Prof. Dr. Michael N. Hall

Biozentrum
University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 512 Phone: +41 61 267 21 50
Email: m.hall-at-unibas.ch
Curriculum Vitae

Administrative Assistant

Brigitte Olufsen
Biozentrum, Room 510
Phone: +41 61 267 21 45
Fax: +41 61 267 21 48
Email: brigitte.olufsen-at-unibas.ch

Debora Neyer
Biozentrum, Room 508
Phone: +41 61 267 21 51
Fax: +41 61 267 21 48
Email: debbie.neyer-at-unibas.ch

News

Aberrant mTOR signaling impairs whole body physiology

The protein mTOR is a central controller of growth and metabolism. Deregulation...more

Prof. Michael N. Hall - new member of the “National Academy of Sciences”

The biochemist, Prof. Michael N. Hall from the Biozentrum of the University of...more

Prof. Michael N. Hall awarded Breakthrough Prize in Life Sciences 2014

December 12th, 2013, was a memorable day for Prof. Michael Hall. As one of six...more

Research group Michael N. Hall

TOR signaling and the control of cell growth

Understanding the molecular mechanisms that control growth and metabolism in health and disease may reveal new therapeutic strategies for a wide variety of disorders.

Model of the catalytic region of human TOR.

Cell growth is a highly regulated, plastic process controlled by TOR-dependent pathways in response to nutrients, growth factors and energy.

TOR is a major controller of cell growth

TOR is a conserved protein kinase that controls a wide range of metabolic processes. More importantly, TOR is a central controller of cell growth that plays a key role in development and ageing. TOR is implicated in many disorders including cancer, cardiovascular disease, diabetes, and obesity. The aim of our research is to elucidate the mechanisms by which TOR is regulated and in turn how it controls its many processes in both health and disease.

Investigating TOR signaling in human tumors

We study TOR signaling and growth control in the yeast Saccharomyces cerevisiae, in mammalian cells, in mice and in human tumors using biochemical, genetic and cell biological approaches. The work with human tumors is a translational research project that relies on close collaborations with clinicians.

New therapeutic strategies

Cell division, growth and death are the most fundamental features of life. Our studies contribute to understanding the important process of cell growth. Understanding TOR signaling and how it is dysregulated in disease may reveal new therapeutic strategies for a wide variety of disorders.