Prof. Dr. Peter Scheiffele

Biozentrum
University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 276A Phone: +41 61 267 21 94
Email: peter.scheiffele-at-unibas.ch
Curriculum Vitae

Administrative Assistant

Anja Streb
Biozentrum, Room 210
Phone: +41 61 267 21 81
Fax: +41 61 267 20 78
Email: anja.streb-at-unibas.ch

News

Stéphane Baudouin receives Junior Debiopharm Award 2013

Stéphane Baudouin, PostDoc in the laboratory of Peter Scheiffele, has been...more

New regulator discovered for information transfer in the brain

The protein mSYD1 has a key function in transmitting information between...more

EMBO Memberships for Christoph Dehio and Peter Scheiffele

Prof. Christoph Dehio and Prof. Peter Scheiffele from the Biozentrum of the...more

Research group Peter Scheiffele

Mechanisms in the formation of neuronal networks

Knowledge of the cellular and molecular processes that control the development of nerve cell networks in the brain may help us to understand psychiatric disorders.

Synapses in the mouse cerebellum: a climbing fiber axon and its synapses are marked with the green fluorescent protein.

The brain is one of the most fascinating and complex systems in the body. It controls sensory perceptions, emotions, and actions and makes it possible to form memories and learn highly specialized behaviors. Changes in the connectivity and function of neurons underlie disorders such as autism and schizophrenia, which pose significant challenges to today's society.

Bases of neuronal network formation

The aim of our research is to understand the mechanisms in the formation of neuronal networks in the central nervous system. We are therefore primarily investigating the cellular interactions and molecular signals that regulate neuronal connectivity during embryonic and postnatal development of the brain.

Synapses as key sites

We are focusing on the study of synapses, the information interfaces of neuronal networks. We are seeking to understand how synapses are formed, in particular how neurons recognize the correct synaptic partners and initiate neuronal links with them, and how inappropriate connections are eliminated. We apply a broad range of molecular, anatomic, and electrophysiological methods that allow us to analyze the specificity and function of neuronal synapses in the intact brain tissue of transgenic mice and in cultured cells.

Models for psychiatric disorders

Our experimental models for mechanisms of neuronal network formation serve not only the aims of basic research but also provide insights into functional changes that occur in disease. We analyze the neuronal consequences of risk factors for autism and apply our models to test therapeutic strategies.