Electron Tomography Application To obtain a 3D model for objects that are too thick or vary too much in size and shape for single particle electron microscopy (≥ 1 micrometer thick), e.g., small cells, cellular organelles…
Applications Single particle analysis is generally used to determine the 3D structure of globular proteins and protein complexes at high resolution. Method Grids holding purified protein samples are plunge-frozen in liquid…
Protein Filaments Applications To determine the structure of filaments and their subunits at high resolution. Method Grids holding purified filament samples are plunge-frozen in liquid ethane and imaged. The 3D structure(s)…
Cryo-FIB milling Application A specialized technique for TEM specimen preparation to mill a bulk specimen with focused gallium (Ga) ions. The target region of the specimen can be selectively thinned down to a desired shape…
Thin Sectioning Application To determine the ultrastructure of whole tissues and cells at ~2nm resolution by transmission electron microscopy (TEM). Method Tissues or cells are chemically fixed, dehydrated, embedded in resin…
FEI Titan Krios TEM (300kV) Top left: Front protective enclosure of the Titan Krios. Top right: Detail of the microscope from inside the enclosure, showing the complexity of the microscope mainframe. Bottom: Operation…
Thermo Fisher Scientific Glacios TEM Configuration 200kV X-FEG optics. C-TWIN objective lens. Autoloader for multi-grid loading at cryo-LN2 temperature and automated exchange of grid to column. The Glacios instrument is…
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