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Laura de Smalen, PhD Student, Group Handschin Why did you decide to do a PhD? During my bachelor's in Nutrition and Dietetics, I developed a strong interest in the causes and mechanisms that underlie the human diseases that…

Evolution of viruses and bacteria We want to understand the dynamics of evolution and the forces that drive it. Evolution of plants and animals tend to happen over centuries of even longer time-scales. Microbial organisms,…

Stem cells and their niche in the adult mammalian brain Neural stem cells continuously generate new neurons in restricted areas of the adult mammalian brain. Adult stem cells reside in specialized niches that support their…

Starting immediately or as per agreement How does life emerge from molecules and cells? This is the central question that motivates us. With curiosity and passion, we investigate the entire spectrum ranging from the atom to…

Principles of intracellular organization Asymmetry is an inherent property of most cells. Proteins and mRNA have to be distributed at specific cellular locales to perform their assigned function or to be translated in a…

Uropathogenic Escherichia coli (UPEC) and urinary tract infections (UTIs) Deciphering UPEC in-vivo physiology To truly understand how UPEC behave inside the human bladder, we go straight to the source – analyzing urine…

Computational structure biology Protein structure modeling The main interest of our group is the development of methods and algorithms for molecular modeling and simulations of three-dimensional protein structures and their…

Cell signaling and dynamics in bacterial growth, adaptation, and persistence Our studies aim at understanding the molecular and cellular principles involved in the growth, differentiation and behavior of bacterial cells. We…

Motor circuit function Behavior is the common output of the nervous system. Despite their importance, the mechanisms by which neuronal circuits produce actions appropriately aligned with needs and intentions are poorly…

Nuclear magnetic resonance spectroscopy of biomolecules We apply and develop high-resolution Nuclear Magnetic Resonance (NMR) methods to elucidate structure, function, and dynamics of biological macromolecules. The…