC1 in skeletal muscle fibers in response to nerve injury has so far not been studied in…


Survival strategy of messenger RNAs during cellular sugar shortage

If a cell encounters a stress situation, whether it is due to nutrient restriction or osmotic shock, the cell reacts immediately to ensure its survival. Prof. Anne Spang’s research group at the Biozentrum of the University…


How the key protein mTOR controls cell growth

Cells proliferate by dividing repeatedly. Each cell division produces two daughter cells, which must first grow to a certain size before they can divide, too. This requires an increased production of cell components,…


Venture Kick support for Biozentrum spin-off Aukera Therapeutics

It was only at the beginning of the year that the Biozentrum spin-off Aukera Therapeutics qualified for the BaseLaunch Accelerator program. Now the two young entrepreneurs Dr. Stefan Imseng and Dr. Dritan Liko can add…


A new layer of control in embryonic development

Genes provide the blueprint for life, determining when and where proteins are made. This process involves two key steps: transcription, from DNA to messenger mRNA (mRNA), and translation, where mRNA is decoded into proteins.…


Liver cancer: Lipid synthesis promotes tumor formation

In Switzerland, about 650 new cases of liver cancer are diagnosed every year. The incidence of the malignant and aggressive liver cell carcinoma has doubled in the last 20 years, especially in developed countries. One…


Aukera Therapeutics qualifies for BaseLaunch funding program

The Biozentrum start-up Aukera Therapeutics was selected to join the BaseLaunch Accelerator Program. With its qualification for this program, the biotech venture receives funding of up to 500,000 Swiss francs as well as…


First Innosuisse project at the Biozentrum

The project entitled «Development of a lead compound for specific mTORC1 inhibition» is the first Innosuisse funded project at the Biozentrum. Replacing the former Swiss Commission for Technology and Innovation (CTI), the…