Human Frontier Science Program: In search of conserved mRNA localization and anchoring mechanisms We have started a new international collaborative program with Prof. Chris Brown (University of Otago, Dunedin, New Zealand)…
Gesetze der Organisation in der Zelle Die korrekte Verteilung von Proteinen und Boten-RNA (mRNA) stellt das Überleben von Zellen sicher. Nur die spezifische Platzierung dieser Moleküle ermöglicht die Entwicklung vielzelliger…
Muscle aging Rapid advances in treating life-threatening, age-related diseases, such as cancer and cardiovascular disease, have extended human lifespan in many developed countries. However, greater longevity has meant more…
Publication list - curated & annotated Recent highlights Bacteria use a general danger signal to trigger biofilm formation - Nature Microbiology 2025 Mechanical properties of biofilms measured with spatial resolution -…
TOR signaling and control of cell growth Fig. 1: Architecture of human mTOR complex 1 Introduction Cell growth is highly regulated. Cells respond to nutrients or other appropriate growth stimuli by up-regulating…
Principles of intracellular organization Asymmetry is an inherent property of most cells. Proteins and mRNA have to be distributed at specific cellular locales to perform their assigned function or to be translated in a…
We study the cellular organization and regulation of metabolism by large macromolecular assemblies as well as giant microbial biosynthetic assembly lines. Our research builds on hybrid use of state-of-the-art cryo electron…
Programme zur Steuerung der Genexpression Obwohl das genetische Material in allen Zellen unseres Körpers mehr oder weniger identisch ist, unterscheidet sich von Zelltyp zu Zelltyp, welche Gene und wie sie abgelesen werden,…
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