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Normalerweise ist die Myc-Konzentration im Muskel niedrig und steigt bei Wachstumsreizen, wie z. B. körperlicher Betätigung. Aufgrund der Tatsache, dass Myc an vielen Wachstumsprozessen beteiligt ist, nahm man bisher an,…

Information flow in self-organized developmental systems Embryonic development is a spectacular display of self-organization of multi-cellular systems, combining transformations of tissue mechanics and patterns of gene…

M. tuberculosis phenotypic diversity in vivo Mycobacterium tuberculosis (Mtb) exhibits remarkable phenotypic diversity, enabling its adaptation to various host environments. The diversity of in vivo niches at granuloma,…

Deconstructing the stress response: molecules, circuits, and behavior Chronic stress is a major risk factor for the development of neuropsychiatric disease. Given the complexity of the stress response, our lab tries to…

Marcin Koltunski is an architect working for the Burckhardt Architecture cabinet in Basel, where he specialized in the design and development of public buildings. His academic path led him to study in multiple countries…

Publications

Publications

From uncharted sequence space to de novo proteins From uncharted sequence space to de novo proteins Biological proteins form mostly tightly clustered families in the pool of possible combinations of canonical amino acids.…

Laufen, atmen oder schreiben – all diese Bewegungen wären ohne unsere Muskeln nicht möglich. Die Anweisung dazu geben die Nerven, die über eine neuromuskuläre Kontaktstelle mit dem Muskel kommunizieren. Eine Schädigung oder…

Predicting interaction partners and generating new protein sequences using protein language models Protein sequences are shaped by functional optimization on the one hand and by evolutionary history, i.e. phylogeny, on the…