Prof. Dr. Silvia Arber

Biozentrum
University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 282A Phone: +41 61 207 20 57
Email: silvia.arber-at-unibas.ch
Curriculum Vitae

Administrative Assistant

Rose Marie Suter
Biozentrum, Room 210
Phone: +41 61 207 09 30
Fax: +41 61 207 20 78
Email: rose-marie.suter-at-unibas.ch

News

Walking is bound hand and foot: How long projecting neurons couple the movement of our limbs

We humans walk with our feet. This is true, but not entirely. Walking, as part...more

"ERC Advanced Investigator Grant" for Peter Scheiffele and again for Silvia Arber

Prof. Peter Scheiffele from the Biozentrum, University of Basel, and Prof....more

Trigger mechanism for recovery after spinal cord injury revealed

After an incomplete spinal cord injury, the body can partially recover basic...more

Research group Silvia Arber

Motor circuit function

The central question of our research concerns the elucidation of mechanisms involved in function, assembly and plasticity of neuronal circuits controlling motor behavior.

Visualization of spinal interneurons with direct connections to motor neurons.

An important function of the nervous system is the production of diverse motor actions. Motor behavior is guided by a combination of intentions and integration of many occurring stimuli. Complex neuronal circuits transmit instructions for motor program execution from the brain via the spinal cord to muscles, ultimately leading to animal behavior.

Organization and function of neuronal circuits

Precise neuronal wiring through synaptic connections plays an important role for the function of neuronal circuits. Our research aims at elucidating how neuronal circuits involved in motor behavior are organized, function in execution, assemble during development and change plastically during learning. 

Circuit connectivity in the motor system

To understand how motor circuits function, we use multi-facetted approaches combining many technologies. These include state-of-the-art mouse genetics, development and implementation of viral technologies for transsynaptic circuit tracing and functional manipulation by opto- and pharmacogenetics, quantitative behavioral analysis, electrophysiology and gene expression profiling of identified neuronal subpopulations.

Precision and malfunctioning of motor circuits

Our research reveals the existence of precise synaptic interactions within dedicated motor circuit modules throughout the nervous system and how these impact on function. Diseases of the nervous system frequently lead to motor behavioral deficits and spinal cord injury causes immobility. Understanding principles of motor circuit function will be essential for future interventions.