Prof. Dr. Michael N. Hall

University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 512 Phone: +41 61 267 21 50
Curriculum Vitae

Administrative Assistant

Brigitte Olufsen
Biozentrum, Room 510
Phone: +41 61 267 21 45
Fax: +41 61 267 21 48


Canada Gairdner International Award 2015.


Architecture of mTOR protein complex solved

For a long time it has been known that the protein TOR – Target of Rapamycin –...more

Prestigious research prize for Michael N. Hall

On March 25th, 2015, the five winners of this year’s “Canada Gairdner...more

Aberrant mTOR signaling impairs whole body physiology

The protein mTOR is a central controller of growth and metabolism. Deregulation...more

Research group Michael N. Hall

TOR signaling and the control of cell growth

Understanding the molecular mechanisms that control growth and metabolism in health and disease may reveal new therapeutic strategies for a wide variety of disorders.

Model of the catalytic region of human TOR.

Cell growth is a highly regulated, plastic process controlled by TOR-dependent pathways in response to nutrients, growth factors and energy.

TOR is a major controller of cell growth

TOR is a conserved protein kinase that controls a wide range of metabolic processes. More importantly, TOR is a central controller of cell growth that plays a key role in development and ageing. TOR is implicated in many disorders including cancer, cardiovascular disease, diabetes, and obesity. The aim of our research is to elucidate the mechanisms by which TOR is regulated and in turn how it controls its many processes in both health and disease.

Investigating TOR signaling in human tumors

We study TOR signaling and growth control in the yeast Saccharomyces cerevisiae, in mammalian cells, in mice and in human tumors using biochemical, genetic and cell biological approaches. The work with human tumors is a translational research project that relies on close collaborations with clinicians.

New therapeutic strategies

Cell division, growth and death are the most fundamental features of life. Our studies contribute to understanding the important process of cell growth. Understanding TOR signaling and how it is dysregulated in disease may reveal new therapeutic strategies for a wide variety of disorders.