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Publications, curated

Publication list - curated & annotated Recent highlights Bacteria use a general danger signal to trigger biofilm formation - Nature Microbiology 2025 Mechanical properties of biofilms measured with spatial resolution -…


Targeting the PI3K/mTOR pathway in cancer, immunity and neurodegenerative disease – from scattergun approaches to highly specific covalent inhibitors

Bayesian modelling of single-cell multi-omics data The last decade has witnessed the irresistible rise of single-cell RNA-seq, a technology which can measure simultaneously the mRNA expression levels of thousands of genes in…


Claudia Keller Valsecchi

Out of the Bubble She grew up with three sisters in Pratteln. Chance led her to molecular biology. Claudia Keller Valsecchi, who once studied at the Biozentrum, has now returned as a professor. In this interview, she talks…


Projects

Evolution of viruses and bacteria We want to understand the dynamics of evolution and the forces that drive it. Evolution of plants and animals tend to happen over centuries of even longer time-scales. Microbial organisms,…


New discovery reveals how diatoms capture CO2 so effectively

Diatoms are too small to see with the naked eye, yet they are one of the most productive algae species in the ocean and play an important role in the global carbon cycle. Using photosynthesis, they absorb large amounts of…


Damaged but not defeated: Bacteria use nano-spearguns to retaliate against attacks

In the world of microbes, peaceful coexistence goes hand in hand with fierce competition for nutrients and space. Certain bacteria outcompete rivals and fend off attackers by injecting them with a lethal cocktail using tiny,…


New insights into blood vessel formation

Blood vessels run throughout the entire body, delivering nutrients and oxygen through the circulating blood. During vessel formation, cells first form local lumens, which then fuse to form a continuous tubular network. The…


Not too young to be a researcher - kids@science at the Biozentrum

The kids@science study week at the University of Basel, introduced in 2008, is very popular among the young researchers. This year, some 120 school children have applied to participate. At the end of January, 81 will receive…


Virulence could be the Achilles heel of pathogens

Bacteria are masters of survival. Pathogens, for example, produce a range of molecules enabling them to infect their hosts and to evade the immune defense. The entero-pathogenic bacterium Salmonella enterica Typhimurium uses…


The mystery of sleep: How does the brain know when it’s time to sleep?

Sleep is universal and essential: not only humans, but even flies and jellyfish sleep for a significant portion of the day. Like eating or mating, sleep is also controlled by motivational drives. Our drive to sleep increases…