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Making and moving synaptic vesicles

Synaptic vesicles have a well-defined composition at the synapse and are essential for neuronal function. Synaptic vesicle proteins (SVps) are trafficked in SV precursors out of the cell body into axons dependent on the kinesin motor UNC-104/KIF1A. We identify potential routes of trafficking some SV proteins. We identify potential routes and genetic pathways for excluding non-synaptic vesicle proteins from SVp transport carriers, for recruiting the synaptic vesicle motor & for efficient transport of the SVp carriers from the neuronal cell body. These genes UNC-16/JIP3, LRK-1/LRRK2, the BORC complex, AP3 and the active zone protein SYD-2/Liprin-alpha act in a hierarchical manner. These pathways also play critical roles in polarized trafficking of synaptic vesicle proteins to prevent their entry into dendrites.