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Single Particles

Applications Single particle analysis is generally used to determine the 3D structure of globular proteins and protein complexes at high resolution. Method Grids holding purified protein samples are plunge-frozen in liquid…


FEI Talos F200C TEM

FEI Talos F200C TEM Configuration 200kV FEG Optics. Cryo-capable with insertable/retactable cryo box. Gatan 626 side-entry cryo holders (LN2 temperature). FEI Ceta 16M Pixel CMOS camera. STEM function. The Talos instrument…


Research Data Management

Where to find information on (image) data management General Research Data Management (RDM) information: Clickable overview to all different aspects of RDM: rdmkit.elixir-europe.org Recommended Metadata for Biological…


Projects

Research Projects The central theme of our research is to understand how stochastic interactions of cells and molecules control the functional behaviour of multicellular systems. We specifically focus on how cells interact…


Projects

Research projects We investigate the physiology of bacterial pathogens ( Salmonella , Pseudomonas , Staphylococcus ) in infected rodent and human tissues, focusing on single-cell behavior and potential applications for novel…


TFS Titan Krios G4

TFS Titan Krios G4 TEM Configuration The Titan Krios G4 from Thermo Fisher Scientific is a high-end transmission cryo-electron microscope designed for ultimate performance and productivity across a wide range of Life Science…


Thermo Fisher Scientific Glacios TEM

Thermo Fisher Scientific Glacios TEM Configuration 200kV X-FEG optics. C-TWIN objective lens. Autoloader for multi-grid loading at cryo-LN2 temperature and automated exchange of grid to column. The Glacios instrument is…


Video Publications

Video Engineered kinases as a tool for phosphorylation of selected targets in vivo "The Dawn of Life" Cells into organs. Forscherportrait Prof. Markus Affolter (German) University of Basel: Interview Prof. Dr. Markus…


Movies

Movies Bacterial nanosized speargun Dynamics of T6SS sheath in Vibrio cholerae. (Basler et al., Nature 2012) Dueling between green Pseudomonas aeruginosa cells (ClpV-GFP) and killing of red Vibrio cholerae cells…


NMJ maintenance and remodeling

NMJ maintenance and remodeling The neuromuscular junction (NMJ) is a chemical synapse that transmits motor neuron action potentials into muscle fiber action potentials (see Figure below). Without this connection, muscle…