40 Years of the Homeobox@Biozentrum
The Symposium on October 1st, 2024, in the new Biozentrum building is aimed at celebrating the discovery of the homeobox 40 years ago with a lineup of selected speakers covering the topic from the past to the future.
The conservation of the homeobox from invertebrates to vertebrates, identified by the Gehring and De Robertis labs at the Biozentrum in 1984, marks a significant breakthrough in developmental biology. The homeobox is a specific DNA sequence found in homeobox genes that is essential for regulating the development of organisms. These genes encode transcription factors that control the expression of other genes, ensuring the proper development of body segments and organs.
The discovery of the conservation of these sequences across different species, from fruit flies (Drosophila) to mammals, was revolutionary, for it suggested that genes at work during invertebrate and vertebrate development had been evolutionary conserved over hundreds of millions of years.
October 1st 2024
Biozentrum, University of Basel, Switzerland
Organizer: Markus Affolter
Zoom Link
The meeting can also be attended via Zoom. For the access data please write to: markus.affolterunibasch.
click to download poster
Program 40 Years HOX Conservation | |
| Program download PDF File | |
| 09:00-09:15 | Opening statement Alex Schier, Director, Biozentrum, University of Basel, Switzerland |
| Chair: Bill McGinnis | |
| 09:15-10:00 | Mike Levine, Princeton University, USA "From Hox Stripes to Behavior" |
| 10:00-10:45 | Ingrid Lohmann, University of Heidelberg, Germany "The Role of Hox Genes in Shaping my Career Axis" |
| 10:45-11:30 | Coffee break |
| 11:30-12:15 | Richard Mann, Zuckerman Institute/Columbia University, USA "Understanding Transcription Factor Specificity with a Hox Lens" |
| 12:15-13:00 | Marie Kmita, Institut de Recherches Cliniques de Montréal, Canada "Hox Pioneering Function" |
| 13:00-14:00 | Lunch |
| 14:00-14:45 | Nicoletta Bobola, University of Manchester, UK "Specific Reconfiguration of Transcription Networks by Homeodomain Combinatorial Binding" |
| 14:45-15:30 | Denis Duboule, EPFL, Switzerland "Of Läckerli and Hox Genes" |
| 15:30-16:15 | Coffee break |
| 16:15-17:00 | Deneen M. Wellik, University of Wisconsin-Madison, USA "HoxPG11 Regulation of Osteochondrial Differentiation" |
| 17:00-17:45 | Eddy De Robertis, University of California, USA "The Homeobox and the Evo-Devo Revolution" |
| 17:45- | Apéro |
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