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Treating muscular disease – Santhera and Biozentrum join forces

Santhera Pharmaceuticals has started a collaboration with Prof. Markus Rüegg, who pioneered a novel gene therapy approach for the treatment of type 1 congenital muscular dystrophy (MDC1A). MDC1A is a severe form of…


"Even Omicron has three variants"

There is talk about Omicron being the beginning of the end and the start of an endemic situation. What exactly does that mean? If the pandemic becomes endemic, it means that a certain balance is established between the virus…


Electron Tomography

Electron Tomography Application To obtain a 3D model for objects that are too thick or vary too much in size and shape for single particle electron microscopy (≥ 1 micrometer thick), e.g., small cells, cellular organelles…


T3 Pharmaceuticals awarded highest endowed startup prize

T3 Pharmaceuticals is one of top five startup companies selected by the W.A. de Vigier Foundation. The winning companies were selected from a record number of 256 applications in a multi-step process. At the award ceremony…


Uropathogenic Escherichia coli (UPEC) and Urinary Tract Infections (UTIs)

Uropathogenic Escherichia coli (UPEC) and urinary tract infections (UTIs) Deciphering UPEC in-vivo physiology To truly understand how UPEC behave inside the human bladder, we go straight to the source – analyzing urine…


Emergence of globular protein folds from random amino acid sequences

Emergence of globular protein folds from random amino acid sequences The origin and evolution of protein folds are among the most challenging, long-standing problems in biology. Emphasizing the challenge, evolutionary…


Aukera Therapeutics Comes Out of Stealth and Enters Preclinical Efficacy Studies

Aukera Therapeutics was founded in 2021 at the Biozentrum, University of Basel. Built on pioneering academic research and deep mTOR expertise, the company is now officially emerging from stealth as it advances its lead…


Past Biozentrum Discovery Seminar Series

Biozentrum Discovery Seminars Biozentrum Discovery (BZD) is a seminar series, which alternates between talks by renowned guest speakers and seminars given by graduate students and postdocs from the Biozentrum. Since its…


"Omicron will be dominant in Europe in about four weeks"

To which extent is Nextstrain currently being used for research into the SARS-CoV-2 virus? We have more data on SARS-CoV-2 than ever before for a single virus. There are now six million fully sequenced virus genomes…


Projects

Research Projects Biophysical Principles of Chaperone Function Molecular chaperones play a key role in cellular processes, including protein homeostasis, but also in membrane protein transport and biogenesis. We employ…